070305-高分子化学与物理
0703J1-纳米科学与技术

纳米药物载体，生物医用高分子，自组装多肽

2007-09--2012-07   北京大学   理学博士
2003-09--2007-07   山东大学   理学学士

   

2023-03~现在, 国家纳米科学中心, 研究员
2019-03~2023-03,国家纳米科学中心, 项目研究员
2018-06~2019-06,美国布兰迪斯大学, 访问学者
2016-03~2019-03,国家纳米科学中心, 副研究员
2012-07~2016-03,国家纳米科学中心, 助理研究员
2007-09~2012-07,北京大学, 理学博士
2003-09~2007-07,山东大学, 理学学士

   

（ 1 ） 一种pH敏感的多肽聚合物及其制备方法和应用, 2020, 第 2 作者, 专利号: ZL201710137612.9

（ 2 ） 一种具有抗肿瘤活性的多肽聚合物制备方法, 2016, 第 2 作者, 专利号: ZL201410160139.2

   

（1） An Ultrasound-Induced Self-Clearance Hydrogel for Male Reversible Contraception, ACS NANO, 2022, 第 17 作者  通讯作者
（2） Intracellular Self-Immolative Polyprodrug with Near-Infrared Light Guided Accumulation and in Vivo Visualization of Drug Release, ADVANCED MATERIALS, 2022, 第 6 作者  通讯作者
（3） Hybrid Plasmonic Nanodumbbells Engineering for Multi-Intensified Second Near-Infrared Light Induced Photodynamic Therapy, ACS NANO, 2021, 第 8 作者  通讯作者
（4） Precise magnetic resonance imaging-guided sonodynamic therapy for drug-resistant bacterial deep infection, BIOMATERIALS, 2021, 第 10 作者  通讯作者
（5） Regulating Twisted Skeleton to Construct Organ-Specific Perylene for Intensive Cancer Chemotherapy, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2021, 第 8 作者  通讯作者
（6） In Vivo Self-Assembly Induced Cell Membrane Phase Separation for Improved Peptide Drug Internalization, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2021, 第 7 作者  通讯作者
（7） Near-Infrared Laser-Triggered In Situ Dimorphic Transformation of BF2-Azadipyrromethene Nanoaggregates for Enhanced Solid Tumor Penetration, ACS NANO, 2020, 第 11 作者  通讯作者
（8） Cell-Penetrating Peptides and Polymers for Improved Drug Delivery, CHEMNANOMAT, 2020, 第 3 作者  通讯作者
（9） Photothermal-Promoted Morphology Transformation in Vivo Monitored by Photoacoustic Imaging, NANO LETTERS, 2020, 第 8 作者  通讯作者
（10） Ultrasound-Activated Cascade Effect for Synergistic Orthotopic Pancreatic Cancer Therapy, ISCIENCE, 2020, 第 5 作者  通讯作者
（11） Site���Specific Construction of Long���Term Drug Depot for Suppression of Tumor Recurrence, Small, 2019, 第 7 作者  通讯作者
（12） Endogenous Reactive Oxygen Species-Triggered Morphology Transformation for Enhanced Cooperative Interaction with Mitochondria, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2019, 第 8 作者  通讯作者
（13） Autocatalytic Morphology Transformation Platform for Targeted Drug Accumulation, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2019, 第 5 作者  通讯作者
（14） Microenvironment-Induced In Situ Self-Assembly of Polymer-Peptide Conjugates That Attack Solid Tumors Deeply, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2019, 第 7 作者  通讯作者
（15） Programmable Construction of Peptide-Based Materials in Living Subjects: From Modular Design and Morphological Control to Theranostics, ADVANCED MATERIALS, 2019, 第 2 作者  通讯作者
（16） Enzyme-sensitive cytotoxic peptide-dendrimer conjugates enhance cell apoptosis and deep tumor penetration, BIOMATERIALS SCIENCE, 2018, 第 7 作者  通讯作者
（17） Near-Infrared Laser-Driven in Situ Self-Assembly as a General Strategy for Deep Tumor Therapy, NANO LETTERS, 2018, 第 5 作者  通讯作者
（18） A self-destructive nanosweeper that captures and clears amyloid beta-peptides, NATURE COMMUNICATIONS, 2018, 第 6 作者
（19） High-Performance Identification of Human Bladder Cancer Using a Signal Self-Amplifiable Photoacoustic Nanoprobe, ACS APPLIED MATERIALS & INTERFACES, 2018, 第 7 作者  通讯作者
（20） An in Situ Intracellular Self-Assembly Strategy for Quantitatively and Temporally Monitoring Autophagy, ACS NANO, 2017, 第 8 作者
（21） One-pot synthesis of pH-responsive hyperbranched polymer-peptide conjugates with enhanced stability and loading efficiency for combined cancer therapy, POLYMER CHEMISTRY, 2017, 第 5 作者  通讯作者
（22） Polymer-klak peptide conjugates induce cancer cell death through synergistic effects of mitochondria damage and autophagy blockage, BIOCONJUGATE CHEMISTRY, 2017, 第 1 作者
（23） Polymeric nanoparticles promote macrophage reversal from M2 to M1 phenotypes in the tumor microenvironment, BIOMATERIALS, 2017, 第 6 作者
（24） Reconfigurable peptide nanotherapeutics at tumor microenvironmental ph, ACS APPLIED MATERIALS & INTERFACES, 2017, 第 1 作者
（25） In situ monitoring intracellular structural change of nanovehicles through photoacoustic signals based on phenylboronate-linked rgd-dextran/purpurin 18 conjugates, BIOMACROMOLECULES, 2017, 第 7 作者  通讯作者
（26） An "on-site transformation" strategy for treatment of bacterial infection, ADVANCED MATERIALS, 2017, 第 4 作者  通讯作者
（27） Ph-sensitive polymeric nanoparticles modulate autophagic effect via lysosome impairment, SMALL, 2016, 第 6 作者
（28） A general strategy for facile synthesis and in situ screening of self-assembled polymer-peptide nanomaterials, ADVANCED MATERIALS, 2016, 第 1 作者
（29） Self-assembled ros-sensitive polymer-peptide therapeutics incorporating built-in reporters for evaluation of treatment efficacy, BIOMACROMOLECULES, 2016, 第 1 作者
（30） Synthesis of self-reporting polymeric nanoparticles for in situ monitoring of endocytic microenvironmental pH, CHEMICAL COMMUNICATIONS, 2015, 第 1 作者
（31） A pH-responsive natural cyclopeptide RA-V drug formulation for improved breast cancer therapy, JOURNAL OF MATERIALS CHEMISTRY B, 2015, 第 1 作者
（32） Self-Assembled Autophagy-Inducing Polymeric Nanoparticles for Breast Cancer Interference In-Vivo, ADVANCED MATERIALS, 2015, 第 3 作者
（33） Self-assembly of cytotoxic peptide conjugated poly(beta-amino ester)s for synergistic cancer chemotherapy, JOURNAL OF MATERIALS CHEMISTRY B, 2015, 第 1 作者
（34） One-pot Synthesis of pH-sensitive Poly(RGD-co-��-amino ester)s for Targeted Intracellular Drug Delivery, Polym. Chem., 2014, 

   

（ 1 ） 自组装多肽聚合物, 负责人, 国家任务, 2023-01--2025-12
（ 2 ） 微环境响应原位聚集诱导发光材料及其在肿瘤动态可视化中的研究, 负责人, 国家任务, 2021-12--2025-12
（ 3 ） 可形变多肽纳米材料在体原位构建抗癌药物库及其生物学效应研究, 负责人, 国家任务, 2019-01--2022-12
（ 4 ） 温敏型聚合物-多肽连接体的体内自组装行为及抗癌性能研究, 负责人, 国家任务, 2017-01--2020-12
（ 5 ） 新型功能性多肽聚合物的制备及其抗癌性能研究, 负责人, 国家任务, 2013-01--2016-12