Mitochondrial Stress Response and Aging

2005-09--2010-06   Beijing Normal University / Beijing Institute of Life Sciences  Doctoral

2001-09--2005-06   Beijing Normal University   Bachelor

2016-09 ~ Now, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Principal Investigator

2012-09 ~ 2016-09, University of California, Berkeley, Postdoctoral

2010-12 ~ 2012-08, the United States Salk Institute, Postdoctoral

(^# Co-first author; * Corresponding author)

Li XY, Li JS, Zhu D, Zhang N, Hao XS, Zhang WF, Zhang Q, Liu YL, Wu XY and Tian Y* (2022). Protein disulfide isomerase PDI-6 assists Wnt secretion to coordinate inter-tissue UPR^mt and lifespan. Cell Reports, 39(10):110931.

Zhu D^#, Li XY^#, Tian Y* (2022). Mitochondrial-to-nuclear Communication in Aging: An Epigenetic Perspective. Trends in Biochemical Sciences, in press. DOI: https://doi.org/10.1016/j.tibs.2022.03.008

Zhang Q, Tian Y* (2022). Molecular Insights into the Transgenerational Inheritance of Stress Memory. Journal of Genetics and Genomics, 49(2):89-95.

Zhang Q, Wang ZH, Zhang WF, Wen QB, Li XY, Zhou J, Wu XY, Guo YQ, Liu YL, Wei CS, Qian WF, Tian Y* (2021). The Memory of Neuronal Mitochondrial Stress is Inherited Transgenerationally via Elevated mtDNA Levels. Nature Cell Biology, 23(8):870-880.

Wang YL^#, He KX^#, Sheng BF^#, Lei XQ, Tao WY, Zhu XL, Wei Z, Fu RJ, Wang AL, Bai SD, Zhang Z, Hong N, Ye C, Tian Y, Wang J, Li MS, Zhang KG, Li L, Yang H*, Li HB*, Flavell RA*, Zhu S* (2021). The RNA Helicase Dhx15 Mediates Wnt-Induced Antimicrobial Protein Expression in Paneth Cells. PNAS, 118(4):e2017432118.

Rong BW^#, Zhang Q^#, Wan JK, Xing SH, Dai RF, Li Y, Cai JB, Xie JY, Song Y, Chen JW, Zhang L, Yan GQ, Zhang W, Gao H, Han JD, Qu QH, Ma HH*, Tian Y*, Lan F* (2020). Ribosome 18S m⁶A Methyltransferase METTL5 Promotes Translation Initiation and Breast Cancer Cell Growth. Cell Reports, 33(12):108544.

Zhu D^#, Wu XY^#, Zhou J, Li XY, Huang XH, Li JS, Wu JB, Bian Q, Wang YC and Tian Y* (2020). NuRD Mediates Mitochondrial Stress-Induced Longevity via Chromatin Remodeling in Response to Acetyl-CoA Level. Science Advances, 6(31):eabb2529.

Zhang Q^#, Wu XY^#, Chen P^#, Liu LM, Xin N, Tian Y* and Dillin A* (2018). The Mitochondrial Unfolded Protein Response is Mediated Cell-non-Autonomously by Retromer-Dependent Wnt Signaling. Cell, 174(4):870-883.e17.

Tian Y, Garcia G, Bian Q, Steffen KK, Joe L, Wolff S, Meyer BJ and Dillin A* (2016). Mitochondrial Stress Induces Chromatin Reorganization to Promote Longevity and UPR^mt. Cell, 165(5):1197-1208.

Tian Y^#, Merkwirth C^# and Dillin A* (2016). Mitochondrial UPR: A Double-Edged Sword. Trends in Cell Biology, 26(8):563-565.

Berendzen KM^#, Durieux J^#, Shao LW, Tian Y, Kim H, Wolff S, Liu Y and Dillin A* (2016). Neuroendocrine Coordination of Mitochondrial Stress Signaling and Proteostasis. Cell, 166(6):1553-1563.e10.

Russell RC, Tian Y, Yuan H, Park HW, Chang YY, Kim J, Kim H, Neufeld TP, Dillin A and Guan KL* (2013). ULK1 Induces Autophagy by Phosphorylating Beclin-1 and Activating VPS34 Lipid Kinase. Nature Cell Biology, 15(7):741-750.

Tian Y^#, Li Z^#, Hu W^#, Ren H^#, Tian E, Zhao Y, Lu Q, Huang X, Yang P, Li X, Wang X, Kovacs A, Yu L* and Zhang H* (2010a). C. elegans Screen Identifies Autophagy Genes Specific to Multicellular Organisms. Cell, 141(6):1042-1055.

Tian Y, Ren HY, Zhao Y, Lu Q, Huang XX, Yang PG and Zhang H* (2010b). Four Metazoan Autophagy Genes Regulate Cargo Recognition, Autophagosome Formation and Autolysosomal Degradation. Autophagy, 6(7):984-985.

​

Mitochondrial stress; Aging

（1）Mitochondrial metabolite mediates longevity via epigenomes   2021中国衰老科学大会   2021-04-25
（2）线粒体应激反应调控   中国细胞生物学学会2021年全国学术大会   2021-04-14
（3）线粒体应激和衰老    2020年线粒体与人类疾病论坛   2020-12-12
（4）The intercellular regulation of mitochondrial homeostasis and aging    中国生物化学与分子生物学会2020年全国学术会议   2020-10-22
（5）The intercellular regulation of mitochondrial homeostasis and aging    中国细胞生物学学会2020年全国学术大会   2020-08-06
（6）线粒体应激和衰老    中国卒中学会脑健康分会2020年学术年会暨认知障碍性疾病高峰论坛   2020-01-05
（7）The intercellular regulation of mitochondrial homeostasis and aging   冷泉港亚洲会议—Mitochondria and Metabolism in Health and disease   2019-11-14
（8）Wnt signaling mediates intercellular mitochondrial unfolded protein response and longevity   北京生命科学研究所Symposium on Fundamental Questions of Aging   2019-10-30
（9）线粒体应激反应与衰老   第七届中国衰老与抗衰老学术大会   2019-10-19
（10）Mitochondrial unfolded protein response and aging   2019年线粒体生物学研讨会   2019-07-19
（11）Wnt signaling mediates intercellular mitochondrial stress response and aging   第22届国际线虫大会   2019-06-22
（12）Wnt signaling mediates intercellular mitochondrial homeostasis and metabolism   2019年第三届中国生物物理学会代谢生物学分会学术研讨会   2019-05-11
（13）Wnt signaling mediates intercellular mitochondrial stress response and aging   2019 国际衰老生物学大会   2019-04-19
（14）Wnt signaling mediates intercellular mitochondrial stress response   中国细胞生物学学会第17次全国会员代表大会暨2019年全国学术大会   2019-04-10
（15）Wnt signaling mediates intercellular mitochondrial stress response   J-mit国际研讨会   2018-12-07
（16）Mitochondrial Stress response and aging   OsakaMito2018   2018-12-04
（17）Wnt signaling mediates intercellular mitochondrial stress response   日本分子生物学会第41届年会   2018-11-30
（18）Wnt signaling mediates intercellular mitochondrial unfolded protein response   线虫前沿论坛   2018-09-14
（19）Mitochondrial Stress response and aging   首届衰老科学前沿论坛暨衰老细胞生物学分会成立大会   2018-09-13
（20）Epigenetic Control of Mitochondrial Stress-induced Longevity in C.elegans   第20届欧洲生物能学会议   2018-08-25
（21）The mitochondrial unfolded protein response is mediated cell-non-autonomously by Wnt signaling   第五届中国秀丽线虫大会   2018-08-20
（22）Regulation of organismal mitochondrial proteostasis in C. elegans   2018年线粒体生物学大会   2018-04-22
（23）The Epigenetics control of mitochondrial stress-induced longevity in C. elegans   2018年第一届国际青年科学家线粒体大会   2018-04-20
（24）Epigenetic Control of Mitochondrial Stress-induced Longevity in C.elegans   2017年表观遗传学会议   2017-11-07
（25）Regulation of organismal mitochondrial proteostasis in C.elegans   2017年冷泉港线粒体大会   2017-10-16
（26）Mitochondrial Stress andaging   第一届吴瑞青年学者论坛   2017-10-13
（27）Epigenetic Control of Mitochondrial Stress-induced Longevity   第二届金砖国家青年论坛   2017-07-27
（28）Epigenetic Control of Mitochondrial Stress-induced Longevity   线粒体质量控制大会   2017-07-04
（29）Epigenetic Control of Mitochondrial Stress-induced Longevity in C. elegans   2017疾病模式动物国际研讨会   2017-05-27

已指导学生

朱頔  博士研究生  071007-遗传学  

李心宇  博士研究生  071007-遗传学  

张茜  博士研究生  071009-细胞生物学  

现指导学生

陈鹏  博士研究生  071009-细胞生物学  

李佳晟  博士研究生  071009-细胞生物学  

文庆博  博士研究生  071009-细胞生物学  

郝旭昇  博士研究生  071007-遗传学  

张文峰  博士研究生  071007-遗传学  

张宁  博士研究生  071009-细胞生物学  

郭永青  博士研究生  071009-细胞生物学  

周俊  博士研究生  071009-细胞生物学  

张乐源  博士研究生  071009-细胞生物学  

孙敏益  博士研究生  071009-细胞生物学  

蒋亚云  硕士研究生  090102-作物遗传育种  

王子豪  博士研究生  071009-细胞生物学  

2010        Ray Wu Prize

2012        Glenn Foundation for medical research fellowship

2016        The Beijing Science and Technology Award (The second Prize, Ranked 4th)

2019        Excellent Tutor Award of University of Chinese Academy of Sciences

2019        The National Natural Science Award (The Second Prize, Ranked 3rd)

2021        The “excellent” in the final review of the CAS Hundred Talents Program

2022        Chinese Zoological Society Youth Science and Technology Award