基本信息
盛能印  男  博导  中国科学院昆明动物研究所
电子邮件: shengnengyin@mail.kiz.ac.cn
通信地址: 云南省昆明市盘龙区龙欣路17号
邮政编码:

招生信息

   
招生专业
071006-神经生物学
071009-细胞生物学
071010-生物化学与分子生物学
招生方向
大脑进化发育,神经突触发育和功能调控

教育背景

2003-09--2011-01   中国科学学院上海生物化学与细胞生物学研究所   博士学位
1999-09--2003-07   南开大学生命科学学院   学士学位

工作经历

   
工作简历
2017-08~现在, 中国科学学院昆明动物所, 研究员
2011-08~2017-07,美国加州大学旧金山分校分子细胞药理系, 博士后
2003-09~2011-01,中国科学学院上海生物化学与细胞生物学研究所, 博士学位
1999-09~2003-07,南开大学生命科学学院, 学士学位

出版信息

   
发表论文
(1) RNF220-mediated K63-linked polyubiquitination stabilizes Olig proteins during oligodendroglial development and myelination, Science Advances, 2024, 
(2) Strategies for Dissecting the Genetic Driving of Conserved Noncoding-Elements for Evolutionary Development of the Corpus Callosum, Neuroscience Bulletin, 2024, 
(3) Primate-specific BTN3A2 protects against SARS-CoV-2 infection by interacting with and reducing ACE2, EBioMedicine, 2024, 
(4) Diverse CMT2 neuropathies are linked to aberrant G3BP interactions in stress granules, CELL, 2023, 第 15 作者
(5) Integrative omics reveals rapidly evolving regulatory sequences driving primate brain evolution, Molecular Biology and Evolution, 2023, 
(6) Correlative Assembly of Subsynaptic Nanoscale Organizations During Development, Frontiers in Synaptic Neuroscience, 2022, 第 11 作者
(7) Dysfunction of AMPA receptor GluA3 is associated with aggressive behavior in human, Molecular Psychiatry, 2022, 第 16 作者
(8) Enhancing GluN2A-type NMDA receptors impairs long-term synaptic plasticity and learning and memory, Molecular Psychiatry, 2022, 第 0 作者
(9) The schizophrenia-associated missense variant rs13107325 regulates dendritic spine density, TRANSLATIONAL PSYCHIATRY, 2022, 第 11 作者
(10) KKK879-881 motif is an ER-retention signal in GluN2A-NMDA receptor, MOLECULAR PSYCHIATRY, 2022, 第 0 作者
(11) RNF220 is an E3 ubiquitin ligase for AMPA receptors to regulate synaptic transmission, SCIENCE ADVANCES, 2022, 第 11 作者
(12) A novel missense variant in ACAA1 contributes to early-onset Alzheimer���s disease, impairs lysosomal function, and facilitates amyloid-�� pathology and cognitive decline, SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2021, 第 16 作者
(13) Identification of the primate-specific gene BTN3A2 as an additional schizophrenia risk gene in the MHC loci, EBIOMEDICINE, 2019, 第 11 作者
(14) Complement C7 is a novel risk gene for Alzheimer's disease in Han Chinese, Complement C7 is a novel risk gene for Alzheimer's disease in Han Chinese, NATIONAL SCIENCE REVIEW, 2019, 第 20 作者
(15) Signal peptide represses GluK1 surface and synaptic trafficking through binding to amino-terminal domain, NATURE COMMUNICATIONS, 2018, 第 11 作者
(16) LTP requires postsynaptic PDZ-domain interactions with glutamate receptor/auxiliary protein complexes, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 第 11 作者
(17) Postsynaptic delta 1 glutamate receptor assembles and maintains hippocampal synapses via Cbln2 and neurexin, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 第 3 作者
(18) A slow excitatory postsynaptic current mediated by a novel metabotropic glutamate receptor in CA1 pyramidal neurons, NEUROPHARMACOLOGY, 2017, 第 1 作者
(19) Amino-terminal domains of kainate receptors determine the differential dependence on Neto auxiliary subunits for trafficking, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, 第 1 作者
(20) Phosphorylation of the kainate receptor (KAR) auxiliary subunit Neto2 at serine 409 regulates synaptic targeting of the KAR subunit GluK1, JOURNAL OF BIOLOGICAL CHEMISTRY, 2017, 第 2 作者
(21) Neto auxiliary proteins control both the trafficking and biophysical properties of the kainate receptor GluK1, ELIFE, 2015, 第 1 作者
(22) ESC-Derived Basal Forebrain Cholinergic Neurons Ameliorate the Cognitive Symptoms Associated with Alzheimer���s Disease in Mouse Models, STEM CELL REPORTS, 2015, 第 7 作者
(23) The transcription factor Pou3f1 promotes neural fate commitment via activation of neural lineage genes and inhibition of external signaling pathways, ELIFE, 2014, 第 7 作者
(24) A Cortical Circuit for Gain Control by Behavioral State, CELL, 2014, 第 4 作者
(25) BMP signaling pathway and spinal cord development, BMP signaling pathway and spinal cord development, 生物学前沿:英文版, 2012, 
(26) AP2 gamma regulates neural and epidermal development downstream of the BMP pathway at early stages of ectodermal patterning, CELL RESEARCH, 2012, 第 3 作者
(27) Retinoic acid regulates bone morphogenic protein signal duration by promoting the degradation of phosphorylated Smad1, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 第 1 作者
(28) The function of BMP signaling pathway during the central nervous system development, Chinese Journal of Cell Biology, 2009, 第 2 作者
(29) NDST1-dependent heparan sulfate regulates BMP signaling and internalization in lung development, JOURNAL OF CELL SCIENCE, 2009, 第 4 作者
(30) Id Sustains Hes1 Expression to Inhibit Precocious Neurogenesis by Releasing Negative Autoregulation of Hes1, DEVELOPMENTAL CELL, 2007, 第 2 作者

科研活动

   
科研项目
( 1 ) 突触后定位分子ZC4H2在神经突 触功能调控中的作用机制研究, 负责人, 地方任务, 2024-03--2027-02
( 2 ) 云南省灵长类脑类器官与精神疾病探索创新团队, 参与, 地方任务, 2024-03--2027-02
( 3 ) 灵长类特有分子BTN3A2在突触功能调控进化中的作用机制研究, 负责人, 国家任务, 2024-01--2027-12
( 4 ) 低氧环境与大脑发育及功能调控, 负责人, 中国科学院计划, 2024-01--2026-12
( 5 ) 哺乳动物乳腺和大脑新皮层起源的进化发育机制解析, 负责人, 国家任务, 2023-12--2028-11
( 6 ) 实验动物新型科研基础设施体系构建, 参与, 地方任务, 2023-08--2026-07
参与会议
(1)胼胝体进化发育与神经发育障碍疾病   第七届全国发育生物学大会   2024-09-01
(2)The role of X-linked intellectual disability factor ZC4H2 in regulating brain function and synaptic transmission   第十二届神经细胞生物学前沿研讨会   2023-11-16
(3)胼胝体进化发育与神经发育障碍疾病   中国神经科学学会神经干细胞和组织工程分会第三届学术年会   2023-10-16
(4)Evolutionary regulation of neural synapse function by primate specific gene family Butyrophilins   第十五届“中国神经科学学会全国学术会议”   2022-11-27
(5)RNF220 is an E3 ubiquitination ligase for AMPA receptors to regulate excitatory synaptic transmission   第十届神经细胞生物学前沿研讨会   2021-10-27
(6)The molecular bases for excitatory synaptic transmission and plasticity   首届“神经生物理青年科学论坛”   2020-12-19
(7)The molecular bases for excitatory synaptic transmission and brain physiology   第九届神经细胞生物学前沿研讨会   2020-11-06