基本信息
史桂芝 女 中国科学院生物物理研究所
电子邮件: 1184808652@qq.com
通信地址: 大屯路15号 中科院生物物理研究所
邮政编码: 100101
电子邮件: 1184808652@qq.com
通信地址: 大屯路15号 中科院生物物理研究所
邮政编码: 100101
教育背景
2007-04--2008-05 美国纽约大学 高级访问学者研究2002-06--2004-06 汕头大学 病理与病理生理学(法医病理专业)/博士后研究1995-09--2000-06 山东医科大学 人体解剖与组织胚胎学系(硕博连读)/博士学位1990-09--1995-06 山东医科大学 临床医学(本科)/学士学位
工作经历
工作简历
2007-04~2008-05,美国纽约大学, 高级访问学者研究2002-06~2004-06,汕头大学, 病理与病理生理学(法医病理专业)/博士后研究2000-07~2014-09,济南市妇幼保健院, 临床医师1995-09~2000-06,山东医科大学, 人体解剖与组织胚胎学系(硕博连读)/博士学位1990-09~1995-06,山东医科大学, 临床医学(本科)/学士学位
社会兼职
2016-10-01-今,子宫内膜癌筛查专家委员会委员,
2013-05-13-今,济南市留学人员联谊会, 理事
2013-05-13-今,济南市留学人员联谊会, 理事
教授课程
医学病理学基础与临床医学实验动物学与疾病模型
专利与奖励
奖励信息
(1) 朱李月华优秀教师奖, 研究所(学校), 2021(2) 研究生优秀课程奖, 研究所(学校), 2019(3) 济南市高层次人才计划, 三等奖, 市地级, 2013
出版信息
发表论文
(1) C6orf223 promotes colorectal cancer growth and metastasis by facilitating PRMT5-MEP50 multiprotein complex assembling, The Journal of Clinical Investigation , 2025, 第 14 作者(2) Transferrin receptor 1 nuclear translocation facilitates tumor progression via p53-mediated chromatin interactions and genome-wide alterations, Signal Transduction and Targeted Therapy, 2025, 第 7 作者(3) A deep learning framework for predicting endometrial cancer from cytopathologic images with different staining styles, PLoS One, 2024, 第 3 作者(4) Targeting intratumor heterogeneity suppresses colorectal cancer chemoresistance and metastasis, EMBO REPORTS, 2023, 第 11 作者(5) Designing glucose utilization "highway" for recombinant biosynthesis, Metabolic Engineering, 2023, 第 7 作者 通讯作者(6) CLMP is a tumor suppressor that determines alltrans retinoic acid response in colorectal cancer, Developmental Cell, 2023, 第 16 作者(7) Micro-histology combined with cytology improves the diagnostic accuracy of endometrial lesions, Cancer Medicine, 2023, 第 8 作者(8) Effects of food emulsiffers on high fat-diet-induced obesity, intestinal inflammation, changes in bile acid proffle, and liver dysfunction, Food Research International, 2023, 第 5 作者(9) CLMP is a tumor suppressor that determines all -trans retinoic acid response in colorectal cancer, DEVELOPMENTAL CELL, 2023, 第 10 作者(10) Insights into the insertion reaction mechanism of phosphenium cation and oxirane: a theoretical study, JOURNAL OF CHEMICAL SCIENCES, 2022, 第 3 作者(11) Intestinal Micro���ora Changes in Patients with Mild Alzheimer���s Disease in a Chinese Cohort, Journal of Alzheimer’s Disease, 2022, 第 2 作者(12) Clinically Applicable Pathological Diagnosis System for Cell Clumps in Endometrial Cancer Screening via Deep Convolutional Neural Networks., Cancers, 2022, 第 12 作者(13) CD146 is a Novel ANGPTL2 Receptor that Promotes Obesity by Manipulating Lipid Metabolism and Energy Expenditure, ADVANCED SCIENCE, 2021, 第 18 作者(14) Creatine promotes cancer metastasis through activation of Smad2/3, CELL METABOLISM, 2021, 第 8 作者(15) Chromatin Remodeling of Colorectal Cancer Liver Metastasis is Mediated by an HGF-PU.1-DPP4 Axis, ADVANCED SCIENCE, 2021, 第 17 作者(16) A Clinical Comparative Study of Two Different Endometrial Cell Samplers for Evaluation of Endometrial Lesions by Cytopathological Diagnosis, Cancer Management and Research, 2020, 第 11 作者(17) Comparison of Cervical Cytopathological Diagnosis Using Innovative Qi Brush and Traditional Cervex-Brush (R) Combi, FRONTIERS IN MEDICINE, 2020, 第 11 作者(18) Clinical Evaluation of Li Brush Endometrial Samplers for Diagnosing Endometrial Lesions in Women With Intrauterine Devices, FRONTIERS IN MEDICINE, 2020, 第 13 作者(19) Theoretical study on the reaction between silacyclopropenylidene and three-membered heterocyclic compounds (azirane and oxirane): An alternative approach to the formation of heterocyclic silylene, PROGRESS IN REACTION KINETICS AND MECHANISM, 2020, 第 4 作者(20) Phosphorylation switches protein disulfide isomerase activity to maintain proteostasis and attenuate ER stress, EMBO JOURNAL, 2020, 第 7 作者(21) Development of a highly efficient and specific l-theanine synthase, APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2020, 第 5 作者(22) Biomineralization Synthesis of Cobalt Nanozyme in SP94-ferritin Nanocage for Prognostic Diagnosis of Hepatocellular Carcinoma, ACS Appl. Mater. Interfaces, 2019, 第 1 作者(23) Biomineralization Synthesis of the Cobalt Nanozyme in SP94-Ferritin Nanocages for Prognostic Diagnosis of Hepatocellular Carcinoma, ACS APPLIED MATERIALS & INTERFACES, 2019, 第 5 作者(24) Promiscuous enzymatic activity-aided multiple-pathway network design for metabolic flux rearrangement in hydroxytyrosol biosynthesis, NATURE COMMUNICATIONS, 2019, 第 8 作者(25) Targeting the functional interplay between endoplasmic reticulum oxidoreductin-1�� and protein disulfide isomerase suppresses the progression of cervical cancer, EBIOMEDICINE, 2019, 第 5 作者(26) Validation of Molecular Typing for Endometrial Screening Test That Predicts Benign and Malignant Lesions, FRONTIERS IN ONCOLOGY, 2019, 第 11 作者(27) 陈锐,杨曦,任玉波等.子宫内膜细胞学诊断报告系统(2017)及临床处理建议, DOI:10.19538/j.fk2017100114, 中国实用妇科与产科杂志, 2017, 第 1 作者(28) 子宫内膜细胞学诊断报告系统(2017)及临床处理建议, @@, 中国实用妇科与产科杂志, 2017, 第 4 作者(29) Xiaomeng He, Junjing Yu, Min Wang,et al. Bap180/Baf180 is required to maintain homeostasis of intestinal innate immune response in Drosophila and mice���J���. DOI:10.1038/nmicrobiol.2017.56, Nature microbiology, 2017, 第 1 作者(30) Ying Zhang, Yuanyuan Xue, Chunwei Cao, et al. Thyroid hormone regulates hematopoiesis via the TR-KLF9 axis. DOI:10.1182/blood-2017-05-783043, Blood, 2017, 第 1 作者(31) Bap180/baf180 is required to maintain homeostasis of intestinal innate immune response in drosophila and mice, NATURE MICROBIOLOGY, 2017, 第 7 作者
发表著作
( 1 ) 子宫内膜细胞病理学图谱, ATLAS OF ENDOMETRIUM CYTOPATHOLOGY, 北京大学医学出版社, 2018-07, 第 4 作者( 2 ) 子宫内膜癌筛查临床与病理, 人民卫生出版社, 2020-07, 第 其他 作者( 3 ) 法医学, 浙江大学出版社, 2025-04, 第 其他 作者
科研活动
科研项目
( 1 ) 利用基因编辑技术构建新型肝细胞癌小鼠模型及其肝癌致病机制研究, 参与, 国家任务, 2018-01--2021-12( 2 ) 细胞块病理仪及其相关试剂方法的研制, 负责人, 境内委托项目, 2016-11--2018-10( 3 ) CD71作为癌症诊断标志物的研究, 参与, 研究所自主部署, 2015-01--2017-12
参与会议
(1)子宫内膜细胞学诊断注意事项 第七届国际子宫内膜病变临床和病理进展医学大会 2022-09-17(2)从病理诊断角度探讨子宫内膜细胞学筛查中存在的问题及解决思路 第六届子宫内膜病变临床与病理新进展高峰论坛 2021-10-31(3)子宫内膜细胞学筛查及相关问题探讨 第八届妇科肿瘤诊治&子宫内膜癌的筛查及早期诊断 2021-07-03(4)细胞学与组织学同步筛查用于子宫内膜癌及癌前病变的可行性探讨 妇科肿瘤诊治&子宫内膜癌的筛查及早期诊断研讨会 2018-10-27(5)子宫内膜细胞学诊断 及相关问题探讨 生殖内分泌与辅助生殖技术学习班 2018-09-14(6)子宫内膜细胞学诊断注意 事项及相关问题探讨 2017 年子宫内膜癌的筛查及早期诊断 (子宫内膜细胞学技术培训班) 会议 2017-09-02(7)子宫内膜细胞学诊断及相关问题探讨 2016年子宫内膜癌的筛查及早期诊断培训班 2016-10-21(8)子宫内膜细胞学筛查的临床意义 山东省第四次细胞学会议 2014-09-13