基本信息
李斐  女  硕导  中国科学院烟台海岸带研究所
电子邮件: fli@yic.ac.cn
通信地址: 山东烟台莱山区春晖路17号
邮政编码:

招生信息

   
招生专业
083001-环境科学
招生方向
海岸带生态毒理学
计算毒理学
生态风险评价

教育背景

2004-09--2010-07   大连理工大学   环境科学博士学位(硕博连读)
2000-09--2004-07   大连理工大学   环境工程学士学位

工作经历

   
工作简历
2015-10~现在, 中国科学院烟台海岸带研究所, 副研究员
2010-07~2015-09,中国科学院烟台海岸带研究所, 助理研究员
2004-09~2010-07,大连理工大学, 环境科学博士学位(硕博连读)
2000-09~2004-07,大连理工大学, 环境工程学士学位

专利与奖励

   
奖励信息
(1) 新污染物环境光化学持久性及毒性得计算毒理学研究, 一等奖, 国家级, 2023
(2) 渤海典型污染物生态毒理效应与分子生物标志物研究, 二等奖, 市地级, 2018
专利成果
( 1 ) 评估和预测有机磷酸酯阻燃剂对模拟生物膜损伤的方法, 2018, 第 2 作者, 专利号: CN108733972A

出版信息

   
发表论文
(1) Abnormality of mussel in the early developmental stages induced by graphene and triphenyl phosphate: In silico toxicogenomic data-mining, in vivo, and toxicity pathway-oriented approach, AQUATIC TOXICOLOGY, 2023, 第 11 作者
(2) Critical target identification and human health risk ranking of metal ions based on mechanism-driven modeling, CHEMOSPHERE, 2022, 第 11 作者
(3) Potential adverse outcome pathways with hazard identification of organophosphate esters, SCIENCE OF THE TOTAL ENVIRONMENT, 2022, 第 11 作者
(4) Toxicity pathways of lipid metabolic disorders induced by typical replacement flame retardants via data-driven analysis, in silico and in vitro approaches, CHEMOSPHERE, 2022, 第 11 作者
(5) Critical features identification for chemical chronic toxicity based on mechanistic forecast models, ENVIRONMENTAL POLLUTION, 2022, 第 11 作者
(6) Integration of Computational Toxicology, Toxicogenomics Data Mining, and Omics Techniques to Unveil Toxicity Pathways, ACS SUSTAINABLE CHEMISTRY & ENGINEERING, 2021, 第 11 作者
(7) Graphene-triphenyl phosphate (TPP) co-exposure in the marine environment: Interference with metabolism and immune regulation in mussel Mytilus galloprovincialis, ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2021, 第 11 作者
(8) New insights into the mechanism of hepatocyte apoptosis induced by typical organophosphate ester: An integrated in vitro and in silico approach, ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2021, 第 11 作者
(9) Toxicological effects of graphene on mussel Mytilus galloprovincialis hemocytes after individual and combined exposure with triphenyl phosphate, MARINE POLLUTION BULLETIN, 2020, 第 11 作者
(10) Transcriptomic, proteomic and metabolomic profiling unravel the mechanisms of hepatotoxicity pathway induced by triphenyl phosphate (TPP), ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2020, 第 11 作者
(11) Combinatorial immune and stress response, cytoskeleton and signal transduction effects of graphene and triphenyl phosphate (TPP) in mussel Mytilus galloprovincialis, JOURNAL OF HAZARDOUS MATERIALS, 2019, 第 11 作者
(12) 基于电化学方法研究石墨烯和磷酸三苯酯(TPP)与模拟生物膜间的相互作用, 科学通报, 2017, 第 1 作者
(13) Toxicological effects of tris(2-chloropropyl) phosphate in human hepatic cells, CHEMOSPHERE, 2017, 第 1 作者
(14) Occurrence and spatial distribution of organophosphorus flame retardants and plasticizers in the Bohai and Yellow Seas, China, MARINE POLLUTION BULLETIN, 2017, 第 4 作者
(15) 石墨烯与抑癌基因p53 DNA片段相互作用的分子模拟与光谱学验证, Studies on the Interaction between Graphene and p53-DNA by Molecular Dynamics Simulations and Spectroscopic Methods, 生态毒理学报, 2017, 第 3 作者
(16) An integrated proteomic and metabolomic study on the gender-specific responses of mussels Mytilus galloprovincialis totetrabromobisphenol A (TBBPA), CHEMOSPHERE, 2016, 第 2 作者
(17) 化学品甲状腺干扰效应的计算毒理学研究进展, 科学通报, 2015, 第 3 作者
(18) In Silico Investigation of the Thyroid Hormone Activity of Hydroxylated Polybrominated Diphenyl Ethers, CHEMICAL RESEARCH IN TOXICOLOGY, 2015, 第 3 作者
(19) Affinities of organophosphate flame retardants to tumor suppressor gene p53: an integrated in vitro and in silico study., TOXICOLOGY LETTERS, 2015, 第 1 作者
(20) Glutathione S-transferase ( GST ) gene expression profiles in two marine bivalves exposed to BDE-47 and their potential molecular mechanisms, CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY, 2015, 第 1 作者
(21) DNA Nanostructure-Based Magnetic Beads for Potentiometric Aptasensing, ANALYTICAL CHEMISTRY, 2015, 第 3 作者
(22) 典型持久性有机污染物与抑癌基因相互作用的分子模拟与验证, 科学通报, 2015, 第 3 作者
(23) Toxicological evaluation of two pedigrees of clam Ruditapes philippinarum as bioindicators of heavy metal contaminants using metabolomics, ENVIRONMENTALTOXICOLOGYANDPHARMACOLOGY, 2015, 第 11 作者
(24) Multiple biomarkers of the cytotoxicity induced by BDE-47 in human embryonic kidney cells, CHEMOSPHERE, 2015, 第 11 作者
(25) Determination and prediction of the binding interaction between organophosphate flame retardants and p53., CHEMICAL RESEARCH IN TOXICOLOGY, 2014, 第 11 作者
(26) The interaction between organic phosphate ester and p53: An integrated experimental and in silico approach, MARINE POLLUTION BULLETIN, 2014, 第 11 作者
(27) Docking and QSAR study on the binding interactions between polycyclic aromatic hydrocarbons and estrogen receptor, ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2012, 第 1 作者
(28) Docking and 3D-QSAR studies on the Ah receptor binding affinities of polychlorinated biphenyls (PCBs), dibenzo- p -dioxins (PCDDs) and dibenzofurans (PCDFs), ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 2011, 第 1 作者
(29) Probing the Primary Mechanisms Affecting the Environmental Distribution of Estrogen and Androgen Isomers, ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2011, 第 3 作者
(30) Noncovalent interactions between hydroxylated polycyclic aromatic hydrocarbon and DNA: Molecular docking and QSAR study, ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 2011, 第 1 作者
(31) QSAR studies on the depuration rates of polycyclic aromatic hydrocarbons, polybrominated diphenyl ethers and polychlorinated biphenyls in mussels ( Elliptio complanata ), SAR AND QSAR IN ENVIRONMENTAL RESEARCH, 2011, 
(32) Hormone activity of hydroxylated polybrominated diphenyl ethers to human thyroid receptors ��: in vitro and in silico investigations, Environmental Health Perspectives, 2010, 第 1 作者
(33) Estrogenic Activity of Anthraquinone Derivatives: In Vitro and In Silico Studies, CHEMICAL RESEARCH IN TOXICOLOGY, 2010, 第 1 作者
(34) Modeling photoinduced toxicity of PAHs based on DFT-calculated descriptors, CHEMOSPHERE, 2009, 第 3 作者
(35) Determination and prediction of xenoestrogens by recombinant yeast-based assay and QSAR, CHEMOSPHERE, 2009, 第 1 作者
(36) Characterization of oxidative damage induced by nanoparticles via mechanism-driven machine learning approaches, SCIENCE OF THE TOTAL ENVIRONMENT, 第 11 作者
发表著作
Persistent organic pollutants (POPs): Analytical techniques, environmental processes and biological effects. Chapter 17 – QSARs on the thyroid hormone effects of polybrominated diphenyl ether (PBDE) derivatives, Elsevier, 2015-03, 第 1 作者
QSAR in Safety Evaluation and Risk Assessment. Fei Li, et al. Chapter 38 - QSAR models in marine ecotoxicology and risk assessment., Elsevier Inc., 2023-01, 第 其他 作者

科研活动

   
科研项目
( 1 ) 数据驱动和机制驱动下典型全(多)氟化合物胁迫对海洋敏感物种的毒性通路研究, 负责人, 国家任务, 2024-01--2027-12
( 2 ) 小清河-莱州湾区域新型全氟化合物筛查识别、人群暴露及健康效应研究, 负责人, 国家任务, 2024-01--2026-12
( 3 ) 典型全氟化合物(PFASs)对双壳贝类毒性的有害结局路径, 负责人, 地方任务, 2024-01--2026-12
( 4 ) 泰山学者青年专家, 负责人, 其他, 2024-01--2026-12
( 5 ) 典型有机磷酸酯阻燃剂的跨膜机制及其与关键蛋白的相互作用, 负责人, 国家任务, 2017-01--2020-12
( 6 ) 有机磷酸酯阻燃剂的生态毒理, 负责人, 中国科学院计划, 2017-01--2020-12
( 7 ) 典型人工纳米颗粒在不同生态系统中的环境行为及食物链中的关键过程, 负责人, 国家任务, 2016-01--2020-12
( 8 ) Binding Interactions Between Anthraquinone Derivatives and DNA: An Integrated Experimental Determination and Molecular Simulation Approach, 负责人, 其他国际合作项目, 2012-09--2015-12
( 9 ) 典型有机磷酸酯阻燃剂对DNA功能基因的损伤机制和构效关系研究, 负责人, 国家任务, 2012-01--2014-12
( 10 ) 多环芳烃对DNA损伤机制的计算模拟与验证, 负责人, 其他国际合作项目, 2011-01--2013-12