100102-免疫学
071009-细胞生物学

免疫学-代谢与免疫
细胞生物学-组织干细胞与微环境

2006-09--2009-06   上海交通大学   博士学位
2003-08--2006-06   上海交通大学   硕士学位

   

2020-04~现在, 中国科学院上海营养与健康研究所, 研究员/课题组长
2015-12~2020-03,中国科学院上海生命科学研究院, 研究员
2011-11~2015-11,中国科学院上海生命科学研究院, 副研究员
2009-11~2011-06,德国明斯特大学, 博士后
2006-09~2009-06,上海交通大学, 博士学位
2003-08~2006-06,上海交通大学, 硕士学位

2024-01-01-2025-12-31,Cellular Immunology, 执行主编
2023-06-29-2026-12-29,中国细胞生物学学会干细胞生物学会分会, 委员
2021-01-01-今,出生缺陷防控关键技术国家工程实验室技术委员会, 委员
2020-07-01-2023-12-31,Cellular Immunology, 副主编
2017-11-27-2020-12-31,上海医师协会整合医学会, 理事
2017-10-22-今,中国整形美容协会干细胞研究与应用分会, 常务理事
2017-01-16-今,NPG旗下Cell Death and Diseases期刊, 专栏主编
2017-01-01-今,Journal of Immunology and Regenerative Medicine, 编委

   

（1） 国家"万人计划"青年拔尖人才, 国家级, 2020
（2） 中国细胞生物学会干细胞生物学分会“青年研究员奖”, 其他, 2019
（3） 中国科学院青年促进会“优秀会员”, 院级, 2017
（4） 上海市青年科技启明星, 市地级, 2014

（ 1 ） 非IGF1R结合型的物质在预防和/或治疗炎症性疾病中的应用, 2021, 第 2 作者, 专利号: CN113164606A

（ 2 ） 含胰岛素样生长因子-2的药物组合物及其应用, 2021, 第 2 作者, 专利号: CN108114271B

（ 3 ） 预激活间充质干细胞在治疗皮肤创伤的免疫生物学方面的应用, 2021, 第 2 作者, 专利号: CN112402454A

（ 4 ） 低氧处理的间充质干细胞及其应用, 2020, 第 4 作者, 专利号: CN106167789B

   

（1） Oleic acid availability impacts thymocyte preprogramming and subsequent peripheral Treg cell differentiation., Nature Immunology, 2024, 
（2） Characteristic and fate determination of adipose precursors during adipose tissue remodeling., Cell Regneration, 2023, 
（3） MHC class Ib-restricted CD8+ T cells possess strong tumoricidal activities., Proc Natl Acad Sci U S A., 2023, 
（4） Glycolytic neutrophils accrued in the spleen compromise anti-tumour T cell immunity in breast cancer., Nature Metabolism, 2023, 
（5） SCD1 Sustains Homeostasis of Bulge Niche via Maintaining Hemidesmosomes in Basal Keratinocytes., Advanced Science, 2023, 
（6） Reciprocal regulation of mesenchymal stem cells and immune responses., Cell Stem Cell, 2022, 第 1 作者
（7） Mesenchymal stromal cells equipped by IFN�� empower T cells with potent anti-tumor immunity., Oncogene, 2022, 第 1 作者  通讯作者
（8） Heterogeneity of tyrosine-based melanin anabolism regulates pulmonary and cerebral organotropic colonization microenvironment of melanoma cells., Theranostics, 2022, 
（9） Loss of p53 in mesenchymal stem cells promotes alteration of bone remodeling through negative regulation of osteoprotegerin. Loss of p53 in mesenchymal stem cells promotes alteration of bone remodeling through negative regulation of osteoprotegerin., Cell Death and Differentiation, 2021, 
（10） Syncytia formation during SARS-CoV-2 lung infection: a disastrous unity to eliminate lymphocytes., Cell Death and Differentiation, 2021, 
（11） Lung mesenchymal stromal cells influenced by Th2 cytokines mobilize neutrophils and facilitate metastasis by producing complement C3, Nature Communications, 2021, 
（12） Steroids enable mesenchymal stromal cells to promote CD8+T cell proliferation via VEGF-C., Advanced Science, 2021, 
（13） IGF2R-initiated proton rechanneling dictates an anti-inflammatory property in macrophages., Science Advances, 2020, 
（14） Scd1 controls de novo beige fat biogenesis through succinate-dependent regulation of mitochondrial complex II., Proc Natl Acad Sci U S A., 2020, 
（15） 苏州大学附属第一医院分析COVID-19感染的免疫应答, COVID-19 infection: the perspectives on immune responses, Cell Death & Differentiation, 2020, 第 2 作者
（16） Mesenchymal stromal cells pretreated with pro���inflammatory cytokines promote skin wound healing through VEGFC ���mediated angiogenesis, STEM CELLS TRANSLATIONAL MEDICINE, 2020, 第 10 作者
（17） Phosphatase SHP1 impedes mesenchymal stromal cell immunosuppressive capacity modulated by JAK1/STAT3 and P38 signals, CELL AND BIOSCIENCE, 2020, 第 5 作者  通讯作者
（18） The endothelial basement membrane - a check point for entry of pathogenic T cells into the brain., Journal of Experimental Medicine., 2020, 第 2 作者
（19） IGF-2 preprograms maturing macrophages to acquire oxidative phosphorylation-dependent anti-inflammatory properties, EUROPEAN JOURNAL OF IMMUNOLOGY, 2019, 
（20） Fibrotic liver microenvironment promotes Dll4 and SDF-1-dependent T-cell lineage development, CELL DEATH AND DISEASE, 2019, 第 20 作者
（21） Single cell transcriptomic analysis of human mesenchymal stem cells reveals limited heterogeneity, CELL DEATH AND DISEASE, 2019, 第 0 作者
（22） IGF-2 Preprograms Maturing Macrophages to Acquire Oxidative Phosphorylation-dependent Anti-inflammatory Properties., Cell Metabolism, 2019, 
（23） Immune Regulatory Mechanisms of Mesenchymal Stem Cells., Nature Reviews Nephrology, 2018, 第 1 作者  通讯作者
（24） Downregulation of CXCL12 in Mesenchymal Stromal Cells by TGF�� Promotes Breast Cancer Metastasis., Oncogene, 2017, 第 1 作者  通讯作者
（25） TNF��-activated Mesenchymal Stromal Cells Promote Breast Cancer Metastasis through Recruiting CXCR2+ Neutrophils., Oncogene, 2017, 
（26） Tumour-associated mesenchymal stem/stromal cells: emerging therapeutic targets, NATURE REVIEWS DRUG DISCOVERY, 2017, 第 4 作者  通讯作者
（27） Fate decision of mesenchymal stem cells: adipocytes or osteoblasts?, CELL DEATH AND DIFFERENTIATION, 2016, 
（28） Type I interferons exert anti-tumor effect via reversing immunosuppression mediated by mesenchymal stromal cells, ONCOGENE, 2016, 
（29） Local proliferation initiates macrophage accumulation in adipose tissue during obesity, CELL DEATH & DISEASE, 2016, 
（30） Tumour cell-derived exosomes endow mesenchymal stromal cells with tumour-promotion capabilities, ONCOGENE, 2016, 
（31） SHP1 Regulates Bone Mass by Directing Mesenchymal Stem Cell Differentiation, CELL REPORTS, 2016, 第 18 作者  通讯作者
（32） CD11b regulates obesity-induced insulin resistance via limiting alternative activation and proliferation of adipose tissue macrophages, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 第 15 作者
（33） Histone deacetylase inhibitors prevent activation-induced cell death and promote anti-tumor immunity, ONCOGENE, 2015, 
（34） Rethinking regeneration: empowerment of stem cells by inflammation, CELL DEATH AND DIFFERENTIATION, 2015, 
（35） Plasticity of mesenchymal stem cells in immunomodulation: pathological and therapeutic implications, NATURE IMMUNOLOGY, 2014, 第 1 作者

   

（ 1 ） 组织器官发育与稳态维持的关键脂质代谢物及其调控网络, 负责人, 国家任务, 2022-12--2027-11
（ 2 ） 血管内皮生长因子-C在糖皮质激素干扰间充质干细胞免疫抑制功能中的机制研究, 负责人, 国家任务, 2021-01--2024-12
（ 3 ） 万人计划青年拔尖人才, 负责人, 国家任务, 2020-01--2022-12
（ 4 ） 上海人才发展基金, 负责人, 地方任务, 2020-01--2022-12
（ 5 ） 炎症微环境与MSCs相互作用调控肝肾纤维化进程的机制, 负责人, 国家任务, 2018-07--2022-12
（ 6 ） 细胞间粘附分子-1在脂肪前体细胞识别和分化调节中的作用及机制, 负责人, 国家任务, 2018-01--2021-12
（ 7 ） p53家族调控骨重塑和骨肉瘤的机制研究, 负责人, 国家任务, 2018-01--2020-12
（ 8 ） 中国科学院青年创新促进会优秀会员项目, 负责人, 中国科学院计划, 2018-01--2020-12
（ 9 ） CD11b调控巨噬细胞状态对肥胖及其相关的胰岛素抵抗的影响及机制, 负责人, 国家任务, 2016-01--2019-12
（ 10 ） 造血干细胞移植的免疫学基础研究, 参与, 国家任务, 2015-01--2019-08

（1）How non-essential fatty acid maintains tissue homeostasis?   2024-04-08
（2）Tumor associated mesenchymal stem/stromal cells: emerging therapeutic targets   2024-01-24
（3）Novel strategies to empower anti-tumor T cell immunity   3. 2023年福建省免疫学会免疫与转化医学学术年会   2023-12-31
（4）How non-essential fatty acids maintain tissue homeostasis   2023-09-19
（5）Lipid metabolites in controlling stem cells and tissue microenvironment   云南省医学会细胞生物学分会   2022-12-22
（6）间充质基质细胞与肿瘤免疫微环境   5. 第十一届中国乳腺癌干细胞高峰论坛   2022-12-09
（7）Lipid metabolism in the dialogue between stem cells and tissue microenvironment   第六届全国基质生物学学术会议   2022-12-04
（8）Lipid metabolism in the dialogue between stem cells and tissue microenvironment   2022-08-15
（9）Novel paracrine factors from mesenchymal stem cells to shape immune responses   第十一届干细胞年会   2021-12-13
（10）Immunomodulation of Mesenchymal Stem Cells: Pathological and Therapeutic Implications    第一届张江细胞治疗国际峰会   2019-11-14
（11）Switching macrophages: a novel therapeutic strategy for autoimmune diseases   第九届Cell Death and Disease会议   2019-11-04
（12）Switching macrophages: a novel therapeutic strategy for autoimmune diseases   Springer-NPG PRESS Cell Death and Differentiation “Cancer, Immunity & Inflammation” Annual Meeting   2019-09-10
（13）Inflammation controls the differentiation potential of mesenchymal stem cells in adipose tissue   第十七届全球华人科学家大会   2019-07-22
（14）Immunoregulation by mesenchymal stem cells through metabolism   第六届Macau Symposium on Biomedical Sciences   2019-06-12
（15）Immunoregulation by Mesenchymal Stem Cells through Metabolism   2018年吉林省干细胞第三届学术论坛——暨海峡两岸干细胞交流会议   2018-05-27
（16）间充质干细胞的免疫调节特性和临床应用   手术与细胞治疗学术委员会成立暨全国首届学术研讨会   2017-10-28
（17）Inflammation Controls the Differentiation Potential of Mesenchymal Stem Cells in Adipose Tissue   第七届中国干细胞年会   2017-07-07
（18）The Interplay between Mesenchymal Stem Cells and Immune Cells in Adipose Tissue   第7届Cell Death and Disease会议   2016-10-18
（19）Crosstalk between Mesenchymal Stem Cells and Inflammation in the Tumor Microenvironment   第五届中国干细胞年会   2015-11-13
（20）免疫微环境中的间充质干细胞与免疫应答   第一精准医疗与免疫诊断研讨会   2015-04-04
（21）Interplay between Mesenchymal Stem Cells and Inflammation in the Tumor Microenvironment   DIA（药物信息协会）第六届年会   2014-05-11