070302-分析化学

结构化学生物学

   

（1） G-quadruplex in mitochondria as a possible biomarker for mitophagy detection, INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2024, 第 8 作者  通讯作者
（2） Irbesartan overcomes gemcitabine resistance in pancreatic cancer by suppressing stemness and iron metabolism via inhibition of the Hippo/YAP1/c-Jun axis, JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2023, 第 19 作者
（3） "One stone, two birds": a mitochondria-targeted fluorescent probe for the detection of viscosity and HSO3- in living cells, ANALYST, 2023, 第 5 作者
（4） Design and Screening of Fluorescent Probes Based upon Hemicyanine Dyes to Sensitively Respond to HSO3 (-) in Living Cells, JOURNAL OF ORGANIC CHEMISTRY, 2023, 第 5 作者
（5） An inner salt derivative of Thioflavin T designed for live-cell imaging of mitochondrial G-quadruplexes, SENSORS AND ACTUATORS B-CHEMICAL, 2023, 第 7 作者  通讯作者
（6） RNA G-quadruplex in live cells lighted-up by a thiazole orange analogue for SCA36 identification, INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2023, 第 7 作者  通讯作者
（7） A supramolecular biosensor for monitoring lysosomal DNase activity in vivo and identifying tumor cells by responding to G-quadruplex hydrolysis, SENSORS AND ACTUATORS: B. CHEMICAL, 2023, 第 2 作者  通讯作者
（8） New insights into the effect of molecular crowding environment induced by dimethyl sulfoxide on the conformation and stability of G-quadruplex, Chinese Chemical Letters, 2022, 第 3 作者
（9） An organic molecular compound for in situ identification of mitochondrial G-quadruplexes in live cells, JOURNAL OF MATERIALS CHEMISTRY B, 2022, 第 9 作者  通讯作者
（10） Magnetically Boosted Generation of Intracellular Reactive Oxygen Species toward Magneto-Photodynamic Therapy, JOURNAL OF PHYSICAL CHEMISTRY B, 2022, 第 5 作者
（11） A hybrid aggregate FRET probe from the mixed assembly of cyanine dyes for highly specific monitoring of mitochondria autophagy, ANALYTICA CHIMICA ACTA, 2021, 第 7 作者  通讯作者
（12） NMR-based plasma metabolomics of adult B-cell acute lymphoblastic leukemia, MOLECULAR OMICS, 2021, 第 5 作者  通讯作者
（13） A cyanine dye supramolecular FRET switch driven by G-quadruplex to monitor mitophagy, DYES AND PIGMENTS, 2021, 第 7 作者  通讯作者
（14） An increase in DNA G-quadruplex formation in acute myelocytic leukemia is detected by a supramolecular probe, SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2021, 第 5 作者  通讯作者
（15） Chelerythrine as a fluorescent light-up ligand for an i-motif DNA structure, NEW JOURNAL OF CHEMISTRY, 2021, 第 2 作者  通讯作者
（16） An organic molecular compound for in situ identification of mitochondrial G-quadruplexes in live cells, JOURNAL OF MATERIALS CHEMISTRY B, 2021, 第 9 作者  通讯作者
（17） A novel approach for the screening analysis of anticancer compounds from traditional Chinese medicine by a G-quadruplex functionalized magnetic system, ANALYTICAL METHODS, 2020, 第 4 作者
（18） Insulin-like growth factor type I selectively binds to G-quadruplex structures, BBA - GENERAL SUBJECTS, 2019, 第 2 作者  通讯作者
（19） Monitoring autophagy in live cells with a fluorescent light-up probe for G-quadruplex structures, CHEMICAL COMMUNICATIONS, 2019, 第 2 作者  通讯作者
（20） A Lead (II) Ion Sensor Based on Selective Recognition of G-quadruplex for Ethyl-substitutive Thioflavin T, CHEMISTRYSELECT, 2019, 第 5 作者
（21） Insulin-like growth factor type I selectively binds to G-quadruplex structures, BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2019, 第 2 作者  通讯作者
（22） Multi-approach cysteine detection based on supramolecular transformation induced by G-quadruplexes, ANALYTICAL METHODS, 2019, 第 5 作者  通讯作者
（23） Direct visualization of nucleolar G-quadruplexes in live cells by using a fluorescent light-up probe, BBA - GENERAL SUBJECTS, 2018, 第 2 作者
（24） Real-time monitoring of DNA G-quadruplexes in living cells with a small-molecule fluorescent probe, NUCLEIC ACIDS RESEARCH, 2018, 第 2 作者  通讯作者
（25） HTG-四链体对甲基氮杂杯6吡啶的构象调控, Conformational Regulation Effect on Methylazacalix6pyridine by HT G-Quadruplex, 化学通报, 2018, 第 7 作者
（26） Direct visualization of nucleolar G-quadruplexes in live cells by using a fluorescent light-up probe, BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2018, 第 2 作者  通讯作者
（27） Serum Metabolomics of Burkitt Lymphoma Mouse Models, PLOS ONE, 2017, 第 7 作者
（28） Stabilization of G-quadruplex DNA and inhibition of Bcl-2 expression by a pyridostatin analog, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2016, 第 6 作者  通讯作者
（29） Colorimetric detection of sodium ion in serum based on the G-quadruplex conformation related DNAzyme activity, ANALYTICA CHIMICA ACTA, 2016, 第 1 作者  通讯作者
（30） A colorimetric and fluorometric dual-modal DNA logic gate based on the response of a cyanine dye supramolecule to G-quadruplexes, NEW JOURNAL OF CHEMISTRY, 2016, 第 2 作者  通讯作者
（31） Reversible regulation of the supramolecular chirality of a cyanine dye by using the G-quadruplex structure as a template, CHEMICAL COMMUNICATIONS, 2016, 第 2 作者  通讯作者
（32） DNA G-四链体识别探针研究进展, Research Progress in the Probes Targeting DNA G-quadruplex, 化学通报（印刷版）, 2016, 第 2 作者
（33） Thioflavin T as an efficient fluorescence sensor for selective recognition of RNA G-quadruplexes, SCIENTIFIC REPORTS, 2016, 第 5 作者
（34） Visual detection of mercury(II) based on recognition of the G-quadruplex conformational transition by a cyanine dye supramolecule, ANALYST, 2015, 第 3 作者
（35） Pyridostatins selectively recognize two different forms of the human telomeric G-quadruplex structures and their anti-tumor activities in vitro, TETRAHEDRON, 2015, 第 7 作者
（36） A colorimetric lead (II) ions sensor based on selective recognition of G-quadruplexes by a clip-like cyanine dye, TALANTA, 2015, 第 1 作者
（37） i-Motif-modulated fluorescence detection of silver(I) with an ultrahigh specificity, ANALYTICA CHIMICA ACTA, 2015, 第 2 作者  通讯作者
（38） A supramolecular probe for colorimetric detection of Pb2+ based on recognition of G-quadruplex, RSC ADVANCES, 2015, 第 2 作者
（39） G-quadruplex induced chirality of methylazacalix6pyridine via unprecedented binding stoichiometry: en route to multiplex controlled molecular switch, SCIENTIFIC REPORTS, 2015, 第 6 作者
（40） Directly lighting up RNA G-quadruplexes from test tubes to living human cells, NUCLEIC ACIDS RESEARCH, 2015, 第 5 作者
（41） Controllable cy3-MTC-dye aggregates and its applications served as a chemosensor, DYES AND PIGMENTS, 2015, 第 3 作者
（42） Recognizing parallel-stranded G-quadruplex by cyanine dye dimer based on dual-site binding mode, CHINESE CHEMICAL LETTERS, 2015, 第 5 作者
（43） Construction of DNA logic gates utilizing a H+/Ag+ induced i-motif structure, CHEM. COMMUN., 2014, 第 2 作者
（44） A colorimetric temperature sensor of a cyanine dye supramolecule and its application in reversible switch, APPL. PHYS. LETT., 2014, 第 1 作者
（45） A newly identified G-quadruplex as a potential target regulating Bcl-2 expression, BBA-GEN. SUBJECTS, 2014, 第 1 作者
（46） A supramolecular probe for colorimetric detection of Pb2+ based on recognition of G-quadruplex, RSC ADV., 2014, 第 1 作者
（47） i-Motif-modulated fluorescence detection of silver (I) with an ultrahigh specificity, ANAL. CHIM. ACTA, 2014, 第 1 作者
（48） A newly identified G-quadruplex as a potential target regulating Bcl-2 expression, BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2014, 第 1 作者  通讯作者
（49） A colorimetric temperature sensor of a cyanine dye supramolecule and its application in reversible switch, APPLIED PHYSICS LETTERS, 2014, 第 1 作者
（50） A colorimetric and fluorometric dual-modal supramolecular chemosensor and its application for HSA detection, ANALYST, 2014, 第 1 作者  通讯作者
（51） Construction of DNA logic gates utilizing a H+/Ag+ induced i-motif structure, CHEMICAL COMMUNICATIONS, 2014, 第 2 作者  通讯作者
（52） Novel dual-functional regulation of a chair-like antiparallel G-quadruplex inducing assembly-disassembly of a cyanine dye, PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2013, 第 7 作者
（53） A dual-site simultaneous binding mode in the interaction between parallel-stranded G-quadruplex d(TGGGGT)(4) and cyanine dye 2,2 '-diethyl-9-methyl-selenacarbocyanine bromide, NUCLEIC ACIDS RESEARCH, 2013, 第 6 作者
（54） G4LDB: a database for discovering and studying G-quadruplex ligands, NUCLEIC ACIDS RESEARCH, 2013, 第 4 作者
（55） A novel signal-amplified strategy based on assembly reactivation for highly specific and sensitive detection of chair-like antiparallel G-quadruplex, ANALYST, 2013, 第 6 作者
（56） Roles of flanking sequences in the binding between unimolecular parallel-stranded G-quadruplexes and ligands, CHINESE SCIENCE BULLETIN, 2013, 第 4 作者
（57） 基于一种新型的G-四链体对钾钠离子不同响应的钾钠离子比值的检测, CHEMICAL COMMUNICATIONS, 2013, 第 1 作者
（58） Quantification of the Na+/K+ ratio based on the different response of a newly identified G-quadruplex to Na+ and K+, CHEMICAL COMMUNICATIONS, 2013, 第 1 作者
（59） Recognize three different human telomeric G-quadruplex conformations by quinacrine, ANALYST, 2012, 第 1 作者
（60） Visual detection of potassium by a cyanine dye supramolecular aggregate responsive to G-quadruplex motif transition, ANALYST, 2012, 第 1 作者
（61） Regulating the Conformation of Methylazacalix6pyridine by Oligonucleotide BCL-2 2345 and Its Recognition of Hydroxymethylpiperazinofullerene, JOURNAL OF PHYSICAL CHEMISTRY LETTERS, 2012, 第 6 作者
（62） The Interaction of Telomeric DNA and C-myc22 G-Quadruplex with 11 Natural Alkaloids, NUCLEIC ACID THERAPEUTICS, 2012, 第 2 作者
（63） Controllable assembly and cycling conversion of various supramolecular aggregates of a cyanine dye, APPLIED PHYSICS LETTERS, 2011, 第 1 作者  通讯作者
（64） Research Progress of RNA Quadruplex, NUCLEIC ACID THERAPEUTICS, 2011, 第 2 作者
（65） 西方反科学思潮研究述评, 哲学动态, 2011, 第 1 作者
（66） 近代反科学思潮的思想来源, Anti-science Thoughts in the Period of Modern Scientific Revolution, 科普研究, 2011, 第 1 作者
（67） A stabilizing and denaturing dual-effect for natural polyamines interacting with G-quadruplexes depending on concentration, BIOCHIMIE, 2011, 第 1 作者
（68） Fishing potential antitumor agents from natural plant extracts pool by dialysis and G-quadruplex recognition, TALANTA, 2011, 第 4 作者
（69） 科学与反科学认知分歧探源, 自然辩证法通讯, 2010, 第 1 作者
（70） Temperature-sensitive supramolecules self-assembled by G-quadruplex DNA, INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2010, 第 1 作者
（71） 18世纪-19世纪中叶的浪漫主义反科学思潮——一种另类认识论和方法论, Trend of Anti-science on Romanticism In the Beginning of Eighteenth and the Middle of Nineteenth Century, 自然辩证法研究, 2010, 第 1 作者
（72） Polyethylenimine effectively induces, stabilizes, and regulates intramolecular G-quadruplexes, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, 第 1 作者
（73） Stabilizing parallel G-quadruplex DNA by a new class of ligands: Two non-planar alkaloids through interaction in lateral grooves, BIOCHIMIE, 2009, 第 10 作者
（74） 梯级水电投资的动态规划模型, The Dynamic Programming Model of Cascaded Hydropower Investment, 兵工学报, 2009, 第 3 作者
（75） Formation of an Intramolecular G-Quadruplex of Human Telomere Induced by Poly(L-lysine) under Salt-Deficient Conditions, JOURNAL OF PHYSICAL CHEMISTRY B, 2009, 第 5 作者
（76） Fast screening and structural elucidation of G-quadruplex ligands from a mixture via G-quadruplex recognition and NMR methods, BIOCHIMIE, 2009, 第 4 作者
（77） “同致光荣，共赴梦想”——《自然辩证法通讯》创刊30周年有感, 自然辩证法通讯, 2008, 第 1 作者
（78） Regulation and recognization of the extended G-quadruplex by rutin, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2007, 第 1 作者

   

（ 1 ） 单个癌基因G-四链体检测探针的构建及在恶性肿瘤临床诊断的应用研究, 负责人, 国家任务, 2024-01--2027-12
（ 2 ） 核酸G-四链体荧光检测探针设计及其在恶性肿瘤临床诊断的应用研究, 负责人, 地方任务, 2023-11--2026-12
（ 3 ） Claudin18.2诱导胰腺癌间质纤维化的机制研究, 负责人, 地方任务, 2022-10--2025-09