基本信息
胡立刚  男  硕导  中国科学院生态环境研究中心
电子邮件: lghu@rcees.ac.cn
通信地址: 北京市海淀区双清路18号
邮政编码:

招生信息

   
招生专业
083001-环境科学
070302-分析化学
0703J5-食品安全与健康
招生方向
分析毒理
环境健康

教育背景

2001-09--2006-07   中国科学院生态环境研究中心   博士
1993-09--1997-07   北京科技大学   学士

工作经历

   
工作简历
2015-03~现在, 中国科学院生态环境研究中心, 助理研究员、研究员
2010-01~2014-07,The University of Hong Kong, Postdoc fellow
2006-11~2009-12,Florida International University, Postdoc Research Associate
2001-09~2006-07,中国科学院生态环境研究中心, 博士
1993-09~1997-07,北京科技大学, 学士
社会兼职
2017-04-12-今,中国环境科学学会环境化学分会委员,

教授课程

分析毒理学
现代食品分析

专利与奖励

   
奖励信息
(1) 中国分析测试协会科学技术奖-CAIA奖, 特等奖, 其他, 2021
专利成果
( 1 ) 面罩型呼吸采样器及呼吸测试面罩, 2021, 第 1 作者, 专利号: CN113188853A

( 2 ) 血桥限位器, 2021, 第 1 作者, 专利号: CN113081079A

( 3 ) 污泥在土壤资源化利用中的风险检测方法, 2021, 第 1 作者, 专利号: CN112526109B

( 4 ) 呼气代谢测定系统, 2021, 第 1 作者, 专利号: CN113009125A

( 5 ) 用于模式鱼类胚胎连续培养及观测的装置和方法, 2020, 第 1 作者, 专利号: CN111849772A

( 6 ) 用于单细胞分析的电感耦合等离子体质谱进样系统, 2020, 第 1 作者, 专利号: CN211785309U

( 7 ) 金属蛋白分析系统, 2020, 第 1 作者, 专利号: CN211785305U

( 8 ) 铅结合蛋白基因、包含其的蛋白及其应用, 2020, 第 1 作者, 专利号: CN108610400B

( 9 ) 用于蛋白分离的水平柱状凝胶电泳装置, 2020, 第 4 作者, 专利号: CN106749504B

( 10 ) 用于红细胞的单个细胞标记的试剂盒及其检测方法, 2020, 第 1 作者, 专利号: CN111157433A

( 11 ) 可控释放银离子的纳米银、制备方法和抗菌剂, 2019, 第 3 作者, 专利号: CN106513704B

( 12 ) 用于蛋白分离的电泳槽及采用其的柱状凝胶电泳装置, 2019, 第 4 作者, 专利号: CN106770595B

( 13 ) 高通量微量自动进样系统, 2019, 第 1 作者, 专利号: CN208766081U

( 14 ) 用于重金属污染物吸附的负载结构及其制备方法与应用, 2019, 第 1 作者, 专利号: CN109603746A

( 15 ) 用于高通量质谱检测的多功能模块化样品前处理器件及其使用方法, 2019, 第 4 作者, 专利号: CN109613106A

( 16 ) 用于蛋白分离的洗脱装置及采用其的柱状凝胶电泳装置, 2019, 第 4 作者, 专利号: CN106770596B

( 17 ) 基质辅助激光解吸-串联飞行时间质谱仪靶板, 2018, 第 1 作者, 专利号: CN107180739B

( 18 ) 雾化室、采用其的进样系统和ICP-MS, 2018, 第 1 作者, 专利号: CN105929012B

( 19 ) 大气中持久性有机污染物主动采样套筒, 2018, 第 1 作者, 专利号: CN107843463A

( 20 ) 基质辅助激光解析‑串联飞行时间质谱仪靶板, 2017, 第 1 作者, 专利号: CN107180739A

( 21 ) 用于蛋白分离的柱状凝胶管及采用其的柱状凝胶电泳装置, 2017, 第 4 作者, 专利号: CN106769357A

( 22 ) 用于分离和检测金属蛋白和小分子化合物的系统和方法, 2016, 第 3 作者, 专利号: CN105758943A

出版信息

   
发表论文
(1) The critical role of feed spacer channel porosity in membrane biofouling: Insights and implications, JOURNAL OF MEMBRANE SCIENCE, 2022, 第 7 作者
(2) Katabatic Wind and Sea-Ice Dynamics Drive Isotopic Variations of Total Gaseous Mercury on the Antarctic Coast, ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2021, 第 10 作者
(3) Evidence of Foodborne Transmission of the Coronavirus (COVID-19) through the Animal Products Food Supply Chain, ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2021, 第 1 作者
(4) Guest Comment: Environmental Transmission and Control of COVID-19 Special Issue, ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2021, 第 5 作者
(5) Identification and interaction mechanism of protein corona on silver nanoparticles with different sizes and the cellular responses, JOURNAL OF HAZARDOUS MATERIALS, 2021, 第 6 作者
(6) 无固定相分离-电感耦合等离子体质谱法在环境中痕量金属纳米颗粒分析中的应用, Application of non-stationary phase separation hyphenated with inductively coupled plasma mass spectrometry in the analysis of trace metal-containing nanoparticles in the environment, 色谱, 2021, 第 6 作者
(7) Mercury Inputs Into Eastern China Seas Revealed by Mercury Isotope Variations in Sediment Cores, JOURNAL OF GEOPHYSICAL RESEARCH-OCEANS, 2021, 第 5 作者
(8) Interaction of mercury ion (Hg2+) with blood and cytotoxicity attenuation by serum albumin binding, JOURNAL OF HAZARDOUS MATERIALS, 2021, 第 7 作者
(9) Unified Probability Distribution and Dynamics of Lead Contents in Human Erythrocytes Revealed by Single-Cell Analysis, ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2021, 通讯作者
(10) Characterization of the mercury-binding proteins in tuna and salmon sashimi: Implications for health risk of mercury in food, CHEMOSPHERE, 2021, 通讯作者
(11) Altered immune cells in the liver and spleen of mice as a typical immune response to graphene oxide exposure, MATERIALS & DESIGN, 2021, 通讯作者
(12) A 3D-printed modularized purification system for rapid, high-throughput MALDI-MS analysis of small-volume biological samples, CHEMICAL COMMUNICATIONS, 2020, 通讯作者
(13) Tetrabromobisphenol A Perturbs Erythropoiesis and Impairs Blood Circulation in Zebrafish Embryos, ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2020, 第 6 作者
(14) Terrestrial mercury transformation in the Tibetan Plateau: New evidence from stable isotopes in upland buzzards, JOURNAL OF HAZARDOUS MATERIALS, 2020, 第 9 作者
(15) Environmetallomics: Systematically investigating metals in environmentally relevant media, TRAC-TRENDS IN ANALYTICAL CHEMISTRY, 2020, 通讯作者
(16) Revisiting the forms of trace elements in biogeochemical cycling: Analytical needs and challenges, TRAC-TRENDS IN ANALYTICAL CHEMISTRY, 2020, 通讯作者
(17) 3D打印便携式凝胶电泳装置用于蛋白质的快速检测, 3D printed portable gel electrophoresis device for rapid detection of proteins, 色谱, 2020, 第 7 作者
(18) Identification and characterization of Gd-binding proteins in NIH-3T3 cells, TALANTA, 2020, 第 3 作者
(19) 3D Printing Challenges in Enabling Rapid Response to Public Health Emergencies, 3D Printing Challenges in Enabling Rapid Response to Public Health Emergencies, 创新(英文), 2020, 第 6 作者
(20) High-Throughput Single Cell Analysis Reveals the Heterogeneity of QDots-Induced Response in Macrophages, ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS, 2020, 第 2 作者
(21) Determination and characterization of metal nanoparticles in clams and oysters, ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2020, 通讯作者
(22) Property-Activity Relationship of Black Phosphorus at the Nano-Bio Interface: From Molecules to Organisms, CHEMICAL REVIEWS, 2020, 第 6 作者
(23) New evidence for atmospheric mercury transformations in the marine boundary layer from stable mercury isotopes, ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 第 9 作者
(24) Perturbation of Normal Algal Growth by Black Phosphorus Nanosheets: The Role of Degradation, ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS, 2020, 第11作者
(25) Cadmium-binding proteins in human blood plasma, ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2020, 通讯作者
(26) Mercury isotope variations within the marine food web of Chinese Bohai Sea: Implications for mercury sources and biogeochemical cycling, JOURNAL OF HAZARDOUS MATERIALS, 2020, 第 6 作者
(27) 3D printed portable gel electrophoresis device for rapid detection of proteins, CHINESE JOURNAL OF CHROMATOGRAPHY, 2020, 通讯作者
(28) PM2.5 induces vascular permeability increase through activating MAPK/ERK signaling pathway and ROS generation, JOURNAL OF HAZARDOUS MATERIALS, 2020, 第 7 作者
(29) Occurrence of Mercurous Hg(I) Species in Environmental Solid Matrices as Probed by Mild 2-Mercaptoethanol Extraction and HPLC-ICP-MS Analysis, ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS, 2020, 第 7 作者
(30) 典型人冠状病毒的环境行为及传播方式, Environmental behavior and transmission of representative human coronaviruses, 环境化学, 2020, 第 5 作者
(31) An Imperative Need for Research on the Role of EnvironmentalFactors in Transmission of Novel Coronavirus (COVID-19), ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2020, 第 3 作者
(32) Environmental impacts on the transmission and evolution of COVID-19 combing the knowledge of pathogenic respiratory coronaviruses, ENVIRONMENTAL POLLUTION, 2020, 第 5 作者
(33) 新型冠状病毒2019-nCoV的一些初步认识, Preliminary understanding of the novel coronavirus 2019-nCoV, 环境化学, 2020, 第 7 作者
(34) Tracking Mercury in Individual Tetrahymena Using a Capillary Single-Cell Inductively Coupled Plasma Mass Spectrometry Online System, ANALYTICAL CHEMISTRY, 2020, 通讯作者
(35) Monitoring AuNP Dynamics in the Blood of a Single Mouse Using Single Particle Inductively Coupled Plasma Mass Spectrometry with an Ultralow-Volume High-Efficiency Introduction System, ANALYTICAL CHEMISTRY, 2020, 通讯作者
(36) Heterogenous Internalization of Nanoparticles at Ultra-Trace Concentration in Environmental Individual Unicellular Organisms Unveiled by Single-Cell Mass Cytometry, ACS NANO, 2020, 第 13 作者
(37) Bacterial resistance to lead: Chemical basis and environmental relevance, JOURNAL OF ENVIRONMENTAL SCIENCES, 2019, 第 6 作者
(38) Analysis of silver-associated proteins in pathogen via combination of native SDS-PAGE, fluorescent staining, and inductively coupled plasma mass spectrometry, JOURNAL OF CHROMATOGRAPHY A, 2019, 通讯作者
(39) Effect of air pollution control devices on mercury isotopic fractionation in coal-fired power plants, CHEMICAL GEOLOGY, 2019, 第 7 作者
(40) 3D printed gel electrophoresis device coupling with ICP-MS for online separation and detection of metalloproteins, TALANTA, 2019, 通讯作者
(41) A unique Pb-binding flagellin as an effective remediation tool for Pb contamination in aquatic environment, JOURNAL OF HAZARDOUS MATERIALS, 2019, 通讯作者
(42) An Integrated Model for Input and Migration of Mercury in Chinese Coastal Sediments, ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2019, 第 6 作者
(43) Association of maternal serum copper during early pregnancy with the risk of spontaneous preterm birth: A nested case-control study in China, ENVIRONMENT INTERNATIONAL, 2019, 第 9 作者
(44) Uptake and Transformation of Silver Nanoparticles and Ions by Rice Plants Revealed by Dual Stable Isotope Tracing, ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2019, 第 3 作者
(45) Deciphering molecular mechanism of silver by integrated omic approaches enables enhancing its antimicrobial efficacy in E . coli, PLoS Biology, 2019, 第 9 作者
(46) Role of protein corona in the biological effect of nanomaterials: Investigating methods, Trends in Analytical Chemistry, 2019, 第 9 作者
(47) Per- and polyfluoroalkyl substances display structure-dependent inhibition towards UDP-glucuronosyltransferases, ENVIRONMENTAL POLLUTION, 2019, 第 6 作者
(48) 3D printing of small device for analytical and environmental applications, ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2019, 第 1 作者
(49) 七株硫酸盐还原菌汞甲基化能力的比较, Methylation of mercury in seven sulfate-reducing bacteria, 环境化学, 2019, 第 8 作者
(50) Role of protein corona in the biological effect of nanomaterials: Investigating methods, TRAC-TRENDS IN ANALYTICAL CHEMISTRY, 2019, 第 9 作者
(51) A case report of conjoined twins in medaka fish, MOLECULAR REPRODUCTION AND DEVELOPMENT, 2019, 通讯作者
(52) Scattered Light Imaging Enables Real-Time Monitoring of Label-Free Nanoparticles and Fluorescent Biomolecules in Live Cells, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2019, 第 5 作者
(53) Two-dimensional (weak anion exchange chromatography-gel electrophoresis) separations coupling to inductively coupled plasma mass spectrometry strategy for analysis of metalloproteins, TALANTA, 2018, 通讯作者
(54) Characterization of mercury-binding proteins in human neuroblastoma SK-N-SH cells with immobilized metal affinity chromatography, TALANTA, 2018, 通讯作者
(55) Headspace Solid-Phase Microextraction Coupled to Miniaturized Microplasma Optical Emission Spectrometry for Detection of Mercury and Lead, ANALYTICAL CHEMISTRY, 2018, 第 2 作者
(56) Mutual detoxification of mercury and selenium in unicellular Tetrahymena, JOURNAL OF ENVIRONMENTAL SCIENCES, 2018, 第 6 作者
(57) Insight into the endocrine disrupting effect and cell response to butyltin compounds in H295R cell: Evaluated with proteomics and bioinformatics analysis, SCIENCE OF THE TOTAL ENVIRONMENT, 2018, 通讯作者
(58) Antibacterial mechanism of silver nanoparticles in pseudomonas aeruginosa: proteomics approach, METALLOMICS, 2018, 通讯作者
(59) Determination of particulate AgNPs in rat brain and liver, ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2018, 第 4 作者
(60) Characterization of mercury-binding proteins in rat blood plasma, CHEMICAL COMMUNICATIONS, 2018, 通讯作者
(61) Methylmercury exposure alters RNA splicing in human neuroblastoma SK-N-SH cells: Implications from proteomic and post-transcriptional responses, Environmental Pollution, 2018, 第 8 作者
(62) Tracing aquatic bioavailable Hg in three different regions of China using fish Hg isotopes, ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2018, 第 8 作者
(63) Speciation and bioaccessibility of arsenic in traditional Chinese medicines and assessment of its potential health risk, SCIENCE OF THE TOTAL ENVIRONMENT, 2018, 第 6 作者
(64) 3d printing of graphene-doped target for "matrix-free'' laser desorption/ionization mass spectrometry, CHEMICAL COMMUNICATIONS, 2018, 通讯作者
(65) Organotin exposure stimulates steroidogenesis in H295R Cell via cAMP pathway, ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2018, 第 7 作者
(66) Methylmercury exposure alters rna splicing in human neuroblastoma sk-n-sh cells: implications from proteomic and post-transcriptional, ENVIRONMENTAL POLLUTION, 2018, 通讯作者
(67) Identification of emerging brominated chemicals as the transformation products of tetrabromobisphenol a (tbbpa) derivatives in soil, ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2017, 第 4 作者
(68) Tetrabromobisphenol a (tbbpa) exhibits specific antimicrobial activity against gram-positive bacteria without detectable resistance, CHEMICAL COMMUNICATIONS, 2017, 第 6 作者
(69) Isotope tracers to study the environmental fate and bioaccumulation of metal-containing engineered nanoparticles: techniques and applications, CHEMICAL REVIEWS, 2017, 第 3 作者
(70) 3d printing techniques in environmental science and engineering will bring new innovation, ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2017, 第 1 作者
(71) Surface ligand controls silver ion release of nanosilver and its antibacterial activity against Escherichia coli, INTERNATIONAL JOURNAL OF NANOMEDICINE, 2017, 
(72) Determining the Cytotoxicity of Rare Earth Element Nanoparticles in Macrophages and the Involvement of Membrane Damage., ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2017, 第 6 作者
(73) Structure-dependent hematological effects of per- and. polyfluoroalkyl substances on activation of plasma kallikrein-kinin system cascade, ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2017, 通讯作者
(74) Analytical methods, formation, and dissolution of cinnabar and its impact on environmental cycle of mercury, CRITICAL REVIEWS IN ENVIRONMENTAL SCIENCE AND TECHNOLOGY, 2017, 通讯作者
(75) Improved Biocompatibility of Black Phosphorus Nanosheets by Chemical Modification., ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2017, 第 7 作者
(76) Integrative approach for the analysis of the proteome-wide response to bismuth drugs in helicobacter pylori, CHEMICAL SCIENCE, 2017, 第 2 作者
(77) 高效液相色谱-电喷雾-串联质谱研究四溴双酚A双(2-羟乙基醚)诱导大鼠嗜铬细胞瘤细胞呼吸链氧化磷酸化和能量代谢紊乱, Tetrabromobisphenol A bis (2-hydroxyethyl ether) induced dysfunction of the respiratory chain oxidative phosphorylation and energy metabolism in rat pheochromocytoma cells by high performance liquid chromatography-electrospray ionization-tandem mass spect, 色谱, 2017, 第 2 作者
(78) Distinct toxicological characteristics and mechanisms of Hg2+ and MeHg in Tetrahymena under low concentration exposure, AQUATIC TOXICOLOGY, 2017, 第 5 作者
(79) Integration of fluorescence imaging with proteomics enables visualization and identification of metallo-proteomes in living cells, METALLOMICS, 2017, 第 3 作者
(80) Occurrence and speciation of polymeric chromium(III), monomeric chromium(III) and chromium(VI) in environmental samples, CHEMOSPHERE, 2016, 通讯作者
(81) Superoxide-Mediated Extracellular Biosynthesis of Silver Nanoparticles by the Fungus Fusarium oxysporum, ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS, 2016, 第 3 作者
(82) Exposure, tissue biodistribution, and biotransformation of nanosilver, NANOIMPACT, 2016, 第 2 作者
(83) Silver nanoparticles induced neurotoxicity through oxidative stress in rat cerebral astrocytes is distinct from the effects of silver ions, NEUROTOXICOLOGY, 2016, 第 6 作者
(84) SK-N-SH细胞内汞结合蛋白和汞调控蛋白的研究, 中国化学会第十一届全国生物医药色谱及相关技术学术交流会(大会特邀报告及墙报)论文摘要集, 2016, 第 2 作者
(85) The potential neurotoxicity of emerging tetrabromobisphenol A derivatives based on rat pheochromocytoma cells, CHEMOSPHERE, 2016, 第 4 作者
(86) Sulfidation as a Natural Antidote to Metallic Nanoparticles Is Overestimated: CuO Sulfidation Yields CuS Nanoparticles with Increased Toxicity in Medaka (Oryzias latipes) Embryos, ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2015, 第 2 作者
(87) Bio-coordination of bismuth in Helicobacter pylori revealed by immobilized metal affinity chromatography, CHEMICAL COMMUNICATIONS, 2015, 第 5 作者
(88) On-line coupling of continuous-flow gel electrophoresis with inductively coupled plasma-mass spectrometry to quantitatively evaluate intracellular metal binding properties of metallochaperones HpHypA and HpHspA in E. coli cells, METALLOMICS, 2015, 第 2 作者
(89) Rapid labeling of intracellular His-tagged proteins in living cells, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 第 3 作者
(90) Fluorescence-based techniques for the investigation of localization and functions of proteins, PROTEIN SCIENCE, 2015, 第 3 作者
(91) Silver nanoparticle exposure induces rat motor dysfunction through decrease in expression of calcium channel protein in cerebellum, TOXICOLOGY LETTERS, 2015, 第 7 作者
(92) Matching metals to proteins by a metallomic approach, JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, 2014, 第 2 作者
(93) Metallomics in environmental and health related research:Current status and perspectives, CHINESE SCIENCE BULLETIN, 2013, 通讯作者
(94) Identification of Metal-Associated Proteins in Cells by Using Continuous-Flow Gel Electrophoresis and Inductively Coupled Plasma Mass Spectrometry, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2013, 第 1 作者
(95) Arsenic toxicity in the human nerve cell line SK-N-SH in the presence of chromium and copper, CHEMOSPHERE, 2013, 第 1 作者
(96) 砷的生物地球化学, Biogeochemistry of Arsenic, 化学进展, 2009, 第 1 作者
(97) MALDI-TOF-MS 在化学污染物生化活性研究中的应用, 2006, 第 1 作者
(98) MALDI-TOF-MS在化学污染生物活性研究中的应用, 2005, 第 1 作者
(99) 毛细管气相色谱与原子吸收联用测定水貂皮及其毛发中的有机汞, 分析化学, 1998, 第 2 作者

科研活动

   
科研项目
( 1 ) 复合纳米材料和高分辨质谱一体化结合的新型污染物复杂环境样品分析方法研究, 参与, 国家任务, 2016-01--2016-12
( 2 ) 金属-黑碳颗粒物复合污染的界面自由基化学过程及其健康效应, 参与, 国家任务, 2016-01--2018-12
( 3 ) 3D打印技术研制ICP-MS单细胞测定技术接口, 负责人, 国家任务, 2017-01--2020-12
( 4 ) 大气金属细颗粒物动物体内赋存研究方法及分布特征, 负责人, 国家任务, 2018-01--2021-12
( 5 ) 生命过程中外源污染物的暴露途径和归趋, 参与, 国家任务, 2022-01--2026-12