基本信息
韩雪祥  男    中国科学院分子细胞科学卓越创新中心
电子邮件: xuexiang.han@sibcb.ac.cn
通信地址: 上海市徐汇区岳阳路320号细胞楼805
邮政编码:

招生信息

   
招生专业
071010-生物化学与分子生物学
0710J1-纳米科学与技术
招生方向
脂质纳米粒,RNA药物递送

教育背景

2014-09--2019-07   清华大学   博士
2010-09--2014-07   上海大学   本科

工作经历

   
工作简历
2024-02~现在, 中国科学院分子细胞科学卓越创新中心, 研究员
2020-01~2024-01,宾夕法尼亚大学, 博士后
2014-09~2019-07,清华大学, 博士
2010-09~2014-07,上海大学, 本科

专利与奖励

   
奖励信息
(1) 博士研究生国家奖学金, 一等奖, 国家级, 2018
专利成果
( 1 ) 一种酸响应介孔硅纳米药物及其制备方法和应用, 2022, 第 4 作者, 专利号: CN109464671B

( 2 ) 一种IDO1多肽纳米抑制剂及其制备方法和应用, 2021, 第 2 作者, 专利号: CN111035623B

出版信息

   
发表论文
(1) In situ combinatorial synthesis of degradable branched lipidoids for systemic delivery of mRNA therapeutics and gene editors, Nature Communications, 2024, 第 1 作者
(2) Ligand-tethered lipid nanoparticles for targeted RNA delivery to treat liver fibrosis, NATURE COMMUNICATIONS, 2023, 第 1 作者
(3) Adjuvant lipidoid-substituted lipid nanoparticles augment the immunogenicity of SARS-CoV-2 mRNA vaccines, NATURE NANOTECHNOLOGY, 2023, 第 1 作者
(4) In situ PEGylation of CAR T cells alleviates cytokine release syndrome and neurotoxicity, Nature Materials, 2023, 第 2 作者
(5) A Bioinspired Nanoprobe with Multilevel Responsive T-1-Weighted MR Signal-Amplification Illuminates Ultrasmall Metastases, ADVANCED MATERIALS, 2020, 第 5 作者
(6) Emerging nanomedicines for anti-stromal therapy against desmoplastic tumors, Biomaterials, 2020, 第 1 作者
(7) Nanomaterials for Therapeutic RNA Delivery, MATTER, 2020, 第 1 作者
(8) Modularly Designed Peptide Nanoprodrug Augments Antitumor Immunity of PD-L1 Checkpoint Blockade by Targeting Indoleamine 2,3-Dioxygenase, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2020, 第 1 作者
(9) Sulforaphane Mediates Glutathione Depletion via Polymeric Nanoparticles to Restore Cisplatin Chemosensitivity, ACS NANO, 2019, 第 2 作者
(10) Dopamine Delivery via pH-Sensitive Nanoparticles for Tumor Blood Vessel Normalization and an Improved Effect of Cancer Chemotherapeutic Drugs, ADVANCED HEALTHCARE MATERIALS, 2019, 第 5 作者
(11) Cooperatively Responsive Peptide Nanotherapeutic that Regulates Angiopoietin Receptor Tie2 Activity in Tumor Microenvironment To Prevent Breast Tumor Relapse after Chemotherapy, ACS NANO, 2019, 第 13 作者
(12) In Situ Self-Assembled Nanofibers Precisely Target Cancer-Associated Fibroblasts for Improved Tumor Imaging, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2019, 第 7 作者
(13) An Extendable Star-Like Nanoplatform for Functional and Anatomical Imaging-Guided Photothermal Oncotherapy, ACS NANO, 2019, 第 1 作者
(14) Reshaping Prostate Tumor Microenvironment To Suppress Metastasis via Cancer-Associated Fibroblast Inactivation with Peptide Assembly-Based Nanosystem, ACS NANO, 2019, 第 5 作者
(15) Targeted Co-delivery of the Iron Chelator Deferoxamine and a HIF1 alpha Inhibitor Impairs Pancreatic Tumor Growth, ACS NANO, 2019, 第 9 作者
(16) Synthesis and Imaging of Biocompatible Graphdiyne Quantum Dots, ACS APPLIED MATERIALS & INTERFACES, 2019, 第 5 作者
(17) Say No to Tumors: NO Matters, MATTER, 2019, 第 1 作者
(18) Targeted brain delivery of rabies virus glycoprotein 29-modified deferoxamine-loaded nanoparticles reverses functional deficits in parkinsonian mice, ACS NANO, 2018, 第 5 作者
(19) Nanomedicine Assembled by Coordinated Selenium-Platinum Complexes Can Selectively Induce Cytotoxicity in Cancer Cells by Targeting the Glutathione Antioxidant Defense System, ACS BIOMATERIALS SCIENCE & ENGINEERING, 2018, 第 3 作者
(20) Epidermal Growth Factor Receptor-Targeting Peptide Nanoparticles Simultaneously Deliver Gemcitabine and Olaparib To Treat Pancreatic Cancer with Breast Cancer 2 (BRCA2) Mutation, ACS NANO, 2018, 第 7 作者
(21) Delivery of small interfering RNA against Nogo-B receptor via tumor-acidity responsive nanoparticles for tumor vessel normalization and metastasis suppression, BIOMATERIALS, 2018, 第 4 作者
(22) Injectable hexapeptide hydrogel for localized chemotherapy prevents breast cancer recurrence, ACS APPLIED MATERIALS & INTERFACES, 2018, 第 5 作者

科研活动

   
科研项目
( 1 ) 新型脂质纳米粒的构建和RNA药物递送, 负责人, 国家任务, 2024-02--2027-02
( 2 ) RNA折叠与适配体技术升级, 参与, 中国科学院计划, 2023-10--2028-09