基本信息

朱凌 女 硕导 国家纳米科学中心
电子邮件: zhul@nanoctr.cn
通信地址: 北京市中关村北一条11号
邮政编码:
电子邮件: zhul@nanoctr.cn
通信地址: 北京市中关村北一条11号
邮政编码:
招生信息
招生专业
0703J1-纳米科学与技术
招生方向
纳米生物医学
教育背景
2009-05--2013-06 西班牙国立巴斯克大学(Universidad del País Vasco, España) 分子生物和生物医学博士
2005-10--2006-10 英国约克大学(University of York, UK) 生物信息硕士
2000-09--2005-07 重庆医科大学 临床医学学士
2005-10--2006-10 英国约克大学(University of York, UK) 生物信息硕士
2000-09--2005-07 重庆医科大学 临床医学学士
工作经历
工作简历
2020-04~现在, 国家纳米科学中心, 特聘研究员
2018-02~现在, 国家纳米科学中心, 副研究员
2015-10~2018-01,国家纳米科学中心, 助理研究员
2013-10~2015-09,国家纳米科学中心, 博士后
2009-05~2013-06,西班牙国立巴斯克大学(Universidad del País Vasco, España), 分子生物和生物医学博士
2006-10~2008-09,英国伦敦大学玛丽王后学院(Queen Mary Universiy of London, UK), 工程师
2005-10~2006-10,英国约克大学(University of York, UK), 生物信息硕士
2000-09~2005-07,重庆医科大学, 临床医学学士
2018-02~现在, 国家纳米科学中心, 副研究员
2015-10~2018-01,国家纳米科学中心, 助理研究员
2013-10~2015-09,国家纳米科学中心, 博士后
2009-05~2013-06,西班牙国立巴斯克大学(Universidad del País Vasco, España), 分子生物和生物医学博士
2006-10~2008-09,英国伦敦大学玛丽王后学院(Queen Mary Universiy of London, UK), 工程师
2005-10~2006-10,英国约克大学(University of York, UK), 生物信息硕士
2000-09~2005-07,重庆医科大学, 临床医学学士
社会兼职
2023-04-29-2027-05-30,中国生物医学工程学会医学检验工程分会青年副主任委员, 青年副主任委员
专利与奖励
专利成果
( 1 ) 一种类肽及其制备方法和应用, 2020, 第 1 作者, 专利号: 201710081264.8
( 2 ) 一种类肽及其制备方法和应用, 2020, 第 2 作者, 专利号: 201710124106.6
( 3 ) 羧基化量子点编码荧光微球及其制备方法和应用, 2020, 第 3 作者, 专利号: 202010397482.4
( 4 ) 磁性八面体铂掺杂金纳米壳、其制备方法和应用, 2020, 第 3 作者, 专利号: 202010307231.2
( 5 ) 一种类肽抑制剂、其制备方法及应用, 2019, 第 1 作者, 专利号: 201610082090.2
( 6 ) 一种自动化类肽纳米片层合成装置及其应用, 2019, 第 4 作者, 专利号: 201510530574.4
( 7 ) 一种类肽纳米片层、其制备方法及应用, 2018, 第 3 作者, 专利号: 201810910741.1
( 8 ) PAMAM-多肽复合物、其制备方法和应用, 2018, 第 3 作者, 专利号: 201810876149.4
( 9 ) 用于乳腺癌检测及分子分型的外泌体检测装置和应用, 2018, 第 3 作者, 专利号: 201810515962.9
( 10 ) 用于非小细胞肺癌检测及分期判断的外泌体检测装置及应用, 2018, 第 3 作者, 专利号: 201810516834.6
( 11 ) 用于侵袭性和非侵袭性垂体瘤判断的外泌体检测装置和应用, 2018, 第 3 作者, 专利号: 201810515862.6
( 12 ) 用于胶质瘤早期检测、动态监测和预后判断的外泌体检测装置和应用, 2018, 第 3 作者, 专利号: 201810515960.X
( 2 ) 一种类肽及其制备方法和应用, 2020, 第 2 作者, 专利号: 201710124106.6
( 3 ) 羧基化量子点编码荧光微球及其制备方法和应用, 2020, 第 3 作者, 专利号: 202010397482.4
( 4 ) 磁性八面体铂掺杂金纳米壳、其制备方法和应用, 2020, 第 3 作者, 专利号: 202010307231.2
( 5 ) 一种类肽抑制剂、其制备方法及应用, 2019, 第 1 作者, 专利号: 201610082090.2
( 6 ) 一种自动化类肽纳米片层合成装置及其应用, 2019, 第 4 作者, 专利号: 201510530574.4
( 7 ) 一种类肽纳米片层、其制备方法及应用, 2018, 第 3 作者, 专利号: 201810910741.1
( 8 ) PAMAM-多肽复合物、其制备方法和应用, 2018, 第 3 作者, 专利号: 201810876149.4
( 9 ) 用于乳腺癌检测及分子分型的外泌体检测装置和应用, 2018, 第 3 作者, 专利号: 201810515962.9
( 10 ) 用于非小细胞肺癌检测及分期判断的外泌体检测装置及应用, 2018, 第 3 作者, 专利号: 201810516834.6
( 11 ) 用于侵袭性和非侵袭性垂体瘤判断的外泌体检测装置和应用, 2018, 第 3 作者, 专利号: 201810515862.6
( 12 ) 用于胶质瘤早期检测、动态监测和预后判断的外泌体检测装置和应用, 2018, 第 3 作者, 专利号: 201810515960.X
出版信息
发表论文
(1) Nanoparticles for the treatment of spinal cord injury, Neural Regeneration Resaerch, 2025,
(2) Ultrasound-nanovesicles interplay for theranostics, Advanced Drug Delivery Reviews, 2024,
(3) T lymphocyte-derived immunogenic hybrid nanovesicles for immunosuppression reversion and boosted photothermal immunotherapy, Nano Today, 2024,
(4) Dual-functional extracellular vesicles enable synergistic treatment via m6A reader YTHDF1-targeting epigenetic regulation and chemotherapy, Nano Research, 2023,
(5) Nanomaterials for visualized tumor surgical navigation and postoperative recurrence inhibition, Nano Research, 2023,
(6) Nano-imaging agents for brain diseases: environmentally responsive imaging and therapy, Nano Research, 2023,
(7) The Landscape of Biomimetic Nanovesicles in Brain Diseases, Advanced Materials, 2023,
(8) m6A Reader YTHDF1-targeting Engineered Small Extracellular Vesicles for Gastric Cancer Therapy Via Epigenetic and Immune Regulation, Advanced Materials, 2023,
(9) Recent advances in lipid nanovesicles for targeted treatment of spinal cord injury, Frontiers in Bioengineering and Biotechnology, 2023,
(10) Emerging Sensing and In Situ Detection Technologies for the Analysis of Extracellular Vesicle miRNAs, Advanced Nanobiomed Research, 2023,
(11) In vitro diagnostic technologies for the detection of extracellular vesicles: current status and future directions, VIEW, 2023,
(12) Extracellular Vesicles as Delivery Vehicles for Therapeutic Nucleic Acids in Cancer Gene Therapy: Progress and Challenges, Pharmaceutics, 2022,
(13) HER2 status of CTCs by peptide-functionalized nanoparticles as the diagnostic biomarker of breast cancer and predicting the efficacy of anti-HER2 treatment, Frontiers in Bioengineering and Biotechnology, 2022,
(14) Single-Vesicle Infrared Nanoscopy for Noninvasive Tumor Malignancy Diagnosis, Journal of the American Chemical Society, 2022,
(15) Nanostructures and Nanotechnologies for the Detection of Extracellular Vesicle, Advanced Biology, 2022,
(16) Quantitative nanomechanical analysis of small extracellular vesicles for tumor malignancy indication, Advanced Science, 2021,
(17) Persistent regulation of tumor hypoxia microenvironment via a bioinspired Pt-based oxygen nanogenerator for multimodal imaging-guided synergistic phototherapy, ACS Chem. Neurosci., 2021,
(18) Diagnosis of mild cognitive impairment and Alzheimer���s disease by the plasma and serum amyloid-beta 42 assay through highly sensitive peptoid nanosheet sensor, ACS Applied Materials & Interfaces, 2020,
(19) Persistent regulation of tumor hypoxia microenvironment via a bioinspired Pt-based oxygen nanogenerator for multimodal imaging-guided synergistic phototherapy, Advanced Science, 2020,
(20) Improved tumor targeting and penetration by a dual-functional poly(amidoamine) dendrimer for the therapy of triple-negative breast cancer, Journal of Materials Chemistry B, 2019,
(21) In situ observation of amyloid nucleation and fibrillation by FastScan atomic force microscopy, The Journal of Physical Chemistry Letters, 2019,
(22) Emerging nanotechnologies for liquid biopsy: the detection of circulating tumor cells and extracellular vesicles, Advanced Materials, 2019,
(23) Evaluation of serum extracellular vesicles as noninvasive diagnostic markers of glioma, Theranostics, 2019,
(24) Detection of Parkinson���s disease through the peptoid recognizing ��-synuclein in serum, ACS Chemical Neuroscience, 2019,
(25) Diagnosis of invasive nonfunctional pituitary adenomas by serum extracellular vesicles, Analytical Chemistry, 2019,
(26) Noninvasive Diagnosis and molecular phenotyping of breast cancer through microbead-assisted flow cytometry detection of tumor-derived extracellular vesicles, Small Methods, 2018,
(27) Antiamyloidogenic activity of A��42-binding peptoid in modulating amyloid oligomerization, Small, 2017,
(28) Antibody-mimetic peptoid nanosheet for label-free serum-based diagnosis of Alzheimer's disease, Advanced Materials, 2017, 第 1 作者
(29) Label-free quantitative detection of tumor-derived exosomes through surface plasmon resonance imaging, Analytical Chemistry, 2014, 第 1 作者
(2) Ultrasound-nanovesicles interplay for theranostics, Advanced Drug Delivery Reviews, 2024,
(3) T lymphocyte-derived immunogenic hybrid nanovesicles for immunosuppression reversion and boosted photothermal immunotherapy, Nano Today, 2024,
(4) Dual-functional extracellular vesicles enable synergistic treatment via m6A reader YTHDF1-targeting epigenetic regulation and chemotherapy, Nano Research, 2023,
(5) Nanomaterials for visualized tumor surgical navigation and postoperative recurrence inhibition, Nano Research, 2023,
(6) Nano-imaging agents for brain diseases: environmentally responsive imaging and therapy, Nano Research, 2023,
(7) The Landscape of Biomimetic Nanovesicles in Brain Diseases, Advanced Materials, 2023,
(8) m6A Reader YTHDF1-targeting Engineered Small Extracellular Vesicles for Gastric Cancer Therapy Via Epigenetic and Immune Regulation, Advanced Materials, 2023,
(9) Recent advances in lipid nanovesicles for targeted treatment of spinal cord injury, Frontiers in Bioengineering and Biotechnology, 2023,
(10) Emerging Sensing and In Situ Detection Technologies for the Analysis of Extracellular Vesicle miRNAs, Advanced Nanobiomed Research, 2023,
(11) In vitro diagnostic technologies for the detection of extracellular vesicles: current status and future directions, VIEW, 2023,
(12) Extracellular Vesicles as Delivery Vehicles for Therapeutic Nucleic Acids in Cancer Gene Therapy: Progress and Challenges, Pharmaceutics, 2022,
(13) HER2 status of CTCs by peptide-functionalized nanoparticles as the diagnostic biomarker of breast cancer and predicting the efficacy of anti-HER2 treatment, Frontiers in Bioengineering and Biotechnology, 2022,
(14) Single-Vesicle Infrared Nanoscopy for Noninvasive Tumor Malignancy Diagnosis, Journal of the American Chemical Society, 2022,
(15) Nanostructures and Nanotechnologies for the Detection of Extracellular Vesicle, Advanced Biology, 2022,
(16) Quantitative nanomechanical analysis of small extracellular vesicles for tumor malignancy indication, Advanced Science, 2021,
(17) Persistent regulation of tumor hypoxia microenvironment via a bioinspired Pt-based oxygen nanogenerator for multimodal imaging-guided synergistic phototherapy, ACS Chem. Neurosci., 2021,
(18) Diagnosis of mild cognitive impairment and Alzheimer���s disease by the plasma and serum amyloid-beta 42 assay through highly sensitive peptoid nanosheet sensor, ACS Applied Materials & Interfaces, 2020,
(19) Persistent regulation of tumor hypoxia microenvironment via a bioinspired Pt-based oxygen nanogenerator for multimodal imaging-guided synergistic phototherapy, Advanced Science, 2020,
(20) Improved tumor targeting and penetration by a dual-functional poly(amidoamine) dendrimer for the therapy of triple-negative breast cancer, Journal of Materials Chemistry B, 2019,
(21) In situ observation of amyloid nucleation and fibrillation by FastScan atomic force microscopy, The Journal of Physical Chemistry Letters, 2019,
(22) Emerging nanotechnologies for liquid biopsy: the detection of circulating tumor cells and extracellular vesicles, Advanced Materials, 2019,
(23) Evaluation of serum extracellular vesicles as noninvasive diagnostic markers of glioma, Theranostics, 2019,
(24) Detection of Parkinson���s disease through the peptoid recognizing ��-synuclein in serum, ACS Chemical Neuroscience, 2019,
(25) Diagnosis of invasive nonfunctional pituitary adenomas by serum extracellular vesicles, Analytical Chemistry, 2019,
(26) Noninvasive Diagnosis and molecular phenotyping of breast cancer through microbead-assisted flow cytometry detection of tumor-derived extracellular vesicles, Small Methods, 2018,
(27) Antiamyloidogenic activity of A��42-binding peptoid in modulating amyloid oligomerization, Small, 2017,
(28) Antibody-mimetic peptoid nanosheet for label-free serum-based diagnosis of Alzheimer's disease, Advanced Materials, 2017, 第 1 作者
(29) Label-free quantitative detection of tumor-derived exosomes through surface plasmon resonance imaging, Analytical Chemistry, 2014, 第 1 作者
发表著作
Molecular Self-Assembly for Nanobiomaterial Fabrication, Nanobiomaterials: Classification, Fabrication and Biomedical Applications, Wiley-VCH, 2018-01, 第 1 作者
科研活动
科研项目
( 1 ) 基于近场红外光谱的单囊泡肿瘤精准诊断研究, 负责人, 国家任务, 2024-01--2027-12
( 2 ) 基于原子力谱和纳米红外光谱的肿瘤源性细胞外囊泡研究, 负责人, 国家任务, 2020-01--2023-12
( 3 ) 中国科学院青年创新促进会, 负责人, 中国科学院计划, 2018-01--2021-12
( 4 ) 基于特异性识别多肽和流式细胞术的肿瘤源性外泌体检测及分子分型, 负责人, 国家任务, 2017-01--2019-12
( 5 ) 基于特异性识别多肽的乳腺癌循环肿瘤细胞检测及分子分型, 参与, 地方任务, 2016-01--2018-12
( 2 ) 基于原子力谱和纳米红外光谱的肿瘤源性细胞外囊泡研究, 负责人, 国家任务, 2020-01--2023-12
( 3 ) 中国科学院青年创新促进会, 负责人, 中国科学院计划, 2018-01--2021-12
( 4 ) 基于特异性识别多肽和流式细胞术的肿瘤源性外泌体检测及分子分型, 负责人, 国家任务, 2017-01--2019-12
( 5 ) 基于特异性识别多肽的乳腺癌循环肿瘤细胞检测及分子分型, 参与, 地方任务, 2016-01--2018-12
参与会议
(1)细胞外囊泡肿瘤精准诊疗 第四届微纳米技术与医疗健康创新大会 2024-05-25
(2)细胞外囊泡在肿瘤精准诊疗中的研究 2023中国生物材料大会 2023-10-12
(3)Single Small Extracellular Vesicle Physical Measurement for Non-invasive Tumor Diagnosis 2023-08-26
(4)中国生物物理学会纳米生物学分会 2023 学术年会 中国生物物理学会纳米生物学分会 2023 学术年会 2023-08-21
(5)单个细胞外囊泡物性表征在肿瘤体外诊断中的研究 中国化学会第33届学术年会参会证明 2023-06-17
(6)细胞外囊泡检测在肿瘤精确诊断中的应用 2023中国生物医学工程大会暨创新医疗峰会 2023-05-18
(7)细胞外囊泡检测及肿瘤体外诊断应用 中国生物物理学会纳米生物学分会2022学术年会 2022-08-26
(8)细胞外囊泡在肿瘤诊疗一体化中的研究 2022(第六届)细胞外囊泡前沿与转化大会 2022-04-28
(9)细胞外囊泡检测及临床应用 中国生物物理学会纳米生物学分会第七届学术年会 2021-06-03
(10)重大慢性疾病血清生物标志物高灵敏检测纳米技术 中国化学会第 32 届学术年会 2021-04-19
(11)液体活检纳米技术的临床研究 2020中国科学院青年创新促进会学术年会 2020-10-27
(12)Peptoid Nanostructures and Liquid Biopsy, 第八届中国国际纳米科学技术会议 2019-08-16
(13)类肽纳米结构在阿尔兹海默症早期体液诊断中的研究 中国微米纳米技术学会纳米科学技术分会第五届年会2018全国纳米生物与医学学术会议 2018-10-25
(14)Antibody-mimetic Peptoid Nanosheets for the Non-invasive Early Diagnosis of Alzheimer’s Disease 第九届亚洲纳米科学和纳米技术会议 2018-10-18
(15)类肽纳米结构在疾病体液检测中的研究 第三届青年纳米论坛 2018-10-11
(16)Peptoid Nanostructures for the Diagnosis and Treatment of Alzheimer’s Disease 第十六次中国暨国际生物物理大会 朱凌 2018-08-27
(17)Peptoids and Their Bioinspired Nanostructures Towards the Diagnosis and Treatment of Alzheimer’s Disease 2017-08-29
(18)High Affinity Peptoids and Their Bioinspired Nanostructures in Modulating Amyloid Oligomerization and In Vitro Diagnosis of Alzheimer’s Disease 中国微米纳米技术学会纳米科学技术分会第四届年会暨2016国际纳米生物与医学学术会议 2016-12-07
(19)Towards better cell membrane mimics: cholesterol-containing supported lipid bilayer on TiO2 2012-04-26
(20)Towards better cell membrane mimics: cholesterol-containing supported lipid bilayer on TiO2 2011-10-19
(2)细胞外囊泡在肿瘤精准诊疗中的研究 2023中国生物材料大会 2023-10-12
(3)Single Small Extracellular Vesicle Physical Measurement for Non-invasive Tumor Diagnosis 2023-08-26
(4)中国生物物理学会纳米生物学分会 2023 学术年会 中国生物物理学会纳米生物学分会 2023 学术年会 2023-08-21
(5)单个细胞外囊泡物性表征在肿瘤体外诊断中的研究 中国化学会第33届学术年会参会证明 2023-06-17
(6)细胞外囊泡检测在肿瘤精确诊断中的应用 2023中国生物医学工程大会暨创新医疗峰会 2023-05-18
(7)细胞外囊泡检测及肿瘤体外诊断应用 中国生物物理学会纳米生物学分会2022学术年会 2022-08-26
(8)细胞外囊泡在肿瘤诊疗一体化中的研究 2022(第六届)细胞外囊泡前沿与转化大会 2022-04-28
(9)细胞外囊泡检测及临床应用 中国生物物理学会纳米生物学分会第七届学术年会 2021-06-03
(10)重大慢性疾病血清生物标志物高灵敏检测纳米技术 中国化学会第 32 届学术年会 2021-04-19
(11)液体活检纳米技术的临床研究 2020中国科学院青年创新促进会学术年会 2020-10-27
(12)Peptoid Nanostructures and Liquid Biopsy, 第八届中国国际纳米科学技术会议 2019-08-16
(13)类肽纳米结构在阿尔兹海默症早期体液诊断中的研究 中国微米纳米技术学会纳米科学技术分会第五届年会2018全国纳米生物与医学学术会议 2018-10-25
(14)Antibody-mimetic Peptoid Nanosheets for the Non-invasive Early Diagnosis of Alzheimer’s Disease 第九届亚洲纳米科学和纳米技术会议 2018-10-18
(15)类肽纳米结构在疾病体液检测中的研究 第三届青年纳米论坛 2018-10-11
(16)Peptoid Nanostructures for the Diagnosis and Treatment of Alzheimer’s Disease 第十六次中国暨国际生物物理大会 朱凌 2018-08-27
(17)Peptoids and Their Bioinspired Nanostructures Towards the Diagnosis and Treatment of Alzheimer’s Disease 2017-08-29
(18)High Affinity Peptoids and Their Bioinspired Nanostructures in Modulating Amyloid Oligomerization and In Vitro Diagnosis of Alzheimer’s Disease 中国微米纳米技术学会纳米科学技术分会第四届年会暨2016国际纳米生物与医学学术会议 2016-12-07
(19)Towards better cell membrane mimics: cholesterol-containing supported lipid bilayer on TiO2 2012-04-26
(20)Towards better cell membrane mimics: cholesterol-containing supported lipid bilayer on TiO2 2011-10-19