基本信息

王光中 男 博导 中国科学院上海营养与健康研究所
电子邮件: guangzhong.wang@picb.ac.cn
通信地址: 上海市岳阳路320号
邮政编码:
电子邮件: guangzhong.wang@picb.ac.cn
通信地址: 上海市岳阳路320号
邮政编码:
招生信息
招生专业
0710Z2-计算生物学
招生方向
计算生物学-生物信息学、系统神经科学,节律生物学
教育背景
2007-08--2010-09 德国杜塞尔多夫大学 博士2002-09--2006-07 山东理工大学 学士
工作经历
工作简历
2016-03~现在, 中国科学院上海生命科学研究院, 研究员2007-08~2010-09,德国杜塞尔多夫大学, 博士2002-09~2006-07,山东理工大学, 学士
出版信息
发表论文
(1) Cynomolgus-rhesus hybrid macaques serve as a platform for imprinting studies, The Innovation, 2023, (2) Noncoding transcripts are linked to brain resting-state activity in non-human primates, Cell Reports, 2023, (3) scBrainMap: a landscape for cell types and associated genetic markers in the brain, Database, 2023, (4) Brain-wide and cell-specific transcriptomic insights into MRI-derived cortical morphology in macaque monkeys, Nat Commun, 2023, (5) Gene networks under circadian control exhibit diurnal organization in primate organs, Commun Biol, 2022, (6) Rapid Body-Wide Transcriptomic Turnover During Rhesus Macaque Perinatal Development, Front Physiol, 2021, (7) Genome-wide circadian regulation: A unique system for computational biology, COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL, 2020, 第 5 作者 通讯作者(8) Chromatin-Binding Protein PHF6 Regulates Activity-Dependent Transcriptional Networks to Promote Hunger Response, CELL REPORTS, 2020, 第 16 作者(9) Epigenetic inheritance of circadian period in clonal cells, ELIFE, 2020, 第 5 作者(10) Significant Evolutionary Constraints on Neuron Cells Revealed by Single-Cell Transcriptomics, GENOME BIOLOGY AND EVOLUTION, 2020, 第 3 作者 通讯作者(11) Twin-peak temporal regulation during human neocortical development, CELL DISCOVERY, 2019, 第 2 作者 通讯作者(12) A single factor dominates the behavior of rhythmic genes in mouse organs, BMC GENOMICS, 2019, 第 4 作者 通讯作者(13) Structural analysis of fungal CENP-H/I/K homologs reveals a conserved assembly mechanism underlying proper chromosome alignment, NUCLEIC ACIDS RESEARCH, 2019, 第 10 作者(14) Application of Computational Biology to Decode Brain Transcriptomes, GENOMICS PROTEOMICS & BIOINFORMATICS, 2019, 第 2 作者 通讯作者(15) Understanding Molecular Mechanisms of the Brain Through Transcriptomics, FRONTIERS IN PHYSIOLOGY, 2019, 第 2 作者 通讯作者(16) Application of Computational Biology to Decode Brain Transcriptomes, Application of Computational Biology to Decode Brain Transcriptomes, GENOMICS, 2019, 第 2 作者(17) Twin-peak temporal regulation during human neocortical development, CELL DISCOVERY, 2019, (18) Decoding nervous system by single-cell RNA sequencing, 定量生物学, 2017, 第 2 作者(19) Human Genomic Signatures of Brain Oscillations During Memory Encoding, CEREBRAL CORTEX (NEW YORK, NY), 2017, 第 2 作者(20) Dscam1 web server: online prediction of Dscam1 self- and hetero-affinity, BIOINFORMATICS, 2017, 第 4 作者 通讯作者(21) Correspondence between Resting-State Activity and Brain Gene Expression, NEURON, 2015, 第 1 作者(22) Cycling Transcriptional Networks Optimize Energy Utilization on a Genome Scale, CELL REPORTS, 2015, 第 1 作者(23) Improvement of Dscam homophilic binding affinity throughout Drosophila evolution, 2014, 第 6 作者(24) Decoding human gene expression signatures in the brain, TRANSCRIPTION, 2013, 第 1 作者(25) Human-Specific Transcriptional Networks in the Brain, NEURON, 2012, 第 8 作者(26) he effects of Network Neighbours on Protein Evolution., PLoS One, 2011, 第 1 作者(27) A Gene's Ability to Buffer Variation Is Predicted by Its Fitness Contribution and Genetic Interactions, PLOS ONE, 2011, 第 1 作者 通讯作者(28) Exploring the common molecular basis for the universal DNA mutation bias: revival of L��wdin mutation model, Biochem Biophys Res Commun., 2011, 第 1 作者(29) Transcriptional coupling of neighbouring genes and gene expression noise: evidence that gene orientation and non-coding transcripts are modulators of noise, Genome Biol Evol., 2011, 第 1 作者(30) Coexpression of Linked Gene Pairs Persists Long after Their Separation, GENOME BIOLOGY AND EVOLUTION, 2011, (31) Amino acid composition in endothermic vertebrates is biased in the same direction as in thermophilic prokaryotes, BMC EVOLUTIONARY BIOLOGY, 2010, 第 1 作者(32) Does negative auto-regulation increase gene duplicability?, BMC EVOLUTIONARY BIOLOGY, 2009, 第 2 作者(33) Phase-dependent mutation in protein-coding sequences, Biochem. Biophys. Res. Commun., 2007, 第 1 作者(34) Neighboring-site effects of amino acid mutation, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2007, 第 1 作者(35) Sterol biosynthesis and prokaryotes-to-eukaryotes evolution, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2007, 第 2 作者(36) Unexpected amino acid composition of modern Reptilia and its implications in molecular mechanisms of dinosaur extinction, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2005, (37) Application of Computational Biology for Decoding Brain Transcriptomes, GENOMICS, PROTEOMICS & BIOINFORMATICS, 第 2 作者 通讯作者
科研活动
科研项目
( 1 ) 应用三代测序技术研究节律性选择剪接, 负责人, 国家任务, 2022-01--2025-12( 2 ) 大脑高级功能相关基因的系统生物学分析, 负责人, 国家任务, 2019-01--2020-12( 3 ) 基于形态与组学空间信息的细胞分型全脑测绘系统, 参与, 国家任务, 2019-01--2023-12( 4 ) 节律调控网络对通路转录活动中优化耗能的研究, 负责人, 国家任务, 2017-01--2019-12( 5 ) 卵巢癌临床关键问题导向的诊疗标志物验证及应用研究, 参与, 国家任务, 2016-09--2020-12( 6 ) 精准医学大数据整合与管理分析的标准化体系构建, 参与, 国家任务, 2016-07--2020-12
参与会议
(1)Decoding the Complexity of Brain Transcriptomics 第十二届国际基因组学大会 2017-10-26(2)Human genomic signatures of brain oscillations during memory encoding 生物信息学与智能信息处理 2017年学术会议 2017-06-16