基本信息

王祥喜 男 博导 中国科学院生物物理研究所
电子邮件: xiangxi@ibp.ac.cn
通信地址: 北京市朝阳区大屯路15号6719房间
邮政编码:
电子邮件: xiangxi@ibp.ac.cn
通信地址: 北京市朝阳区大屯路15号6719房间
邮政编码:
招生信息
招生专业
071011-生物物理学
招生方向
病毒学、结构生物学
教育背景
2009-09--2014-06 中国科学院大学 理学博士学位2005-09--2009-06 四川大学 理学学士学位
工作经历
工作简历
2014-11~现在, 中国科学院生物物理研究所, 研究员2014-07~2014-10,中国科学院生物物理研究所, 副研究2009-09~2014-06,中国科学院大学, 理学博士学位2005-09~2009-06,四川大学, 理学学士学位
专利与奖励
奖励信息
(1) 万人计划青年拔尖人才, 部委级, 2019(2) 2019年度中国科学十大进展, 部委级, 2019(3) 2018年度中国生命科学十大进展, 部委级, 2018(4) 中国科协首届青年托举工程入选者, 部委级, 2015(5) 第四届贝时璋青年生物物理学家奖, 部委级, 2015
专利成果
( 1 ) 一种猪瘟抗原表位制备及其应用, 2020, 第 1 作者, 专利号: 00000( 2 ) 基于乙肝核心抗原的HSV分型用蛋白,试剂盒及方法和应用, 2020, 第 1 作者, 专利号: 00000( 3 ) ALD及其作为EV71病毒和CAV16病毒抑制剂的用途, 2020, 第 1 作者, 专利号: 00001( 4 ) 一种重组脊髓灰质炎病毒样颗粒及其制备方法与应用, 2020, 第 1 作者, 专利号: 00002
出版信息
发表论文
(1) Structural and molecular basis for foot-andmouth disease virus neutralization by two potent protective antibodies, Structural and molecular basis for foot-and-mouth disease virus neutralization by two potent protective antibodies, PROTEIN & CELL, 2022, 第 12 作者 通讯作者(2) Structural and functional characterizations of infectivity and immune evasion of SARS-CoV-2 Omicron, CELL, 2022, 第 23 作者(3) Memory B cell repertoire from triple vaccinees against diverse SARS-CoV-2 variants, Nature, 2022, 第 1 作者 通讯作者(4) A proof of concept for neutralizing antibody-guided vaccine design against SARS-CoV-2, A proof of concept for neutralizing antibody-guided vaccine design against SARS-CoV-2, NATIONAL SCIENCE REVIEW, 2021, 第 26 作者 通讯作者(5) SARS-CoV-2 spike protein interacts with and activates TLR4 (Mar, 10.1038/s41422-021-00495-9, 2021), CELL RESEARCH, 2021, 第 10 作者(6) Structural basis for neutralization of an anicteric hepatitis associated echovirus by a potent neutralizing antibody, CELL DISCOVERY, 2021, 第 9 作者 通讯作者(7) Structure-based development of three- and four-antibody cocktails against SARS-CoV-2 via multiple mechanisms, Structure-based development of three- and four-antibody cocktails against SARS-CoV-2 via multiple mechanisms, CELL RESEARCH, 2021, 第 11 作者 通讯作者(8) Structure-based development of human antibody cocktails against SARS-CoV-2, Structure-based development of human antibody cocktails against SARS-CoV-2, CELL RESEARCH, 2021, 第 15 作者 通讯作者(9) Nanometer-resolution in situ structure of the SARS-CoV-2 postfusion spike protein, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 第 10 作者(10) Safety, tolerability, and immunogenicity of an inactivated SARS-CoV-2 vaccine in healthy adults aged 18���59 years: a randomised, double-blind, placebo-controlled, phase 1/2 clinical trial, LANCET INFECTIOUS DISEASES, 2021, 第 18 作者(11) Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies, Nature, 2021, 第 1 作者 通讯作者(12) Rational development of a human antibody cocktail that deploys multiple functions to confer Pan-SARS-CoVs protection, Rational development of a human antibody cocktail that deploys multiple functions to confer Pan-SARS-CoVs protection, CELL RESEARCH, 2021, 第 44 作者 通讯作者(13) Double lock of a potent human therapeutic monoclonal antibody against SARS-CoV-2, Double lock of a potent human therapeutic monoclonal antibody against SARS-CoV-2, NATIONAL SCIENCE REVIEW, 2021, 第 11 作者(14) Characterization and structural basis of a lethal mouse-adapted SARS-CoV-2, NATURE COMMUNICATIONS, 2021, 第 29 作者 通讯作者(15) Induction of alarmin S100A8/A9 mediates activation of aberrant neutrophils in the pathogenesis of COVID-19, CELL HOST & MICROBE, 2021, 第 22 作者 通讯作者(16) Hand-foot-and-mouth disease virus receptor KREMEN1 binds the canyon of Coxsackie Virus A10, NATURE COMMUNICATIONS, 2020, 第 6 作者(17) Structures of the portal vertex reveal essential protein-protein interactions for Herpesvirus assembly and maturation, Structures of the portal vertex reveal essential protein-protein interactions for Herpesvirus assembly and maturation, PROTEIN & CELL, 2020, 第 16 作者 通讯作者(18) Serotype specific epitopes identified by neutralizing antibodies underpin immunogenic differences in Enterovirus B, NATURE COMMUNICATIONS, 2020, 第 13 作者 通讯作者(19) Structures of Echovirus 30 in complex with its receptors inform a rational prediction for enterovirus receptor usage, NATURE COMMUNICATIONS, 2020, 第 11 作者(20) Structural basis for neutralization of SARS-CoV-2 and SARS-CoV by a potent therapeutic antibody, SCIENCE, 2020, 第 23 作者 通讯作者(21) Development of an inactivated vaccine candidate for SARS-CoV-2, SCIENCE, 2020, 第 31 作者 通讯作者(22) Design, Synthesis, and Evaluation of Novel Enterovirus 71 Inhibitors as Therapeutic Drug Leads for the Treatment of Human Hand, Foot, and Mouth Disease, JOURNAL OF MEDICINAL CHEMISTRY, 2020, 第 9 作者(23) Architecture of the herpesvirus genomepackaging complex and implications for DNA translocation, Architecture of the herpesvirus genome-packaging complex and implications for DNA translocation, PROTEIN & CELL, 2020, 第 8 作者 通讯作者(24) Structural basis for neutralization of hepatitis A virus informs arational design of highly potent inhibitors, PLOS BIOLOGY, 2019, 第 11 作者 通讯作者(25) Architecture of African swine fever virus and implications for viral assembly, SCIENCE, 2019, 第 11 作者 通讯作者(26) Neutralization Mechanisms of Two Highly Potent Antibodies against Human Enterovirus 71, MBIO, 2018, 第 11 作者 通讯作者(27) Structural basis for neutralization of Japanese encephalitis virus by two potent therapeutic antibodies, NATURE MICROBIOLOGY, 2018, 第 17 作者 通讯作者(28) Structure of the herpes simplex virus type 2 C-capsid with capsid-vertex-specific component, NATURE COMMUNICATIONS, 2018, 第 13 作者 通讯作者(29) Cryo-EM structure of Type III-A CRISPR effector complex, CELL RESEARCH, 2018, 第 5 作者 通讯作者(30) Cryo-EM structure of a herpesvirus capsid at 3.1 angstrom, SCIENCE, 2018, 第 12 作者 通讯作者(31) Structures of Coxsackievirus A10 unveil the molecular mechanisms of receptor binding and viral uncoating, NATURE COMMUNICATIONS, 2018, 第 11 作者(32) Potent neutralization of hepatitis A virus reveals a receptor mimic mechanism and the receptor recognition site, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, 第 1 作者 通讯作者(33) Near-atomic structure of Japanese encephalitis virus reveals critical determinants of virulence and stability, NATURE COMMUNICATIONS, 2017, 第 1 作者(34) Structure of human Aichi virus and implications for receptor binding, NATURE MICROBIOLOGY, 2016, 第 2 作者(35) Structure of Ljungan virus reveals a novel mechanism for picornavirus genome packaging, Nature Communications, 2015, 第 1 作者(36) Hepatitis A virus and the origins of picornaviruses, NATURE, 2015, 第 1 作者(37) More powerful virus inhibitors from structure-based analysis of HEV71 capsid-binding molecules, NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2014, 第 2 作者(38) Molecular mechanism of SCARB2-mediated attachment and uncoating of EV71, PROTEIN & CELL, 2014, 第 2 作者(39) Picornavirus uncoating intermediate captured in atomic detail, NATURE COMMUNICATIONS, 2013, 第 2 作者(40) An open conformation determined by a structural switch for 2A protease from coxsackievirus A16, An open conformation determined by a structural switch for 2A protease from coxsackievirus A16, PROTEIN & CELL, 2013, 第 2 作者(41) A sensor-adaptor mechanism for enterovirus uncoating from structures of EV71, NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2012, 第 1 作者
科研活动
科研项目
( 1 ) 病毒结构与临床应用, 负责人, 国家任务, 2024-01--2028-12( 2 ) 病毒、病毒感染与宿主免疫, 参与, 国家任务, 2020-01--2024-12( 3 ) 基于多维高级结构的减毒疫苗设计与合成, 负责人, 国家任务, 2019-07--2024-06( 4 ) 非洲猪瘟病毒应急专项-病毒重要蛋白的结构与功能研究, 负责人, 中国科学院计划, 2019-01--2021-12( 5 ) 万人计划青年拔尖人才, 参与, 其他国际合作项目, 2019-01--2022-12( 6 ) 疱疹病毒等复制与组装调控机理研究, 负责人, 中国科学院计划, 2018-09--2023-06( 7 ) 鼻咽癌等临床重要问题的多学科协同研究, 负责人, 中国科学院计划, 2018-01--2022-12( 8 ) 甲型肝炎病毒与中和性抗体可变区Fab复合物的三维结构和免疫原性研究, 负责人, 国家任务, 2016-01--2019-12( 9 ) 新发、再发传染病病原体的结构研究,课题一“针对病毒入侵 过程的抗病毒结构生物学研究, 负责人, 国家任务, 2015-12--2018-08( 10 ) 青年托举工程, 参与, 其他国际合作项目, 2015-01--2017-12( 11 ) 中科院青年研究员, 参与, 中国科学院计划, 2014-10--2019-10( 12 ) 中科院青年研究员, 参与, 中国科学院计划, 2014-10--2019-10