张集慧-中国科学院大学-UCAS

基本信息

张集慧女硕导中国科学院微生物研究所
电子邮件： zhang.jihui@im.ac.cn
通信地址：中国科学院微生物研究所
邮政编码：

研究领域

微生物次级代谢产物的生物合成与调控；抗肿瘤药物研发；抗过敏药物研发；

研究内容

研究领域为微生物次级代谢产物的生物合成与调控、抗肿瘤以及抗过敏药物的研发。采用基因工程、仪器分析和和酶学等手段对微生物次级代谢产物的生物合成和调控机制进行解析，以获得新型的活性化合物和前体药物，并建立细胞和动物活性检测模型进行化合物筛选和活性优化。曾经从事的研究项目有链霉菌中信号分子介导的抗生素生物合成与调控、新型过敏反应中信号转导途径的阻断研究以及真菌活性次级代谢产物的分析等。有关研究成果发表在J Allergy Clin Immun、Met Eng、Allergy、Sci China Life Sciences等知名国际刊物上。在应用研究领域获得了抗过敏的候选药物和国际PCT专利，已经在美国、中国、日本、澳大利亚等多个国家授权。

教育背景

1994-09--1999-09 中国医学科学院博士
1988-09--1992-07 中国药科大学学士

主要工作经历

2019-10~2024-05,中国科学院微生物研究所, 项目研究员
2013-12~2019-09,中国科学院微生物研究所, 副研究员
2003-05~2013-11,Institute for Infection & Immunity, St George’s, University of London，UK, 博士后，生物项目主管
2003-01~2003-04,法国巴黎第十一大学 (University of Paris-sud), 博士后
1999-09~2002-05,中国科学院微生物研究所, 博士后

出版信息

代表性论文 (* 通讯作者； # 共同第一作者)

Wai Tuck Soh#, Jihui Zhang#, Morley D Hollenberg, Harissios Vliagoftis, Marc E Rothenberg, Caroline L Sokol, Clive Robinson, Alain Jacquet. Protease allergens as initiators-regulators of allergic inflammation. Allergy, 2023, 78(5):1148-1168. IF11.8, Top 4.7%
Jihui Zhang#, Jie Chen#, Kimberley Allen-Philbey, Chathuri Perera Baruhupolage, Theresa Tachie-Menson, Shannon C. Mangat, David R. Garrod, Clive Robinson*. Innate generation of thrombin and intracellular oxidants in airway epithelium by allergen Der p 1. The Journal ofAllergy and Clinical Immunology, 2016, 138(4): 1224–1227. IF10.2, Top 5.8%
Jie Chen#, Jihui Zhang#, Theresa Tachie-Menson,Neha Shukla, David R. Garrod, Clive Robinson*. Allergen-dependent oxidant formation requires purinoceptor activation of ADAM 10 and prothrombin. The Journal ofAllergy and Clinical Immunology, 2017, 139( 6): 2023–2026. IF10.2, Top 5.8%
Jihui Zhang, JM Saint-Remy, David. R. Garrod, Clive Robinson. Comparative enzymology of native and recombinant house dust mite allergen Der p 1. Allergy, 2009, 64(3):469-77. IF11.8, Top 4.7%
Jihui Zhang, John M Hamilton, David. R. Garrod, Clive Robinson. Interactions between mature Der p 1 and its free prodomain indicate membership of a new family of C1 peptidases. Allergy, 2007: 62: 1302–1309. IF11.8, Top 4.7%
Jihui Zhang, Huarong Tan *. Microbial quorum sensing signaling molecules and their roles in the biosynthesis of natural products. Science China Life Sciences, 2023, 66(10): 2429-2432. IF7.3, Top 3.2%
Xiang Liu, Wenxi Wang, Junyue Li, Yue Li, Jihui Zhang*, Huarong Tan*. A widespread response of Gram-negative bacterial acyl-homoserine lactone receptors to Gram-positive Streptomyces γ-butyrolactone signaling molecules. . Science China Life Sciences, 2021, 64(10):1575-1589. IF7.3, Top 3.2%
Dong Li, Jihui Zhang*, Yuqing Tian, Huarong Tan*. Enhancement of salinomycin production by ribosome engineering in Streptomyces albus. Science China Life Sciences, 2019, 62(2): 276–279. IF7.3, Top 3.2%
Junyue Li, Wenxi Wang, Xiang Liu, Yuqing Tian, Huarong Tan*, Jihui Zhang*. A butenolide signaling system synergized with biosynthetic gene modules led to effective activation and enhancement of silent oviedomycin production in Streptomyces. Metabolic Engineering, 2022, 72:289-296. IF 7.6, Top 9.5%
Xiang Liu#, Yue Li#, Junyue Li#, Jinwei Ren, Dong Li, Shijia Zhang, Yao Wu, Jine Li*, Huarong Tan*, Jihui Zhang*. Cinnamoyl lipids as novel signaling molecules modulate the physiological metabolism of cross-phylum microorganisms. Communications Biology, 2024, 7(1):1231. IF5.6, Top 11.5%
Xiang Liu#, Jine Li#, Yue Li, Junyue Li, Huiying Sun, Jiazhen Zheng, Jihui Zhang*, Huarong Tan*. A visualization reporter system for characterizing antibiotic biosynthetic gene clusters expression with high-sensitivity. Communication Biology, 2022, 5(1):901. IF5.6, Top 11.5%
Junyue Li#, Kai Wang#, Luo Sainan, Yuqing Tian, Yue Li, Hu Songnian, Huarong Tan, Jihui Zhang*, Jine Li*. Co-expression of a pair of interdependent regulators coding genes ovmZ and ovmW awakens the production of angucyclinones antibiotics in Streptomyces neyagawaensis. Microbial Cell Factories, 2024, 23(1): 202. IF5.5, Top 23.3%
Ning Liu#, Yang Xu#, Fei Shang, Huiying Sun, Xiang Liu, Huang Ying, Huarong Tan*, Jihui Zhang*. New insights into the dihydro-mureidomycin biosynthesis controlled by two unusual proteins in Streptomyces roseosporus. Microbial Cell Factories, 2023, 22(1): 255. IF5.5, Top 23.3%
Yuqing Tian#, Dong Li#, Kai Wang, Baoting Wei, Jihui Zhang*, Jine Li*. An efficient method for targeted cloning of large DNA fragments from Streptomyces. Applied Microbiology Biotechnology, 2023, 107(18): 5749-5760. IF4.9, Top 28.4%
Jihui Zhang, Jie Chen, Jonathan P Richardson, Nicola-Jane Francis-Newton, Pei F Lai, Kerry Jenkins, Meriel R Major, Rebekah E Key, Mark E Stewart, Stuart Firth-Clark, Steven M Lloyd, Gary K Newton, Trevor R Perrior, David R Garrod, Clive Robinson*. Targeting an Initiator Allergen Provides Durable and Expansive Protection against House Dust Mite Allergy. ACS Pharmacology & Translational Science, 2022, 5(9): 735-751. ESCI IF4.9, Top 12.6%
Dong Li#, Yuqing Tian#, Xiang Liu, Wenxi Wang, Yue Li, Huarong Tan*, Jihui Zhang*. Reconstitution of a mini-gene cluster combined with ribosome engineering led to effective enhancement of salinomycin production in Streptomyces albus, Microbial Biotechnology, 2020, 14: 2356-2368. IF5.8, Top 15.2%
Jiazhen Zheng#, Yue Li#, Hanye Guan, Junyue Li, Dong Li, Jihui Zhang*, Huarong Tan*. Component Optimization of Neomycin Biosynthesis via the Reconstitution of a Combinatorial Mini-Gene-Cluster in Streptomyces fradiae. ACS Synthetic Biology, 2020, 9(9):2493-2501. IF4.2, Top 24.1%
Jihui Zhang, Jie Chen, Clive Robinson*. Cellular and molecular events in the airway epithelium defining the interaction between House Dust Mite Group 1 allergens and innate defences. International Journal of Molecular Sciences, 2018, 19 (11): 3549. IF 5.6, Top 20.9%
Wenxi Wang#, Jihui Zhang#*, Xiang Liu, Dong Li, Yue Li, Yuqing Tian, Huarong Tan*. Identification of a butenolide signaling system that regulates nikkomycin biosynthesis in Streptomyces. Journal ofBiological Chemistry, 2018, 293(52): 20029–20040. IF4.4, Top 31.8%
Jihui Zhang, Jie Chen, Jie Zuo, Gary K Newton, Mark R Stewart, Trevor R Perrior, David R Garrod, Clive Robinson*. Allergen Delivery Inhibitors: Characterisation of potent and selective Inhibitors of Der p 1 and their attenuation of airway responses to house dust mite allergens. International Journal of Molecular Sciences,2018, 19(10):3166. IF 5.6, Top 20.9%
Jihui Zhang, Jie Chen, Gary K. Newton, Trevor R. Perrior, Clive Robinson*. Allergen Delivery Inhibitors: A rationale for targeting sentinel innate immune signaling of Group 1 house dust mite allergens through structure-based protease inhibitor design. Molecular Pharmacology, 2018, 94(3): 1007-1030. IF3.5, Top 34.9%
Jihui Zhang#, Jie Chen#, Shannon C Mangat, Chathuri Perera Baruhupolage, David R Garrod, Clive Robinson*. Pathways of airway oxidant formation by house dust mite allergens and viral RNA converge through myosin motors pannexons and Toll‐like receptor 4. Immunity, Inflammation and Disease, 2018, 6(2): 276-296. IF3.1, Top 56.1%
Bing Li, Xiaofang Tian, Chunlan Wang, Xu Zeng, Yongmei Xing, Hong Ling, Wanqiang Yin, Lixia Tian, Zhixia Meng, Jihui Zhang*, Shunxing Guo*. SWATH label-free proteomics analyses revealed the roles of oxidative stress and antioxidant defensing system in sclerotia formation of Polyporus umbellatus. Scientific Report, 2017, 7: 41283. IF4.3, Top 18.3%
Cheng Lu, Guojian Liao, Jihui Zhang*, Huarong Tan*. Identification of novel tylosin analogues generated by a wblA disruption mutant of Streptomyces ansochromogenes. Microbial Cell Factories, 2015, 14(1):1-11. IF5.5, Top 23.3%

专利

1. 张集慧，孙慧莹，李月，田宇清，谭华荣。恶唑霉素高产工程菌株及其构建方法与应用。申请日期：2023-12-22，中国, 申请号：202311782213.X。

2. 李金娥，魏宝霆，李俊乐，田宇清，张集慧，谭华荣。菌株及其在制备泰乐菌素A中的应用。申请日期：2023-04-01, 中国, 申请号：CN202310345421.7。

3. 李金娥，王艳艳，田宇清，刘翔，张集慧，谭华荣。利用昆虫细胞杆状病毒表达系统表达软骨素6-O-硫酸转移酶的方法及应用。申请日期：2023-03-27, 中国, 申请号：CN202310306737.5。

4. 谭华荣，李月，郑家珍，张集慧，田宇清，关晗晔。新霉素生物合成基因簇遗传改造的工程菌及其应用。申请日期：2022-05-13, 中国, CN201811176264.7。

5. 谭华荣，王凯，田宇清，张集慧，李金娥。产furaquinocin的工程菌株及其构建与应用。申请日期：2022-05-16，中国，申请号：CN202210531425.X。

6. 谭华荣，王凯，田宇清，张集慧，李金娥。产四角霉素的工程菌株及其构建与应用。申请时间：2022-04-17，中国，申请号：CN202210442435.6。

7. 谭华荣，刘翔，张集慧，李月，李金娥。可视化检测基因表达的试剂盒及其应用。申请时间：2021-11-16，中国, 申请号：CN202111355337.0。

8. 谭华荣，刘翔，张集慧，孙慧莹，李金娥。筛选提高恶唑霉素类化合物产量的共培养体系的方法及其应用。申请时间：2021-11-16，中国, 申请号：CN202111356220.4。

9. 谭华荣，张集慧，李俊乐，刘翔，李金娥。一种提高oviedomycin产量的方法。申请时间：2021-11-11，中国, 申请号：CN202111334266.6，。

10. ROBINSON, Clive; ZHANG, Jihui; GARROD, David, Ronald; PERRIOR, Trevor, Robert; NEWTON, Gary, Karl; JENKINS, Kerry; BEEVERS, Rebekah, Elisabeth; MAJOR, Meriel, Ruth; STEWART, Mark, Richard. Pyruvamide compounds as inhibitors of dust mite group 1 peptidase allergen and their use. International No. PCT/GB2011/000079; 2011-07-18。WO/2011/089396

著作

1. Jihui Zhang, Clive Robinson. Chapter 14: Novel Method for the Purification of House Dust Mite Allergen Der p 1 and Its Use in Structure-Based Chemical Design of Novel Inhibitors. In: Lympany P., Jones M. (eds) Allergy. Methods in Molecular Biology. ISSN 1940-6029, ISBN978-1-4939-9591-2. Humana, New York, NY. Vol (2020). 2019.06.09. 185-205.

2. 张集慧，郭顺星. 参编《药用植物内生真菌生物学》/郭顺星编著，第38章 “促进金线莲生长的粘帚霉属内生真菌的代谢产物”。科学出版社，ISBN 978-7-03-047685-2. 2016, 786-805.

3. Clive Robinson, Jihui Zhang and Geoffrey A. Stewart. Interactions between Allergens and the Airway Epithelium. ‘The Pulmonary Epithelium in Health and Disease’ D. Proud. Publisher, Wiley. 2008.

4. Geoffrey A. Stewart, Jihui Zhang and C. Robinson. The structure and function of allergens. In:‘Middleton’s Allergy Principles and Practice’ 7th Edition, Chapter 35, volume 2 pp35.1-35.36. Philadelphia, 2008.

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