Dr. Lijing Fang, Professor, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences.
Research Areas
Education
2002-2007 Ph.D. in Organic Chemistry, Lanzhou University
1998-2002 B.S. Lanzhou UniversityExperience
2020-present Professor, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences.
2016-2020 Associate Professor, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences.
2011-2015 Assistant Professor, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences.
2007-2010 Postdoctoral Associate, Texas A&M University, USA.
Teaching Experience
Advances in Chemical Biology
Publications
1. Jiwei Zheng, Wanyi He, Jing Li……., Hongchang Li,* Liang Chen,* Lijing Fang*. Bifunctional Compounds as Molecular Degraders for Integrin-facilitated Targeted Protein Degradation, J. Am. Chem. Soc., 2022, doi: 10.1021/jacs.2c08367.
2. Chunlei Wu, Yanyan Li, Zhehong Cheng……., Hongchang Li,* Lijing Fang*. Cell-penetrating riboflavin conjugate for antitumor photodynamic therapy. Chin. Chem. Lett., 2022, 33, 4339-44.
3. Sifeng Li, Taimin Wang, Xingchen Li, Lijing Fang, Hongbin Zhai*, Bin Cheng*. Dearomatization–rearomatization strategy of tyrosine for peptide/protein modification through thiol-addition reactions. Green Chemistry, 2022, DOI: 10.1039/d2gc03464f.
4. Chunlei Wu, Zhehong Cheng, Danyi Lu, Ke Liu, Yulian Cheng, Pengxin Wang, Yimin Zhou, Meiqing Li, Ximing Shao, Hongchang Li,* Wu Su,* Lijing Fang*. A Novel N-methylated Cyclodepsipeptide Prodrug for Targeted Cancer Therapy, Journal of Medicinal Chemistry, 2021, J. Med. Chem., 2021, 64, 991-1000.
5. Pengxin Wang, Yulian Cheng, Chunlei Wu, Yimin Zhou, Zhehong Cheng, Hongchang Li, Rui Wang,* Wu Su,* Lijing Fang*. Tyrosine-Specific Modification via a Novel Dearomatization-Rearomatization Strategy: Facile Access to Azobenzene Functionalized Peptides. Org. Lett., 2021, 23, 4137-4141.
6. Pengxin Wang, Yulian Cheng, Chunlei Wu, Ruixiang Luo, Caibing Ma, Yimin Zhou, Zilong Ma, Rui Wang,* Wu Su,* Lijing Fang*. Dearomatization–rearomatization strategy of tyrosine for peptide/protein modification through thiol-addition reactions. Chem. Commun. 2021, 57, 12968-12971.
7. Wenli Shi, Danyi Lu, Chunlei Wu, Meiqing Li, Zhihao Ding, Yanyan Li, Binghua Chen, Xian Lin, Wu Su, Ximing Shao, Zhihui Xia, Lijing Fang*, Ke Liu*, Hongchang Li*. Coibamide A kills cancer cells through inhibiting autophagy, Biochemical and Biophysical Research Communications,. 2021, 547, 52-58.
8. Meiqing Li, Danyi Lu, Yulian Cheng, Chunlei Wu, Jianchao Zhang, Wenli Shi, Zhihao Ding, Yanyan Li, Binghua Cheng, Xian Lin, Ximing Shao, Hongchang Li, Lijing Fang*, Ke Liu*, Wu Su*. A novel pyrrole-imidazole polyamide targets Aurora kinase A and suppresses tumor growth in vivo, Biochemical and Biophysical Research Communications 2021, 571, 167-173.
9. Meiqing Li, Ximing Shao, Chunlei Wu, Danyi Lu, Ke Liu, Wei Wang, Jiakai Liu, Hongchang Li*, Wu Su*, Lijing Fang*. Chlorotoxin-derived bicyclic peptides for targeted imaging of glioblastomas. Chem. Commun. 2020, 56, 9537-9540.
10. Guiyang Yao; Wei Wang, Lijiao Ao, Zhehong Cheng, Chunlei Wu, Zhengyin Pan, Ke Liu, Hongchang Li, Wu Su*, Lijing Fang*, Improved Total Synthesis and Biological Evaluation of Coibamide A Analogues. J. Med. Chem., 2018, 61, 8809-8916.
11. Zhehong Cheng, Wei Wang, Chunlei Wu, Xiaohua Zou, Lijing Fang*, Wu Su*, Pu Wang*, Novel Pyrrole−Imidazole Polyamide Hoechst Conjugate Suppresses Epstein−Barr Virus Replication and Virus-Positive Tumor Growth. J. Med. Chem., 2018, 61, 6674-6684.
12. Ke Liu#, Lijing Fang#, Haiyan Sun#, Zhengyin Pan, Jianchao Zhang, Juntao Chen, Ximing Shao, Wei Wang, Yuanyan Tan, Zhihao Ding, Lijiao Ao, Chunlei, Wu, Xiaoqi Liu, Huashun Li, Rui Wang*, Wu Su* and Hongchang Li*. Targeting Polo-like Kinase 1 by a Novel Pyrrole-imidazole Polyamide-Hoechst Conjugate Suppresses Tumor Growth in vivo. Mol. Cancer Ther., 2018, 17, 988‒1002.
13. Zhengyin Pan, Chunlei Wu, Wei Wang, Zhehong Cheng, Guiyang Yao, Ke Liu, Hongchang Li, Lijing Fang*, Wu Su*. Total Synthesis and Stereochemical Assignment of Gymnopeptides A and B. Org. Lett., 2017, 19, 4420‒4423.
14. Chunlei Wu; Zhengyin Pan; Guiyang Yao; Wei Wang; Lijing Fang*; Wu Su*. Synthesis and structure–activity relationship studies of teixobactin analogues. RSC Advances 2017, 7, 1923–6.
15. Guiyang Yao, Zhengyin Pan, Chunlei Wu, Wei Wang, Lijing Fang*, Wu Su*, Efficient synthesis and stereochemical revision of coibamide A, J. Am. Chem. Soc. 2015, 137, 13488–91.
16. Lijing Fang; Guiyang Yao; Zhengyin Pan; Chunlei Wu; Heng-Shan Wang; Glenn A. Burley; Wu Su*. Fully automated synthesis of DNA-binding Py-Im polyamides using a triphosgene coupling strategy. Org. Lett. 2015, 17, 158–61.
17. Lijing Fang; Chunlei Wu; Zaidan Yu; Peng Shang; Yongxian Cheng; Yuefeng Peng*; Wu Su*. Triphosgene-mediated couplings in the solid phase: total synthesis of brachystemin A. Eur. J. Org. Chem. 2014, 7572–6.
18. Lijing Fang; Jiong Yang* Fei Yang, Enantioselective synthesis of a diastereomer of iriomoteolide- 1a. What is the correct structure of the natural product? Org. Lett. 2010, 12, 3124.
19. Lijing Fang; Haoran Xue Jiong Yang*, Synthesis of the C1−C12 Fragment of Iriomoteolide 1a by Sequential Catalytic Asymmetric Vinylogous Aldol Reactions. Org. Lett. 2008, 10, 4645.
Research Interests
1) Design and synthesis of peptide drug.
2) Synthesis and structure-activity relationship of bioactive organic molecules.
Students
Lijiao Ao, Ph.D. (2014.9-2018.12), Biochemistry and molecular biology
Zhehong Cheng, Master (2015.9-2018.6), Bioengineering