081703-生物化工
081704-应用化学
086000-生物与医药

生物分子组装、生物材料和纳米药物及新型抗肿瘤治疗技术

2007-09--2013-07   中国科学院理化技术研究所   博士学位
2003-09--2007-07   武汉大学   学士学位

   

2017-08~现在, 中国科学院过程工程研究所, 副研究员
2015-09~2017-07,中国科学院过程工程研究所, 助理研究员
2013-08~2015-08,中国科学院过程工程研究所, 博士后

   

   

[1] Duan, Li, Fan, Jinlong, Tian, Deshun, Kang, Yu, Wu, Qianru, Zhang, Xiangbo, Li, Pengcheng, Wang, Li, Shen, Guizhi, Qiu, Pengju. Effect of heteroatoms on the binding properties of preorganized claw-type phenanthroline-based ligands towards lanthanide cations. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS[J]. 2023, 第 9 作者663: http://dx.doi.org/10.1016/j.colsurfa.2023.131019.
[2] Wang, Li, Shen, Guizhi, Yan, Xuehai. Bio-inspired short peptide self-assembly: From particles to functional materials. PARTICUOLOGY. 2022, 第 2 作者64(5): 14-34, http://dx.doi.org/10.1016/j.partic.2021.05.007.
[3] Geng, Rui, Chang, Rui, Zou, Qianli, Shen, Guizhi, Jiao, Tifeng, Yan, Xuehai. Biomimetic Nanozymes Based on Coassembly of Amino Acid and Hemin for Catalytic Oxidation and Sensing of Biomolecules. SMALL[J]. 2021, 第 4 作者17(19): http://dx.doi.org/10.1002/smll.202008114.
[4] Liu, Yilin, Zhao, Luyang, Shen, Guizhi, Chang, Rui, Zhang, Yi, Yan, Xuehai. Coordination self-assembly of natural flavonoids into robust nanoparticles for enhanced in vitro chemo and photothermal cancer therapy. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS[J]. 2020, 第 3 作者  通讯作者  598: http://dx.doi.org/10.1016/j.colsurfa.2020.124805.
[5] Yang, Mengyao, Xing, Ruirui, Shen, Guizhi, Yuan, Chengqian, Yan, Xuehai. A versatile cyclic dipeptide hydrogelator: Self-assembly and rheology in various physiological conditions. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS[J]. 2019, 第 3 作者572: 259-265, http://dx.doi.org/10.1016/j.colsurfa.2019.04.020.
[6] Yang, Mengyao, Yuan, Chengqian, Shen, Guizhi, Chang, Rui, Xing, Ruirui, Yan, Xuehai. Cyclic dipeptide nanoribbons formed by dye-mediated hydrophobic self-assembly for cancer chemotherapy. JOURNAL OF COLLOID AND INTERFACE SCIENCE[J]. 2019, 第 3 作者557: 458-464, http://dx.doi.org/10.1016/j.jcis.2019.09.049.
[7] Liu, Yamei, Shen, Guizhi, Zhao, Luyang, Zou, Qianli, Jiao, Tifeng, Yan, Xuehai. Robust Photothermal Nanodrugs Based on Covalent Assembly of Nonpigmented Biomolecules for Antitumor Therapy. ACS APPLIED MATERIALS & INTERFACES[J]. 2019, 第 2 作者11(45): 41898-41905, http://dx.doi.org/10.1021/acsami.9b13966.
[8] Zhou, Lingyun, Lv, Fengting, Liu, Libing, Shen, Guizhi, Yan, Xuehai, Bazan, Guillermo C, Wang, Shu. Cross-Linking of Thiolated Paclitaxel-Oligo(p-phenylene vinylene) Conjugates Aggregates inside Tumor Cells Leads to "Chemical Locks" That Increase Drug Efficacy. ADVANCEDMATERIALS[J]. 2018, 第 4 作者30(10): https://www.webofscience.com/wos/woscc/full-record/WOS:000426720400007.
[9] Shao, Jingxin, Abdelghani, Mona, Shen, Guizhi, Cao, Shoupeng, Williams, David S, van Hest, Jan C M. Erythrocyte Membrane Modified Janus Polymeric Motors for Thrombus Therapy. ACS NANO[J]. 2018, 第 3 作者12(5): 4877-4885, http://dx.doi.org/10.1021/acsnano.8b01772.
[10] Xing, Ruirui, Li, Shukun, Zhang, Ning, Shen, Guizhi, Mohwald, Helmuth, Yan, Xuehai. Self-Assembled Injectable Peptide Hydrogels Capable of Triggering Antitumor Immune Response. BIOMACROMOLECULES[J]. 2017, 第 4 作者18(11): 3514-3523, http://dx.doi.org/10.1021/acs.biomac.7b00787.
[11] 沈桂芝. Markus Antonietti. Hybridizing Carbon Nitride Colloids with a Shell of Water-Soluble Conjugated Polymers for Tunable Full-Color Emission and Synergistic Cell Imaging. ACS Appl. Mater. Inter.. 2017, 第 1 作者
[12] Zou, Qianli, Abbas, Manzar, Zhao, Luyang, Li, Shukun, Shen, Guizhi, Yan, Xuehai. Biological Photothermal Nanodots Based on Self-Assembly of Peptide Porphyrin Conjugates for Antitumor Therapy. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2017, 第 5 作者139(5): 1921-1927, https://www.webofscience.com/wos/woscc/full-record/WOS:000393848400041.
[13] Liu, Yamei, Ma, Kai, Jiao, Tifeng, Xing, Ruirui, Shen, Guizhi, Yan, Xuehai. Water-Insoluble Photosensitizer Nanocolloids Stabilized by Supramolecular Interfacial Assembly towards Photodynamic Therapy. SCIENTIFIC REPORTS[J]. 2017, 第 5 作者  通讯作者  7: http://dx.doi.org/10.1038/srep42978.
[14] Zhao, Luyang, Shen, Guizhi, Ma, Guanghui, Yan, Xuehai. Engineering and delivery of nanocolloids of hydrophobic drugs. ADVANCES IN COLLOID AND INTERFACE SCIENCE[J]. 2017, 第 2 作者249: 308-320, http://dx.doi.org/10.1016/j.cis.2017.04.008.
[15] Cui, Qianling, Xu, Jingsan, Shen, Guizhi, Zhang, Chao, Li, Lidong, Antonietti, Markus. Hybridizing Carbon Nitride Colloids with a Shell of Water-Soluble Conjugated Polymers for Tunable Full-Color Emission and Synergistic Cell Imaging. ACS APPLIED MATERIALS & INTERFACES[J]. 2017, 第 3 作者9(50): 43966-43974, https://www.webofscience.com/wos/woscc/full-record/WOS:000418783700064.
[16] 沈桂芝. 界面组装设计疏水纳米药物及其抗肿瘤应用研究. 中国化学会第30届学术年会-第三十一分会：胶体与界面化学. 2016, 第 1 作者1, http://ir.ipe.ac.cn/handle/122111/25342.
[17] Shen, Guizhi, Xing, Ruirui, Zhang, Ning, Chen, Chengjun, Ma, Guanghui, Yan, Xuehai. Interfacial Cohesion and Assembly of Bioadhesive Molecules for Design of Long Term Stable Hydrophobic Nanodrugs toward Effective Anticancer Therapy. ACS NANO[J]. 2016, 第 1 作者10(6): 5720-5729, http://ir.ipe.ac.cn/handle/122111/21170.
[18] Wang, Juan, Shen, Guizhi, Ma, Kai, Jiao, Tifeng, Liu, Kai, Yan, Xuehai. Dipeptide concave nanospheres based on interfacially controlled self-assembly: from crescent to solid. PHYSICAL CHEMISTRY CHEMICAL PHYSICS[J]. 2016, 第 2 作者18(45): 30926-30930, http://www.irgrid.ac.cn/handle/1471x/1179143.
[19] Ma, Kai, Xing, Ruirui, Jiao, Tifeng, Shen, Guizhi, Chen, Chengjun, Li, Junbai, Yan, Xuehai. Injectable Self-Assembled Dipeptide-Based Nanocarriers for Tumor Delivery and Effective In Vivo Photodynamic Therapy. ACS APPLIED MATERIALS & INTERFACES[J]. 2016, 第 4 作者  通讯作者  8(45): 30759-30767, http://www.irgrid.ac.cn/handle/1471x/1179145.
[20] Zhou, Chao, Abbas, Manzar, Zhang, Min, Zou, Qianli, Shen, Guizhi, Chen, Chengjun, Peng, Hongshang, Yan, Xuehai. One-Step Nanoengineering of Hydrophobic Photosensitive Drugs for the Photodynamic Therapy. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY[J]. 2015, 第 5 作者15(12): 10141-10148, http://ir.ipe.ac.cn/handle/122111/19905.
[21] 沈桂芝, 马凯, 闫学海. 基于生物启发材料的组装设计疏水纳米药物. 2015年中国化工学会年会. 2015, 第 1 作者http://ir.ipe.ac.cn/handle/122111/20398.
[22] Liu, Kai, Xing, Ruirui, Chen, Chengjun, Shen, Guizhi, Yan, Linyin, Zou, Qianli, Ma, Guanghui, Moehwald, Helmuth, Yan, Xuehai. Peptide-Induced Hierarchical Long-Range Order and Photocatalytic Activity of Porphyrin Assemblies. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2015, 第 4 作者54(2): 500-505, http://www.irgrid.ac.cn/handle/1471x/944978.
[23] 沈桂芝, 阎林胤, 张宁, 陈成军, 闫学海. 基于生物粘附分子的界面组装设计疏水纳米药物. 中国化学会第十五届胶体与界面化学会议. 2015, 第 1 作者http://ir.ipe.ac.cn/handle/122111/20399.
[24] Zhao, Fenfang, Shen, Guizhi, Chen, Chengjun, Xing, Ruirui, Zou, Qianli, Ma, Guanghui, Yan, Xuehai. Nanoengineering of Stimuli-Responsive Protein-Based Biomimetic Protocells as Versatile Drug Delivery Tools. CHEMISTRY-A EUROPEAN JOURNAL[J]. 2014, 第 2 作者20(23): 6880-6887, http://www.irgrid.ac.cn/handle/1471x/857838.
[25] Cui, Qianling, Shen, Guizhi, Yan, Xuehai, Li, Lidong, Moehwald, Helmuth, Bargheer, Matias. Fabrication of Au@Pt Multibranched Nanoparticles and Their Application to In Situ SERS Monitoring. ACS APPLIED MATERIALS & INTERFACES[J]. 2014, 第 2 作者6(19): 17075-17081, http://www.irgrid.ac.cn/handle/1471x/944859.
[26] Cui, Qianling, Shen, Guizhi, Wu, Feipeng, Wang, Erjian. Two-step phase transition via in situ hydrolysis of thermosensitive polymeric micelles with acid-labile core. COLLOID AND POLYMER SCIENCE[J]. 2013, 第 2 作者291(10): 2469-2473, https://www.webofscience.com/wos/woscc/full-record/WOS:000324559200022.

   

（ 1 ） 环二肽自组装：分子设计，结构调控和免疫活性的研究, 主持, 国家级, 2017-01--2019-12
（ 2 ） 光敏剂功能化寡肽的自组装:分子设计、结构调控与光动力, 参与, 国家级, 2015-01--2018-12
（ 3 ） 仿生光合成系统中的介尺度结构和机制研究, 参与, 国家级, 2015-01--2017-12
（ 4 ） 细胞微环境双重响应的光动力药物载体的构建与应用研究, 参与, 国家级, 2015-01--2017-12
（ 5 ） 基于血液组分白蛋白和红细胞构建的仿生靶向纳米颗粒用于肿瘤的协同治疗, 参与, 国家级, 2015-01--2017-12
（ 6 ） 肽调控自组装光热纳米药物及抗肿瘤应用研究, 参与, 部委级, 2016-08--2021-07
（ 7 ） 载低分子量肝素的多肽/红细胞缓释载体用于抗血栓的治疗, 参与, 省级, 2015-01--2016-12