基本信息
雷敏 男 硕导 中国科学院上海药物研究所
电子邮件: mlei@simm.ac.cn
通信地址: 上海浦东新区松涛路647弄
邮政编码: 201203
电子邮件: mlei@simm.ac.cn
通信地址: 上海浦东新区松涛路647弄
邮政编码: 201203
招生信息
招生专业
100701-药物化学100800-中药学
招生方向
药物合成
教育背景
2007-09--2010-12 华东理工大学 博士2004-09--2007-06 浙江工业大学 硕士1997-09--2001-06 浙江工业大学 学士
工作经历
工作简历
2013-10~2018-06,中国科学院上海药物研究所, 副研究员2013-03~2013-10,中国科学院上海药物研究所, 助理研究员2011-03~2013-03,中国科学院上海药物研究所, 博士后2007-09~2010-12,华东理工大学, 博士2004-09~2007-06,浙江工业大学, 硕士1997-09~2001-06,浙江工业大学, 学士
专利与奖励
专利成果
( 1 ) 参芪提取物及其活性组分在恶病质及其相关疾病中的应用, 2023, 第 3 作者, 专利号: CN115671158A( 2 ) 乌天麻的高效液相色谱鉴别方法, 2023, 第 3 作者, 专利号: CN115598229A( 3 ) 5-Fu损伤模型及其构建方法、参芪制剂的质量评控方法, 2022, 第 3 作者, 专利号: CN115449509A( 4 ) 大戟属中草药的质量检测方法, 2022, 第 4 作者, 专利号: CN115236212A( 5 ) 天麻均一多糖及其制备方法和应用, 2022, 第 2 作者, 专利号: CN114805629A( 6 ) 参芪提取物及其活性组分在制备治疗或预防中枢神经炎症药物中的应用, 2022, 第 3 作者, 专利号: CN114632085A( 7 ) 蟾酥甾二烯衍生物及其制备方法和应用, 2022, 第 2 作者, 专利号: CN114507268A( 8 ) 蟾酥甾二烯衍生物及其制备方法和应用, 2022, 第 2 作者, 专利号: CN114507268A( 9 ) 沙蟾毒精衍生物及其制备方法、包含该衍生物的组合物、及其用途, 2022, 第 4 作者, 专利号: CN110483608B( 10 ) 蟾酥甾二烯衍生物及其制备方法和应用、药物组合物, 2021, 第 2 作者, 专利号: CN112920253A( 11 ) 欧夹竹桃苷衍生物及其制备方法、药物组合物和用途, 2021, 第 2 作者, 专利号: CN112778393A( 12 ) 沙蟾毒精衍生物及其制备方法、包含该衍生物的组合物、及其用途, 2019, 第 4 作者, 专利号: CN110483608A( 13 ) 基于离线2D LC-MS结合代谢物预测三七叶皂苷成分的方法, 2019, 第 5 作者, 专利号: CN109596766A( 14 ) 一类磺酰胺基取代的酰胺类衍生物在制备用于治疗阿尔茨海默病的药物中的用途, 2017, 第 3 作者, 专利号: CN106466313A( 15 ) 一类牛蒡子苷元氨基甲酸酯衍生物在制备用于治疗阿尔茨海默病的药物中的用途, 2016, 第 3 作者, 专利号: CN105616400A( 16 ) 4′-氨基-4′-去羟基-欧夹竹桃苷和4′-氨基-4′-去羟基-夹竹苷A及其用途, 2015, 第 3 作者, 专利号: CN105037474A( 17 ) 一类反式-1-(吲哚-3-基)-2-(喹啉-4-基)-乙烯衍生物的用途及组合物, 2015, 第 3 作者, 专利号: CN104840461A( 18 ) 一类二芳酰胺类衍生物及其制备方法、药物组合物及用途, 2015, 第 5 作者, 专利号: CN104341316A( 19 ) 一种用于治疗阿尔茨海默病的制剂及其制备方法, 2014, 第 3 作者, 专利号: CN104069263A( 20 ) 缩酚酸衍生物的用途, 2014, 第 4 作者, 专利号: CN103664623A( 21 ) 蟾毒灵衍生物、其制备方法、药物组合物及用途, 2014, 第 3 作者, 专利号: CN103570792A( 22 ) 原人参二醇衍生物及其制备方法、包含该衍生物的组合物及其用途, 2014, 第 5 作者, 专利号: CN103570790A( 23 ) 牛蒡子苷元碳酰胺衍生物及其制备方法、包含该衍生物的组合物、及其用途, 2013, 第 4 作者, 专利号: CN103467417A( 24 ) 文朵灵衍生物的医药用途, 2013, 第 4 作者, 专利号: CN103304565A( 25 ) 蟾毒配基衍生物及其制备方法、包含该衍生物的组合物、及其用途, 2012, 第 6 作者, 专利号: CN102532235A
出版信息
发表论文
(1) Design, synthesis and biological evaluation of betulinic acid derivatives as potential inhibitors of 3CL-protease of SARS-CoV-2, STEROIDS, 2024, 第 6 作者 通讯作者(2) An improved strategy for identification and annotation of easily in-sourced dissociation diterpene lactones from plant natural products: Taking Andrographis paniculata (Burm. f.) as an example, RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 2023, 第 11 作者(3) Lung CT image enhancement based on total variational frame and wavelet transform, INTERNATIONAL JOURNAL OF IMAGING SYSTEMS AND TECHNOLOGY, 2022, 第 4 作者(4) Information Entropy-Based Strategy for the Quantitative Evaluation of Extensive Hyperspectral Images to Better Unveil Spatial Heterogeneity in Mass Spectrometry Imaging, ANALYTICAL CHEMISTRY, 2022, 第 10 作者(5) Structural Characterization of a Polysaccharide from Gastrodia elata and Its Bioactivity on Gut Microbiota, MOLECULES, 2021, 第 2 作者(6) Structural characterization of two novel polysaccharides from Gastrodia elata and their effects on Akkermansia muciniphila, INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2021, 第 2 作者(7) Restoring perturbed oxylipins with Danqi Tongmai Tablet attenuates acute myocardial infarction, PHYTOMEDICINE, 2021, 第 8 作者(8) A five-dimensional data collection strategy for multicomponent discovery and characterization in Traditional Chinese Medicine: Gastrodia Rhizoma as a case study, JOURNAL OF CHROMATOGRAPHY A, 2021, 第 11 作者 通讯作者(9) A new method for the synthesis of chalcone derivatives promoted by PPh3/I(2)under non-alkaline conditions, SYNTHETIC COMMUNICATIONS, 2021, 第 9 作者 通讯作者(10) An unexpected reaction of cinobufagin analogues in the presence of PPh3/I-2, MONATSHEFTE FUR CHEMIE, 2020, 第 8 作者 通讯作者(11) PPh3/I-2-catalyzed one-pot synthesis of 4,6-diarylpyrimidin-2(1H)-ones, SYNTHETIC COMMUNICATIONS, 2020, 第 2 作者(12) A Network-Based Approach to Explore the Mechanisms of Uncaria Alkaloids in Treating Hypertension and Alleviating Alzheimer���s Disease, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 第 5 作者(13) Design, synthesis and anti-tumor activities of carbamate derivatives of cinobufagin, STEROIDS, 2020, 第 5 作者 通讯作者(14) Active constituents and mechanisms of Respiratory Detox Shot, a traditional Chinese medicine prescription, for COVID-19 control and prevention: Network-molecular docking-LC���MS E analysis, JOURNAL OF INTEGRATIVE MEDICINE-JIM, 2020, 第 11 作者(15) Synthesis of oleandrin derivatives and their cytotoxic activity, STEROIDS, 2020, 第 7 作者 通讯作者(16) Quantitative analysis of fourteen bufadienolides in Venenum Bufonis crude drug and its Chinese patent medicines by ultra-high performance liquid chromatography coupled with tandem mass spectrometry, JOURNAL OF ETHNOPHARMACOLOGY, 2020, 第 6 作者(17) Gastrodia elata Blume Polysaccharides: A Review of Their Acquisition, Analysis, Modification, and Pharmacological Activities, MOLECULES, 2019, 第 7 作者 通讯作者(18) PPh3/I-2/HCOOH: An efficient CO source for the synthesis of phthalimides, TETRAHEDRON, 2019, 第 3 作者 通讯作者(19) Palladium-catalyzed carbonylative Sonogashira cross-coupling for the synthesis of alkynones with formic acid as the CO source, MONATSHEFTE FUR CHEMIE, 2019, 第 5 作者 通讯作者(20) Novel C-17 spirost protostane-type triterpenoids from Alismaplantago-aquatica with anti-inflammatory activity inCaco-2cells, ACTA PHARMACEUTICA SINICA B, 2019, 第 4 作者(21) Novel C-17 spirost protostane-type triterpenoids from Alisma plantago-aquatica with antiinflammatory activity in Caco-2 cells, Novel C-17 spirost protostane-type triterpenoids from Alismaplantago-aquaticawith anti-inflammatory activity inCaco-2cells, 药学学报:英文版, 2019, 第 4 作者(22) A high-efficiency strategy integrating offline two-dimensional separation and data post-processing with dereplication: Characterization of bufadienolides in Venenum Bufonis as a case study, JOURNAL OF CHROMATOGRAPHY A, 2019, 第 8 作者(23) Four New Depsides Isolated from Salvia miltiorrhiza and Their Significant Nerve-Protective Activities, MOLECULES, 2018, 第 5 作者(24) A green, efficient and rapid procedure for the hydrogenation of nitroarenes to formanilides in water medium, Monatsh. Chem. 2018, 149, 527–533, 2018, 第 1 作者 通讯作者(25) A green, efficient, and rapid procedure for the hydrogenation of nitroarenes to formanilides in water, MONATSHEFTE FUR CHEMIE, 2018, 第 4 作者 通讯作者(26) Compact system for onsite calibration of 1000kV voltage transformers, IETSCIENCEMEASUREMENTTECHNOLOGY, 2018, 第 3 作者(27) Discovery and structure-activity relationships study of thieno2,3-bpyridine analogues as hepatic gluconeogenesis inhibitors, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 第 4 作者(28) Design, synthesis and biological evaluation of LX2343 derivatives as neuroprotective agents for the treatment of Alzheimer's disease, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 第 4 作者(29) Synthesis and glucose-stimulate insulin secretion (GSIS) evaluation of vindoline derivatives, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 第 3 作者 通讯作者(30) A l(1) Norm Based Image Prior Combination in Multiframe Superresolution, MATHEMATICAL PROBLEMS IN ENGINEERING, 2017, 第 1 作者(31) Thamnolia vermicularis extract improves learning ability in app/ps1 transgenic mice by ameliorating both a beta and tau pathologies, ACTA PHARMACOLOGICA SINICA, 2017, 第 3 作者(32) Two new dimmeric xanthanolides isolated from Xanthiurn mogolium Kitag plant, TETRAHEDRON LETTERS, 2017, 第 4 作者 通讯作者(33) Two new dimmeric xanthanolides isolated from Xanthium mogolium Kitag plant, TETRAHEDRON LETTERS, 2017, 第 4 作者(34) 莪术二酮转化为莪术醇的方法优化, The optimization on transformation from Curdione to Curcumol, 武汉轻工大学学报, 2017, 第 3 作者(35) Palladium-Catalyzed Formylation of Aryl Iodides with HCOOH as CO Source, ORGANIC LETTERS, 2017, 第 4 作者 通讯作者(36) Thamnolia vermicularis extract improves learning ability in APP/PS1 transgenic mice by ameliorating both A�� and Tau pathologies, ACTA PHARMACOLOGICA SINICA, 2017, 第 3 作者(37) Pd(II)-catalyzed cascade Heck/intramolecular C(sp2)���H amidation reaction: An efficient route to 4-aryl-2-quinolinones, TETRAHEDRON, 2017, 第 3 作者 通讯作者(38) A facile and efficient method for the synthesis of N-substituted isoindolin-1-one derivatives under Pd(OAc)2/HCOOH system, TETRAHEDRON LETTERS, 2017, 第 6 作者 通讯作者(39) Knockdown of Apolipoprotein E Enhanced Sensitivity of Hep3B Cells to Cardiac Steroids via Regulating Na+/K+-ATPase Signalosome, MOLECULAR CANCER THERAPEUTICS, 2016, 第 6 作者(40) Synthesis and biological evaluation of bufalin-3-yl nitrogen-containing-carbamate derivatives as anticancer agents, STEROIDS, 2016, 第 1 作者 通讯作者(41) A facile and efficient method for the synthesis of alkynone by carbonylative Sonogashira coupling using CHCl3 as the CO source, RSC ADVANCES, 2016, 第 2 作者 通讯作者(42) Synthesis and decreasing A�� content evaluation of arctigenin-4-yl carbamate derivatives, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2016, 第 3 作者(43) Synthesis and decreasing a beta content evaluation of arctigenin-4-yl carbamate derivatives, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2016, 第 3 作者 通讯作者(44) Synthesis and decreasing Ab content evaluation of arctigenin-4-yl carbamate derivatives, Bioorg. Med. Chem. Lett. 2016, 26, 2988–2991, 2016, 第 1 作者 通讯作者(45) Synthesis and cytotoxicity evaluation of 4 '-amino-4 '-dehydroxyloleandrin derivatives, FITOTERAPIA, 2016, 第 2 作者 通讯作者(46) Acetohydrazone: A Transient Directing Group for Arylation of Unactivated C(sp(3))-H Bonds, ORGANIC LETTERS, 2016, 第 2 作者 通讯作者(47) Synthesis of 3,4-disubstituted-furan-2(5H)-one derivatives by Suzuki���Miyaura reaction, TETRAHEDRON, 2015, 第 1 作者(48) BBT improves glucose homeostasis by ameliorating beta-cell dysfunction in type 2 diabetic mice, JOURNAL OF ENDOCRINOLOGY, 2015, 第 4 作者(49) Synthesis and cytotoxicity evaluation of 4-amino-4-dehydroxylarctigenin derivatives in glucose-starved A549 tumor cells, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2015, 第 1 作者(50) Catalyst-free synthesis of isoindolin-1-imine derivatives via multi-component reaction in water medium, MONATSHEFTE FUR CHEMIE, 2015, 第 3 作者 通讯作者(51) Ullmann-type C���N coupling reaction catalyzed by CuI/metformin, TETRAHEDRON, 2014, 第 3 作者 通讯作者(52) Synthesis of 1,2-disubstituted 1,2-dihydropyrrolo3,4-bindol-3(4H)-one derivatives, MONATSHEFTE FUR CHEMIE, 2014, 第 3 作者 通讯作者(53) Synthesis of 1-aryl indoles via coupling reaction of indoles and aryl halides catalyzed by CuI/metformin, TETRAHEDRON, 2014, 第 2 作者 通讯作者(54) Synthesis of C-10 Tabersonine Analogues by Palladium-Catalyzed Cross-Coupling Reactions, SYNTHESIS-STUTTGART, 2014, 第 2 作者 通讯作者(55) SIMPLE AND EFFICIENT METHOD FOR THE SYNTHESIS OF 1-((ARYL)(2-OXOINDOLIN-3-YL-)METHYL)UREA AND 1-((ARYL)(2-OXOINDOLIN-3-YL-)METHYL)THIOUREA DERIVATIVES, SYNTHETIC COMMUNICATIONS, 2014, 第 2 作者 通讯作者(56) Design, synthesis, and SAR of embelin analogues as the inhibitors of PAI-1 (plasminogen activator inhibitor-1), BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2014, 第 5 作者(57) Cytotoxic cucurbitane triterpenoids isolated from the rhizomes of Hemsleya amabilis, FITOTERAPIA, 2014, 第 4 作者(58) Synthesis of 2-substituted-3-(1H-indol-3-yl)-isoindolin-1-one derivatives in water under catalyst-free conditions, GREEN CHEMISTRY, 2014, 第 2 作者(59) Synthesis and structure���activity relationships study of cytotoxic bufalin 3-nitrogen-containing-ester derivatives, STEROIDS, 2013, 第 4 作者(60) 20(S)-Protopanaxadiol (PPD) analogues chemosensitize multidrug-resistant cancer cells to clinical anticancer drugs, BIOORGANIC & MEDICINAL CHEMISTRY, 2013, 第 5 作者(61) Cytotoxic cardenolides from the root bark of Calotropis gigantea, STEROIDS, 2013, 第 2 作者 通讯作者(62) A green and efficient ammonium acetate-catalyzed one-pot synthesis of 4-(2-hydroxynaphthalen-1-yl)(phenyl)methyl-3-methyl-1H-pyrazol-5-ol derivatives, MONATSHEFTE FUR CHEMIE, 2013, 第 2 作者 通讯作者(63) Synthesis and biological evaluation of arctigenin ester and ether derivatives as activators of AMPK, BIOORGANIC & MEDICINAL CHEMISTRY, 2013, 第 4 作者(64) A facile and efficient method for the synthesis of N-substituted 3-oxoisoindoline-1-carbonitrile derivatives catalyzed by sulfamic acid, ARKIVOC, 2013, 第 3 作者 通讯作者(65) Synthesis of benzo-annulated 1,3-oxazine derivatives through the multi-component reaction of arynes with N-heteroaromatics and aldehydes or ketones, TETRAHEDRON, 2013, 第 2 作者 通讯作者(66) Thiamine hydrochloride (VB1)-catalyzed one-pot synthesis of (E)-N-benzylidene-2-phenyl-1H-benzodimidazo1,2-aimidazol-3-amine derivatives, TETRAHEDRON, 2013, 第 2 作者 通讯作者(67) Synthesis of 3-(1H-benzodimidazol-1-yl)isoindolin-1-one derivatives promoted by EtOH���AcOH solvent system, TETRAHEDRON LETTERS, 2013, 第 3 作者 通讯作者(68) Catalyst-free one-pot synthesis of isoindolin-1-imine derivatives via three-component reaction, ARKIVOC, 2013, 第 4 作者 通讯作者(69) A catalyst-free reaction in water: synthesis of benzo4,5imidazo1,2-apyrimido4,5-dpyrimidin-4(1H)-one derivatives, GREEN CHEMISTRY, 2012, 第 2 作者(70) Facile and green method for the synthesis of 4-amino-1,2-dihydrobenzo 4,5imidazo1,2-apyrimidine-3-carbonitriles catalysed by ammonium acetate, JOURNAL OF CHEMICAL RESEARCH, 2012, 第 3 作者 通讯作者(71) 长期施肥对水稻土有机碳分布及化学结合形态的影响, Effects of long-term fertilization on the distribution patterns and chemically bound forms of organic carbon in paddy soils., 生态学杂志, 2012, 第 1 作者(72) Thiamine hydrochloride (VB1): an efficient promoter for the one-pot synthesis of benzo4,5imidazo1,2-apyrimidine and 1,2,4triazolo1,5-a pyrimidine derivatives in water medium, GREEN CHEMISTRY, 2012, 第 2 作者(73) ONE-POT SYNTHESIS OF 1H-BENZIMIDAZOLE DERIVATIVES USING THIAMINE HYDROCHLORIDE AS A REUSABLE ORGANOCATALYST, SYNTHETIC COMMUNICATIONS, 2012, 第 1 作者(74) Thiamine hydrochloride (VB1) as an efficient promoter for the one-pot synthesis of 2,3-dihydroquinazolin-4(1H)-ones, TETRAHEDRON LETTERS, 2012, 第 3 作者 通讯作者(75) Novel One-Pot Synthesis of 2-Substituted 3-Alkoxyisoindolin-1-imine Derivatives from 2-Cyanobenzaldehyde, Amine, and Alcohol, SYNTHESIS-STUTTGART, 2012, 第 3 作者 通讯作者(76) Synthesis of 8-oxoprotoberberines using acid-mediated cyclization or the Heck reaction, MONATSHEFTE FUR CHEMIE, 2012, 第 5 作者 通讯作者(77) Ceric ammonium nitrate-promoted oxidative coupling reaction for the synthesis and evaluation of a series of anti-tumor amide anhydrovinblastine analogs, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 第 2 作者(78) First total synthesis of salvianolic acid C, tournefolic acid A, and tournefolal, ARKIVOC, 2012, 第 3 作者 通讯作者(79) A facile protocol for the synthesis of 4-aryl-1,4,7,8-tetrahydro-3,5-dimethyldipyrazolo3,4-b:4 ',3 '-epyridine derivatives by a Hantzsch-type reaction, MONATSHEFTE FUR CHEMIE, 2011, 第 2 作者 通讯作者(80) An unexpected multi-component reaction to synthesis of 3-(5-amino-3-methyl-1H-pyrazol-4-yl)-3-arylpropanoic acids in ionic liquid, TETRAHEDRON LETTERS, 2011, 第 2 作者 通讯作者(81) A facile and efficient method for the synthesis of solasodine from diosgenin, TETRAHEDRON, 2011, 第 3 作者(82) Potential AMPK activators of cucurbitane triterpenoids from Siraitia grosvenorii Swingle, BIOORGANIC & MEDICINAL CHEMISTRY, 2011, 第 4 作者(83) A green, efficient, and rapid procedure for the synthesis of 2-amino-3-cyano-1,4,5,6-tetrahydropyrano3,2-cquinolin-5-one derivatives catalyzed by ammonium acetate, TETRAHEDRON LETTERS, 2011, 第 1 作者(84) ChemInform Abstract: Acetohydrazone: A Transient Directing Group for Arylation of Unactivated C(sp3)���H Bonds., CHEMINFORM, 第 2 作者
科研活动
科研项目
( 1 ) 基于“靶向递送-低氧激活”策略的蟾酥甾二烯抗肿瘤前药研究, 负责人, 国家任务, 2023-01--2026-12( 2 ) 靶向自噬的抗AD个性化药物先导物的发现, 负责人, 中国科学院计划, 2016-06--2018-06