100706-药理学
100800-中药学

心血管药理学
临床中药学

2000-04--2004-04   日本关西医科大学   药理学博士学位
1995-09--1998-07   沈阳药科大学   药理学硕士学位
1988-09--1992-07   沈阳药科大学   药剂学学士学位

   

2006-04~现在, 中国科学院上海药物研究所, 研究员
2000-04~2004-04,日本关西医科大学, 药理学博士学位
1995-09~1998-07,沈阳药科大学, 药理学硕士学位
1988-09~1992-07,沈阳药科大学, 药剂学学士学位

2014-08-31-2018-08-31,世界中医药学会联合会气血专业委员会, 理事
2014-08-31-2019-06-21,中国微循环学会痰瘀专业委员会委员, 委员
2014-04-01-今,世界中联专业委员会, 委员

高等药理学
心血管药理学

   

（1） 2023年浦东新区明珠工程师称号, 其他, 2023
（2） 中华中医药学会科学技术奖, 一等奖, 部委级, 2015

（ 1 ） 治疗出血性疾病的化合物及其组合物, 2022, 第 1 作者, 专利号: 2022106149048

（ 2 ） 天然化合物及其衍生物在治疗动脉病变中的应用, 2021, 第 1 作者, 专利号: CN113750085A

（ 3 ） 用于治疗动脉病变的药物及其用途, 2021, 第 1 作者, 专利号: CN112823797A

（ 4 ） 用于治疗动脉相关疾病的药物及其用途, 2021, 第 1 作者, 专利号: CN112569219A

（ 5 ） 一种药物组合物及其应用, 2021, 第 1 作者, 专利号: CN112438973A

（ 6 ） 同时减少出血和微血管阻塞风险的药物, 2019, 第 1 作者, 专利号: CN110604734A

（ 7 ） 单核/巨噬细胞在主动脉损伤中的诊断和治疗应用, 2019, 第 1 作者, 专利号: CN109490540A

（ 8 ） 单核/巨噬细胞在主动脉损伤中的诊断和治疗应用, 2019, 第 1 作者, 专利号: CN109490540A

（ 9 ） 多聚体丹酚酸在制备用于抑制主动脉瘤或主动脉夹层的发生或发展的药物中的用途, 2014, 第 2 作者, 专利号: CN104055760A

（ 10 ） 一种药物组合物及其用途, 2014, 第 2 作者, 专利号: CN102908355B

（ 11 ） 一种药物组合物及其用途, 2013, 第 2 作者, 专利号: CN102908355A

（ 12 ） 三聚体丹酚酸的用途, 2012, 第 2 作者, 专利号: CN102309477A

（ 13 ） 丹酚酸B的用途, 2011, 第 2 作者, 专利号: CN101496798B

（ 14 ） 丹参提取物的新用途, 2009, 第 2 作者, 专利号: CN101411746

   

（1） Eugenol restrains abdominal aortic aneurysm progression with down-regulations on NF-kappa B and COX-2, PHYTOTHERAPY RESEARCH, 2022, 第 11 作者
（2） Single-Cell Sequencing of Immune Cells in Human Aortic Dissection Tissue Provides Insights Into Immune Cell Heterogeneity, FRONTIERS IN CARDIOVASCULAR MEDICINE, 2022, 第 11 作者
（3） Progression and Regression of Abdominal Aortic Aneurysms in Mice, Progression and Regression of Abdominal Aortic Aneurysms in Mice, CURRENT MEDICAL SCIENCE, 2021, 第 11 作者
（4） Macrophage-biomimetic anti-inflammatory liposomes for homing and treating of aortic dissection, JOURNAL OF CONTROLLED RELEASE, 2021, 第 11 作者
（5） Rosmarinic acid suppresses abdominal aortic aneurysm progression in apolipoprotein E-de���cient mice., Planta Med., 2021, 第 11 作者
（6） Effects of Salvianolic Acid B/ginsenoside Rg1 Combination Against Chronic Pulmonary Embolism Induced by Polystyrene Microspheres, FOLIA BIOLOGICA-KRAKOW, 2021, 第 11 作者
（7） Targeted depletion of monocyte/macrophage suppresses aortic dissection with the spatial regulation of MMP-9 in the aorta, LIFE SCIENCES, 2020, 第 11 作者
（8） Cardioprotection of salvianolic acid B and ginsenoside Rg1 combination on subacute myocardial infarction and the underlying mechanism, PHYTOMEDICINE, 2019, 第 11 作者
（9） Cell Permeable NBD Peptide-Modified Liposomes by Hyaluronic Acid Coating for the Synergistic Targeted Therapy of Metastatic Inflammatory Breast Cancer, MOLECULAR PHARMACEUTICS, 2019, 第 5 作者
（10） 4种小鼠腹主动脉瘤模型的比较, 4 abdominal aortic aneurysm mouse models, 中南药学, 2018, 第 3 作者
（11） 急性主动脉综合征研究进展, 中华外科杂志, 2018, 第 3 作者
（12） Constituents of Mediterranean Spices Counteracting Vascular Smooth Muscle Cell Proliferation: Identification and Characterization of Rosmarinic Acid Methyl Ester as a Novel Inhibitor, MOLECULAR NUTRITION & FOOD RESEARCH, 2018, 第 6 作者
（13） Cardio-protection of ultrafine granular powder for Salvia miltiorrhiza Bunge against myocardial infarction, JOURNAL OF ETHNOPHARMACOLOGY, 2018, 第 11 作者
（14） Incidence and Risk Factors for Retrograde Type A Dissection and Stent Graft-Induced New Entry after Thoracic Endovascular Aortic Repair, JOURNAL OF VASCULAR SURGERY, 2018, 第 12 作者
（15） Cardioprotection of salvianolic acid B and ginsenoside Rg1 combination on subacute myocardial infarction and the underlying mechanism., PHYTOMEDICINE, 2018, 第 11 作者
（16） Xanthohumol Blocks Proliferation and Migration ofVascular Smooth Muscle Cells in Vitro and ReducesNeointima Formation in Vivo, JOURNAL OF NATURAL PRODUCTS, 2017, 第 4 作者
（17） Plasma Amino Acid Profile in Patients with Aortic Dissection, SCIENTIFIC REPORTS, 2017, 第 11 作者
（18） A Novel Bufalin Derivative Exhibited Stronger Apoptosis-Inducing Effect than Bufalin in A549 Lung Cancer Cells and Lower Acute Toxicity in Mice, PLOS ONE, 2016, 第 6 作者
（19） Knockdown of Apolipoprotein E Enhanced Sensitivity of Hep3B Cells to Cardiac Steroids via Regulating Na+/K+-ATPase Signalosome, MOLECULAR CANCER THERAPEUTICS, 2016, 第 8 作者
（20） Salvianolic acid A inhibits endothelial dysfunction and vascular remodeling in spontaneously hypertensive rats, LIFE SCIENCES, 2016, 第 14 作者
（21） Agglutinin isolated from Arisema heterophyllum Blume induces apoptosis and autophagy in A549 cells through inhibiting PI3K/Akt pathway and inducing ER stress, Agglutinin isolated from Arisema heterophyllum Blume induces apoptosis and autophagy in A549 cells through inhibiting PI3K/Akt pathway and inducing ER stress, 中国天然药物, 2016, 第 10 作者
（22） Bufalin derivative BF211 inhibits proteasome activity in human lung cancer cells in vitro by inhibiting beta 1 subunit expression and disrupting proteasome assembly, ACTA PHARMACOLOGICA SINICA, 2016, 第 8 作者
（23） Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation, NATURE COMMUNICATIONS, 2016, 第 25 作者
（24） Bufalin derivative BF211 inhibits proteasome activity in human lung cancer cells in vitro by inhibiting β1 subunit expression and disrupting proteasome assembly, bufalinderivativebf211inhibitsproteasomeactivityinhumanlungcancercellsinvitrobyinhibiting1subunitexpressionanddisruptingproteasomeassembly, ACTAPHARMACOLOGICASINICA, 2016, 第 8 作者
（25） Amelioration of salvianolic acid C on aortic structure in apolipoprotein E-deficient mice treated with angiotension II, LIFE SCIENCES, 2016, 第 11 作者
（26） Possible target-related proteins and signal network of bufalin in A549 cells suggested by both iTRAQ-based and label-free proteomic analysis, PROTEOMICS, 2016, 第 10 作者
（27） Proteomic Analysis Revealed the Important Role of Vimentin in Human Cervical Carcinoma HeLa Cells Treated With Gambogic Acid, MOLECULAR & CELLULAR PROTEOMICS, 2016, 第 7 作者
（28） Agglutinin isolated from Arisema heterophyllum Blume induces apoptosis and autophagy in A549 cells through inhibiting PI3K/Akt pathway and inducing ER stress, Agglutinin isolated from Arisema heterophyllum Blume induces apoptosis and autophagy in A549 cells through inhibiting PI3K/Akt pathway and inducing ER stress, CHINESEJOURNALOFNATURALMEDICINES, 2016, 第 10 作者
（29） Nano-LC-ESI MS/MS analysis of proteins in dried sea dragon Solenognathus hardwickii and bioinformatic analysis of its protein expression profiling, CHINESE JOURNAL OF NATURAL MEDICINES, 2016, 第 5 作者
（30） Neutral Loss Ion Mapping Experiment Combined with Precursor Mass List and Dynamic Exclusion for Screening Unstable Malonyl Glucoside Conjugates, JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 2016, 第 6 作者
（31） Proteasome Inhibition Contributed to the Cytotoxicity of Arenobufagin after Its Binding with Na, K-ATPase in Human Cervical Carcinoma HeLa Cells, PLOS ONE, 2016, 第 6 作者
（32） A reproducible analytical system based on the multi-component analysis of triterpene acids in Ganoderma lucidum, PHYTOCHEMISTRY, 2015, 第 10 作者
（33） Proteomic and bioinformatic analyses of possible targetrelated proteins of gambogic acid in human breast carcinoma MDA-MB-231 cells, Proteomic and bioinformatic analyses of possible targetrelated proteins of gambogic acid in human breast carcinoma MDA-MB-231 cells, 中国天然药物, 2015, 第 8 作者
（34） Discriminatory Components Retracing Strategy for Monitoring the Preparation Procedure of Chinese Patent Medicines by Fingerprint and Chemometric Analysis, PLOS ONE, 2015, 第 9 作者
（35） Ginsenoside Rg1 and ginsenoside Rb1 play different roles in myocardial infarction rats in combination with salvianolic acid B., J Chin Med Assoc, 2015, 第 11 作者
（36） AN EFFICIENT AND TARGET-ORIENTED SAMPLE ENRICHMENT METHOD FOR PREPARATIVE SEPARATION OF MINOR ALKALOIDS BY PH-ZONE-REFINING COUNTER-CURRENT CHROMATOGRAPHY, AN EFFICIENT AND TARGET-ORIENTED SAMPLE ENRICHMENT METHOD FOR PREPARATIVE SEPARATION OF MINOR ALKALOIDS BY PH-ZONE-REFINING COUNTER-CURRENT CHROMATOGRAPHY, 世界中医药杂志英文版, 2015, 第 9 作者
（37） The Safety Evaluation of Salvianolic Acid B and Ginsenoside Rg1 Combination on Mice, MDPI, 2015, 第 14 作者
（38） Proteomic and bioinformatic analyses of possible target-related proteins of gambogic acid in human breast carcinoma MDA-MB-231 cells, CHINESE JOURNAL OF NATURAL MEDICINES, 2015, 第 8 作者
（39） Simultaneous quantitation of five Panax notoginseng saponins by multi heart-cutting two-dimensional liquid chromatography: Method development and application to the quality control of eight Notoginseng containing Chinese patent medicines, JOURNAL OF CHROMATOGRAPHY A, 2015, 第 10 作者
（40） A green protocol for efficient discovery of novel natural compounds: Characterization of new ginsenosides from the stems and leaves of Panax ginseng as a case study, ANALYTICA CHIMICA ACTA, 2015, 第 7 作者
（41） The Safety Evaluation of Salvianolic Acid B and Ginsenoside Rg1 Combination on Mice, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2015, 第 14 作者
（42） Ultra-performance liquid chromatography of amino acids for the quality assessment of pearl powder, JOURNAL OF SEPARATION SCIENCE, 2015, 第 10 作者
（43） Ginsenoside Rg1 and Rb1, in combination with salvianolic acid B, play different roles in myocardial infarction in rats, JOURNAL OF THE CHINESE MEDICAL ASSOCIATION, 2015, 第 11 作者
（44） Inhibition on Proteasome beta 1 Subunit Might Contribute to the Anti-Cancer Effects of Fangchinoline in Human Prostate Cancer Cells, PLOS ONE, 2015, 第 8 作者
（45） UHPLC-LTQ-Orbitrap MS combined with spike-in method for plasma metabonomics analysis of acute myocardial ischemia rats and pretreatment effect of Danqi Tongmai tablet, MOLECULAR BIOSYSTEMS, 2015, 第 6 作者
（46） Combined Salvianolic Acid B and Ginsenoside Rg1 Exerts Cardioprotection against Ischemia/Reperfusion Injury in Rats, PLOS ONE, 2015, 第 11 作者
（47） An efficient and target-oriented sample enrichment method for preparative separation of minor alkaloids by pH-zone-refining counter-current chromatography, JOURNAL OF CHROMATOGRAPHY A, 2015, 第 10 作者
（48） Ambidalmines A���E and ambidimerine F: Bioactive dihydrobenzophenanthridine alkaloids from Corydalis ambigua var. amurensis, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2014, 第 3 作者
（49） A single, multi-faceted, enhanced strategy to quantify the chromatographically diverse constituents in the roots of Euphorbia kansui, JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2014, 第 0 作者
（50） Tumor penetrability and anti-angiogenesis using iRGD-mediated delivery of doxorubicin-polymer conjugates, BIOMATERIALS, 2014, 第 5 作者
（51） Ambiguanine A���G, hexahydrobenzophenanthridine alkaloids from Corydalis ambigua var. amurensis, PHYTOCHEMISTRY, 2014, 第 2 作者
（52） HPLC/qTOF-MS-oriented characteristic components data set and chemometric analysis for the holistic quality control of complex TCM preparations: Niuhuang Shangqing pill as an example, JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2014, 第 8 作者
（53） Salvianolic acid A, a matrix metalloproteinase-9 inhibitor of Salvia miltiorrhiza, attenuates aortic aneurysm formation in apolipoprotein E-deficient mice, PHYTOMEDICINE, 2014, 第 11 作者
（54） Salvianolic Acid A, a Novel Matrix Metalloproteinase-9 Inhibitor, Prevents Cardiac Remodeling in Spontaneously Hypertensive Rats, PLOS ONE, 2013, 第 11 作者
（55） Pharmacological tools for the development of traditional Chinese medicine, TRENDS IN PHARMACOLOGICAL SCIENCES, 2013, 第 3 作者
（56） A dynamic multiple reaction monitoring method for the multiple components quantification of complex traditional Chinese medicine preparations: Niuhuang Shangqing pill as an example, JOURNAL OF CHROMATOGRAPHY A, 2013, 第 7 作者
（57） An integrated exact mass spectrometric strategy for comprehensive and rapid characterization of phenolic compounds in licorice, RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 2013, 第 9 作者
（58） 鱼腥草素钠对BALB/c小鼠的急性毒性及其对细胞的损伤, 中国药理学与毒理学杂志, 2012, 第 3 作者
（59） Rapid preparative isolation of a new phenylpropanoid glycoside and four minor compounds from Sparganium stoloniferum using high-speed counter-current chromatography as a fractionation tool, JOURNAL OF SEPARATION SCIENCE, 2012, 第 9 作者
（60） Proteomic studies on protective effects of salvianolic acids, notoginsengnosides and combination of salvianolic acids and notoginsengnosides against cardiac ischemic-reperfusion injury, JOURNAL OF ETHNOPHARMACOLOGY, 2012, 第 5 作者
（61） Comparison of two officinal Chinese pharmacopoeia species of Ganoderma based on chemical research with multiple technologies and chemometrics analysis, JOURNAL OF CHROMATOGRAPHY A, 2012, 第 9 作者
（62） Study of Luan-Pao-Prescription on ovarian dysfunction in rats, JOURNAL OF ETHNOPHARMACOLOGY, 2012, 第 1 作者
（63） The protective effects of ginsenoside Rg1 against hypertension target-organ damage in spontaneously hypertensive rats, BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2012, 第 11 作者
（64） Paraptosis accompanied by autophagy and apoptosis was induced by celastrol, a natural compound with influence on proteasome, ER stress and Hsp90, JOURNAL OF CELLULAR PHYSIOLOGY, 2012, 第 6 作者
（65） Differential Proteomic Analysis of Platelets Suggested Possible Signal Cascades Network in Platelets Treated with Salvianolic Acid B, PLOS ONE, 2011, 第 8 作者
（66） Proteomic Assessment of Tanshinone II A Sodium Sulfonate on Doxorubicin Induced Nephropathy, AMERICAN JOURNAL OF CHINESE MEDICINE, 2011, 第 9 作者
（67） Cardio-Protection of Salvianolic Acid B through Inhibition of Apoptosis Network, PLOS ONE, 2011, 第 13 作者
（68） Matrix metalloproteinase-9 induces cardiac fibroblast migration, collagen and cytokine secretion: Inhibition by salvianolic acid B from Salvia miltiorrhiza, PHYTOMEDICINE, 2011, 第 11 作者
（69） Clarifying the signal network of salvianolic acid B using proteomic assay and bioinformatic analysis, PROTEOMICS, 2011, 第 8 作者
（70） Ruggedness and robustness of conversion factors in method of simultaneous determination of multi-components with single reference standard, JOURNAL OF CHROMATOGRAPHY A, 2011, 第 10 作者
（71） Tanshinone IIA Increases mRNA Expression of Efflux Transporters in Cultured Human Intestinal Cell, AMERICAN JOURNAL OF CHINESE MEDICINE, 2010, 第 9 作者
（72） Cardioprotection and Matrix Metalloproteinase-9 Regulation of Salvianolic Acids on Myocardial Infarction in Rats, PLANTA MEDICA, 2009, 第 1 作者
（73） 新生大鼠心肌细胞原代培养方法优化, 亚太传统医药, 2009, 第 4 作者
（74） Phytochemical analysis of traditional Chinese medicine using liquid chromatography coupled with mass spectrometry, JOURNAL OF CHROMATOGRAPHY A, 2009, 第 7 作者
（75） Tanshinone IIA sodium sulfonate protects against cardiotoxicity induced by doxorubicin in vitro and in vivo, FOOD AND CHEMICAL TOXICOLOGY, 2009, 第 11 作者
（76） Proteomic analysis of possible target-related proteins of cyclophosphamide in mice thymus, FOOD AND CHEMICAL TOXICOLOGY, 2009, 第 6 作者
（77） Possible target-related proteins of salvianolic acids in rat platelets, PHYTOCHEMISTRY LETTERS, 2008, 第 5 作者
（78） Interaction of Ganoderma triterpenes with doxorubicin and proteomic characterization of the possible molecular targets of Ganoderma triterpenes, CANCER SCIENCE, 2008, 第 6 作者
（79） Analysis of major chemical constituents in Luan-Pao-Prescription using liquid chromatography coupled with electrospray ionization mass spectrometry, NATURAL PRODUCT COMMUNICATIONS, 2008, 第 3 作者
（80） Salvianolic acids prevent acute doxorubicin cardiotoxicity in mice through suppression of oxidative stress, FOOD AND CHEMICAL TOXICOLOGY, 2008, 第 1 作者
（81） Proteomic analysis of differential protein expression in rat platelets treated with notoginsengnosides, PHYTOMEDICINE, 2008, 第 4 作者
（82） Structure elucidation and NMR spectral assignments of three new lignan glycosides from Akebia trifoliatia, MAGNETIC RESONANCE IN CHEMISTRY, 2008, 第 5 作者

   

（ 1 ） 纤维蛋白(原)/αMß2整合素通路在主动脉夹层疾病进程的作用机制研究, 负责人, 国家任务, 2023-01--2026-12
（ 2 ） 缺血性脑卒中的新药开发, 负责人, 中国科学院计划, 2021-10--2024-10
（ 3 ） CIGB500防治COVID-19心脏和肺脏的急、慢性并发症研究, 负责人, 国家任务, 2021-10--2024-09
（ 4 ） 抗缺血性脑卒中新药的临床前研究, 负责人, 地方任务, 2021-08--2024-07
（ 5 ） 抗心肌缺血再灌注损伤的新药研究, 负责人, 中国科学院计划, 2018-08--2021-07
（ 6 ） 靶向单核/巨噬细胞对主动脉夹层的防治作用和机理研究, 负责人, 国家任务, 2018-01--2021-12
（ 7 ） 丹参与三七防治心力衰竭的研究, 负责人, 中国科学院计划, 2016-11--2018-06
（ 8 ） miR876-3p/CyPA调控通路在主动脉夹层 疾病进程中的作用研究, 负责人, 中国科学院计划, 2016-01--2018-12
（ 9 ） 丹酚酸B/人参皂苷Rg1复方的临床前研究, 负责人, 地方任务, 2016-01--2019-09
（ 10 ） 丹酚酸B和人参皂苷Rg1组合对心肌内出血的保护作用和作用机理研究, 负责人, 国家任务, 2016-01--2019-12
（ 11 ） 丹参中抗主动脉瘤的活性单体发现与研究, 负责人, 地方任务, 2014-10--2017-09
（ 12 ） 抗心肌缺血再灌注损伤的中药复方研究, 负责人, 国家任务, 2013-01--2015-12
（ 13 ） 主动脉夹层治疗靶点的发现与丹参治疗作用的研究, 负责人, 国家任务, 2012-01--2015-12

（1）Cardioprotection of salvianolic acid B and ginsenoside Rg1 combination and the underlying mechanism,   2018-10-23
（2）Drug Discovery of Abdominal Aortic Aneurysm   2017-06-17
（3）Protective effects and mechanism of Salviae miltiorrhizae in cardiovascular disease   2015-10-21