基本信息
汪铭  男  博导  中国科学院化学研究所
电子邮件: mingwang@iccas.ac.cn
通信地址: 海淀区中关村北一街2号
邮政编码: 100190

招生信息

   
招生专业
0703Z1-化学生物学
招生方向
药物递送及示踪、化学生物学

教育背景

2006-09--2009-06   中国科学院化学研究所   博士
2003-09--2006-06   北京师范大学   硕士
1999-09--2003-06   安庆师范大学   学士

工作经历

   
工作简历
2016-07~现在, 中国科学院化学研究所, 研究员
2011-07~2016-06,美国塔夫茨大学(Tufts University), 博士后
2009-07~2011-06,美国犹他大学(University of Utah), 博士后
2006-09~2009-06,中国科学院化学研究所, 博士
2003-09~2006-06,北京师范大学, 硕士
1999-09~2003-06,安庆师范大学, 学士

教授课程

化学生物学分析
纳米药物递送前沿

出版信息

   
发表论文
(1) CRISPR/Cas9基因编辑非病毒递送系统, Non-viral Delivery of CRISPR/Cas9 Genome Editing, 高等学校化学学报, 2023, 第 3 作者
(2) Intracellular delivery of bacterial effectors for cancer therapy using biodegradable lipid nanoparticles, BIOMATERIALS SCIENCE, 2023, 通讯作者
(3) CRISPR/Cas9基因编辑非病毒递送系统, Non-viral Delivery of CRISPR/Cas9 Genome Editing, CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE, 2023, 通讯作者
(4) A Combinatorial Library of Biodegradable Lipid Nanoparticles Preferentially Deliver mRNA into Tumor Cells to Block Mutant RAS Signaling, ADVANCED FUNCTIONAL MATERIALS, 2022, 通讯作者
(5) Orthogonal Chemical Activation of Enzyme-Inducible CRISPR/Cas9 for Cell-Selective Genome Editing, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2022, 通讯作者
(6) Intracellular Delivery of Glutathione Peroxidase Degrader Induces Ferroptosis In Vivo, Angewandte Chemie International Edition, 2022, 通讯作者
(7) Enzyme-catalyzed activation of Pro-PROTAC for cell-selective protein degradation, CCS Chemistry, 2022, 通讯作者
(8) Biodegradable Metal-Organic-Frameworks-Mediated Protein Delivery Enables Intracellular Cascade Biocatalysis and Pyroptosis In Vivo, ACS APPLIED MATERIALS & INTERFACES, 2022, 通讯作者
(9) A Conformational Restriction Strategy for the Control of CRISPR/Cas Gene Editing with Photoactivatable Guide RNAs, Angewandte Chemie International Edition, 2022, 通讯作者
(10) Integration of Palladium Nanoparticles with Surface Engineered Metal-Organic Frameworks for Cell-Selective Bioorthogonal Catalysis and Protein Activity Regulation, ACS APPLIED MATERIALS & INTERFACES, 2022, 通讯作者
(11) Spatiotemporal Delivery of CRISPR/Cas9 Genome Editing Machinery Using Stimuli-Responsive Vehicles, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2021, 通讯作者
(12) DNAzyme-Catalyzed Cellular Oxidative Stress Amplification for Pro-protein Activation in Living Cells, CHEMBIOCHEM, 2021, 通讯作者
(13) In-Situ Encapsulation of Protein into Nanoscale Hydrogen-Bonded Organic Frameworks for Intracellular Biocatalysis, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2021, 通讯作者
(14) Suppression of the Self-Nucleation Effect of Semicrystalline Polymers by Confinement, MACROMOLECULES, 2021, 第 1 作者
(15) Tetraphenylethylene-Featured Fluorescent Supramolecular Nanoparticles for Intracellular Trafficking of Protein Delivery and Neuroprotection, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2021, 通讯作者
(16) Nanoscale metal-organic frameworks for the intracellular delivery of CRISPR/Cas9 genome editing machinery, BIOMATERIALS SCIENCE, 2021, 通讯作者
(17) Hierarchical Self-assembly of Discrete Metal-Organic Cages into Supramolecular Nanoparticles for Intracellular Protein Delivery, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2021, 通讯作者
(18) CRSIPR/Cas9: Magic scissors for genome editing, CHINESE SCIENCE BULLETIN-CHINESE, 2020, 通讯作者
(19) Unveiling the Role of DJ-1 Protein in Vesicular Storage and Release of Catecholamine with Nano/Micro-Tip Electrodes, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2020, 第 9 作者
(20) Crystallization, Orientation, and Solid-Solid Crystal Transition of Polybutene-1 Confined within Nanoporous Alumina, MACROMOLECULES, 2020, 第 3 作者
(21) 活性氧簇响应型纳米药物对活体小鼠角膜新生血管形成抑制作用的评估, In vivo investigation of the effectiveness of reactive oxygen species-responsive nanomedicine in suppressing corneal neovascularization, 中华实验眼科杂志, 2020, 第 3 作者
(22) CRISPR/Cas9技术:基因魔剪, CRSIPR/Cas9: Magic scissors for genome editing, 科学通报, 2020, 第 1 作者
(23) Cationic Lipid-based Intracellular Delivery of Bacterial Effectors for Rewiring Malignant Cell Signaling, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2020, 通讯作者
(24) An activity-based two-photon fluorescent probe for real-time and reversible imaging of oxidative stress in the rat brain, CHEMICAL COMMUNICATIONS, 2020, 通讯作者
(25) CRISPR/Cas9技术:基因魔剪, 科学通报, 2020, 第 1 作者
(26) Inhibition of retinal neovascularization by VEGF siRNA delivered via bioreducible lipid-like nanoparticles, GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 2020, 第 4 作者
(27) Designing biodegradable lipid nanoparticles for enhanced intracellular delivery and genome editing, ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2019, 第 1 作者
(28) Integrating Combinatorial Lipid Nanoparticle and Chemically Modified Protein for Intracellular Delivery and Genome Editing, ACCOUNTS OF CHEMICAL RESEARCH, 2019, 通讯作者
(29) Engineering nucleic acid chemistry for precise and controllable CRISPR/Cas9 genome editing, Engineering nucleic acid chemistry for precise and controllable CRISPR/Cas9 genome editing, SCIENCE BULLETIN, 2019, 通讯作者
(30) Enzyme-Instructed Activation of Pro-protein Therapeutics In Vivo, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2019, 通讯作者
(31) Developing chemically modified redox-responsive proteins as smart therapeutics, CHEMICAL COMMUNICATIONS, 2019, 通讯作者
(32) Identification of Flavin Mononucleotide as a Cell-Active Artificial N-6-Methyladenosine RNA Demethylase, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2019, 通讯作者
(33) Cell-Selective Messenger RNA Delivery and CRISPR/Cas9 Genome Editing by Modulating the Interface of Phenylboronic Acid-Derived Lipid Nanoparticles and Cellular Surface Sialic Acid, ACS APPLIED MATERIALS & INTERFACES, 2019, 通讯作者
(34) Selective RNA interference and gene silencing using reactive oxygen species-responsive lipid nanoparticles, CHEMICAL COMMUNICATIONS, 2019, 通讯作者
(35) Nanoscale ATP-Responsive Zeolitic Imidazole Framework-90 as a General Platform for Cytosolic Protein Delivery and Genome Editing., JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2019, 通讯作者
(36) Intracellular delivery and biodistribution study of CRISPR/Cas9 ribonucleoprotein loaded bioreducible lipidoid nanoparticles, BIOMATERIALS SCIENCE, 2019, 第 7 作者
(37) A single-atom Fe-N-4 catalytic site mimicking bifunctional antioxidative enzymes for oxidative stress cytoprotection, CHEMICAL COMMUNICATIONS, 2019, 第 6 作者
(38) Identification of Flavin Mononucleotide as Cell-Active Artificial N6-Methyladenosine RNA Demethylase, Angew. Chem. Int. Ed., 2019, 
(39) Fast and Efficient CRISPR/Cas9 Genome Editing In Vivo Enabled by Bioreducible Lipid and Messenger RNA Nanoparticles, ADVANCED MATERIALS, 2019, 通讯作者
(40) A Photoactive Platinum(IV) Anticancer Complex Inhibits Thioredoxin-Thioredoxin Reductase System Activity by Induced Oxidization of the Protein, INORGANIC CHEMISTRY, 2018, 第 8 作者
(41) Integrating synthetic protein chemistry and nanoparticles for intracellular delivery and targeted cancer therapy, ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2018, 第 1 作者
(42) A Novel Lipidoid-MicroRNA Formulation Promotes Calvarial Bone Regeneration, BIOMATERIALS, 2018, 第 2 作者
(43) Exploring Ferredoxin-Dependent Glutamate Synthase as an Enzymatic Bioelectrocatalyst., JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2018, 第 5 作者
(44) Supramolecularly Engineered Circular Bivalent Aptamer for Enhanced Functional Protein Delivery, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2018, 通讯作者
(45) A highly selective fluorescence turn-on detection of ClO- with 1-methyl-1,2-dihydropyridine-2-thione unit modified tetraphenylethylene, CHEMICAL COMMUNICATIONS, 2017, 第 5 作者
(46) Hyaluronic acid modification of RNase A and its intracellular delivery using lipid-like nanoparticles, JOURNAL OF CONTROLLED RELEASE, 2017, 第 9 作者
(47) Mitochondria Targeted Nanoscale Zeolitic Imidazole Framework-90 (ZIF-90) for ATP Imaging in Live Cells, J. Am. Chem. Soc., 2017, 
(48) Mitochondria Targeted Nanoscale Zeolitic Imidazole Framework-90 for ATP Imaging in Live Cells, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2017, 通讯作者
(49) Synergistic Coordination and Hydrogen Bonding Interaction Modulate the Emission of Iridium Complex for Highly Sensitive Glutamine Imaging in Live Cells, ANALYTICAL CHEMISTRY, 2016, 第 2 作者
(50) Enzyme-driven i-motif DNA folding for logic operations and fluorescent biosensing, CHEMICAL COMMUNICATIONS, 2015, 第 1 作者
(51) Synthesis of Shape-Persistent Macrocycles by a One-Pot Suzuki-Miyaura Cross-Coupling Reaction, CHEMISTRY-A EUROPEAN JOURNAL, 2011, 第 2 作者
(52) Fluorescent bio/chemosensors based on silole and tetraphenylethene luminogens with aggregation-induced emission feature, JOURNAL OF MATERIALS CHEMISTRY, 2010, 第 1 作者
(53) Electric-Field-Induced Alignment of Charged Organic Nanowires, JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 2009, 第 1 作者
(54) Visual observation of G-quadruplex DNA with the label-free fluorescent probe silole with aggregation-induced emission, BIOORGANIC & MEDICINAL CHEMISTRY, 2009, 第 2 作者
(55) Fluorescence enhancement upon gelation and thermally-driven fluorescence switches based on tetraphenylsilole-based organic gelators, CHEMICAL PHYSICS LETTERS, 2009, 第 1 作者
(56) Continuous Colorimetric Assay for Acetylcholinesterase and Inhibitor Screening with Gold Nanoparticles, LANGMUIR, 2009, 第 1 作者
(57) Convenient and continuous fluorometric assay method for acetylcholinesterase and inhibitor screening based on the aggregation-induced emission, ANALYTICAL CHEMISTRY, 2009, 第 1 作者
(58) A Fluorescence Turn-on Detection of Cyanide in Aqueous Solution Based on the Aggregation-Induced Emission, ORGANIC LETTERS, 2009, 第 2 作者
(59) Continuous On-Site Label-Free ATP Fluorometric Assay Based on Aggregation-Induced Emission of Silole, LANGMUIR, 2009, 第 2 作者
(60) The convenient fluorescence turn-on detection of heparin with a silole derivative featuring an ammonium group, CHEMICAL COMMUNICATIONS, 2008, 第 1 作者
(61) Fluorescence turn-on detection of dna and label-free fluorescence nuclease assay based on the aggregation-induced emission of silole, ANALYTICAL CHEMISTRY, 2008, 第 1 作者

科研活动

   
科研项目
( 1 ) 基于基因编辑技术调控肿瘤免疫微环境的功能性纳米材料, 负责人, 国家任务, 2017-07--2022-06