基本信息
李乐乐  男  博导  国家纳米科学中心
电子邮件: lilele@nanoctr.cn
通信地址: 北京市海淀区中关村北一条11号南楼220
邮政编码: 100190

研究领域

本课题组主要从事精准化学测量及纳米生物技术在癌症等重大疾病的诊断与治疗领域的基础应用研究。 

研究方向  

1. 精准化学测量; 

2. 疾病精准诊疗。 

招生信息

   
招生专业
0703J1-纳米科学与技术
070301-无机化学
070302-分析化学

教育背景

2005-09--2010-07   北京大学   博士
2005-09--2010-07   内蒙古大学   学士

工作经历

   
工作简历
2012-11~2016-07,麻省理工学院/哈佛大学, 博士后
2010-09~2012-11,伊利诺伊大学厄巴纳-香槟分校, 博士后

专利与奖励

   
奖励信息
(1) 基金委“优青”, 国家级, 2018
(2) 青年**** (A类), , 国家级, 2016

出版信息

   
发表论文
(1) Nd3+-Sensitized Upconversion Metal-Organic Frameworks for Mitochondria-Targeted Amplified Photodynamic Therapy, Angew. Chem., Int. Ed., 2020, 通讯作者
(2) Time-Resolved Activation of pH Sensing and Imaging in Vivo by Remotely Controllable DNA Nanomachine, Nano Lett., 2020, 通讯作者
(3) Engineering of Upconverted Metal–Organic Frameworks for Near-Infrared Light-Triggered Combinational Photodynamic/Chemo-/Immunotherapy against Hypoxic Tumors, J. Am. Chem. Soc., 2020, 通讯作者
(4) A Photochromic Upconversion Nanoarchitecture: towards Activatable Bioimaging and Dual NIR Light-programmed Singlet Oxygen Generation, Chem. Sci., 2019, 通讯作者
(5) Functional DNA Molecules Enable Selective and Stimuli-Responsive Nanoparticles for Biomedical Applications, Acc. Chem. Res., 2019, 通讯作者
(6) Light-Activated Nanoprobes for Biosensing and Imaging, Adv. Mater., 2019, 通讯作者
(7) An Acidic-Microenvironment-Driven DNA Nanomachine Enables Specific ATP Imaging in the Extracellular Milieu of Tumor, Adv. Mater., 2019, 通讯作者
(8) A Biomimetic Coordination Nanoplatform for Controlled Encapsulation and Delivery of Drug-Gene Combinations, Angew. Chem., Int. Ed., 2019, 通讯作者
(9) Near-infrared Light-Initiated Hybridization Chain Reaction for Spatially and Temporally Resolved Signal Amplification, Angew. Chem., Int. Ed., 2019, 通讯作者
(10) Engineering Multifunctional DNA Hybrid Nanospheres through Coordination-Driven Self-Assembly, Angew. Chem., Int. Ed., 2019, 通讯作者
(11) A NIR Light-Gated DNA Nanodevice for Spatiotemporally Controlled Imaging of MicroRNA in Cells and Animals, J. Am. Chem. Soc., 2019, 通讯作者
(12) NIR-Light-Mediated Spatially Selective Triggering of Anti-Tumor Immunity via Upconversion Nanoparticle-Based Immunodevices, Nat. Commun., 2019, 通讯作者
(13) Metal-DNA Coordination-Driven Self-Assembly: A Conceptual Methodology to Expand the Repertoire of DNA Nanobiotechnology, Chem. Eur. J., 2019, 通讯作者
(14) Upconversion Luminescence-Activated DNA Nanodevice for ATP Sensing in Living Cells, J. Am. Chem. Soc., 2018, 通讯作者
(15) Imparting Designer Biorecognition Functionality to Metal–Organic Frameworks by a DNA-Mediated Surface Engineering Strategy, Small, 2018, 通讯作者
(16) Trace water mediated growth of oriented single-crystalline mesoporous metal–organic frameworks on gold nanorods, Chem. Commun., 2018, 通讯作者
(17) Heterodimers Made of Upconversion Nanoparticles and Metal-Organic Frameworks, J. Am. Chem. Soc., 2017, 通讯作者
(18) Self-assembled Gemcitabine-Gadolinium Nanoparticles for Magnetic Resonance Imaging and Cancer Therapy, Acta Biomater., 2016, 第 1 作者
(19) Core–Shell Nanostars for Multimodal Therapy and Imaging, Theranostics, 2016, 第 2 作者
(20) Regiospecific Hetero-Assembly of DNA-Functionalized Plasmonic Upconversion Superstructures, J. Am. Chem. Soc., 2015, 第 1 作者
(21) Graphene-DNAzyme Junctions: A Platform for Direct Metal Ion Detection with Ultrahigh Sensitivity, Chem. Sci., 2015, 第 2 作者
(22) Aptamer Photoregulation In Vivo, PNAS, 2014, 第 1 作者
(23) Near-Infrared-Light Mediated Ratiometric Luminescent Sensor for Multimode Visualized Assays of Explosives, Anal. Chem., 2014, 通讯作者
(24) An Exceptionally Simple Strategy for DNA-Functionalized Up-Conversion Nanoparticles as Biocompatible Agents for Nanoassembly, DNA Delivery, and Imaging, J. Am. Chem. Soc., 2013, 第 1 作者
(25) A Vitamin-responsive Mesoporous Nanocarrier with DNA Aptamer-mediated Cell Targeting, Chem. Commun., 2013, 第 1 作者
(26) Biomimetic Surface Engineering of Lanthanide-Doped Upconversion Nanoparticles as Versatile Bioprobes, Angew. Chem., Int. Ed., 2012, 第 1 作者
(27) Polyvalent Mesoporous Silica Nanoparticle-Aptamer Bioconjugates Target Breast Cancer Cells, Adv. Healthcare Mater., 2012, 第 1 作者
(28) Direct Detection of Adenosine in Undiluted Serum Using a Luminescent Aptamer Sensor Attached to a Terbium Complex, Anal. Chem., 2012, 第 1 作者
(29) Hierarchical Self-Assembly of Superlattice Hybrids Consisting of Periodic and Alternating Cores of Porphyrin Molecules Separated by Nanoscale Silica Walls, Langmuir, 2010, 第 1 作者
(30) Orientational Organization of Organic Semiconductors within Periodic Nanoscale Silica Channels: Modification of Fluorophore Photophysics through Hierarchical Self-Assembly, Chem. Eur. J., 2009, 第 1 作者
(31) Facile Synthesis of Macrocellular Mesoporous Foam-like Ce-Sn Mixed Oxide with Nanocrystalline Frameworks by Using Triblock Copolymer as Single-Template, Small, 2009, 第 1 作者
(32) Mesostructured Hybrids Containing Potential Donors and Acceptors with Molecular-scale and Meso-scale Segregation and Ordering: Toward the Development of Smart Materials through Hierarchical Self-assembly, Chem. Mater., 2009, 第 1 作者
(33) Hierarchical r-Al2O3 Monoliths with Highly Ordered 2D Hexagonal Mesopores in Macroporous Walls, Chem. Commun., 2009, 第 1 作者
(34) Hierarchical Self-assembly of pH-Responsive Nanocomposites with Molecular-scale and Mesoscale Periodicities, Chem. Mater., 2008, 第 1 作者
(35) Room Temperature Ionic Liquids Assisted Green Synthesis of Nanocrystalline Porous SnO2 and Their Gas Sensor Behaviors, Cryst. Growth Des., 2008, 第 1 作者
(36) Stabilization of Facial Isomer of Tris(8-hydroxyquinolinate) Aluminum though Confinement in Silica-Surfactant Mesostructures, Appl. Phys. Lett., 2007, 第 1 作者
(37) Optical Sensors Based on Functionalized Mesoporous Silica SBA-15 for the Detection of Multianalytes (H+, Cu2+) in Water, J. Mater. Chem., 2007, 第 1 作者

科研活动

   
科研项目
( 1 ) 基于功能核酸的系统性靶向纳米给药体系, 主持, 市地级, 2016-08--2019-08
( 2 ) 青年****, 主持, 国家级, 2016-09--2019-09
( 3 ) 化学测量学, 主持, 国家级, 2019-01--2021-12
( 4 ) 近红外光触发的靶向性上转换纳米组装体的构建及抗肿瘤效应研究, 主持, 国家级, 2018-01--2021-12