基本信息
李伟 男 博导 中国科学院生物物理研究所
电子邮件: weili007@ibp.ac.cn
通信地址: 北京市朝阳区大屯路15号
邮政编码:
电子邮件: weili007@ibp.ac.cn
通信地址: 北京市朝阳区大屯路15号
邮政编码:
招生信息
招生专业
071011-生物物理学070205-凝聚态物理0703Z1-化学生物学
招生方向
单分子生物物理学染色质动态结构和调控基因转录的分子机制
教育背景
2003-09--2006-05 中国科学院物理研究所 博士2000-09--2003-07 南京师范大学 硕士1996-09--2000-07 南京师范大学 本科
工作经历
工作简历
2023-06~现在, 中国科学院生物物理研究所, 研究员2009-07~2023-05,中国科学院物理研究所, 副研究员2007-10~2009-07,中国科学院物理研究所, 助理研究员2006-05~2007-10,中国科学院化学研究所, 博士后2003-09~2006-05,中国科学院物理研究所, 博士2000-09~2003-07,南京师范大学, 硕士1996-09~2000-07,南京师范大学, 本科
社会兼职
2021-08-01-今,中国生物物理学会单分子生物学分会委员,
2021-08-01-今,中国生物物理学会分子生物物理分会委员,
2021-08-01-今,中国生物物理学会分子生物物理分会委员,
专利与奖励
奖励信息
(1) 高等学校科学研究优秀成果奖, 二等奖, 部委级, 2023(2) 北京市科学技术奖二等奖, 二等奖, 省级, 2018
专利成果
( 1 ) 磁镊荧光装置, 2020, 第 2 作者, 专利号: CN112098376A( 2 ) 用于磁镊装置的磁球坐标的校准方法和校准装置, 2019, 第 2 作者, 专利号: CN110360925A
出版信息
发表论文
(1) H2B ubiquitination recruits FACT to maintain a stable altered nucleosome state for transcriptional activation, NATURE COMMUNICATIONS, 2023, (2) Epstein-Barr virus protein BKRF4 restricts nucleosome assembly to suppress host antiviral responses, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2022, (3) H2A mono-ubiquitination differentiates FACT's functions in nucleosome assembly and disassembly, NUCLEIC ACIDS RESEARCH, 2022, (4) Spatiotemporal three-dimensional transport dynamics of endocytic cargos and their physical regulations in cells, ISCIENCE, 2022, (5) Diffusion Behaviors of Integrins in Single Cells Altered by Epithelial to Mesenchymal Transition, SMALL, 2022, (6) Recognition of the inherently unstable H2A nucleosome by Swc2 is a major determinant for unidirectional H2A.Z exchange, CELL REPORTS, 2021, (7) Revealing Differential Interaction Forces during Nanopore DNA Sequencing, JOURNAL OF PHYSICAL CHEMISTRY B, 2021, (8) 单分子力谱研究组蛋白H2A泛素化修饰调控核小体的分子机制, 医用生物力学, 2021, 第 3 作者(9) DNA polymerase Gp90 activities and regulations on strand displacement DNA synthesis revealed at single-molecule level, FASEB JOURNAL, 2021, (10) Curaxin-Induced DNA Topology Alterations Trigger the Distinct Binding Response of CTCF and FACT at the Single-Molecule Level, BIOCHEMISTRY, 2021, (11) Histone H2A Ubiquitination Reinforces Mechanical Stability and Asymmetry at the Single-Nucleosome Level, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2020, (12) Folding Dynamics of Parallel and Antiparallel G-Triplexes under the Influence of Proximal DNA, JOURNAL OF PHYSICAL CHEMISTRY B, 2018, (13) Dissection of structural dynamics of chromatin fibers by single-molecule magnetic tweezers, Dissection of structural dynamics of chromatin fibers by single-molecule magnetic tweezers, 生物物理学报:英文版, 2018, (14) Effect of Torsion on Cisplatin-Induced DNA Condensation, Effect of Torsion on Cisplatin-Induced DNA Condensation, 中国物理快报(英文版), 2018, (15) Intracellular transport is accelerated in early apoptotic cells, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, (16) Interaction between human telomeric G-quadruplexes characterized by single molecule magnetic tweezers, CHINESE PHYSICS B, 2018, (17) Functions of FACT in Breaking the Nucleosome and Maintaining Its Integrity at the Single-Nucleosome Level, MOLECULAR CELL, 2018, (18) Dissection of structural dynamics of chromatin fibers by single-molecule magnetic tweezers, Dissection of structural dynamics of chromatin fibers by single-molecule magnetic tweezers, 生物物理学报:英文版, 2018, (19) Effect of Torsion on Cisplatin-Induced DNA Condensation, Effect of Torsion on Cisplatin-Induced DNA Condensation, CHINESE PHYSICS LETTERS, 2018, (20) Helicase activity and substrate specificity of RecQ5��, CHINESE PHYSICS. B, 2017, (21) Effects of monovalent cations on folding kinetics of G-quadruplexes, BIOSCIENCE REPORTS, 2017, (22) An optimization algorithm for single-molecule fluorescence resonance (smFRET) data processing, ACTA PHYSICA SINICA, 2017, (23) Helicase activity and substrate specificity of RecQ5 beta, CHINESE PHYSICS B, 2017, (24) FACT Remodels the Tetranucleosomal Unit of Chromatin Fibers for Gene Transcription, MOLECULAR CELL, 2016, (25) Folding Kinetics of Single Human Telomeric G-Quadruplex Affected by Cisplatin, ACS OMEGA, 2016, (26) Iterative homology checking and non-uniform stepping during RecA-mediated strand exchange, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2016, (27) Mapping Intracellular Diffusion Distribution Using Single Quantum Dot Tracking: Compartmentalized Diffusion Defined by Endoplasmic Reticulum, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2015, (28) Catch-bond behavior of DNA condensate under tension, CHINESE PHYSICS B, 2015, (29) Complex kinetics of DNA condensation revealed through DNA twist tracing, PHYSICAL REVIEW E, 2015, (30) A model for chromosome organization during the cell cycle in live E-coli, SCIENTIFIC REPORTS, 2015, (31) Revealing Three Stages of DNA-Cisplatin Reaction by a Solid-State Nanopore, SCIENTIFIC REPORTS, 2015, (32) Condensations of single DNA molecules induced by heptaplatin and its chiral isomer, AIP ADVANCES, 2014, (33) Effects of pH on Oxaliplatin-Induced Condensation of Single DNA Molecules, CHINESE PHYSICS LETTERS, 2014, (34) H3.3 actively marks enhancers and primes gene transcription via opening higher-ordered chromatin, GENES & DEVELOPMENT, 2013, (35) Oxaliplatin and Its Enantiomer Induce Different Condensation Dynamics of Single DNA Molecules, PLOS ONE, 2013, (36) Direct Measurement of Sequential Folding Pathway and Energy Landscape of Human Telomeric G-quadruplex Structures, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2013, (37) Kinetic study of the DNA annealing properties of RECQ5β helicase, Kinetic study of the DNA annealing properties of RECQ5�� helicase, 中国科学通报:英文版, 2012, (38) Kinetic study of the DNA annealing properties of RECQ5 beta helicase, CHINESE SCIENCE BULLETIN, 2012, (39) Impact of DNA Twist Accumulation on Progressive Helical Wrapping of Torsionally Constrained DNA, PHYSICAL REVIEW LETTERS, 2012, (40) Studying the interaction between gyrase and DNA using magnetic tweezers, CHINESE SCIENCE BULLETIN, 2012, (41) RECQ5β解旋酶DNA退火特性的动力学研究, 科学通报, 2012, 第 6 作者(42) Elastic response and length change of single DNA molecules induced by a combination of cisplatin and transplatin, PHYSICAL REVIEW E, 2012, (43) 利用磁镊研究促旋酶与DNA的结合, 科学通报, 2012, 第 4 作者(44) Kinetic study of the DNA annealing properties of RECQ5β helicase, Kinetic study of the DNA annealing properties of RECQ5�� helicase, 中国科学通报:英文版, 2012, (45) Brownian dynamics simulation of the cross-talking effect among modified histones on conformations of nucleosomes, CHINESE PHYSICS B, 2010, (46) Spiking Regularity and Coherence in Complex Hodgkin-Huxley Neuron Networks, Spiking Regularity and Coherence in Complex Hodgkin-Huxley Neuron Networks, 中国物理快报:英文版, 2010, 第 3 作者(47) Spiking Regularity and Coherence in Complex Hodgkin-Huxley Neuron Networks, CHINESE PHYSICS LETTERS, 2010, (48) Brownian dynamics simulation of the cross-talking effect among modified histones on conformations of nucleosomes, Brownian dynamics simulation of the cross-talking effect among modified histones on conformations of nucleosomes, 中国物理:英文版, 2010, 第 2 作者(49) Formation of DNA toroids inside confined droplets adsorbed on mica surfaces, PHYSICAL REVIEW E, 2009, (50) 1H-magnetic resonance spectroscopy screening for animals with acute cerebral infraction suitable for thrombolytic therapy***, NEURAL REGENERATION RESEARCH, 2007, (51) Brownian dynamics simulation of the effect of histone modification on nucleosome structure, PHYSICAL REVIEW E, 2007, (52) Brownian dynamics simulation of directional sliding of histone octamers caused by DNA bending, PHYSICAL REVIEW E, 2006, (53) DNA与组蛋白相互作用的布朗动力学研究, Brownian dynamics simulation of the interaction between DNA and histone, 物理, 2005, 第 1 作者
科研活动
科研项目
( 1 ) MeCP2染色质纤维动态结构及Rett综合症分子机制的探究, 负责人, 国家任务, 2019-01--2022-12( 2 ) Rett综合症分子机制的探究及相关药物高通量筛选磁镊技术的研发, 负责人, 中国科学院计划, 2017-05--2022-06( 3 ) 核小体结构的组装动力学:单分子磁镊技术的新探索, 负责人, 国家任务, 2015-01--2018-12