083001-环境科学

DNA损伤机制

2004-09--2010-07   美国纽约大学   博士
2000-09--2004-06   北京大学   学士

   

2022-01~现在, 中国科学院生态环境研究中心, 副研究员
2011-01~2022-01,中国科学院生态环境研究中心, 助理研究员
2004-09~2010-07,美国纽约大学, 博士
2000-09~2004-06,北京大学, 学士

自由基化学生物学

   

（1） Genome-wide direct quantification of in vivo mutagenesis using high-accuracy paired-end and complementary consensus sequencing, NUCLEIC ACIDS RESEARCH, 2023, 第 4 作者
（2） Mechanism Investigation on DNA Damage Induced by Carcinogenic Haloquinoid Disinfection Byproducts, PROGRESS IN CHEMISTRY, 2022, 第 5 作者  通讯作者
（3） Potent oxidation of DNA by Ru(ii) tri(polypyridyl) complexes under visible light irradiation via a singlet oxygen-mediated mechanism, INORGANIC CHEMISTRY FRONTIERS, 2021, 第 1 作者
（4） The cell-impermeable Ru(II) polypyridyl complex as a potent intracellular photosensitizer under visible light irradiation via ion-pairing with suitable lipophilic counter-anions, FREE RADICAL BIOLOGY AND MEDICINE, 2021, 第 3 作者  通讯作者
（5） Structure-Activity Relationship Investigation on Reaction Mechanism between Chlorinated Quinoid Carcinogens and Clinically-Used Aldoxime Nerve-Agent Antidote under Physiological Condition, CHEMICAL RESEARCH IN TOXICOLOGY, 2021, 第 11 作者
（6） Caffeic Acid Phenyl Ester (CAPE) Protects against Iron-Mediated Cellular DNA Damage through Its Strong Iron-Binding Ability and High Lipophilicity, ANTIOXIDANTS, 2021, 第 5 作者
（7） The critical role of superoxide anion radicals on delaying tetrachlorohydroquinone autooxidation by penicillamine, FREE RADICAL BIOLOGY AND MEDICINE, 2021, 第 8 作者
（8） Mechanistic Study on Oxidative DNA Damage and Modifications by Haloquinoid Carcinogenic Intermediates and Disinfection Byproducts, CHEMICAL RESEARCH IN TOXICOLOGY, 2021, 第 5 作者  通讯作者
（9） First Direct and Unequivocal Electron Spin Resonance Spin-Trapping Evidence for pH-Dependent Production of Hydroxyl Radicals from Sulfate Radicals, ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2020, 第 5 作者
（10） Potent Oxidation of DNA by Haloquinoid Disinfection Byproducts to the More Mutagenic Imidazolone dIz via an Unprecedented Haloquinone-Enoxy Radical-Mediated Mechanism, Environmental Science & Technology, 2020, 第 1 作者
（11） Diethyldithiocarbamate-copper nanocomplex reinforces disulfiram chemotherapeutic efficacy through light-triggered nuclear targeting, THERANOSTICS, 2020, 第 3 作者
（12） An unexpected antioxidant and redox activity for the classic copper-chelating drug penicillamine, FREE RADICAL BIOLOGY AND MEDICINE, 2020, 第 3 作者
（13） Unprecedented strong intrinsic chemiluminescence generation from degradation of halogenated hydroxy-quinoid pollutants by Co(II)-mediated advanced oxidation processes: The critical role of site-specific production of hydroxyl radicals, CHEMICAL ENGINEERING JOURNAL, 2020, 第 7 作者
（14） Potent Oxidation of DNA by Haloquinoid Disinfection Byproducts to the More Mutagenic Imidazolone dlz via an Unprecedented Haloquinone-Enoxy Radical-Mediated Mechanism, ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2020, 第 1 作者
（15） An unexpected new pathway for nitroxide radical production via more reactve nitrogen-centered amidyl radical intermediate during detoxification of the carcinogenic halogenated quinones by N-alkyl hydroxamic acids (vol 146, pg 150, 2020), FREE RADICAL BIOLOGY AND MEDICINE, 2020, 第 6 作者
（16） Unexpected activation of N-alkyl hydroxamic acids to produce reactive N-centered free radicals and DNA damage by carcinogenic chlorinated quinones under normal physiological conditions, FREE RADICAL BIOLOGY AND MEDICINE, 2020, 第 9 作者
（17） Mechanism of synergistic DNA damage induced by caffeic acid phenethyl ester (CAPE) and Cu(II): Competitive binding between CAPE and DNA with Cu(II)/Cu(I), FREE RADICAL BIOLOGY AND MEDICINE, 2020, 第 3 作者
（18） An unusual double radical homolysis mechanism for the unexpected activation of the aldoxime nerve-agent antidotes by polyhalogenated quinoid carcinogens under normal physiological conditions, FREE RADICAL BIOLOGY AND MEDICINE, 2019, 第 2 作者
（19） Mechanism of unprecedented hydroxyl radical production and site-specific oxidative DNA damage by photoactivation of the classic arylhydroxamic acid carcinogens, CARCINOGENESIS, 2019, 第 6 作者
（20） Targeted live-cell nuclear delivery of the DNA ���light-switching��� Ru(II) complex via ion-pairing with chlorophenolate counter-anions: the critical role of binding stability and lipophilicity of the ion-pairing complexes, NUCLEICACIDSRESEARCH, 2019, 第 5 作者
（21） Investigation of the mechanism of cellular uptake, distribution and toxicity of the dna 'light-switch' ru(ii) polypyridyl complexes, PROGRESS IN CHEMISTRY, 2018, 第 6 作者
（22） Intrinsic chemiluminescence production from the degradation of haloaromatic pollutants during environmentally-friendly advanced oxidation processes: Mechanism, structure-activity relationship and potential applications, Intrinsic chemiluminescence production from the degradation of haloaromatic pollutants during environmentally-friendly advanced oxidation processes: Mechanism, structure-activity relationship and potential applications, 环境科学学报：英文版, 2017, 第 5 作者
（23） The Unexpected and Exceptionally Facile Chemical Modification of the Phenolic Hydroxyl Group of Tyrosine by Polyhalogenated Quinones under Physiological Conditions, CHEMICAL RESEARCH IN TOXICOLOGY, 2016, 第 4 作者
（24） An Exceptionally Facile Two-Step Structural Isomerization and Detoxication via a Water-Assisted Double Lossen Rearrangement, SCIENTIFIC REPORTS, 2016, 第 5 作者
（25） 一种新型以碳为中心的醌酮自由基的检测和鉴定, 科学通报, 2013, 第 7 作者
（26） Potent methyl oxidation of 5-methyl-2���-deoxycytidine by halogenated quinoid carcinogens and hydrogen peroxide via a metal-independent mechanism, FREE RADICAL BIOLOGY AND MEDICINE, 2013, 第 1 作者
（27） Molecular mechanism of metal-independent decomposition of lipid hydroperoxide 13-HPODE by halogenated quinoid carcinogens, FREE RADICAL BIOLOGY AND MEDICINE, 2013, 第 6 作者
（28） 不依赖于过渡金属离子的卤代醌介导的新型有机类Fenton反应机理, A Novel Mechanism for Halogenated Quinone- Mediated and Metal-Independent Organic Fenton-Like Reaction, 生物物理学报, 2012, 第 4 作者

   

（ 1 ） 马兜铃酸导致基因毒性的新型自由基机理研究, 参与, 国家任务, 2024-01--2028-12
（ 2 ） 致癌性卤代醌和脂质氢过氧化物诱导产生DNA氧化损伤的自由基机理研究, 负责人, 国家任务, 2020-01--2023-12
（ 3 ） 新型马兜铃酸DNA加合物的形成及致肝癌发生机理研究, 参与, 中国科学院计划, 2019-09--2024-08
（ 4 ） 新型手性多环芳胺-DNA加合物的自由基形成机理和生物学效应, 参与, 国家任务, 2019-01--2023-12
（ 5 ） 致癌性卤代醌和过氧化氢诱导DNA氧化损伤的机理研究, 负责人, 国家任务, 2013-01--2015-12

（1）携手E&H共同促进“环境与健康”学科发展   第三届东北地区环境生态学者论坛    2023-11-26
（2）手性“光开关”钌多吡啶络合物通过闪光猝灭 方法诱导DNA氧化损伤的机理研究   第十二届全国环境化学大会   2023-11-20