光动力抗肿瘤及抗菌研究，精细化学品及药物中间体的光化学合成产业化，光功能材料

化学工程专业硕士

光动力抗肿瘤、光动力抗菌、光电化学转换

2005-09--2010-06   中国科学院理化技术研究所   获得有机化学博士学位
2001-09--2005-06   武汉大学化学与分子科学学院   获得理学学士学位

博士研究生

博士

   

2023-09~2024-05,中国科学院理化技术研究所, 任高级工程师
2013-09~2023-08,中国科学院理化技术研究所, 任副研究员
2010-07~2013-08,中国科学院理化技术研究所, 任助理研究员

   

（ 1 ） 几乎无细胞毒性的钌配合物、其制备、包含其的复合钌纳米颗粒及制备和应用, 发明专利, 2023, 第 3 作者, 专利号: CN115677778A

（ 2 ） 一种具有光催化二氧化碳还原活性的金属钴配合物及其制备方法和应用, 发明专利, 2022, 第 3 作者, 专利号: CN115197280A

（ 3 ） 一种具有光活化抗菌的钌配合物及其制备方法和应用, 发明专利, 2020, 第 1 作者, 专利号: CN111087429A

（ 4 ） 一种具有光活化性能的钌配合物及其制备方法和应用, 2022, 第 3 作者, 专利号: CN110272457B

（ 5 ） 一种具有光活化性能的钌配合物及其制备方法和应用, 发明专利, 2019, 第 3 作者, 专利号: CN110272457A

（ 6 ） 一种钌多吡啶配合物及其制备方法和应用, 发明专利, 2020, 第 3 作者, 专利号: CN111825603A

（ 7 ） 一种多吡啶钌配合物及其制备方法和应用, 发明专利, 2019, 第 3 作者, 专利号: CN109970812A

（ 8 ） 一种利用光敏氧化由双甘膦合成草甘膦的方法, 发明专利, 2017, 第 4 作者, 专利号: CN106632471A

（1） Ru(II) Complexes with Enaminone Structures for Rapid Sterilization of Staphylococcus aureus and MRSA with Little Accumulation of Drug Resistance, CHEMMEDCHEM, 2023, 第 7 作者  通讯作者
（2） An activatable photosensitizer for discriminative imaging and elimination of Gram-positive bacteria, MATERIALS LETTERS, 2023, 第 7 作者  通讯作者
（3） A Photoactivated Ru (II) Polypyridine Complex Induced Oncotic Necrosis of A549 Cells by Activating Oxidative Phosphorylation and Inhibiting DNA Synthesis as Revealed by Quantitative Proteomics, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 第 7 作者
（4） NIR light-driven photocatalytic NAD(P)H oxidation and H2O2 generation in situ for enhanced chemodynamic therapy and immune response, NANO TODAY, 2023, 第 9 作者  通讯作者
（5） Ru/Pt@BSA nanoparticles for efficient photo-catalytic oxidation of NAD(P)H and targeted cancer treatment under hypoxic conditions, CHINESE CHEMICAL LETTERS, 2023, 第 10 作者  通讯作者
（6） Biocompatible hypocrellin A-Fe(iii) nanoparticles exhibiting efficient photo-activated CDT in vitro and in vivo, DALTON TRANSACTIONS, 2022, 第 8 作者  通讯作者
（7） A bioorthogonal assembly based on metallophilic interactions for selective imaging and PDT treatment of cancer cells, INORGANIC CHEMISTRY FRONTIERS, 2022, 第 9 作者  通讯作者
（8） A targeted and efficient CDT system with photocatalytic supplement of H2O2 and hydroxyl radical production at a neutral pH, INORGANIC CHEMISTRY FRONTIERS, 2022, 第 8 作者  通讯作者
（9） The modification of a pyrene group makes a Ru(ii) complex versatile, CHEMICAL COMMUNICATIONS, 2021, 第 8 作者  通讯作者
（10） The Development of Ru(II)-Based Photoactivated Chemotherapy Agents, MOLECULES, 2021, 第 5 作者  通讯作者
（11） Electronic effects on polypyridyl Co complex-based water reduction catalysts, RSC ADVANCES, 2021, 第 7 作者  通讯作者
（12） Pyrene modification enables enhanced two-photon excited ligand dissociation of a Ru(II) complex containing monodentate ligands, INORGANICA CHIMICA ACTA, 2021, 第 8 作者  通讯作者
（13） Selective and Efficient Photoinactivation of Intracellular Staphylococcus aureus and MRSA with Little Accumulation of Drug Resistance: Application of a Ru(II) Complex with Photolabile Ligands, JOURNAL OF MEDICINAL CHEMISTRY, 2021, 第 9 作者  通讯作者
（14） Photo-induced mitochondrial DNA damage and NADH depletion by -NO2 modified Ru(ii) complexes dagger, CHEMICALCOMMUNICATIONS, 2021, 第 8 作者  通讯作者
（15） UCNP@BSA@Ru nanoparticles with tumor-specific and NIR-triggered efficient PACT activity in vivo, DALTON TRANSACTIONS, 2021, 第 7 作者  通讯作者
（16） Polypyridyl Co complex-based water reduction catalysts: why replace a pyridine group with isoquinoline rather than quinoline?, DALTON TRANSACTIONS, 2021, 第 7 作者  通讯作者
（17） A Ru-anthraquinone dyad with triple functions of PACT, photoredox catalysis and PDT upon red light irradiation, DALTON TRANSACTIONS, 2021, 第 6 作者  通讯作者
（18） A Ru(II)-Based Nanoassembly Exhibiting Theranostic PACT Activity in NIR Region, PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION, 2020, 第 9 作者  通讯作者
（19） Fluorination in enhancing photoactivated antibacterial activity of Ru(ii) complexes with photo-labile ligands, RSC ADVANCES, 2020, 第 7 作者  通讯作者
（20） Smart use of "ping-pong" energy transfer to improve the two-photon photodynamic activity of an Ir(iii) complex, CHEMICAL COMMUNICATIONS, 2020, 第 8 作者  通讯作者
（21） A nuclear permeable Ru(ii)-based photoactivated chemotherapeutic agent towards a series of cancer cells: in vitro and in vivo studies, DALTON TRANSACTIONS, 2019, 第 9 作者  通讯作者
（22） Incorporation of 7-dehydrocholesterol into liposomes as a simple, universal and efficient way to enhance anticancer activity by combining PDT and photoactivated chemotherapy, CHEMICAL COMMUNICATIONS, 2019, 第 6 作者  通讯作者
（23） Fluorination on non-photolabile dppz ligands for improving Ru(ii) complex-based photoactivated chemotherapy, DALTON TRANSACTIONS, 2019, 第 9 作者  通讯作者
（24） Chloromethyl-modified Ru(II) complexes enabling large pH jumps at low concentrations through photoinduced hydrolysis, CHEMICAL SCIENCE, 2019, 第 9 作者  通讯作者
（25） Selective Photoinactivation of Methicillin-Resistant Staphylococcus aureus by Highly Positively Charged Ru-II Complexes, CHEMISTRY-A EUROPEAN JOURNAL, 2019, 第 4 作者  通讯作者
（26） Mitochondria targeted and NADH triggered photodynamic activity of chloromethyl modified Ru(ii) complexes under hypoxic conditions, CHEMICAL COMMUNICATIONS, 2019, 第 8 作者  通讯作者
（27） Photoactivatable Ru complexes containing a Ru-O bond: Photoinduced ligand dissociation and DNA damage, JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY, 2018, 第 1 作者  通讯作者
（28） Photoactivatable Ru complexes containing a RusbndO bond: Photoinduced ligand dissociation and DNA damage, JOURNAL OF PHOTOCHEMISTRY & PHOTOBIOLOGY, A: CHEMISTRY, 2018, 第 1 作者
（29） Photocleavable antimicrobial peptide mimics for precluding antibiotic resistance, NEW JOURNAL OF CHEMISTRY, 2018, 第 6 作者  通讯作者
（30） Syntheses of 7-dehydrocholesterol peroxides and their improved anticancer activity and selectivity over ergosterol peroxide, NEW JOURNAL OF CHEMISTRY, 2017, 第 4 作者
（31） 钌（II）光活化化疗试剂研究进展, Advances in Ru(II)-based Photoactivated Chemotherapy Agents, ACTA CHIMICA SINICA, 2017, 第 1 作者  通讯作者
（32） Ru(II)-Complex-Based DNA Photocleaver Having Intense Absorption in the Phototherapeutic Window, INORGANIC CHEMISTRY, 2017, 第 2 作者  通讯作者
（33） 微流光反应技术制备树脂状维生素D3, Preparation of Resin-like Vitamin D3 by Micro-flow Photoreaction, 影像科学与光化学, 2017, 第 2 作者
（34） 含Ru-O键的光活化钌配合物：光致配体解离及DNA光损伤, 2017, 第 3 作者
（35） 钌（II）光活化化疗试剂研究进展, Advances in Ru(II)-based Photoactivated Chemotherapy Agents, ACTA CHIMICA SINICA, 2017, 第 1 作者  通讯作者
（36） A ferrocenyl pyridine-based Ru(II) arene complex capable of generating •OH and 1O2 along with photoinduced ligand dissociation, RSCADV, 2016, 第 1 作者  通讯作者
（37） DNA Photocleavage by Non-innocent Ligand-Based Ru(II) Complexes., INORGANIC CHEMISTRY, 2016, 第 2 作者  通讯作者
（38） 基于non-innocent配体钌配合物的DNA光断裂能力研究, 2016, 第 2 作者
（39） A ferrocenyl pyridine-based Ru(II) arene complex capable of generating center dot OH and O-1(2) along with photoinduced ligand dissociation, RSC ADVANCES, 2016, 第 2 作者  通讯作者
（40） Substituent effect and wavelength dependence of the photoinduced Ru-O homolysis in the Ru(bpy)(2)(py-SO3)(+)-type complexes, DALTON TRANSACTIONS, 2016, 第 2 作者  通讯作者
（41） Photocatalytic hydrogen evolution by Cu(II) complexes, DALTON TRANSACTIONS, 2016, 第 3 作者
（42） An upconversion nanoparticle/Ru(II) polypyridyl complex assembly for NIR-activated release of a DNA covalent-binding agent, RSC ADVANCES, 2016, 第 3 作者
（43） A polypyridyl Co(II) complex-based water reduction catalyst with double H-2 evolution sites, CATALYSIS SCIENCE & TECHNOLOGY, 2016, 第 3 作者
（44） Ru（bpy）2（py-SO3）+型配合物光诱导Ru-O键均裂的取代基效应和波长依赖性, 2016, 第 3 作者
（45） Substituent effect and wavelength dependence of the photoinduced Ru-O homolysis in the Ru(bpy)2(py-SO3)(+)-type complexes., DALTON TRANSACTIONS (CAMBRIDGE, ENGLAND : 2003), 2016, 第 2 作者
（46） Two novel BODIPY-Ru(II) arene dyads enabling effective photo-inactivation against cancer cells, DALTON TRANSACTIONS, 2015, 第 6 作者  通讯作者
（47） A bivalent cationic dye enabling selective photo-inactivation against Gram-negative bacteria., CHEMICAL COMMUNICATIONS (CAMBRIDGE, ENGLAND), 2015, 第 6 作者
（48） A novel azopyridine-based Ru(II) complex with GSH-responsive DNA photobinding ability., CHEMICAL COMMUNICATIONS (CAMBRIDGE, ENGLAND), 2015, 第 1 作者
（49） A bivalent cationic dye enabling selective photo-inactivation against Gram-negative bacteria, CHEMICAL COMMUNICATIONS, 2015, 第 6 作者  通讯作者
（50） Enhanced photocatalytic hydrogen production by introducing the carboxylic acid group into cobaloxime catalysts, DALTON TRANSACTIONS, 2015, 第 3 作者
（51） DNA photocleavage in anaerobic conditions by a Ru(II) complex: a new mechanism, CHEMICAL COMMUNICATIONS, 2015, 第 2 作者  通讯作者
（52） Fine control on the photochemical and photobiological properties of Ru(II) arene complexes, DALTON TRANSACTIONS, 2015, 第 7 作者  通讯作者
（53） A novel azopyridine-based ru(ii) complex with gsh-responsive dna photobinding ability, CHEMICAL COMMUNICATIONS, 2015, 第 1 作者  通讯作者
（54） DNA photocleavage in anaerobic conditions by a Ru(ii) complex: a new mechanism., CHEMICAL COMMUNICATIONS (CAMBRIDGE, ENGLAND), 2015, 第 2 作者
（55） In Vitro Photodynamic Inactivation Effects of Ru(II) Complexes on Clinical Methicillin-resistant Staphylococcus aureus Planktonic and Biofilm Cultures, PHOTOCHEMISTRY AND PHOTOBIOLOGY, 2015, 第 2 作者
（56） Selective Photodynamic Inactivation of Bacterial Cells over Mammalian Cells by New Triarylmethanes, LANGMUIR, 2014, 第 6 作者  通讯作者
（57） An unexpected role of the monodentate ligand in photocatalytic hydrogen production of the pentadentate ligand-based cobalt complexes, CHEMICAL COMMUNICATIONS, 2014, 第 2 作者
（58） Fusion of photodynamic therapy and photoactivated chemotherapy: a novel Ru(II) arene complex with dual activities of photobinding and photocleavage toward DNA, DALTON TRANSACTIONS, 2014, 第 7 作者  通讯作者
（59） Fusion of photodynamic therapy and photoactivated chemotherapy: a novel Ru(II) arene complex with dual activities of photobinding and photocleavage toward DNA., DALTON TRANSACTIONS (CAMBRIDGE, ENGLAND : 2003), 2014, 第 7 作者
（60） BODIPY-modified Ru(II) arene complex-a new ligand dissociation mechanism and a novel strategy to red shift the photoactivation wavelength of anticancer metallodrugs, DALTON TRANSACTIONS, 2013, 第 1 作者
（61） Self-Assembly of Anionic Porphyrins and Alkaline or Alkaline Earth Metal Ions Mediated by Cucurbit7,8uril, CHEMPHYSCHEM, 2013, 第 3 作者
（62） A ruthenium(II) arene complex showing emission enhancement and photocleavage activity towards DNA from singlet and triplet excited states respectively, DALTON TRANSACTIONS, 2013, 第 4 作者  通讯作者
（63） Large improvement in the catalytic activity due to small changes in the diimine ligands: new mechanistic insight into the dirhodium(II,II) complex-based photocatalytic H2 production., INORGANIC CHEMISTRY, 2012, 第 3 作者
（64） Ratiometric fluorescence sensing of bacterial lipopolysaccharide by a simple combination of a cationic dye and an anionic dye, SENSORS AND ACTUATORS B-CHEMICAL, 2012, 第 3 作者
（65） 竹红菌乙素（HB）氧钒（IV）配合物的光动力活性研究, 2012, 第 1 作者
（66） Small change in structure leads to large difference in protein photocleavage: two porphyrins bearing rhodanine-based pendants, PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES, 2012, 第 3 作者
（67） Ruthenium(II)-Arene Complexes with Strong Fluorescence: Insight into the Underlying Mechanism, CHEMISTRY-A EUROPEAN JOURNAL, 2012, 第 1 作者
（68） DNA Photocleavage by a Cationic BODIPY Dye through Both Singlet Oxygen and Hydroxyl Radical: New Insight into the Photodynamic Mechanism of BODIPYs, CHEMPHYSCHEM, 2012, 第 4 作者
（69） Oxovanadium(IV) based hypocrellin B complexes with enhanced photodynamic activity, DALTON TRANSACTIONS, 2012, 第 4 作者  通讯作者
（70） 利用静电吸引作用提高光催化放氢效率, Use Electrostatic Attraction to Improve the Photocatalytic Hydrogen Evolution Efficiency, 影像科学与光化学, 2011, 第 3 作者
（71） Supramolecular assembly of a new squaraine and beta-cyclodextrin for detection of thiol-containing amino acids in water, SUPRAMOLECULAR CHEMISTRY, 2011, 第 2 作者
（72） The effects of micellar media on the photocatalytic H 2 production from water, INTERNATIONAL JOURNAL OF HYDROGEN ENERGY, 2011, 第 5 作者
（73） A new squaraine and Hg2+-based chemosensor with tunable measuring range for thiol-containing amino acids, NEW JOURNAL OF CHEMISTRY, 2011, 第 2 作者
（74） Photodynamic inactivation of Escherichia coli by Ru(II) complexes, PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES, 2011, 第 2 作者
（75） The synthesis and O-1(2) photosensitization of halogenated asymmetric aniline-based squaraines, NEWJOURNALOFCHEMISTRY, 2011, 第 2 作者
（76） Host-Guest Interaction of Hoechst 34580 and Cucurbit7uril, CHEMPHYSCHEM, 2011, 第 2 作者
（77） A new Co(III)–hypocrellin B complex with enhanced photonuclease activity, JOURNAL OF INORGANIC BIOCHEMISTRY, 2011, 第 3 作者
（78） Dinuclear cu(ii) hypocrellin b complexes with enhanced photonuclease activity, INORGANIC CHEMISTRY, 2010, 第 3 作者
（79） DNA photocleavage in anaerobic conditions by a Ru(II) polypyridyl complex with long wavelength MLCT absorption, NEW JOURNAL OF CHEMISTRY, 2010, 第 1 作者
（80） Greatly enhanced binding of a cationic porphyrin towards bovine serum albumin by cucurbit8uril, PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2010, 第 3 作者
（81） ru(bpy)(3-n)(dpb)(n)(2+): unusual photophysical property and efficient dna photocleavage activity, INORGANIC CHEMISTRY, 2010, 第 1 作者
（82） A new phenol red-modified porphyrin as efficient protein photocleaving agent, PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2010, 第 3 作者
（83） A new heteroleptic ruthenium(ii) polypyridyl complex with long-wavelength absorption and high singlet-oxygen quantum yield, CHEMISTRY-A EUROPEAN JOURNAL, 2010, 第 1 作者
（84） DNA photocleavage activity of cobalt(III) polypyridyl complexes containing dpq ligand, JOURNAL OF INORGANIC BIOCHEMISTRY, 2009, 第 2 作者
（85） Ruthenium(ii) terpyridyl complexes exhibiting dna photocleavage: the role of the substituent on monodentate ligand, JOURNAL OF PHYSICAL CHEMISTRY B, 2009, 第 1 作者
（86） 两种结构简单绕丹宁衍生物的合成及其对氟离子的选择性识别研究, Synthesis and Study of Two Simple Rhodanine-based Receptors of Fluoride Anion, 影像科学与光化学, 2009, 第 4 作者
（87） Photodynamic Activity of Ascorbic Acid-modified TiO2 Nanoparticles upon Visible Illumination (> 550 nm), CHEMISTRY LETTERS, 2009, 第 2 作者
（88） Photodynamic properties of a bispyrrolecarboxamide-modified hypocrellin B: The role of affinity and ascorbic acid, JOURNAL OF PHYSICAL CHEMISTRY B, 2008, 第 2 作者
（89） Photoactivatable Ru complexes containing a Ru-O bond: Photoinduced ligand dissociation and DNA damage, JOURNAL OF PHOTOCHEMISTRY & PHOTOBIOLOGY, A: CHEMISTRY, 第 1 作者

   

（ 1 ） 硝基还原酶响应的光敏剂高效及高选择性光动力杀灭胞内金葡及MRSA研究, 负责人, 国家任务, 2024-01--2027-12
（ 2 ） 理想光敏剂的筛选, 负责人, 国家任务, 2018-12--2021-12
（ 3 ） 光致Ru-O配位键均裂及其对乏氧肿瘤细胞的光动力杀伤作用研究, 负责人, 国家任务, 2016-01--2019-12

（1）A NOVEL AZOPYRIDINE-BASED RU(II) COMPLEX WITH GSH-RESPONSIVE DNA PHOTOBINDING ABILITY   2016-04-03
（2）兼具光结合及光断裂DNA功能的新型钌芳烃配合物   中国化学会第29届学术年会   2014-08-04
（3）RUTHENIUM(II)-ARENE COMPLEXES WITH STRONG FLUORESCENCE   第26届国际光化学会议   2013-07-20

已指导学生

达旭文  博士研究生  070303-有机化学  

王占华  硕士研究生  070303-有机化学  

简瑶  博士研究生  070303-有机化学