General

Dr. Lijing Fang, Professor,  Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences.

Research Areas

Chemical biology; Organic synthesis; Medicinal chemistry.

Education

2002-2007     Ph.D. in Organic Chemistry, Lanzhou University

1998-2002     B.S. Lanzhou University

Experience

2020-present  Professor, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences.

2016-2020   Associate Professor, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences.

2011-2015     Assistant Professor, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences.

2007-2010     Postdoctoral Associate, Texas A&M University, USA.

Teaching Experience

Advances in Chemical Biology

Publications

1.       Jiwei Zheng, Wanyi He, Jing Li……., Hongchang Li,* Liang Chen,* Lijing Fang*. Bifunctional Compounds as Molecular Degraders for Integrin-facilitated Targeted Protein Degradation, J. Am. Chem. Soc., 2022, doi: 10.1021/jacs.2c08367.

2.       Chunlei Wu, Yanyan Li, Zhehong Cheng……., Hongchang Li,* Lijing Fang*. Cell-penetrating riboflavin conjugate for antitumor photodynamic therapy. Chin. Chem. Lett., 2022, 33, 4339-44.

3.       Sifeng Li, Taimin Wang, Xingchen Li, Lijing Fang, Hongbin Zhai*, Bin Cheng*. Dearomatization–rearomatization strategy of tyrosine for peptide/protein modification through thiol-addition reactions. Green Chemistry, 2022, DOI: 10.1039/d2gc03464f.

4.       Chunlei Wu, Zhehong Cheng, Danyi Lu, Ke Liu, Yulian Cheng, Pengxin Wang, Yimin Zhou, Meiqing Li, Ximing Shao, Hongchang Li,* Wu Su,* Lijing Fang*. A Novel N-methylated Cyclodepsipeptide Prodrug for Targeted Cancer Therapy, Journal of Medicinal Chemistry, 2021, J. Med. Chem., 2021, 64, 991-1000.

5.       Pengxin Wang, Yulian Cheng, Chunlei Wu, Yimin Zhou, Zhehong Cheng, Hongchang Li, Rui Wang,* Wu Su,* Lijing Fang*. Tyrosine-Specific Modification via a Novel Dearomatization-Rearomatization Strategy: Facile Access to Azobenzene Functionalized Peptides. Org. Lett., 2021, 23, 4137-4141.

6.       Pengxin Wang, Yulian Cheng, Chunlei Wu, Ruixiang Luo, Caibing Ma, Yimin Zhou, Zilong Ma, Rui Wang,* Wu Su,* Lijing Fang*. Dearomatization–rearomatization strategy of tyrosine for peptide/protein modification through thiol-addition reactions. Chem. Commun. 2021, 57, 12968-12971.

7.       Wenli Shi, Danyi Lu, Chunlei Wu, Meiqing Li, Zhihao Ding, Yanyan Li, Binghua Chen, Xian Lin, Wu Su, Ximing Shao, Zhihui Xia, Lijing Fang*, Ke Liu*, Hongchang Li*. Coibamide A kills cancer cells through inhibiting autophagy, Biochemical and Biophysical Research Communications,. 2021, 547, 52-58.

8.       Meiqing Li, Danyi Lu, Yulian Cheng, Chunlei Wu, Jianchao Zhang, Wenli Shi, Zhihao Ding, Yanyan Li, Binghua Cheng, Xian Lin, Ximing Shao, Hongchang Li, Lijing Fang*, Ke Liu*, Wu Su*. A novel pyrrole-imidazole polyamide targets Aurora kinase A and suppresses tumor growth in vivo, Biochemical and Biophysical Research Communications 2021, 571, 167-173.

9.       Meiqing Li, Ximing Shao, Chunlei Wu, Danyi Lu, Ke Liu, Wei Wang, Jiakai Liu, Hongchang Li*, Wu Su*, Lijing Fang*. Chlorotoxin-derived bicyclic peptides for targeted imaging of glioblastomas. Chem. Commun. 2020, 56, 9537-9540.

10.  Guiyang Yao; Wei Wang, Lijiao Ao, Zhehong Cheng, Chunlei Wu, Zhengyin Pan, Ke Liu, Hongchang Li, Wu Su*, Lijing Fang*, Improved Total Synthesis and Biological Evaluation of Coibamide A Analogues. J. Med. Chem.201861, 8809-8916.

11.  Zhehong Cheng, Wei Wang, Chunlei Wu, Xiaohua Zou, Lijing Fang*, Wu Su*, Pu Wang*, Novel Pyrrole−Imidazole Polyamide Hoechst Conjugate Suppresses Epstein−Barr Virus Replication and Virus-Positive Tumor Growth. J. Med. Chem.201861, 6674-6684.

12.  Ke Liu#, Lijing Fang#, Haiyan Sun#, Zhengyin Pan, Jianchao Zhang, Juntao Chen, Ximing Shao, Wei Wang, Yuanyan Tan, Zhihao Ding, Lijiao Ao, Chunlei, Wu, Xiaoqi Liu, Huashun Li, Rui Wang*, Wu Su* and Hongchang Li*. Targeting Polo-like Kinase 1 by a Novel Pyrrole-imidazole Polyamide-Hoechst Conjugate Suppresses Tumor Growth in vivo. Mol. Cancer Ther.201817, 988‒1002.

13.  Zhengyin Pan, Chunlei Wu, Wei Wang, Zhehong Cheng, Guiyang Yao, Ke Liu, Hongchang Li, Lijing Fang*, Wu Su*. Total Synthesis and Stereochemical Assignment of Gymnopeptides A and B. Org. Lett.201719, 4420‒4423.

14.  Chunlei Wu; Zhengyin Pan; Guiyang Yao; Wei Wang; Lijing Fang*; Wu Su*. Synthesis and structure–activity relationship studies of teixobactin analogues. RSC Advances 20177, 1923–6.

15.  Guiyang Yao, Zhengyin Pan, Chunlei Wu, Wei Wang, Lijing Fang*, Wu Su*, Efficient synthesis and stereochemical revision of coibamide A, J. Am. Chem. Soc. 2015137, 13488–91.

16.  Lijing Fang; Guiyang Yao; Zhengyin Pan; Chunlei Wu; Heng-Shan Wang; Glenn A. Burley; Wu Su*. Fully automated synthesis of DNA-binding Py-Im polyamides using a triphosgene coupling strategy. Org. Lett. 201517, 158–61.

17.  Lijing Fang; Chunlei Wu; Zaidan Yu; Peng Shang; Yongxian Cheng; Yuefeng Peng*; Wu Su*. Triphosgene-mediated couplings in the solid phase: total synthesis of brachystemin A. Eur. J. Org. Chem2014, 7572–6.

18.  Lijing Fang; Jiong Yang* Fei Yang, Enantioselective synthesis of a diastereomer of iriomoteolide- 1a. What is the correct structure of the natural product? Org. Lett. 201012, 3124.

19.  Lijing Fang; Haoran Xue Jiong Yang*, Synthesis of the C1−C12 Fragment of Iriomoteolide 1a by Sequential Catalytic Asymmetric Vinylogous Aldol Reactions. Org. Lett. 2008, 10, 4645.

Research Interests

1) Design and synthesis of peptide drug.

2) Synthesis and structure-activity relationship of bioactive organic molecules.


Students

Lijiao Ao, Ph.D. (2014.9-2018.12), Biochemistry and molecular biology

Zhehong Cheng, Master (2015.9-2018.6), Bioengineering