081203-计算机应用技术
081202-计算机软件与理论
0812J3-生物信息学

医疗多模态人工智能
医学图像处理

2011-09--2015-06   中国科学院计算技术研究所   博士
2009-09--2011-06   中国科学院计算技术研究所   硕士
2005-09--2009-07   山东大学   学士

   

2015-07~现在, 中国科学院计算技术研究所, 任职

2022-02-01-今,Frontiers in Bioengineering and Biotechnology, Review Editor
2021-10-01-2023-12-31,中华中医学会感染病分会, 第六届委员会青年委员
2021-02-01-今,Frontiers in Genetics, Review Editor
2020-12-22-2021-12-31,中国抗癌协会肿瘤标志专业委员会, 肿瘤多学科诊断(MDD)协作组委员

   

（1） Clarivate2022全球高被引学者, , 国家级, 2022
（2） 浙江省生物信息学会自然科学奖, 一等奖, 省级, 2021

[1] 任菲, 罗坚诚, 刘志勇, 刘玉东, 张弘, 卜德超. 基于病理图像的TMB分类方法、系统及TMB分析装置. CN: CN110866893B, 2021-04-06.

[2] 卜德超, 赵屹, 靳辉, 赵连鹤. 一种用于挖掘肿瘤标志物的方法以及肿瘤风险筛查方法. CN: CN115602326A, 2023-01-13.

   

[1] Yixuan Qiao, Rui Yang, Yang Liu, Jiaxin Chen, Lianhe Zhao, Peipei Huo, Zhihao Wang, Dechao Bu, Yang Wu, Yi Zhao. DeepFusion: A Deep Bimodal Information Fusion Network for Unraveling Protein-RNA Interactions Using In Vivo RNA Structures. COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL[J]. 2024, 23: 617-625, http://dx.doi.org/10.1016/j.csbj.2023.12.040.
[2] Zihao He, Kai Gao, Lei Dong, Liu Liu, Xinchi Qu, Zhengkai Zou, Yang Wu, Dechao Bu, JinCheng Guo, Yi Zhao. Drug screening and biomarker gene investigation in cancer therapy through the human transcriptional regulatory network (IF=6.3). COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL[J]. 2023, 21: 1557-1572, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9984461/.
[3] Yanan Cheng, Dechao Bu, Qiaoling Zhang, Rebecca Sun, Stephen Lyle, Gang Zhao, Li Dong, Hui Li, Yi Zhao, Jinpu Yu, Xishan Hao. Genomic and transcriptomic profiling indicates the prognosis significance of mutational signature for TMB-high subtype in Chinese patients with gastric cancer (IF=11.4, SCI citations=14). JOURNAL OF ADVANCED RESEARCH[J]. 2022, http://dx.doi.org/10.1016/j.jare.2022.10.019.
[4] Yufan Luo, Liu Liu, Zihao He, Shan Zhang, Peipei Huo, Zhihao Wang Methodolog, Qin Jiaxin, Lianhe Zhao, Yang Wu, Dongdong Zhang, Dechao Bu, Runsheng Chen, Yi Zhao. TREAT: Therapeutic RNAs Exploration inspired by Artificial intelligence Technology (IF=6.3). COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL[J]. 2022, http://dx.doi.org/10.1016/j.csbj.2022.10.011.
[5] Fang, ShuangSang, Dong, Lei, Liu, Liu, Guo, JinCheng, Zhao, LianHe, Zhang, JiaYuan, Bu, DeChao, Liu, XinKui, Huo, PeiPei, Cao, WanChen, Dong, QiongYe, Wu, JiaRui, Zeng, Xiaoxi, Wu, Yang, Zhao, Yi. HERB: a high-throughput experiment- and reference-guided database of traditional Chinese medicine. NUCLEIC ACIDS RESEARCH[J]. 2021, 49(D1): D1197-D1206, http://dx.doi.org/10.1093/nar/gkaa1063.
[6] Ning, Junya, Ye, Yingnan, Bu, Dechao, Zhao, Gang, Song, Tianqiang, Liu, Pengpeng, Yu, Wenwen, Wang, Hailong, Li, Hui, Ren, Xiubao, Ying, Guoguang, Zhao, Yi, Yu, Jinpu. Imbalance of TGF-β1/BMP-7 pathways induced by M2-polarized macrophages promotes hepatocellular carcinoma aggressiveness (IF=12.6, SCI citations=46). MOLECULAR THERAPY[J]. 2021, 29(6): 2067-2087, http://dx.doi.org/10.1016/j.ymthe.2021.02.016.
[7] Luo, Haitao, Bu, Dechao, Shao, Lijuan, Li, Yang, Sun, Liang, Wang, Ce, Wang, Jing, Yang, Wei, Yang, Xiaofei, Dong, Jun, Zhao, Yi, Li, Furong. Single-cell Long Non-coding RNA Landscape of T Cells in Human Cancer Immunity (IF=10.1, SCI citations=11). GENOMICS PROTEOMICS & BIOINFORMATICS[J]. 2021, 19(3): 377-393, http://dx.doi.org/10.1016/j.gpb.2021.02.006.
[8] Zhang, Yuwei, Bu, Dechao, Huo, Peipei, Wang, Zhihao, Rong, Hao, Li, Yanguo, Liu, Jingjia, Ye, Meng, Wu, Yang, Jiang, Zheng, Liao, Qi, Zhao, Yi. ncFANs v2.0: an integrative platform for functional annotation of non-coding RNAs (IF=16.4). NUCLEIC ACIDS RESEARCH[J]. 2021, 49(W1): W459-W468, http://dx.doi.org/10.1093/nar/gkab435.
[9] Bu, Dechao, Luo, Haitao, Huo, Peipei, Wang, Zhihao, Zhang, Shan, He, Zihao, Wu, Yang, Zhao, Lianhe, Liu, Jingjia, Guo, Jincheng, Fang, Shuangsang, Cao, Wanchen, Yi, Lan, Zhao, Yi, Kong, Lei. KOBAS-i: intelligent prioritization and exploratory visualization of biological functions for gene enrichment analysis (IF=16.4,SCI citations=740, ESI highly cited, hot paper). NUCLEIC ACIDS RESEARCH[J]. 2021, 49(W1): W317-W325, http://dx.doi.org/10.1093/nar/gkab447.
[10] Zhao, Lianhe, Wang, Jiajia, Li, Yanyan, Song, Tingrui, Wu, Yang, Fang, Shuangsang, Bu, Dechao, Li, Hui, Sun, Liang, Pei, Dong, Zheng, Yu, Huang, Jianqin, Xu, Mingqing, Chen, Runsheng, Zhao, Yi, He, Shunmin. NONCODEV6: an updated database dedicated to long non-coding RNA annotation in both animals and plants. NUCLEIC ACIDS RESEARCH[J]. 2021, 49(D1): D165-D171, http://dx.doi.org/10.1093/nar/gkaa1046.
[11] Dechao Bu, Yan Xia, JiaYuan Zhang, Wanchen Cao, Peipei Huo, Zhihao Wang, Zihao He, Linyi Ding, Yang Wu, Shan Zhang, Kai Gao, He Yu, Tiegang Liu, Xia Ding, Xiaohong Gu, Yi Zhao. FangNet: Mining herb hidden knowledge from TCM clinical effective formulas using structure network algorithm (IF=6.3, SCI citations=20). COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL[J]. 2021, 19: 62-71, 
[12] Liu, Xinkui, Wu, Yang, Zhang, Yingying, Bu, Dechao, Wu, Chao, Lu, Shan, Huang, Zhihong, Song, Yurong, Zhao, Yi, Guo, Fengying, Ye, Peizhi, Fu, Changgeng, Shen, Liangliang, Zhang, Jingyuan, Wang, Haojia, Duan, Xianchun, Wu, Jiarui. High Throughput Transcriptome Data Analysis and Computational Verification Reveal Immunotherapy Biomarkers of Compound Kushen Injection for Treating Triple-Negative Breast Cancer. FRONTIERS IN ONCOLOGY[J]. 2021, 11: http://dx.doi.org/10.3389/fonc.2021.747300.
[13] Zhang, Junpei, Zhang, Wenting, Ji, Feiyang, Qiu, Jie, Song, Xiaobo, Bu, Dechao, Pan, Gang, Ma, Qingguo, Chen, Jiaxin, Huang, Ruimin, Chang, Yingying, Pei, Dong. A high-quality walnut genome assembly reveals extensive gene expression divergences after whole-genome duplication. PLANT BIOTECHNOLOGY JOURNAL. 2020, 18(9): 1848-1850, http://dx.doi.org/10.1111/pbi.13350.
[14] 韩自强, 卜德超, 张策, 吴桂鑫, 邹玉宝, 王水云, 宋雷, 赵屹, 王继征. 肥厚型心肌病可变剪接图谱分析. 中国分子心脏病学杂志[J]. 2020, 20(1): 3249-3254, http://lib.cqvip.com/Qikan/Article/Detail?id=7101502439.
[15] Wu, Yang, Zhang, Feilong, Yang, Kuo, Fang, Shuangsang, Bu, Dechao, Li, Hui, Sun, Liang, Hu, Hairuo, Gao, Kuo, Wang, Wei, Zhou, Xuezhong, Zhao, Yi, Chen, Jianxin. SymMap: an integrative database of traditional Chinese medicine enhanced by symptom mapping. NUCLEIC ACIDS RESEARCH[J]. 2019, 47(D1): D1110-D1117, https://www.webofscience.com/wos/woscc/full-record/WOS:000462587400152.
[16] Li, Lin, Bu, Dechao, Zhao, Yi. CircRNAwrap - a flexible pipeline for circRNA identification, transcript prediction, and abundance estimation. FEBS LETTERS[J]. 2019, 593(11): 1179-1189, https://www.webofscience.com/wos/woscc/full-record/WOS:000470956700005.
[17] Ma, Qingguo, Bu, Dechao, Zhang, Junpei, Wu, Yang, Pei, Dong. The Transcriptome Landscape of Walnut Interspecies Hybrid (Juglans hindsii x Juglans regia) and Regulation of Cambial Activity in Relation to Grafting. FRONTIERS IN GENETICS[J]. 2019, 10: http://dx.doi.org/10.3389/fgene.2019.00577.
[18] Luo, Haitao, Bu, Dechao, Sun, Liang, Fang, Shuangsang, Liu, Zhiyong, Zhao, Yi. Identification and function annotation of long intervening noncoding RNAs. BRIEFINGS IN BIOINFORMATICS[J]. 2017, 18(5): 789-797, http://dx.doi.org/10.1093/bib/bbw046.
[19] 卜德超, 罗海涛, 焦飞, 方双桑, 谭程夫, 刘志勇, 赵屹. 哺乳动物长链非编码RNA的进化注释. 中国科学. 生命科学[J]. 2016, 46(2): 167-177, https://www.sciengine.com/doi/10.1360/05SCLS-2014-0214.R2.
[20] Zhao, Yi, Li, Hui, Fang, Shuangsang, Kang, Yue, Wu, Wei, Hao, Yajing, Li, Ziyang, Bu, Dechao, Sun, Ninghui, Zhang, Michael Q, Chen, Runsheng. NONCODE 2016: an informative and valuable data source of long non-coding RNAs. NUCLEIC ACIDS RESEARCH[J]. 2016, 44(D1): D203-D208, https://www.webofscience.com/wos/woscc/full-record/WOS:000371261700027.
[21] Wang, Renzhi, Yang, Yakun, Sheng, Miaomiao, Bu, Dechao, Huang, Fengming, Liu, Xiaohai, Zhou, Cuiqi, Dai, Congxin, Sun, Bowen, Zhu, Jindong, Qiao, Yi, Yao, Yong, Zhu, Huijuan, Lu, Lin, Pan, Hui, Feng, Ming, Deng, Kan, Xing, Bing, Lian, Wei, Zhao, Yi, Jiang, Chengyu. Phenotype-Genotype Association Analysis of ACTH-Secreting Pituitary Adenoma and Its Molecular Link to Patient Osteoporosis. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES[J]. 2016, 17(10): https://doaj.org/article/d4aaf1cc955a4c27a7fb296a6ae60663.
[22] Bu DeChao, Luo HaiTao, Jiao Fei, Fang ShuangSang, Tan ChengFu, Liu ZhiYong, Zhao Yi. Evolutionary annotation of conserved long non-coding RNAs in major mammalian species. SCIENCE CHINA-LIFE SCIENCES[J]. 2015, 58(8): 787-798, https://www.sciengine.com/doi/10.1007/s11427-015-4881-9.
[23] 赵屹, 卜德超. 当生物医学遇上大数据. 北大商业评论[J]. 2015, 74-79, http://lib.cqvip.com/Qikan/Article/Detail?id=664365125.
[24] 陈润生. NONCODEv4: exploring the world of long non-coding RNA genes. NUCLEIC ACIDS RESEARCH[J]. 2014, 42(30): D98-D103, https://www.webofscience.com/wos/woscc/full-record/WOS:000331139800016.
[25] Yang, Yakun, Sheng, Miaomiao, Huang, Fengming, Bu, Dechao, Liu, Xiaohai, Yao, Yong, Dai, Congxin, Sun, Bowen, Zhu, Jindong, Jiao, Yonghui, Wei, Zhenqing, Zhu, Huijuan, Lu, Lin, Zhao, Yi, Jiang, Chengyu, Wang, Renzhi. Downregulation of Insulin-like growth factor binding protein 6 is associated with ACTH-secreting pituitary adenoma growth. PITUITARY[J]. 2014, 17(6): 505-513, http://dx.doi.org/10.1007/s11102-013-0535-8.
[26] Zhang Kun, Wang LeHeng, Chi Hao, Bu DeChao, Yuan ZuoFei, Liu Chao, Fan ShengBo, Chen HaiFeng, Zeng WenFeng, Luo HaiTao, Sun RuiXiang, He SiMin, Xie Lu, Zhao Yi. Proteogenomics: Improving Genomes Annotation by Proteomics. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS[J]. 2013, 40(4): 297-308, https://www.webofscience.com/wos/woscc/full-record/WOS:000318059500001.
[27] 赵国光, 焦飞, 廖奇, 罗海涛, 李慧, 孙亮, 卜德超, 余鲲涛, 赵屹, 陈润生. 基于转录组测序在人类全基因组内鉴定与癌症相关的polyadenylation和non-polyadenylation RNA. 中国科学. 生命科学[J]. 2013, 43(5): 376-386, https://www.sciengine.com/doi/10.1360/zc2013-43-5-376.
[28] Sun Liang, Luo HaiTao, Liao Qi, Bu DeChao, Zhao GuoGuang, Liu ChangNing, Liu YuanNing, Zhao Yi. Systematic study of human long intergenic non-coding RNAs and their impact on cancer. SCIENCECHINALIFESCIENCES[J]. 2013, 56(4): 324-334, https://www.webofscience.com/wos/woscc/full-record/WOS:000317610200005.
[29] Zhang Kun, Wang LeHeng, Chi Hao, Bu DeChao, Yuan ZuoFei, Liu Chao, Fan ShengBo, Chen HaiFeng, Zeng WenFeng, Luo HaiTao, Sun RuiXiang, He SiMin, Xie Lu, Zhao Yi. Proteogenomics: Improving Genomes Annotation by Proteomics. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS[J]. 2013, 40(4): 297-308, https://www.webofscience.com/wos/woscc/full-record/WOS:000318059500001.
[30] Luo, Haitao, Sun, Silong, Li, Ping, Bu, Dechao, Cao, Haiming, Zhao, Yi. Comprehensive Characterization of 10,571 Mouse Large Intergenic Noncoding RNAs from Whole Transcriptome Sequencing. PLOS ONE[J]. 2013, 8(8): https://doaj.org/article/c4f72f03442943a6b0cd00606eb2e56b.
[31] 陈润生. Genome-wide identification of cancer-related polyadenylated and non-polyadenylated RNAs in human breast and lung cell lines. SCIENCE CHINA-LIFE SCIENCES[J]. 2013, 56(38): 503-512, http://www.irgrid.ac.cn/handle/1471x/756539.
[32] 陈润生. Long non-coding RNAs function annotation: a global prediction method based on bi-colored networks. NUCLEIC ACIDS RESEARCH[J]. 2013, 41(41): http://www.irgrid.ac.cn/handle/1471x/756478.
[33] 陈润生. Genome-wide identification of cancer-related polyadenylated and non-polyadenylated RNAs in human breast and lung cell lines. SCIENCE CHINA-LIFE SCIENCES[J]. 2013, 56(38): 503-512, http://www.irgrid.ac.cn/handle/1471x/756539.
[34] 陈润生. Utilizing sequence intrinsic composition to classify protein-coding and long non-coding transcripts. NUCLEIC ACIDS RESEARCH[J]. 2013, 41(17): e166-e166, 
[35] Sun, Liang, Luo, Haitao, Bu, Dechao, Zhao, Guoguang, Yu, Kuntao, Zhang, Changhai, Liu, Yuanning, Chen, Runsheng, Zhao, Yi. Utilizing sequence intrinsic composition to classify protein-coding and long non-coding transcripts. NUCLEIC ACIDS RESEARCH[J]. 2013, 41(17): e166-e166, http://dx.doi.org/10.1093/nar/gkt646.
[36] 陈润生. CloudLCA: finding the lowest common ancestor in metagenome analysis using cloud computing. PROTEIN & CELL[J]. 2012, 3(50): 148-152, http://www.irgrid.ac.cn/handle/1471x/756738.
[37] 陈润生. NONCODE v3.0: integrative annotation of long noncoding RNAs. NUCLEIC ACIDS RESEARCH[J]. 2012, 40(51): D210-D215, http://www.irgrid.ac.cn/handle/1471x/756876.
[38] 陈润生. ncFANs: a web server for functional annotation of long non-coding RNAs. NUCLEIC ACIDS RESEARCH[J]. 2011, 39(54): W118-W124, http://www.irgrid.ac.cn/handle/1471x/757406.
[39] Liao, Qi, Liu, Changning, Yuan, Xiongying, Kang, Shuli, Miao, Ruoyu, Xiao, Hui, Zhao, Guoguang, Luo, Haitao, Bu, Dechao, Zhao, Haitao, Skogerbo, Geir, Wu, Zhongdao, Zhao, Yi. Large-scale prediction of long non-coding RNA functions in a coding-non-coding gene co-expression network. NUCLEIC ACIDS RESEARCH[J]. 2011, 39(9): 3864-3878, https://www.webofscience.com/wos/woscc/full-record/WOS:000290589500037.

（1） RNA Mapping：De Novo Approach to Classify Protein-Coding and Noncoding Transcripts Based on Sequence Composition, Springer, 2014-06, 第 2 作者

   

（ 1 ） 生物数据智能化管理及解析和检索系统, 负责人, 国家任务, 2021-12--2024-11
（ 2 ） 名老中医经验研究与推广应用一体化平台构建, 负责人, 国家任务, 2018-12--2022-12
（ 3 ） 基于多模态信息融合的交叉分析算法及智能挖掘技术研发, 负责人, 国家任务, 2022-11--2024-05
（ 4 ） mRNA 疫苗核酸序列设计平台 TheraRNA的优化及验证, 负责人, 地方任务, 2023-01--2025-12

现指导学生

徐珠峰  硕士研究生  085400-电子信息