100104-病理学与病理生理学

雌性配子发育与体外再生
受精机制
雌性生育力维持

2006-06--2008-06   加拿大渥太华大学   访问研究生
2004-09--2010-06   中国科学院动物研究所   理学博士学位
2000-09--2004-06   中国农业大学   理学学士学位

   

2020-08~现在, 中国科学院动物研究所, 研究员，研究组长
2017-01~现在, 中国科学院动物研究所, 研究员
2013-01~2016-12,中国科学院动物研究所, 副研究员
2012-07~2012-12,中国科学院动物研究所, 助理研究员
2010-07~2012-06,中国科学院动物研究所, 博士后
2006-06~2008-06,加拿大渥太华大学, 访问研究生
2004-09~2010-06,中国科学院动物研究所, 理学博士学位
2000-09~2004-06,中国农业大学, 理学学士学位

2023-10-13-2027-10-12,妇幼健康研究会安全避孕专业委员会, 委员
2023-08-01-2027-08-01,中国动物学会细胞与分子显微技术学分会, 常务委员
2022-12-25-2026-07-31,中国解剖学会医学发育生物学分会, 常务委员
2022-12-25-2026-07-31,中国解剖学会青年工作委员会, 委员
2019-09-26-今,中国动物学会生殖生物学分会, 副秘书长
2018-11-01-今,中国生理学会生殖科学专业委员会, 常务委员

现代生殖医学之工程技术
生殖生物学
生殖工程学

   

（1） 全国妇幼健康科学技术奖, 一等奖, 部委级, 2015
（2） 国家人口与计划生育委员会优秀科技成果奖, 一等奖, 部委级, 2011

（ 1 ） 一种体外保存/培养卵母细胞以维持卵母细胞减数分裂停滞的方法, 2011, 第 6 作者, 专利号: CN102258005A

   

（1） A heterozygous ZP2 mutation causes zona pellucida defects and female infertility in mouse and human, ISCIENCE, 2023, 第 11 作者
（2） Supplementation of mitochondria from endometrial mesenchymal stem cells improves oocyte quality in aged mice, CELL PROLIFERATION, 2023, 第 11 作者
（3） PPP4C facilitates homologous recombination DNA repair by dephosphorylating PLK1 during early embryo development, DEVELOPMENT, 2022, 第 11 作者
（4） Kinetochore scaffold 1 regulates SAC function during mouse oocyte meiotic maturation, FASEB JOURNAL, 2022, 第 11 作者
（5） Supplementation of mitochondria from endometrial mesenchymal stem cells improves oocyte quality in aged mice., Cell Proliferation, 2022, 第 11 作者
（6） Maternal EHMT2 is essential for homologous chromosome segregation by regulating Cyclin B3 transcription in oocyte meiosis, INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2022, 第 11 作者
（7） PTHRP PROMOTES DEVELOPMENT OF MOUSE PREIMPLANTATION EMBRYOS THROUGH THE AKT/CYCLIN D1 PATHWAY AND NUCLEAR TRANSLOCATION OF HDAC4, JOURNAL OF CELLULAR PHYSIOLOGY, 2021, 第 8 作者
（8） Specific deletion of protein phosphatase 6 catalytic subunit in Sertoli cells leads to disruption of spermatogenesis, CELL DEATH & DISEASE, 2021, 第 11 作者
（9） METTL3-MEDIATED MRNA N-6-METHYLADENOSINE IS REQUIRED FOR OOCYTE AND FOLLICLE DEVELOPMENT IN MICE, CELL DEATH & DISEASE, 2021, 第 13 作者
（10） Inhibition of CDK4/6 kinases causes production of aneuploid oocytes by inactivating the spindle assembly checkpoint and accelerating first meiotic progression, BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2021, 第 8 作者
（11） FBXO34 REGULATES THE G2/M TRANSITION AND ANAPHASE ENTRY IN MEIOTIC OOCYTES, FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2021, 第 11 作者
（12） SINGLE-CELL RNA SEQUENCING REVEALS SPECIES-SPECIFIC TIME SPANS OF CELL CYCLE TRANSITIONS IN EARLY OOGENESIS, HUMAN MOLECULAR GENETICS, 2021, 第 6 作者
（13） EFFECTS OF MITOCHONDRIA-ASSOCIATED CA(2+)TRANSPORTERS SUPPRESSION ON OOCYTE ACTIVATION, CELL BIOCHEMISTRY AND FUNCTION, 2021, 第 5 作者
（14） Single-cell RNA sequencing reveals the landscape of early female germ cell development, FASEB JOURNAL, 2020, 第 4 作者
（15） Synaptotagmin 1 regulates cortical granule exocytosis during mouse oocyte activation, ZYGOTE, 2020, 第 9 作者
（16） Protein phosphatase 6 is a key factor regulating spermatogenesis, CELL DEATH AND DIFFERENTIATION, 2020, 第 11 作者
（17） Deletion of BAF250a affects oocyte epigenetic modifications and embryonic development, MOLECULAR REPRODUCTION AND DEVELOPMENT, 2020, 第 11 作者
（18） Degradation of Ccnb3 is essential for maintenance of MII arrest in oocyte, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2020, 第 7 作者
（19） CENP-W regulates kinetochore-microtubule attachment and meiotic progression of mouse oocytes, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2020, 第 5 作者
（20） PRC2 and EHMT1 regulate H3K27me2 and H3K27me3 establishment across the zygote genome, NATURE COMMUNICATIONS, 2020, 第 11 作者
（21） Cell division cycle 23 is required for mouse oocyte meiotic maturation, FASEB JOURNAL, 2020, 第 11 作者
（22） Deletion of Ck2 beta gene causes germ cell development arrest and azoospermia in male mice, CELL PROLIFERATION, 2020, 第 2 作者
（23） RNA-Seq transcriptome reveals different molecular responses during human and mouse oocyte maturation and fertilization, BMC GENOMICS, 2020, 第 11 作者
（24） Chronic cadmium exposure causes oocyte meiotic arrest by disrupting spindle assembly checkpoint and maturation promoting factor, REPRODUCTIVE TOXICOLOGY, 2020, 第 8 作者
（25） Single-cell RNA sequencing reveals regulation of fetal ovary development in the monkey (Macaca fascicularis), CELL DISCOVERY, 2020, 第 10 作者
（26） Type 1 diabetes affects zona pellucida and genome methylation in oocytes and granulosa cells, MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2020, 第 6 作者
（27） CENP-T regulates both the G2/M transition and anaphase entry by acting through CDH1 in meiotic oocytes, JOURNAL OF CELL SCIENCE, 2020, 第 6 作者
（28） NEK5 regulates cell cycle progression during mouse oocyte maturation and preimplantation embryonic development, MOLECULAR REPRODUCTION AND DEVELOPMENT, 2019, 第 9 作者
（29） Meiotic chromatid recombination and segregation assessed with human single cell genome sequencing data, JOURNAL OF MEDICAL GENETICS, 2019, 第 3 作者
（30） Absence of mitochondrial DNA methylation in mouse oocyte maturation, aging and early embryo development, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2019, 第 2 作者
（31） Rad9a is involved in chromatin decondensation and post-zygotic embryo development in mice, CELL DEATH AND DIFFERENTIATION, 2019, 第 4 作者
（32） N-acetyl-L-cysteine (NAC) delays post-ovulatory oocyte aging in mouse, AGING-US, 2019, 第 7 作者
（33） Mettl14 is required for mouse postimplantation development by facilitating epiblast maturation, FASEB JOURNAL, 2019, 第 11 作者
（34） Ablation of beta subunit of protein kinase CK2 in mouse oocytes causes follicle atresia and premature ovarian failure, CELL DEATH & DISEASE, 2018, 第 2 作者
（35） The small GTPase RhoA regulates the LIMK1/2-cofilin pathway to modulate cytoskeletal dynamics in oocyte meiosis, JOURNAL OF CELLULAR PHYSIOLOGY, 2018, 第 7 作者
（36） Glucocorticoid exposure affects female fertility by exerting its effect on the uterus but not on the oocyte: lessons from a hypercortisolism mouse model, HUMAN REPRODUCTION, 2018, 第 4 作者
（37） Type 2 diabetes increases oocyte mtDNA mutations which are eliminated in the offspring by bottleneck effect, REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY, 2018, 第 5 作者
（38） Effects of Fullerenol Nanoparticles on Rat Oocyte Meiosis Resumption, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2018, 第 11 作者
（39） Ablation of beta subunit of protein kinase CK2 in mouse oocytes causes follicle atresia and premature ovarian failure, CELL DEATH AND DISEASE, 2018, 第 2 作者
（40） Removal of Mouse Ovary Fat Pad Affects Sex Hormones, Folliculogenesis and Fertility, JOURNAL OF ENDOCRINOLOGY, 2017, 第 7 作者
（41） Geminin Deletion in Pre-Meiotic DNA Replication Stage Causes Spermatogenesis Defect and Infertility, JOURNAL OF REPRODUCTION AND DEVELOPMENT, 2017, 第 11 作者
（42） Transfer of autologous mitochondria from adipose tissue-derived stem cells rescues oocyte quality and infertility in aged mice, AGING-US, 2017, 第 1 作者
（43） Sperm-Carried RNAs Play Critical Roles in Mouse Embryonic Development, ONCOTARGET, 2017, 第 4 作者
（44） Oocyte-Specific Deletion of furin Leads to Female Infertility by Causing Early Secondary Follicle Arrest in Mice, CELL DEATH & DISEASE, 2017, 第 11 作者
（45） CenpH regulates meiotic G2/M transition by modulating the APC/C-Cdh1-cyclin B1 pathway in oocytes, DEVELOPMENT, 2017, 第 4 作者
（46） Oocyte-Specific Deletion of N-WASP Does Not Affect Oocyte Polarity, But Causes Failure of Meiosis II Completion, MOLECULAR HUMAN REPRODUCTION, 2016, 第 1 作者
（47） Nek11 Regulates Asymmetric Cell Division During Mouse Oocyte Meiotic Maturation, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2016, 第 2 作者
（48） Exposure to Aroclor-1254 Impairs Spindle Assembly During Mouse Oocyte Maturation, ENVIRONMENTAL TOXICOLOGY, 2016, 第 8 作者
（49） Geminin Deletion in Mouse Oocytes Results in Impaired Embryo Development and Reduced Fertility, MOLECULAR BIOLOGY OF THE CELL, 2016, 第 11 作者
（50） Protein Phosphatase 6 Protects Prophase I-Arrested Oocytes by Safeguarding Genomic Integrity, PLOS GENETICS, 2016, 第 11 作者
（51） N6-Methyladenosine Sequencing Highlights the Involvement of mRNA Methylation in Oocyte Meiotic Maturation and Embryo Development by Regulating Translation in Xenopus laevis, JOURNAL OF BIOLOGICAL CHEMISTRY, 2016, 第 3 作者
（52） Rad9a Is Required for Spermatogonia Differentiation in Mice, ONCOTARGET, 2016, 第 2 作者
（53） LKB1 Acts as a Critical Gatekeeper of Ovarian Primordial Follicle Pool, ONCOTARGET, 2016, 第 11 作者
（54） Oocyte-specific deletion of N-WASP does not affect oocyte polarity, but causes failure of meiosis II completion, MHR: BASIC SCIENCE OF REPRODUCTIVE MEDICINE, 2016, 第 1 作者
（55） Loss of Protein Phosphatase 6 in Oocytes Causes Failure of Meiosis II Exit and Impaired Female Fertility, JOURNAL OF CELL SCIENCE, 2015, 第 2 作者
（56） Deletion of Mylk1 in Oocytes Causes Delayed Morula-to-Blastocyst Transition and Reduced Fertility Without Affecting Folliculogenesis and Oocyte Maturation in Mice, BIOLOGY OF REPRODUCTION, 2015, 第 9 作者
（57） Nuf2 Is Required for Chromosome Segregation During Mouse Oocyte Meiotic Maturation, CELL CYCLE, 2015, 第 4 作者
（58） Casein Kinase 1 (��, �� and ��) Localize at the Spindle Poles, But May Not Be Essential for Mammalian Oocyte Meiotic Progression, CELL CYCLE, 2015, 第 2 作者
（59） Exogenous Thymine DNA Glycosylase Regulates Epigenetic Modifications and Meiotic Cell Cycle Progression of Mouse Oocytes, MOLECULARHUMANREPRODUCTION, 2015, 第 4 作者
（60） Casein kinase 1 (alpha, delta and epsilon) localize at the spindle poles, but may not be essential for mammalian oocyte meiotic progression, CELL CYCLE, 2015, 第 2 作者
（61） RhoA-Mediated FMNL1 Regulates GM130 for Actin Assembly and Phosphorylates MAPK for Spindle Formation in Mouse Oocyte Meiosis, CELL CYCLE, 2015, 第 5 作者
（62） Confocal Microscopic Analysis of the Spindle and Chromosome Configurations of in vitro-Matured Oocytes from Different Types of Polycystic Ovary Syndrome Patients, GYNECOLOGIC AND OBSTETRIC INVESTIGATION, 2015, 第 4 作者
（63） Cep55 Regulates Spindle Organization and Cell Cycle Progression in Meiotic Oocyte, SCIENTIFIC REPORTS, 2015, 第 4 作者
（64） WASH Complex Regulates Arp2/3 Complex for Actin-Based Polar Body Extrusion in Mouse Oocytes, SCIENTIFIC REPORTS, 2014, 第 4 作者
（65） TGN38 Is Required for the Metaphase I/Anaphase I Transition and Asymmetric Cell Division During Mouse Oocyte Meiotic Maturation, CELL CYCLE, 2014, 第 3 作者
（66） Survivin Is Essential for Fertile Egg Production and Female Fertility in Mice, CELL DEATH & DISEASE, 2014, 
（67） Different Fates of Oocytes with DNA Double-Strand Breaks in Vitro and in Vivo, CELL CYCLE, 2014, 第 3 作者
（68） Rho-GTPase Effector ROCK Phosphorylates Cofilin in Actin-Meditated Cytokinesis During Mouse Oocyte Meiosis, BIOLOGY OF REPRODUCTION, 2014, 第 7 作者
（69） The subcortical maternal complex controls symmetric division of mouse zygotes by regulating F-actin dynamics, NATURE COMMUNICATIONS, 2014, 第 8 作者
（70） Scaffold Subunit Aalpha of PP2A Is Essential for Female Meiosis and Fertility in Mice, BIOLOGY OF REPRODUCTION, 2014, 第 2 作者
（71） The root of reduced fertility in aged women and possible therapentic options: Current status and future perspects, MOLECULAR ASPECTS OF MEDICINE, 2014, 第 2 作者
（72） Dynamin 2 Regulates Actin-Mediated Spindle Migration in Mouse Oocytes, BIOLOGY OF THE CELL, 2014, 第 3 作者
（73） Laser Microbeam-Induced DNA Damage Inhibits Cell Division in Fertilized Eggs and Early Embryos, CELL CYCLE, 2013, 第 6 作者
（74） Specific Disruption of Tsc1 in Ovarian Granulosa Cells Promotes Ovulation and Causes Progressive Accumulation of Corpora Lutea, PLOS ONE, 2013, 第 2 作者
（75） Specific deletion of Cdc42 does not affect meiotic spindle organization/migration and homologous chromosome segregation, but disrupts polarity establishment and cytokinesis in mouse oocyte., Mol Biol Cell, 2013, 
（76） Specific Deletion of Cdc42 Does Not Affect Meiotic Spindle Organization/Migration and Homologous Chromosome Segregation but Disrupts Polarity Establishment and Cytokinesis in Mouse Oocytes, MOLECULAR BIOLOGY OF THE CELL, 2013, 第 1 作者
（77） Overexpression of SET beta, a protein localizing to centromeres, causes precocious separation of chromatids during the first meiosis of mouse oocytes, JOURNAL OF CELL SCIENCE, 2013, 第 2 作者
（78） Specific Deletion of Cdc42 Does Not Affect Meiotic Spindle Organization/Migration and Homologous Chromosome Segregation but Disrupts Polarity Establishment and Cytokinesis in Mouse Oocytes, MOLECULAR BIOLOGY OF THE CELL, 2013, 第 1 作者
（79） The Effects of DNA Double-Strand Breaks on Mouse Oocyte Meiotic Maturation, CELL CYCLE, 2013, 第 4 作者
（80） MKlp2 Inhibitior Paprotrain Affects Polar Body Extrusion during Mouse Oocyte Maturation, REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY, 2013, 第 4 作者
（81） Cyclin O Regulates Germinal Vesicle Breakdown in Mouse Oocytes, BIOLOGY OF REPRODUCTION, 2013, 第 4 作者
（82） Unique insights into maternal mitochondrial inheritance in mice, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 第 5 作者
（83） Septin 7 is required for orderly meiosis in mouse oocytes, CELL CYCLE, 2012, 第 4 作者
（84） New Understandings on Folliculogenesis/Oogenesis Regulation in Mouse as Revealed by Conditional Knockout, JOURNAL OF GENETICS AND GENOMICS, 2012, 第 2 作者
（85） Maternal insulin resistance causes oxidative stress and mitochondrial dysfunction in mouse oocytes, HUMAN REPRODUCTION, 2012, 第 3 作者
（86） Heated spermatozoa: effects on embryonic development and epigenetics, HUMAN REPRODUCTION, 2012, 第 5 作者
（87） Localization and function of the Ska complex during mouse oocyte meiotic maturation, CELL CYCLE, 2012, 第 3 作者
（88） Checkpoint kinase 1 is essential for meiotic cell cycle regulation in mouse oocytes, CELL CYCLE, 2012, 第 3 作者
（89） DYNLT3 Is Required for Chromosome Alignment During Mouse Oocyte Meiotic Maturation, REPRODUCTIVE SCIENCES, 2011, 第 4 作者
（90） Why is Chromosome Segregation Error in Oocytes Increased With Maternal Aging?, PHYSIOLOGY, 2011, 第 11 作者
（91） Spindle Assembly Checkpoint Regulates Mitotic Cell Cycle Progression during Preimplantation Embryo Development, PLOS ONE, 2011, 第 6 作者
（92） JNK2 Participates in Spindle Assembly during Mouse Oocyte Meiotic Maturation, MICROSCOPY AND MICROANALYSIS, 2011, 第 3 作者
（93） Septin1 Is Required for Spindle Assembly and Chromosome Congression in Mouse Oocytes, DEVELOPMENTAL DYNAMICS, 2011, 第 4 作者
（94） GM130, a cis-Golgi protein, regulates meiotic spindle assembly and asymmetric division in mouse oocyte, CELL CYCLE, 2011, 第 2 作者
（95） Arp2/3 Complex Regulates Asymmetric Division and Cytokinesis in Mouse Oocytes, PLOS ONE, 2011, 第 2 作者
（96） ER-alpha 36, a Novel Variant of ER-alpha, Mediates Estrogen-Stimulated Proliferation of Endometrial Carcinoma Cells via the PKC delta/ERK Pathway, PLOS ONE, 2010, 第 3 作者
（97） p38 alpha MAPK is a MTOC-associated protein regulating spindle assembly, spindle length and accurate chromosome segregation during mouse oocyte meiotic maturation, CELL CYCLE, 2010, 第 4 作者
（98） ERK3 Is Required for Metaphase-Anaphase Transition in Mouse Oocyte Meiosis, PLOS ONE, 2010, 第 3 作者
（99） The SUMO pathway functions in mouse oocyte maturation, CELL CYCLE, 2010, 第 1 作者
（100） A novel variant of er-alpha, er-alpha36 mediates testosterone-stimulated erk and akt activation in endometrial cancer hec1a cells, REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY, 2009, 第 4 作者
（101） Effects of gonadotrophins, growth hormone, and activin A on enzymatically isolated follicle growth, oocyte chromatin organization, and steroid secretion, MOLECULAR REPRODUCTION AND DEVELOPMENT, 2008, 第 5 作者
（102） Brefeldin A disrupts asymmetric spindle positioning in mouse oocytes, DEVELOPMENTAL BIOLOGY, 2008, 第 2 作者
（103） Deciphering the dynamics of the ovarian reserve in cynomolgus monkey through a quantitative morphometric study, SCIENCE BULLETIN, 第 13 作者

   

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（ 2 ） 生殖拟器官的建立与调控机制, 参与, 国家任务, 2022-12--2027-11
（ 3 ） 组蛋白甲基转移酶G9a在小鼠卵泡发育及卵母细胞成熟过程中的功能研究, 负责人, 国家任务, 2022-01--2025-12