基本信息
尹琦 女 硕导 中国科学院上海药物研究所
电子邮件: qyin@simm.ac.cn
通信地址: 上海市浦东新区海科路501号1517室
邮政编码:
电子邮件: qyin@simm.ac.cn
通信地址: 上海市浦东新区海科路501号1517室
邮政编码:
招生信息
招生专业
100702-药剂学
招生方向
基于纳米技术的肿瘤靶向药物输送
教育背景
2007-09--2012-06 中国科学院上海药物研究所 理学博士
工作经历
工作简历
2014-10~现在, 中国科学院上海药物研究所, 副研究员2012-07~2014-09,中国科学院上海药物研究所, 助理研究员2007-09~2012-06,中国科学院上海药物研究所, 理学博士
专利与奖励
奖励信息
(1) 中国药学会科学技术奖, 一等奖, 其他, 2015(2) 上海药学科技奖, 一等奖, 其他, 2013
专利成果
( 1 ) 一种可生物降解的非病毒基因载体及其制备方法和应用, 2014, 第 1 作者, 专利号: ZL. 201010279828.7
出版信息
发表论文
(1) Tumor cells-selective bionic nano device exploiting heparanase combats metastatic breast cancer, Advanced Functional Materials, 2018, 通讯作者(2) Ly6Chi monocytes delivering pH-sensitive micelle loading paclitaxel improve targeting therapy of metastatic breast cancer, Advanced Functional Materials, 2017, 通讯作者(3) Co-delivery of docetaxel and silibinin using pH-sensitive micelles improves therapy of metastatic breast cancer, Acta Pharmacologica Sinica, 2017, 通讯作者(4) Tumor microenvironment-adaptive nanoparticles co-deliver paclitaxel and siRNA to inhibit growth and lung metastasis of breast cancer, Advanced Functional Materials, 2016, 通讯作者(5) Dual pH-sensitive micelles with charge-switch for controlling cellular uptake and drug release to treat metastatic breast cancer, Biomaterials, 2016, 通讯作者(6) Inhibition of metastasis and growth of breast cancer by pH-sensitive poly (β-amino ester) nanoparticles co-delivering two siRNA and paclitaxel, Biomaterials, 2015, 通讯作者(7) Shrapnel nanoparticles loading docetaxel inhibit metastasis and growth of breast cancer, Biomaterials, 2015, 通讯作者(8) Bioreducible micelles with endosomal buffering and multidrug resistance-reversing function enhance anti-tumor efficacy of doxorubicin, Journal of Biomedical Nanotechnology, 2015, 第 1 作者(9) Reversal of multidrug resistance by stimuli-responsive drug delivery systems for therapy of tumor, Advanced Drug Delivery Reviews, 2013, 第 1 作者(10) Multifunctional nanoparticles improve therapeutic effect for breast cancer by simultaneously antagonizing multiple mechanisms of multidrug resistance, Biomacromolecules, 2013, 第 1 作者(11) Overcoming multidrug resistance by co-delivery of Mdr-1 and Survivin-targeting RNA with reduction-responsible cationic poly (β-amino esters), Biomaterials, 2012, 第 1 作者(12) Manganese oxide-based multifunctionalized mesoporous silica nanoparticles for pH-responsive MRI, ultrasonography and circumvention of MDR in cancer cells, Biomaterials, 2012, 第 1 作者(13) Bioreducible poly (β-amino esters)/shRNA complex nanoparticles for efficient RNA delivery, Journal of Controlled Release, 2011, 第 1 作者
科研活动
科研项目
( 1 ) 新型肿瘤靶向药物输送系统治疗转移性乳腺癌和肺癌的研究, 负责人, 中国科学院计划, 2015-01--2018-12( 2 ) 基于pH-还原双响应性聚(β-氨基酯)共聚物的多功能纳米粒改善多药耐药肿瘤治疗效果研究, 负责人, 国家任务, 2014-01--2016-12( 3 ) siRNA纳米载药系统在转移性大肠癌动物模型体内的药动学、药效学和初步安全性评价, 负责人, 国家任务, 2014-01--2018-08( 4 ) 靶向治疗肿瘤的新型阳离子聚(β-氨基酯)/RNA 自组装纳米粒的研究, 参与, 国家任务, 2013-01--2017-12( 5 ) 基于红细胞膜的靶向纳米释药系统抗乳腺癌的肺转移研究, 参与, 国家任务, 2017-01--2021-12
参与会议
(1)Polymeric Micelles with Endosomal Buffering Function Reverse Multidrug Resistant of Tumor 2015-07-26(2)Nucleic acid drug nano-delivery systems based on poly (β-amino esters) 第三届亚洲药剂学论坛 2014-05-27