100701-药物化学

药物分析，天然产物分析，液质联用分析，开源离子源研究

   

2014-10~现在, 中国科学院成都生物研究所, 高级工程师（副高级）
2012-07~2014-10,中国科学院成都生物研究所, 工程师

   

   

（1） Automated single-cell analysis by single-cell side-orifice flow cytometry chain electrospray ionization mass spectrometry, TALANTA, 2026, 第 6 作者  通讯作者
（2） Ultrasensitive Detection of Cardiac Troponin I via CRISPR/Cas12a-Mediated Liposomal Amplification Coupled with Electrospray Ionization Mass Spectrometry, Analytical Chemistry, 2026, 第 7 作者  通讯作者
（3） Development and Application of a Comprehensive Non-targeted Screening Strategy for Fentanyl Analogues, JOURNAL OF HAZARDOUS MATERIALS, 2025, 第 2 作者  通讯作者
（4） High-throughput screening of new psychoactive substances and related compounds in food by UHPLC-Q/Orbitrap, FOOD CHEMISTRY, 2025, 第 2 作者
（5） Application of machine learning in LC-MS-based non-targeted analysis, Trends in Analytical Chemistry, 2025, 第 6 作者  通讯作者
（6） CMSSP: A Contrastive Mass Spectra-Structure Pretraining Model for Metabolite Identification, ANALYTICAL CHEMISTRY, 2024, 第 2 作者  通讯作者
（7） Chain electrospray ionization mass spectrometry for ultra-low volume sample analysis, TALANTA, 2024, 第 4 作者  通讯作者
（8） Development and application of a comprehensive nontargeted screening strategy for aristolochic acid analogues, Analytical Chemistry, 2024, 第 6 作者  通讯作者
（9） Pulsed Direct Current Arc-Induced Nanoelectrospray Ionization Mass Spectrometry, Analytical Chemistry, 2024, 第 5 作者  通讯作者
（10） Rapid analysis of the chemical constituents of traditional Tibetan medicine Sbyor‐bzo‐ghi‐wang using ballpoint electrospray ionization technique, Rapid Communications in Mass Spectrometry, 2024, 第 6 作者
（11） 凝胶过滤层析结合液相色谱-串联质谱法测定血清中游离甲状腺激素, Determination of Free Thyroid Hormones in Serum by Gel Filtration Chromatography Combined with Liquid Chromatography-Tandem Mass Spectrometry, 分析测试学报, 2023, 第 4 作者
（12） Microdroplet accelerated reaction for high-efficiency carbon disulfide conversion, Chemical Communications, 2023, 第 2 作者  通讯作者
（13） Determination of 63 mycotoxins in grain products by ultrahigh-performance liquid chromatography coupled with quadrupole-Orbitrap mass spectrometry, FOOD CONTROL, 2023, 第 6 作者
（14） Rapid recognition and targeted isolation of potential anti‐breast cancer xanthones in Hypericum bellum Li by "seed" mass spectra‐based molecular networking and in silico MS/MS fragmentation, Phytochemical Analysis, 2023, 第 3 作者
（15） Automated high‐throughput characterization of microbial metabolites and species using array ballpoint electrospray ionization technique, Rapid Communications in Mass Spectrometry, 2023, 第 4 作者  通讯作者
（16） A novel functionalized covalent organic framework/carbon nanotube composite as an effective online solid-phase extraction sorbent for simultaneous detection of 33 steroid hormones in pork, FOOD CHEMISTRY, 2022, 第 4 作者
（17） Purification and mass spectrometry study of Maillard reaction impurities in five acyclic nucleoside antiviral drugs, JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2022, 第 5 作者  通讯作者
（18） Performing 2D-1D-2D Mass Spectrometry Imaging Using Strings, Analytical Chemistry, 2022, 第 2 作者  通讯作者
（19） Study on the separation mechanism of solid-substrate electrospray ionization mass spectrometry, JOURNAL OF SEPARATION SCIENCE, 2021, 第 4 作者
（20） Ultrasonic Sputter Desorption Mass Spectrometry Technique for Minimally Invasive Tissue Analysis, ANALYTICAL CHEMISTRY, 2021, 第 3 作者  通讯作者
（21） Rapid screening of 70 colorants in dyeable foods by using ultra-high-performance liquid chromatography–hybrid quadrupole–Orbitrap mass spectrometry with customized accurate-mass database and mass spectral library, FOOD CHEMISTRY, 2021, 第 5 作者
（22） 基于HPLC-MS/MS快速筛选阿卡波糖及其类似物的菌株, Rapid Screening of Acarbose and Its Analogs in Fermentation Broth Based on HPLC-MS/MS, 质谱学报, 2021, 第 4 作者
（23） Corrigendum to "A 6/5/5/7 heterotetracyclic indole derivative alkaloid isolated from Typhonium giganteum" Tetrahedron Lett. (2020) 151497, TETRAHEDRON LETTERS, 2020, 第 5 作者
（24） Extensive screening of cyclopeptide toxins in mushrooms by ultra-high-performance liquid chromatography coupled with quadrupole-Orbitrap mass spectrometry, FOOD CHEMISTRY, 2020, 第 4 作者
（25） Online Scavenging of Trace Analytes in Complex Matrices for Fast Analysis by Carbon Dioxide Bubbling Extraction Coupled with Gas Chromatography-Mass Spectrometry, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2020, 第 2 作者
（26） High-sensitivity detection of therapeutic drugs in complex biofluids using a packed ballpoint-electrospray ionization technique, ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2020, 第 3 作者
（27） 基于分子式数据库策略的FM-searcher软件在危害物非目标筛查分子式预测中的应用, Application of FM-Searcher Software to Prediction of Molecular Formula in the Non-target Screening of Hazard Components Based on Molecular Formula Database Strategy, 质谱学报, 2020, 第 4 作者
（28） Flow controllable three-dimensional paper-based microfluidic analytical devices fabricated by 3D printing technology, ANALYTICA CHIMICA ACTA, 2019, 第 2 作者  通讯作者
（29） Analysis of Compounds Dissolved in Nonpolar Solvents by Electrospray Ionization on Conductive Nanomaterials, JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 2018, 第 1 作者
（30） Low-cost and convenient ballpoint tip-protected liquid-phase microextraction for sensitive analysis of organic molecules in water samples, ANALYTICA CHIMICA ACTA, 2018, 第 2 作者  通讯作者
（31） 天然产物的质谱智能解析研究, 中国科学 : 化学, 2017, 第 1 作者
（32） Determination of Sulfonamides in Chicken Muscle by Pulsed Direct Current ElectroSpray Ionization Tandem Mass Spectrometry, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2017, 第 3 作者  通讯作者
（33） Intelligent interpretation of mass spectra of natural products, SCIENTIA SINICA Chimica, 2017, 第 1 作者
（34） 猕猴桃藤山柳化学成分研究, 中草药, 2016, 第 5 作者
（35） Analysis of the lithiated leucosceptroids from Leucosceptrum canum to facilitate their identification and differentiation by electrospray ionization tandem mass spectrometry, Rapid Communications in Mass Spectrometry, 2016, 第 2 作者
（36） Generating Electrospray Ionization on Ballpoint Tips, ANALYTICAL CHEMISTRY, 2016, 第 2 作者
（37） Application of fractionized sampling and stacking for construction of an interface for online heart-cutting two-dimensional liquid chromatography, JOURNALOFCHROMATOGRAPHYA, 2016, 第 2 作者  通讯作者
（38） Structural characterization and antiviral effect of a novel polysaccharide PSP-2B from Prunellae Spica, CARBOHYDRATE POLYMERS, 2016, 第 5 作者
（39） 质谱智能解析方法的建立及其在天然药物分析中的应用, 中国化学会第二届全国质谱分析学术报告会会议摘要集, 2015, 第 1 作者
（40） 质谱-多级质谱联用技术（MS-MS~n）用于茶叶中初级代谢产物的快速鉴定, 中国化学会第二届全国质谱分析学术报告会会议摘要集, 2015, 第 3 作者
（41） 应用探针电喷雾串联质谱快速区分裸蒴中微量同分异构体, 中国化学会第十八届全国有机分析及生物分析学术研讨会论文汇编, 2015, 第 2 作者
（42） Two new diketopiperazines and a new glucosyl sesterterpene from Alternaria alternata, an endophytic fungi from Ceratostigma griffithii, PHYTOCHEMISTRY LETTERS, 2015, 第 4 作者
（43） Development and characterization of a nanodendritic silver-based solid-phase extraction sorbent for selective enrichment of endocrine-disrupting chemicals in water and milk samples, ANALYTICA CHIMICA ACTA, 2015, 第 2 作者
（44） 12-Membered Resorcylic Acid Lactones Isolated from Saccharicola bicolor, an Endophytic Fungi from Bergenia purpurascens, NATURAL PRODUCT COMMUNICATIONS, 2015, 第 4 作者
（45） Fragmentation of protonated 2-(2-phenylethyl)chromones from agarwood: the diagnostic role of ion/neutral complexes as reactive intermediates, EUROPEAN JOURNAL OF MASS SPECTROMETRY, 2015, 第 2 作者
（46） Reversible tuning of the wettability on a silver mesodendritic surface by the formation and disruption of lipid-like bilayers, APPLIED SURFACE SCIENCE, 2015, 第 2 作者
（47） Strategy to rapidly discriminate trace isomeric lignan compounds from Gymnotheca chinensis by probe electrospray ionization tandem mass spectrometry, EUROPEAN JOURNAL OF MASS SPECTROMETRY, 2015, 第 2 作者
（48） 针尖电喷雾质谱方法用于软膏剂药物的直接分析, 中国化学会第二届全国质谱分析学术报告会会议摘要集, 2015, 第 3 作者
（49） 羌活化学成分的UPLC-MS分析, 分析试验室, 2014, 第 2 作者
（50） Advanced ultra-performance liquid chromatography-photodiode array-quadrupole time-of-flight mass spectrometric methods for simultaneous screening and quantification of triterpenoids in Poria cocos, FOOD CHEMISTRY, 2014, 第 1 作者
（51） Fast Separation Method Development for Supercritical Fluid Chromatography Using an Autoblending Protocol, CHROMATOGRAPHIA, 2014, 第 1 作者
（52） Investigation of the Chemical Compositions in Tobacco of Different Origins and Maturities at Harvest by GC-MS and HPLC-PDA-QTOFMS, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2014, 第 1 作者
（53） A rapid and highly specific method to evaluate the presence of 2-(2-phenylethyl) chromones in agarwood by supercritical fluid chromatography-mass spectrometry, EUROPEAN JOURNAL OF MASS SPECTROMETRY, 2014, 第 1 作者
（54） Non-Target Screening of Veterinary Drugs Using Tandem Mass Spectrometry on SmartMass, JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 2013, 第 1 作者
（55） Tandem mass spectrometry fragmentation of the protonated 2-(2-phenylethyl)chromones from Agarwood: radical ions versus non-radical ions, JOURNAL OF MASS SPECTROMETRY, 2013, 第 1 作者
（56） 沉香中2-（2-苯乙基）色酮类化合物加氢离子的电喷雾串联质谱裂解机理研究, 中国化学会第十七届全国有机分析与生物分析学术研讨会, 2013, 第 1 作者
（57） Efficient optimization of ultra-high- performance supercritical fluid chromatographic separation of Rosa sericea by response surface methodology, JOURNAL OF SEPARATION SCIENCE, 2013, 第 3 作者
（58） 滇虎榛叶的化学成分及其抗氧化活性研究, 中草药, 2013, 第 3 作者
（59） Fast analysis of triterpenoids in Ganoderma lucidum spores by ultra-performance liquid chromatography coupled with triple quadrupole mass spectrometry, BIOMEDICAL CHROMATOGRAPHY, 2013, 第 2 作者
（60） Two new cyclic diarylheptanoids from the stems of Ostryopsis nobilis, CHINESE CHEMICAL LETTERS, 2013, 第 2 作者
（61） Tandem mass spectrometric analysis and density functional theory calculations on the fragmentation behavior of two tetradecanoylingenol regioisomers from Euphorbia wallichii, RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 2012, 第 1 作者
（62） 基于分子式数据库的高分辨质谱化合物分子式预测方法, 分析试验室, 2012, 第 1 作者
（63） Discrimination of the seeds of Notopterygium incisum and Notopterygium franchetii by validated HPLC-DAD–ESI-MS method and principal component analysis, JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2011, 第 5 作者
（64） Self-assembly of carboxymethyl konjac glucomannan-g-poly(ethylene glycol) and (alpha-cyclodextrin) to biocompatible hollow nanospheres for glucose oxidase encapsulation, CARBOHYDRATE POLYMERS, 2011, 第 2 作者
（65） MyMolDB: A Micromolecular Database Solution with Open Source and Free Components, JOURNALOFCOMPUTATIONALCHEMISTRY, 2011, 第 1 作者  通讯作者
（66） Preparation and characterization of a poly(ethylene glycol) grafted carboxymethyl konjac glucomannan copolymer, CARBOHYDRATE POLYMERS, 2010, 第 1 作者
（67） Semi-permeable nanocapsules of konjac glucomannan-chitosan for enzyme immobilization, INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2008, 第 2 作者

   

（ 1 ） 原位全息组学时空动态分析仪, 负责人, 中国科学院计划, 2026-04--2029-03
（ 2 ） 自动化天然产物获取机器人系统的高通量质谱离子源的开发, 负责人, 中国科学院计划, 2025-01--2027-12
（ 3 ） 基于三重四极杆质谱的蛋白质生物标志物分析检测及应用研究-课题2, 负责人, 其他, 2024-09--2028-12
（ 4 ） 基于单细胞代谢组学及AI辅助筛选抗类风湿性关节炎活性天然产物, 负责人, 地方任务, 2024-09--2025-08
（ 5 ） 多模式高精度质谱成像装置的研制, 负责人, 中国科学院计划, 2023-10--2024-10
（ 6 ） 微珠电喷雾阵列多形态样品高通量分析装置的开发, 负责人, 中国科学院计划, 2023-01--2024-12
（ 7 ） 中国科学院青年创新促进会-夏兵, 负责人, 其他国际合作项目, 2019-01--2022-12
（ 8 ） 中国科学院关键技术人才-夏兵, 负责人, 其他国际合作项目, 2019-01--2021-12
（ 9 ） 基于质谱碎裂特征的食品化学危害因子非定向筛查技术研究, 负责人, 国家任务, 2018-12--2021-12
（ 10 ） 基于导电纳米材料的电喷雾离子化机理研究, 负责人, 国家任务, 2017-01--2020-12
（ 11 ） 质谱高通量自动进样装置研制, 负责人, 中国科学院计划, 2017-01--2018-12
（ 12 ） 基于计算机辅助分析和液质联用技术的未知食品危害物筛查研究, 负责人, 国家任务, 2014-01--2016-12

已指导学生

赖晓红  硕士研究生  078001-药物化学  

陈香  硕士研究生  078001-药物化学  

谭雨  硕士研究生  086000-生物与医药  

邓顺艳  硕士研究生  078001-药物化学  

黄宇飞  硕士研究生  086000-生物与医药  

王宇  博士研究生  100701-药物化学  

陈璐  博士研究生  100701-药物化学  

现指导学生

金卓琳  硕士研究生  086002-制药工程  

叶钰  硕士研究生  086002-制药工程  

刘子真  硕士研究生  086002-制药工程