100104-病理学与病理生理学

雌性配子发育与体外再生
受精机制
雌性生育力维持

2006-06--2008-06   加拿大渥太华大学   访问研究生
2004-09--2010-06   中国科学院动物研究所   理学博士学位
2000-09--2004-06   中国农业大学   理学学士学位

   

2020-08~现在, 中国科学院动物研究所, 研究员，研究组长
2017-01~现在, 中国科学院动物研究所, 研究员
2013-01~2016-12,中国科学院动物研究所, 副研究员
2012-07~2012-12,中国科学院动物研究所, 助理研究员
2010-07~2012-06,中国科学院动物研究所, 博士后
2006-06~2008-06,加拿大渥太华大学, 访问研究生
2004-09~2010-06,中国科学院动物研究所, 理学博士学位
2000-09~2004-06,中国农业大学, 理学学士学位

2023-10-13-2027-10-12,妇幼健康研究会安全避孕专业委员会, 委员
2023-08-01-2027-08-01,中国动物学会细胞与分子显微技术学分会, 常务委员
2022-12-25-2026-07-31,中国解剖学会医学发育生物学分会, 常务委员
2022-12-25-2026-07-31,中国解剖学会青年工作委员会, 委员
2019-09-26-今,中国动物学会生殖生物学分会, 副秘书长
2018-11-01-今,中国生理学会生殖科学专业委员会, 常务委员

现代生殖医学之工程技术
生殖生物学
生殖工程学

   

（1） 全国妇幼健康科学技术奖, 一等奖, 部委级, 2015
（2） 国家人口与计划生育委员会优秀科技成果奖, 一等奖, 部委级, 2011

（ 1 ） 一种体外保存/培养卵母细胞以维持卵母细胞减数分裂停滞的方法, 2011, 第 6 作者, 专利号: CN102258005A

   

（1） Loss of UBE2S causes meiosis I arrest with normal spindle assembly checkpoint dynamics in mouse oocytes, Development, 2024, 第 12 作者  通讯作者
（2） MEIKIN expression and its C-terminal phosphorylation by PLK1 is closely related the metaphase-anaphase transition by affecting cyclin B1 and Securin stabilization in meiotic oocyte, HISTOCHEMISTRY AND CELL BIOLOGY, 2024, 第 3 作者
（3） Protein phosphatase 4 maintains the survival of primordial follicles by regulating autophagy in oocytes, CELL DEATH & DISEASE, 2024, 第 7 作者
（4） RNF20 Regulates Oocyte Meiotic Spindle Assembly by Recruiting TPM3 to Centromeres and Spindle Poles, ADVANCED SCIENCE, 2024, 第 10 作者  通讯作者
（5） The transgenerational effects of maternal low-protein diet during lactation on offspring, JOURNAL OF GENETICS AND GENOMICS, 2024, 第 11 作者
（6） Fangchinoline inhibits mouse oocyte meiosis by disturbing MPF activity, TOXICOLOGY IN VITRO, 2024, 第 9 作者  通讯作者
（7） A heterozygous ZP2 mutation causes zona pellucida defects and female infertility in mouse and human, ISCIENCE, 2023, 第 13 作者
（8） Supplementation of mitochondria from endometrial mesenchymal stem cells improves oocyte quality in aged mice, CELL PROLIFERATION, 2023, 第 7 作者  通讯作者
（9） PPP4C facilitates homologous recombination DNA repair by dephosphorylating PLK1 during early embryo development, DEVELOPMENT, 2022, 第 7 作者  通讯作者
（10） Kinetochore scaffold 1 regulates SAC function during mouse oocyte meiotic maturation, FASEB JOURNAL, 2022, 第 9 作者  通讯作者
（11） Supplementation of mitochondria from endometrial mesenchymal stem cells improves oocyte quality in aged mice., Cell Proliferation, 2022, 第 1 作者  通讯作者
（12） Maternal EHMT2 is essential for homologous chromosome segregation by regulating Cyclin B3 transcription in oocyte meiosis, INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2022, 第 18 作者  通讯作者
（13） PTHRP PROMOTES DEVELOPMENT OF MOUSE PREIMPLANTATION EMBRYOS THROUGH THE AKT/CYCLIN D1 PATHWAY AND NUCLEAR TRANSLOCATION OF HDAC4, JOURNAL OF CELLULAR PHYSIOLOGY, 2021, 第 8 作者
（14） Specific deletion of protein phosphatase 6 catalytic subunit in Sertoli cells leads to disruption of spermatogenesis, CELL DEATH & DISEASE, 2021, 第 8 作者  通讯作者
（15） METTL3-MEDIATED MRNA N-6-METHYLADENOSINE IS REQUIRED FOR OOCYTE AND FOLLICLE DEVELOPMENT IN MICE, Cell Death and Disease, 2021, 第 13 作者
（16） Inhibition of CDK4/6 kinases causes production of aneuploid oocytes by inactivating the spindle assembly checkpoint and accelerating first meiotic progression, BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2021, 第 8 作者
（17） FBXO34 REGULATES THE G2/M TRANSITION AND ANAPHASE ENTRY IN MEIOTIC OOCYTES, FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2021, 第 10 作者  通讯作者
（18） SINGLE-CELL RNA SEQUENCING REVEALS SPECIES-SPECIFIC TIME SPANS OF CELL CYCLE TRANSITIONS IN EARLY OOGENESIS, HUMAN MOLECULAR GENETICS, 2021, 第 6 作者
（19） EFFECTS OF MITOCHONDRIA-ASSOCIATED CA(2+)TRANSPORTERS SUPPRESSION ON OOCYTE ACTIVATION, CELL BIOCHEMISTRY AND FUNCTION, 2021, 第 5 作者
（20） Single-cell RNA sequencing reveals the landscape of early female germ cell development, FASEB JOURNAL, 2020, 第 4 作者
（21） Synaptotagmin 1 regulates cortical granule exocytosis during mouse oocyte activation, ZYGOTE, 2020, 第 9 作者
（22） Protein phosphatase 6 is a key factor regulating spermatogenesis, CELL DEATH AND DIFFERENTIATION, 2020, 第 10 作者  通讯作者
（23） Deletion of BAF250a affects oocyte epigenetic modifications and embryonic development, MOLECULAR REPRODUCTION AND DEVELOPMENT, 2020, 第 10 作者  通讯作者
（24） Degradation of Ccnb3 is essential for maintenance of MII arrest in oocyte, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2020, 第 7 作者
（25） CENP-W regulates kinetochore-microtubule attachment and meiotic progression of mouse oocytes, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2020, 第 5 作者
（26） PRC2 and EHMT1 regulate H3K27me2 and H3K27me3 establishment across the zygote genome, NATURE COMMUNICATIONS, 2020, 第 14 作者  通讯作者
（27） Cell division cycle 23 is required for mouse oocyte meiotic maturation, FASEB JOURNAL, 2020, 第 10 作者  通讯作者
（28） Deletion of Ck2 beta gene causes germ cell development arrest and azoospermia in male mice, CELL PROLIFERATION, 2020, 第 2 作者
（29） RNA-Seq transcriptome reveals different molecular responses during human and mouse oocyte maturation and fertilization, BMC GENOMICS, 2020, 第 5 作者  通讯作者
（30） Chronic cadmium exposure causes oocyte meiotic arrest by disrupting spindle assembly checkpoint and maturation promoting factor, REPRODUCTIVE TOXICOLOGY, 2020, 第 8 作者
（31） Type 1 diabetes affects zona pellucida and genome methylation in oocytes and granulosa cells, MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2020, 第 6 作者
（32） Single-cell RNA sequencing reveals regulation of fetal ovary development in the monkey (Macaca fascicularis), CELL DISCOVERY, 2020, 第 10 作者
（33） CENP-T regulates both the G2/M transition and anaphase entry by acting through CDH1 in meiotic oocytes, JOURNAL OF CELL SCIENCE, 2020, 第 6 作者
（34） Meiotic chromatid recombination and segregation assessed with human single cell genome sequencing data, JOURNAL OF MEDICAL GENETICS, 2019, 第 3 作者
（35） NEK5 regulates cell cycle progression during mouse oocyte maturation and preimplantation embryonic development, MOLECULAR REPRODUCTION AND DEVELOPMENT, 2019, 第 9 作者
（36） Absence of mitochondrial DNA methylation in mouse oocyte maturation, aging and early embryo development, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2019, 第 2 作者
（37） N-acetyl-L-cysteine (NAC) delays post-ovulatory oocyte aging in mouse, AGING-US, 2019, 第 7 作者
（38） Rad9a is involved in chromatin decondensation and post-zygotic embryo development in mice, CELL DEATH AND DIFFERENTIATION, 2019, 第 4 作者
（39） Mettl14 is required for mouse postimplantation development by facilitating epiblast maturation, FASEB JOURNAL, 2019, 第 14 作者  通讯作者
（40） Ablation of beta subunit of protein kinase CK2 in mouse oocytes causes follicle atresia and premature ovarian failure, CELL DEATH & DISEASE, 2018, 第 2 作者
（41） The small GTPase RhoA regulates the LIMK1/2-cofilin pathway to modulate cytoskeletal dynamics in oocyte meiosis, JOURNAL OF CELLULAR PHYSIOLOGY, 2018, 第 7 作者
（42） Glucocorticoid exposure affects female fertility by exerting its effect on the uterus but not on the oocyte: lessons from a hypercortisolism mouse model, HUMAN REPRODUCTION, 2018, 第 4 作者
（43） Type 2 diabetes increases oocyte mtDNA mutations which are eliminated in the offspring by bottleneck effect, REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY, 2018, 第 5 作者
（44） Effects of Fullerenol Nanoparticles on Rat Oocyte Meiosis Resumption, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2018, 第 10 作者  通讯作者
（45） Ablation of beta subunit of protein kinase CK2 in mouse oocytes causes follicle atresia and premature ovarian failure, CELL DEATH AND DISEASE, 2018, 第 2 作者
（46） Removal of Mouse Ovary Fat Pad Affects Sex Hormones, Folliculogenesis and Fertility, JOURNAL OF ENDOCRINOLOGY, 2017, 第 7 作者
（47） Geminin Deletion in Pre-Meiotic DNA Replication Stage Causes Spermatogenesis Defect and Infertility, JOURNAL OF REPRODUCTION AND DEVELOPMENT, 2017, 第 9 作者  通讯作者
（48） Transfer of autologous mitochondria from adipose tissue-derived stem cells rescues oocyte quality and infertility in aged mice, AGING-US, 2017, 第 1 作者
（49） Sperm-Carried RNAs Play Critical Roles in Mouse Embryonic Development, ONCOTARGET, 2017, 第 4 作者
（50） Oocyte-Specific Deletion of furin Leads to Female Infertility by Causing Early Secondary Follicle Arrest in Mice, CELL DEATH & DISEASE, 2017, 第 10 作者  通讯作者
（51） CenpH regulates meiotic G2/M transition by modulating the APC/C-Cdh1-cyclin B1 pathway in oocytes, DEVELOPMENT, 2017, 第 4 作者
（52） Oocyte-Specific Deletion of N-WASP Does Not Affect Oocyte Polarity, But Causes Failure of Meiosis II Completion, MOLECULAR HUMAN REPRODUCTION, 2016, 第 1 作者
（53） Nek11 Regulates Asymmetric Cell Division During Mouse Oocyte Meiotic Maturation, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2016, 第 2 作者
（54） Geminin Deletion in Mouse Oocytes Results in Impaired Embryo Development and Reduced Fertility, MOLECULAR BIOLOGY OF THE CELL, 2016, 第 9 作者  通讯作者
（55） Exposure to Aroclor-1254 Impairs Spindle Assembly During Mouse Oocyte Maturation, ENVIRONMENTAL TOXICOLOGY, 2016, 第 8 作者
（56） Protein Phosphatase 6 Protects Prophase I-Arrested Oocytes by Safeguarding Genomic Integrity, PLOS GENETICS, 2016, 第 7 作者  通讯作者
（57） N6-Methyladenosine Sequencing Highlights the Involvement of mRNA Methylation in Oocyte Meiotic Maturation and Embryo Development by Regulating Translation in Xenopus laevis, JOURNAL OF BIOLOGICAL CHEMISTRY, 2016, 第 3 作者
（58） Rad9a Is Required for Spermatogonia Differentiation in Mice, ONCOTARGET, 2016, 第 2 作者
（59） LKB1 Acts as a Critical Gatekeeper of Ovarian Primordial Follicle Pool, ONCOTARGET, 2016, 第 6 作者  通讯作者
（60） Oocyte-specific deletion of N-WASP does not affect oocyte polarity, but causes failure of meiosis II completion, MHR: BASIC SCIENCE OF REPRODUCTIVE MEDICINE, 2016, 第 1 作者
（61） Loss of Protein Phosphatase 6 in Oocytes Causes Failure of Meiosis II Exit and Impaired Female Fertility, JOURNAL OF CELL SCIENCE, 2015, 第 2 作者
（62） Deletion of Mylk1 in Oocytes Causes Delayed Morula-to-Blastocyst Transition and Reduced Fertility Without Affecting Folliculogenesis and Oocyte Maturation in Mice, BIOLOGY OF REPRODUCTION, 2015, 第 9 作者
（63） Nuf2 Is Required for Chromosome Segregation During Mouse Oocyte Meiotic Maturation, CELL CYCLE, 2015, 第 4 作者
（64） Casein Kinase 1 (��, �� and ��) Localize at the Spindle Poles, But May Not Be Essential for Mammalian Oocyte Meiotic Progression, CELL CYCLE, 2015, 第 2 作者
（65） Exogenous Thymine DNA Glycosylase Regulates Epigenetic Modifications and Meiotic Cell Cycle Progression of Mouse Oocytes, MOLECULARHUMANREPRODUCTION, 2015, 第 4 作者
（66） Casein kinase 1 (alpha, delta and epsilon) localize at the spindle poles, but may not be essential for mammalian oocyte meiotic progression, CELL CYCLE, 2015, 第 2 作者
（67） RhoA-Mediated FMNL1 Regulates GM130 for Actin Assembly and Phosphorylates MAPK for Spindle Formation in Mouse Oocyte Meiosis, CELL CYCLE, 2015, 第 5 作者
（68） Confocal Microscopic Analysis of the Spindle and Chromosome Configurations of in vitro-Matured Oocytes from Different Types of Polycystic Ovary Syndrome Patients, GYNECOLOGIC AND OBSTETRIC INVESTIGATION, 2015, 第 4 作者
（69） Cep55 Regulates Spindle Organization and Cell Cycle Progression in Meiotic Oocyte, SCIENTIFIC REPORTS, 2015, 第 4 作者
（70） WASH Complex Regulates Arp2/3 Complex for Actin-Based Polar Body Extrusion in Mouse Oocytes, SCIENTIFIC REPORTS, 2014, 第 4 作者
（71） TGN38 Is Required for the Metaphase I/Anaphase I Transition and Asymmetric Cell Division During Mouse Oocyte Meiotic Maturation, CELL CYCLE, 2014, 第 3 作者
（72） Survivin Is Essential for Fertile Egg Production and Female Fertility in Mice, CELL DEATH & DISEASE, 2014, 
（73） Different Fates of Oocytes with DNA Double-Strand Breaks in Vitro and in Vivo, CELL CYCLE, 2014, 第 3 作者
（74） Rho-GTPase Effector ROCK Phosphorylates Cofilin in Actin-Meditated Cytokinesis During Mouse Oocyte Meiosis, BIOLOGY OF REPRODUCTION, 2014, 第 7 作者
（75） The subcortical maternal complex controls symmetric division of mouse zygotes by regulating F-actin dynamics, NATURE COMMUNICATIONS, 2014, 第 8 作者
（76） Scaffold Subunit Aalpha of PP2A Is Essential for Female Meiosis and Fertility in Mice, BIOLOGY OF REPRODUCTION, 2014, 第 2 作者
（77） Dynamin 2 Regulates Actin-Mediated Spindle Migration in Mouse Oocytes, BIOLOGY OF THE CELL, 2014, 第 3 作者
（78） The root of reduced fertility in aged women and possible therapentic options: Current status and future perspects, MOLECULAR ASPECTS OF MEDICINE, 2014, 第 2 作者
（79） Laser Microbeam-Induced DNA Damage Inhibits Cell Division in Fertilized Eggs and Early Embryos, CELL CYCLE, 2013, 第 6 作者
（80） Specific Disruption of Tsc1 in Ovarian Granulosa Cells Promotes Ovulation and Causes Progressive Accumulation of Corpora Lutea, PLOS ONE, 2013, 第 2 作者
（81） Specific deletion of Cdc42 does not affect meiotic spindle organization/migration and homologous chromosome segregation, but disrupts polarity establishment and cytokinesis in mouse oocyte., Mol Biol Cell, 2013, 
（82） Specific Deletion of Cdc42 Does Not Affect Meiotic Spindle Organization/Migration and Homologous Chromosome Segregation but Disrupts Polarity Establishment and Cytokinesis in Mouse Oocytes, MOLECULAR BIOLOGY OF THE CELL, 2013, 第 1 作者
（83） Overexpression of SET beta, a protein localizing to centromeres, causes precocious separation of chromatids during the first meiosis of mouse oocytes, JOURNAL OF CELL SCIENCE, 2013, 第 2 作者
（84） Specific Deletion of Cdc42 Does Not Affect Meiotic Spindle Organization/Migration and Homologous Chromosome Segregation but Disrupts Polarity Establishment and Cytokinesis in Mouse Oocytes, MOLECULAR BIOLOGY OF THE CELL, 2013, 第 1 作者
（85） The Effects of DNA Double-Strand Breaks on Mouse Oocyte Meiotic Maturation, CELL CYCLE, 2013, 第 4 作者
（86） MKlp2 Inhibitior Paprotrain Affects Polar Body Extrusion during Mouse Oocyte Maturation, REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY, 2013, 第 4 作者
（87） Cyclin O Regulates Germinal Vesicle Breakdown in Mouse Oocytes, BIOLOGY OF REPRODUCTION, 2013, 第 4 作者
（88） Unique insights into maternal mitochondrial inheritance in mice, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 第 5 作者
（89） Septin 7 is required for orderly meiosis in mouse oocytes, CELL CYCLE, 2012, 第 4 作者
（90） New Understandings on Folliculogenesis/Oogenesis Regulation in Mouse as Revealed by Conditional Knockout, JOURNAL OF GENETICS AND GENOMICS, 2012, 第 2 作者
（91） Maternal insulin resistance causes oxidative stress and mitochondrial dysfunction in mouse oocytes, HUMAN REPRODUCTION, 2012, 第 3 作者
（92） Heated spermatozoa: effects on embryonic development and epigenetics, HUMAN REPRODUCTION, 2012, 第 5 作者
（93） Localization and function of the Ska complex during mouse oocyte meiotic maturation, CELL CYCLE, 2012, 第 3 作者
（94） Checkpoint kinase 1 is essential for meiotic cell cycle regulation in mouse oocytes, CELL CYCLE, 2012, 第 3 作者
（95） DYNLT3 Is Required for Chromosome Alignment During Mouse Oocyte Meiotic Maturation, REPRODUCTIVE SCIENCES, 2011, 第 4 作者
（96） Why is Chromosome Segregation Error in Oocytes Increased With Maternal Aging?, PHYSIOLOGY, 2011, 第 1 作者  通讯作者
（97） Spindle Assembly Checkpoint Regulates Mitotic Cell Cycle Progression during Preimplantation Embryo Development, PLOS ONE, 2011, 第 6 作者
（98） JNK2 Participates in Spindle Assembly during Mouse Oocyte Meiotic Maturation, MICROSCOPY AND MICROANALYSIS, 2011, 第 3 作者
（99） Septin1 Is Required for Spindle Assembly and Chromosome Congression in Mouse Oocytes, DEVELOPMENTAL DYNAMICS, 2011, 第 4 作者
（100） Arp2/3 Complex Regulates Asymmetric Division and Cytokinesis in Mouse Oocytes, PLOS ONE, 2011, 第 2 作者
（101） GM130, a cis-Golgi protein, regulates meiotic spindle assembly and asymmetric division in mouse oocyte, CELL CYCLE, 2011, 第 2 作者
（102） ER-alpha 36, a Novel Variant of ER-alpha, Mediates Estrogen-Stimulated Proliferation of Endometrial Carcinoma Cells via the PKC delta/ERK Pathway, PLOS ONE, 2010, 第 3 作者
（103） p38 alpha MAPK is a MTOC-associated protein regulating spindle assembly, spindle length and accurate chromosome segregation during mouse oocyte meiotic maturation, CELL CYCLE, 2010, 第 4 作者
（104） ERK3 Is Required for Metaphase-Anaphase Transition in Mouse Oocyte Meiosis, PLOS ONE, 2010, 第 3 作者
（105） The SUMO pathway functions in mouse oocyte maturation, CELL CYCLE, 2010, 第 1 作者
（106） A novel variant of er-alpha, er-alpha36 mediates testosterone-stimulated erk and akt activation in endometrial cancer hec1a cells, REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY, 2009, 第 4 作者
（107） Effects of gonadotrophins, growth hormone, and activin A on enzymatically isolated follicle growth, oocyte chromatin organization, and steroid secretion, MOLECULAR REPRODUCTION AND DEVELOPMENT, 2008, 第 5 作者
（108） Brefeldin A disrupts asymmetric spindle positioning in mouse oocytes, DEVELOPMENTAL BIOLOGY, 2008, 第 2 作者
（109） Deciphering the dynamics of the ovarian reserve in cynomolgus monkey through a quantitative morphometric study, SCIENCE BULLETIN, 第 13 作者

（ 1 ） 生殖医学, Reproductive medicine, 华中科技大学出版社, 2023-10, 第 其他 作者

   

（ 1 ） 哺乳动物着床前胚胎表观调控网络决定细胞命运与谱系分化的分子机制研究, 参与, 国家任务, 2022-12--2025-11
（ 2 ） 生殖拟器官的建立与调控机制, 参与, 国家任务, 2022-12--2027-11
（ 3 ） 组蛋白甲基转移酶G9a在小鼠卵泡发育及卵母细胞成熟过程中的功能研究, 负责人, 国家任务, 2022-01--2025-12