General
Zhiqi Cong, PhD, Professor
Group Leader, Biomimetic Catalysis Group
Shandong Provincial Key Laboratory of Synthetic Biology
Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences
No. 189 Songling Road, Laoshan District
Qingdao, Shandong, 266101, P. R. China
Tel: 86-532-80662758

Research Areas

1. Enzymology and enzyme engineering

2. Bio&biomimetic catalysis

3. Environmental microbiology

Education

July 1999: B.S. in Applied Chemistry, Yanbian University, China

Jun 2002: M.S. in Organic Chemistry, Yanbian University, China

March 2009: PhD in Organic Chemistry, Kumamoto University, Japan


Experience


Work Experience

Jun 2002 ~ Sep 2005: Assistant professor in Yanbian University, China

Apr 2009 ~ Mar 2013: IMS Fellow in Institute for Molecular Science, Japan

Apr 2013 ~ Apr 2016: Researcher, Senior Researcher in Nagoya University, Japan

May 2016 ~ present: Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, China

Teaching Experience

Jun 2002 ~ Sep 2005: Assistant professor in Yanbian University, China

Apr 2009 ~ Mar 2013: IMS Fellow in Institute for Molecular Science, Japan

Apr 2013 ~ Apr 2016: Researcher, Senior Researcher in Nagoya University, Japan

May 2016 ~ present: Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, China

Publications


Papers

1).  Cong, Zhiqi; Shoji, Osami; Kasai, Chie; Kawakami, Norifumi; Sugimoto, Hiroshi; Shiro, Yoshitsugu; Watanabe, Yoshihito. Activation of Wild-type Cytochrome P450BM3 by the Next Generation Decoy Molecules: Enhanced Hydroxylation of Gaseous Alkanes and Crystallographic Evidence. ACS Catal. 2015, 5, 150-156.


2). Kawakami, Norifumi; Cong, Zhiqi; Shoji, Osami; Watanabe, Yoshihito. Highly efficient hydroxylation of gaseous alkanes at reduced temperature catalyzed by cytochrome P450BM3 assisted by decoy molecules. J. Porphyrins Phthalocyanines 2015, 19, 329-334.


3). Cong, Zhiqi; Kinebuchi, Haruki; Kurahashi, Takuya; Fujii, Hiroshi.Factors Affecting Hydrogen-Tunneling Contribution in Hydroxylation Reactions Promoted by Oxoiron(IV) Porphyrin π-Cation Radical Complexes. Inorg. Chem. 2014, 53, 10632-10641.


4). Cong, Zhiqi; Sachiko, Yanagisawa; Kurahashi, Takuya; Takashi, Ogura; Satoru, Nakashima; Fujii, Hiroshi. Synthesis, Charaterization and Reactivity of Hypochloritoiron(III) Porphyrin Complexes. J. Am. Chem. Soc. 2012, 134, 20617-20620.


5). Cong, Zhiqi; Kurahashi, Takuya; Fujii, Hiroshi. Formation of Iron(III) meso-Chloro- Isoporphyrin as a Reactive Chlorinating Agent from Oxo- iron(IV) Porphyrin π-Cation Radical. J. Am. Chem. Soc. 2012, 134, 4469-4472.


6).Cong, Zhiqi; Kurahashi, Takuya; Fujii, Hiroshi. Oxidation of Chloride Ion and Subsequent Chlorination of Organic Compounds by Oxoiron(IV) Porphyrin π-Cation Radical Complexes. Angew. Chem. Int. Ed. 2011, 50, 9935-9939.


7). Cong, Zhiqi; Miki, Takumi; Urakawa, Osamu; Nishino, Hiroshi.Synthesis of Dibenz[b,f]oxepins via Manganese(III)-Based Oxidative 1,2-Radical Rearrangement. J. Org. Chem. 2009, 74(10), 3978-3981.


8). Cong, Zhi-qi; Nishino, Hiroshi. Manganese(III)-mediated direct introduction of 3-oxobutanamides into methoxynaphthalenes. Synthesis 2008, 2686-2694.

Research Interests

1. Rational design of artificial catalytic system based on metalloenzyme

2. Enzymatic catalysis of low carbon molecules

3. Enzymatic conversion of biomass

4. Environmental enzyme catalysis

Conferences

(1)小分子驱动P450单加氧酶选择性氧化气态烷烃   泰山学术论坛-生物无机化学与纳米材料专题   2016-11-04
(2)小分子驱动P450单加氧酶选择氧化气态烷烃   第十六届全国青年催化学术会议   2016-10-21
(3)氯过氧化物酶Hypochlorito-Iron(III) Porophyrin模型中间体的研究   中国化学会第十三届全国生物无机化学会议   2016-10-13
(4)Synergistic Effect of Decoy Molecule andSite-directed Mutation Leading to A P450   CONG, Zhiqi; SHOJI, Osami; KASAI, Chie; SUGIMOTO, Hiroshi; SHIRO, Yoshitsugu; WATANABE, Yoshihito   2016-03-24
(5)Activation of Wild-type Cytochrome P450BM3 by the 2nd-generation of Decoy Molecules: Hydroxylation of Small Alkanes and Mechanism   2015-07-24
(6)Construction of Small Alkane Hydroxylase by P450BM3-decoy Molecule System   Cong, Zhiqi; Shoji, Osami; Kasai, Chie; Sugimoto, Hiroshi; Shiro, Yoshitsugu; Watanabe, Yoshihito   2015-03-27
(7)Powerful Activation of Cytochrome P450BM3 by Second-Generation Decoy Molecules and the Hydroxylation of Small Alkanes    Cong, Zhiqi; Shoji, Osami; Kasai, Chie; Sugimoto, Hiroshi; Shiro, Yoshitsugu; Watanabe, Yoshihito   2014-11-15
(8)Arousal of Wild-type Cytochrome P450 by second-generation decoy molecules: toward the hydroxylation of gaseous alkanes   2014-09-24
(9)“Hydroxylation of gaseous alkanes catalyzed by Wild-type Cytochrome P450: Development of Second-Generation Decoy Molecules and Studies of Reaction mechanism based on crystal structure analysis”    Cong, Zhiqi; Shoji, Osami; Kasai, Chie; Sugimoto, Hiroshi; Shiro, Yoshitsugu; Watanabe, Yoshihito   2014-09-11
(10) “New Generation of Decoy Molecules to Powerfully Activate Cytochrome P450BM3 for Small Alkanes Hydroxylation”    Cong, Zhiqi; Shoji, Osami; Kasai, Chie; Sugimoto, Hiroshi; Shiro, Yoshitsugu; Watanabe, Yoshihito   2014-03-26
(11) “Synthesis, Charaterization and Reactivity of Hypochlorite-Iron(III) Porphyrin Complexes.”   CONG, Zhiqi; YANAGISAWA, Sachiko; KURAHASHI, Takuya; OGURA, Takashi; FUJII, Hiroshi   2012-11-16
(12) “Synthesis and Chlorinating Reactivity of Iron(III) meso-Chloro-Isoporphyrins.”    CONG, Zhiqi; KURAHASHI, Takuya; FUJII, Hiroshi   2012-09-21
(13)“Oxidation of Chloride Ion by Compound I Model Complex and Related Chlorination of Organic Compounds.”   CONG, Zhiqi; KURAHASHI, Takuya; FUJII, Hiroshi   2011-11-04
(14) “Hydrogen Tunneling Effect on Alkane Hydroxylation by High-valent Oxoiron porphyrin Model Complexes.”   CONG, Zhiqi; KURAHASHI, Takuya; FUJII, Hiroshi   2011-03-26
(15) “Hydrogen Tunneling Effect on Hydrocarbon Hydroxylation by Oxoiron(IV) Porphyrin π-Cation Radical Complexes.”    CONG, Zhiqi; FUJII, Hiroshi   2010-11-10
(16)“Synthesis of Dibenz[b,f]oxepins from 2-(9-Xanthenyl)malonate.”    CONG, Zhiqi; NISHINO, Hiroshi   2008-03-26

Collaboration

1. Alkane oxidation by heme enzymes

    Collaboration with Watanabe's Laboratory in Nagoya University

2. Understanding molecular mechanism of heme enzyme by model complexes

    Collaboration with Fujii's Laboratory in Nara Women University

Students

Present students

Nana Ma  02  63228  (M2) 

Panxia Zhao  02  63228 (M1)