基本信息
郁峰  男  博导  中国科学院上海应用物理研究所
email: yufeng@sinap.ac.cn
address: 上海市浦东新区张衡路239号
postalCode:

招生信息

   
招生专业
070301-无机化学
招生方向
结构生物学,蛋白质晶体学,同步辐射实验方法及应用

教育背景

2005-09--2009-06   中国科学院上海应用物理研究所   博士
2000-09--2004-06   南京师范大学   学士

工作经历

   
工作简历
2021-01~现在, 中国科学院上海高等研究院, 研究员
2018-10~2020-12,中国科学院上海高等研究院, 副研究员
2009-07~2018-10,中国科学院上海应用物理研究所, 副研究员
2005-09~2009-06,中国科学院上海应用物理研究所, 博士
2000-09~2004-06,南京师范大学, 学士

专利与奖励

   
专利成果
( 1 ) 一种原位结晶装置及方法, 2022, 第 4 作者, 专利号: CN113912668A

( 2 ) 一种用于自动上样机械手测试的杜瓦结构, 2020, 第 3 作者, 专利号: CN111103314A

( 3 ) 膜蛋白自动化脂立方相结晶系统, 2016, 第 4 作者, 专利号: CN205368542U

出版信息

   
发表论文
(1) Finback: a web-based data collection system at SSRF biological macromolecular crystallography beamlines, Journal of Synchrotron Radiation, 2024, 第 11 作者
(2) The crystal structures of Sau3AI with and without bound DNA suggest a self-activation-based DNA cleavage mechanism, STRUCTURE, 2023, 第 11 作者
(3) BL02U1: the relocated macromolecular crystallography beamline at the Shanghai Synchrotron Radiation Facility, NUCLEAR SCIENCE AND TECHNIQUES, 2023, 第 11 作者
(4) Complex Crystal Structure Determination of Hsp90(N)-NVP-AUY922 and In Vitro Anti-NSCLC Activity of NVP-AUY922, FRONTIERS IN ONCOLOGY, 2022, 第 11 作者
(5) Structural Study of the Complex of cblC Methylmalonic Aciduria and Homocystinuria-Related Protein MMACHC with Cyanocobalamin, CRYSTALS, 2022, 第 9 作者
(6) 生物大分子晶体学在药物发现中的应用, Application of Macromolecular X-ray Crystallography in Drug Discovery, 药物生物技术, 2021, 第 3 作者
(7) Deploying the Big Data Science Center at the Shanghai Synchrotron Radiation Facility: the first superfacility platform in China, MACHINE LEARNING-SCIENCE AND TECHNOLOGY, 2021, 第 2 作者
(8) Structure and Function of Piezophilic Hyperthermophilic Pyrococcus yayanosii pApase, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 第 11 作者
(9) Protein Crystal Instance Segmentation Based on Mask R-CNN, CRYSTALS, 2021, 第 4 作者
(10) Complex crystal structure determination and anti-non-small-cell lung cancer activity of the Hsp90(N) inhibitor Debio0932, ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 2021, 第 2 作者
(11) Anti-NSCLC activity in vitro of Hsp90N inhibitor KW-2478 and complex crystal structure determination of Hsp90N-KW-2478, JOURNAL OF STRUCTURAL BIOLOGY, 2021, 第 11 作者
(12) Binding and molecular basis of the bat coronavirus RaTG13 virus to ACE2 in humans and other species, CELL, 2021, 第 4 作者
(13) Crystal structure details of Vibrio fischeri DarR and mutant DarR-M202I from LTTR family reveals their activation mechanism, INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2021, 第 11 作者
(14) Microplates for Crystal Growth and in situ Data Collection at a Synchrotron Beamline, CRYSTALS, 2020, 第 7 作者
(15) Both Boceprevir and GC376 efficaciously inhibit SARS-CoV-2 by targeting its main protease, NATURE COMMUNICATIONS, 2020, 第 4 作者
(16) Crystal structures of phage NrS-1 N300-dNTPs-Mg2+ complex provide molecular mechanisms for substrate specificity, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2019, 第 11 作者
(17) Crystal structure and biochemical studies of the bifunctional DNA primase-polymerase from phage NrS-1, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2019, 第 11 作者
(18) Aquarium: an automatic data-processing and experiment information management system for biological macromolecular crystallography beamlines, JOURNAL OF APPLIED CRYSTALLOGRAPHY, 2019, 第 11 作者
(19) Phytophthora sojae Effector PsAvh240 Inhibits Host Aspartic Protease Secretion to Promote Infection, MOLECULAR PLANT, 2019, 第 0 作者
(20) Phytophthora sojae Effector PsAvh240 Inhibits Host Aspartic Protease Secretion to Promote Infection, Phytophthora sojae Effector PsAvh 240 Inhibits Host Aspartic Protease Secretion to Promote Infection, 分子植物:英文版, 2019, 第 0 作者
(21) Crystal structure of the Vibrio cholerae VqmA-ligand-DNA complex provides insight into ligand-binding mechanisms relevant for drug design, JOURNAL OF BIOLOGICAL CHEMISTRY, 2019, 第 11 作者
(22) An integrated remote data collection system for macromolecular crystallography beamline at SSRF, NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT, 2019, 第 5 作者
(23) Large conformation shifts of Vibrio cholerae VqmA dimer in the absence of target DNA provide insight into DNA-binding mechanisms of LuxR-type receptors, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2019, 第 11 作者
(24) Upgrade of macromolecular crystallography beamline BL17U1 at SSRF, NUCLEAR SCIENCE AND TECHNIQUES, 2018, 第 12 作者
(25) New design for multi-crystal data collection at SSRF, New design for multi-crystal data collection at SSRF, 核技术(英文版), 2018, 第 7 作者
(26) New design for multi-crystal data collection at SSRF, NUCLEARSCIENCEANDTECHNIQUES, 2018, 第 7 作者
(27) Identification of a nanobody specific to human pulmonary surfactant protein A, SCIENTIFIC REPORTS, 2017, 第 6 作者
(28) Structural and mechanistic insights into the biosynthesis of CDP-archaeol in membranes, CELL RESEARCH, 2017, 第 5 作者
(29) The crystal structure of Pyrococcus furiosus RecJ implicates it as an ancestor of eukaryotic Cdc45, NUCLEIC ACIDS RESEARCH, 2017, 第 3 作者
(30) Mini-beam modes on standard MX beamline BL17U at SSRF, REVIEW OF SCIENTIFIC INSTRUMENTS, 2017, 第 2 作者
(31) Structural and mechanistic insights into the biosynthesis of CDP-archaeol in membranes, Structural and mechanistic insights into the biosynthesis of CDP-archaeol in membranes, CELL RESEARCH, 2017, 第 5 作者
(32) Crystal structure and enantioselectivity of terpene cyclization in SAM-dependent methyltransferase TleD, BIOCHEMICAL JOURNAL, 2016, 第 11 作者
(33) Functional Partition of Cpn60�� and Cpn60�� Subunits in Substrate Recognition and Cooperation with Co-chaperonins, MOLECULAR PLANT, 2016, 第 3 作者
(34) Structural insight into the cooperation of chloroplast chaperonin subunits, BMC BIOLOGY, 2016, 第 3 作者
(35) Automatic crystal centring procedure at the SSRF macromolecular crystallography beamline., JOURNAL OF SYNCHROTRON RADIATION, 2016, 第 6 作者
(36) Functional Partition of Cpn60 alpha and Cpn60 beta Subunits in Substrate Recognition and Cooperation with Co-chaperonins, MOLECULAR PLANT, 2016, 第 3 作者
(37) The macromolecular crystallography beamline of SSRF, NUCLEAR SCIENCE AND TECHNIQUES, 2015, 第 2 作者
(38) A novel nanobody specific for respiratory surfactant protein A has potential for lung targeting, INTERNATIONAL JOURNAL OF NANOMEDICINE, 2015, 第 4 作者
(39) 火球菌 8-氧鸟嘌呤 DNA 糖苷酶基因克隆、表达纯化和酶学性质研究, 微生物学通报, 2014, 第 7 作者
(40) Using Xe as a heavy atom for phase determination of protein trichosanthin structure, NUCLEAR SCIENCE AND TECHNIQUES, 2014, 第 3 作者
(41) Recognition of Outer Membrane Proteins Using Adaptive Neuro-Fuzzy Inference Systems, 2014 11TH INTERNATIONAL CONFERENCE ON FUZZY SYSTEMS AND KNOWLEDGE DISCOVERY (FSKD), 2014, 第 5 作者
(42) 火球菌RecJ蛋白的表达纯化及结晶, 核技术, 2013, 第 6 作者
(43) Analysis of the selectivity filter of the voltage-gated sodium channel Na_vRh, CELL RESEARCH, 2013, 第 9 作者
(44) Structural Insights into the Mechanism for Recognizing Substrate of the Cytochrome P450 Enzyme TxtE, PLOS ONE, 2013, 第 11 作者
(45) Structural basis for the modular recognition of single-stranded RNA by PPR proteins, NATURE, 2013, 第 6 作者
(46) The crystal structure of human GDP-L-fucose synthase, ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2013, 第 5 作者
(47) Structure insights into mechanisms of ATP hydrolysis and the activation of human heat-shock protein 90, Structure insights into mechanisms of ATP hydrolysis and the activation of human heat-shock protein 90, 生物化学与生物物理学报:英文版, 2012, 第 4 作者
(48) Structure insights into mechanisms of ATP hydrolysis and the activation of human heat-shock protein 90, ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2012, 第 4 作者
(49) Crystal Structures of N-terminal Domain of Human Hsp90 With ATP Analogues Reveal The Functional Regulation of Hsp90, PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2012, 第 4 作者
(50) 热休克蛋白90的N端与ATP类似物的晶体结构揭示其功能调控, Crystal Structures of N-terminal Domain of Human Hsp90 With ATP Analogues Reveal The Functional Regulation of Hsp90���, 生物化学与生物物理进展, 2012, 第 4 作者
(51) Structural biology investigation of EMF effect on insulin in solution, Structural biology investigation of EMF effect on insulin in solution, 核技术:英文版, 2011, 第 8 作者
(52) Structural biology investigation of EMF effect on insulin in solution, NUCLEAR SCIENCE AND TECHNIQUES, 2011, 第 8 作者
(53) The sandwich method for protein crystallization and its effect on crystal growth, ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2010, 第 4 作者
(54) Cytotoxicity and wound healing properties of PVA/ws-chitosan/glycerol hydrogels made by irradiation followed by freeze-thawing, RADIATION PHYSICS AND CHEMISTRY, 2010, 第 5 作者
(55) Epitaxial Growth of Trichosanthin Protein Crystals on Mica Surface, CRYSTAL GROWTH & DESIGN, 2010, 第 3 作者
(56) Determining the DUF55-domain structure of human thymocyte nuclear protein 1 from crystals partially twinned by tetartohedry., ACTA CRYSTALLOGRAPHICA. SECTION D, BIOLOGICAL CRYSTALLOGRAPHY, 2009, 第 1 作者
(57) Crystal structure and function of C-terminal Sau3AI domain, BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 2009, 第 2 作者
(58) Determining the DUF55-domain structure of human thymocyte nuclear protein 1 from crystals partially twinned by tetartohedry, ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 2009, 第 1 作者
(59) 多波长反常散射法解析Sau3AI蛋白C端结构域晶体结构, Structural determination of C-terminal domain of Sau3AI protein by multi-wavelength anomalous dispersion method, 核技术, 2008, 第 2 作者
(60) Equations for determining tetartohedral twin fractions, ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 2008, 第 2 作者
(61) Investigation of PVA/ws-chitosan hydrogels prepared by combined gamma-irradiation and freeze-thawing, CARBOHYDRATE POLYMERS, 2008, 第 4 作者
(62) Phytophthora sojae effector PsAvh240 inhibits a host aspartic protease secretion to promote infection, MOLECULAR PLANT, 第 0 作者

科研活动

   
科研项目
( 1 ) 临床严重耐药致病菌通用疫苗研发, 负责人, 国家任务, 2021-12--2024-11