基本信息
殷诺雅  女  硕导  中国科学院生态环境研究中心
电子邮件: nyyin@rcees.ac.cn
通信地址: 北京市海淀区双清路18号
邮政编码:

招生信息

   
招生专业
083001-环境科学
071008-发育生物学
071009-细胞生物学
招生方向
干细胞毒理学,环境科学
干细胞生物学
环境污染物的健康效应评估

教育背景

2009-07--2015-01   中国科学院大学   博士
2005-09--2009-06   北京大学   学士

工作经历

   
工作简历
2009-07~2015-01,中国科学院大学, 博士
2005-09~2009-06,北京大学, 学士

教授课程

干细胞毒理学

专利与奖励

   
专利成果
( 1 ) 诱导人多能干细胞分化为肺泡细胞或肺泡类器官的培养基及方法, 2021, 第 3 作者, 专利号: CN113215080A

( 2 ) 一种肝脏类器官模型及其建立方法和应用, 2019, 第 3 作者, 专利号: CN110373380A

( 3 ) 一种筛选和/或评价物质的方法及其应用, 2019, 第 3 作者, 专利号: CN110031613A

( 4 ) 一种微孔模具, 2019, 第 3 作者, 专利号: CN208914398U

出版信息

   
发表论文
(1) Understanding the Effects of Per- and Polyfluoroalkyl Substances on Early Skin Development: Role of Ciliogenesis Inhibition and Altered Microtubule Dynamics, Science of the Total Environment, 2024, 
(2) Advancing Environmental Toxicology In Vitro: From Immortalized Cancer Cell Lines to 3D Models Derived from Stem Cells, Environment & Health, 2024, 
(3) Assessing developmental neurotoxicity of emerging environmental chemicals using multiple in vitro models: A comparative analysis, Environmental Pollution, 2024, 
(4) Development of a simplified human embryonic stem cell-based retinal pre-organoid model for toxicity evaluations of common pollutants, Cutaneous and Ocular Toxicology, 2023, 
(5) Developmental toxicity assessments for TBBPA and its commonly used analogs with a human embryonic stem cell liver differentiation model, CHEMOSPHERE, 2023, 第 11 作者
(6) Tox21-Based Comparative Analyses for the Identification of Potential Toxic Effects of Environmental Pollutants, Environmental Science & Technology, 2022, 第 3 作者
(7) Environmentally relevant exposure to TBBPA and its analogues may not drastically affect human early cardiac development, ENVIRONMENTAL POLLUTION, 2022, 第 11 作者
(8) TBBPA, TBBPS, and TCBPA disrupt hESC hepatic differentiation and promote the proliferation of differentiated cells partly via up-regulation of the FGF10 signaling pathway, JOURNAL OF HAZARDOUS MATERIALS, 2021, 第 4 作者
(9) Development of Human Lung Induction Models for Air Pollutants' Toxicity Assessment, ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2021, 第 10 作者
(10) Evaluation of the effects of low nanomolar bisphenol A-like compounds��� levels on early human embryonic development and lipid metabolism with human embryonic stem cell in vitro differentiation models, JOURNAL OF HAZARDOUS MATERIALS, 2021, 第 11 作者
(11) 皮肤中原代黑色素细胞和角质形成细胞同时分离法及其在超细颗粒物毒性效应评价中的应用, Isolation of Primary Human Foreskin Melanocytes/Keratinocytes for Ultrafine Particles' Toxicity Evaluations, 生态毒理学报, 2020, 第 2 作者
(12) 核苷(酸)类似物在妊娠期乙型肝炎患者中的安全性研究进展, The safety research progress of nucleoside/nucleotide analogues used in HBV-infected pregnant women, 中国药物应用与监测, 2020, 第 2 作者
(13) A human embryonic stem cell-based in vitro model revealed that ultrafine carbon particles may cause skin inflammation and psoriasis, A human embryonic stem cell-based in vitro model revealed that ultrafine carbon particles may cause skin inflammation and psoriasis, JOURNAL OF ENVIRONMENTAL SCIENCES, 2020, 第 4 作者
(14) Tetrabromobisphenol A(TBBPA): A controversial environmental pollutant, Tetrabromobisphenol A (TBBPA): A controversial environmental pollutant, JOURNAL OF ENVIRONMENTAL SCIENCES, 2020, 第 2 作者
(15) Silver nanoparticles (AgNPs) and AgNO3 perturb the specification of human hepatocyte-like cells and cardiomyocytes, SCIENCE OF THE TOTAL ENVIRONMENT, 2020, 第 11 作者
(16) A human embryonic syem cell-based in vitro model revealed that ultrafine carbon particles may cause skin inflammation and psoriasis, Journal of Environmental Sciences (China), 2020, 第 1 作者
(17) 人多能干细胞在环境污染物风险评估中的应用与展望, Application and Prospect of Human Pluripotent Stem Cells in Risk Assessment of Environmental Pollutants, 生态毒理学报, 2020, 第 4 作者
(18) 药店药师药学服务质量能力提升需求调研及培训探索, Survey on the Demands and Training of Improving Pharmaceutical Care of Pharmacists Worked in Retail Pharmacies, 中国药业, 2020, 第 6 作者
(19) Bisphenol A and several derivatives exert neural toxicity in human neuron-like cells by decreasing neurite length, FOOD AND CHEMICAL TOXICOLOGY, 2020, 第 2 作者
(20) The short-chain perfluorinated compounds PFBS,PFHxS, PFBA and PFHxA, disrupt human mesenchymal stem cell self-renewal and adipogenic differentiation, The short-chain perfluorinated compounds PFBS, PFHxS, PFBA and PFHxA, disrupt human mesenchymal stem cell self-renewal and adipogenic differentiation, JOURNAL OF ENVIRONMENTAL SCIENCES, 2020, 第 3 作者
(21) Effects of per- and poly-fluorinated alkyl substances on pancreatic and endocrine differentiation of human pluripotent stem cells, CHEMOSPHERE, 2020, 第 3 作者
(22) Non-cytotoxic silver nanoparticle levels perturb human embryonic stem cell-dependent specification of the cranial placode in part via FGF signaling, JOURNAL OF HAZARDOUS MATERIALS, 2020, 第 11 作者
(23) Silver nanoparticles (AgNPs) and AgNO3 perturb the specification of human hepatocyte-like cells and cardiomycytes, Science of the Total Environment, 2020, 第 11 作者
(24) F���53B and PFOS treatments skew human embryonic stem cell invitro cardiac differentiation towards epicardial cells by partly disrupting the WNT signaling pathway, ENVIRONMENTAL POLLUTION, 2020, 第 4 作者
(25) Establishment of a human embryonic stem cell-based liver differentiation model for hepatotoxicity evaluations, ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2019, 第 3 作者
(26) Embryonic stem cell- and transcriptomics-based in vitro analyses reveal that bisphenols A, F and S have similar and very complex potential developmental toxicities, ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2019, 第 1 作者
(27) 5-fluorouracil-induced neurotoxicity in rat cerebellum granule cells involves oxidative stress and activation of caspase-3 pathway, INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2019, 第 2 作者
(28) Typical halogenated flame retardants affect human neural stem cell gene expression during proliferation and differentiation via glycogen synthase kinase 3 beta and T3 signaling, ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2019, 第 4 作者
(29) Toxicogenomic analyses of the effects of BDE-47/209, TBBPA/S and TCBPA on early neural development with a human embryonic stem cell in vitro differentiation system, TOXICOLOGY AND APPLIED PHARMACOLOGY, 2019, 第 3 作者
(30) Assessment of the carcinogenic effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin using mouse embryonic stem cells to form teratoma in vivo, TOXICOLOGY LETTERS, 2019, 第 5 作者
(31) 北京市5家“三甲”医院周边零售药店的分布、药品供给和执业药师配备情况调研, Study on the Distribution,Drug Supply and Quantity of Licensed Pharmacists in Retail Pharmacies around 5 Third Grade Class A Hospitals from Beijing, 中国药房, 2019, 第 5 作者
(32) Human Pluripotent Stem Cells as Tools for Predicting Developmental Neural Toxicity of Chemicals: Strategies, Applications, and Challenges, STEM CELLS AND DEVELOPMENT, 2019, 第 2 作者
(33) Embryoid body-based RNA-seq analyses reveal a potential TBBPA multifaceted developmental toxicity, JOURNAL OF HAZARDOUS MATERIALS, 2019, 第 3 作者
(34) Environmental and human relevant PFOS and PFOA doses alter human mesenchymal stem cell self-renewal, adipogenesis and osteogenesis, ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2019, 第 3 作者
(35) New insights into mechanism of bisphenol analogue neurotoxicity: implications of inhibition of O-GlcNAcase activity in PC12 cells, ARCHIVES OF TOXICOLOGY, 2019, 第 3 作者
(36) Typical halogenated ���ame retardants a���ect human neural stem cell gene expression during proliferation and di���erentiation via glycogen synthase kinase 3 beta and T3 signaling, Ecotoxicology and Environmental Safety, 2019, 第 1 作者
(37) 人胚胎干细胞在药物毒性风险评估中的研究进展, Research progress on human embryonic stem cells in drug-induced toxicity, 现代药物与临床, 2019, 第 6 作者
(38) TBBPA and Its Alternatives Disturb the Early Stages of Neural Development by Interfering with the NOTCH and WNT Pathways, ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2018, 第 1 作者
(39) Non-cytotoxic nanomolar concentrations of bisphenol A induce human mesenchymal stem cell adipogenesis and osteogenesis, ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2018, 第 4 作者
(40) 干细胞毒理学在大气污染健康风险评估中的应用, The application of stem cell toxicology in the health risk assessments of atmospheric pollution, 中国科学:化学, 2018, 第 2 作者
(41) Pfoa and pfos disrupt the generation of human pancreatic progenitor cells, ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS, 2018, 第 2 作者
(42) Response to Comment on "TBBPA and its alternatives disturb the early stages of neural development by interfering with the NOTCH and WNT pathways", ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2018, 第 1 作者
(43) Bisphenol F Disrupts Thyroid Hormone Signaling and Postembryonic Development in Xenopus laevis, ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2018, 第 4 作者
(44) DEP and DBP induce cytotoxicity in mouse embryonic stem cells and abnormally enhance neural ectoderm development, ENVIRONMENTAL POLLUTION, 2018, 第 1 作者
(45) Evaluation of the early developmental neural toxicity of F-53B, as compared to PFOS, with an invitro mouse stem cell differentiation model, CHEMOSPHERE, 2018, 第 1 作者
(46) Assessment of the developmental neurotoxicity of silver nanoparticles and silver ions with mouse embryonic stem cells in vitro, Journal of Interdisciplinary Nanomedicine, 2018, 
(47) Prospects and frontiers of stem cell toxicology, STEM CELLS AND DEVELOPMENT, 2017, 第 2 作者
(48) Silver nanoparticles induced neurotoxicity through oxidative stress in rat cerebral astrocytes is distinct from the effects of silver ions, NEUROTOXICOLOGY, 2016, 第 2 作者
(49) Stem cell toxicology: a powerful tool to assess pollution effects on human health, NATIONAL SCIENCE REVIEW, 2016, 第 2 作者
(50) 基于干细胞毒理学研究双酚A污染物的健康效应, 中国毒理学会第七次全国毒理学大会暨第八届湖北科技论坛, 2015, 第 2 作者
(51) Vitamin E attenuates silver nanoparticle-induced effects on body weight and neurotoxicity in rats, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2015, 第 1 作者
(52) Assessment of Bisphenol A (BPA) neurotoxicity in vitro with mouse embryonic stem cells, JOURNAL OF ENVIRONMENTAL SCIENCES-CHINA, 2015, 第 1 作者
(53) Assessment of Bisphenol A (BPA) neurotoxicity in vitro with mouse embryonic stem cells, JOURNAL OF ENVIRONMENTAL SCIENCES, 2015, 第 1 作者
(54) The Rise of Stem Cell Toxicology, ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2015, 第 2 作者
(55) Silver nanoparticle exposure induces rat motor dysfunction through decrease in expression of calcium channel protein in cerebellum, TOXICOLOGY LETTERS, 2015, 第 1 作者
(56) 纳米银的脑神经毒性效应研究, 第八届全国分析毒理学大会暨中国毒理学会分析毒理专业委员会第五届会员代表大会, 2014, 第 1 作者
(57) 基于表面调控的纳米银生物毒性研究, 第八届全国分析毒理学大会暨中国毒理学会分析毒理专业委员会第五届会员代表大会, 2014, 第 2 作者
(58) 四溴双酚-A衍生物神经毒性效应筛选与毒性机制研究, 第十届全国生物医药色谱及相关技术学术交流会, 2014, 第 2 作者
(59) Effects of polycyclic musks HHCB and AHTN on steroidogenesis in H295R cells, CHEMOSPHERE, 2013, 第 2 作者
(60) The ex vivo and in vivo biological performances of graphene oxide and the impact of surfactant on graphene oxide���s biocompatibility., JOURNAL OF ENVIRONMENTAL SCIENCES-CHINA, 2013, 第 5 作者
(61) The ex vivo and in vivo biological performances of graphene oxide and the impact of surfactant on graphene oxide���s biocompatibility, JOURNAL OF ENVIRONMENTAL SCIENCES, 2013, 第 5 作者
(62) Graphene Oxide Induces Toll-like Receptor 4 (TLR4)-Dependent Necrosis in Macrophages, ACS NANO, 2013, 第 7 作者
(63) 纳米银抗菌活性的调控研究, 第七届全国环境化学学术大会, 2013, 第 2 作者
(64) Effects of polycyclic musks HHCB and AHTN on steroidogenesis in H295R cells, CHEMOSPHERE, 2013, 第 2 作者
(65) Estrogen-like response of perfluorooctyl iodide in male medaka (Oryzias latipes) based on hepatic vitellogenin induction, ENVIRONMENTAL TOXICOLOGY, 2013, 第 4 作者
(66) 含朱砂中成药对大鼠肾脏氧化应激的影响, 第七届全国环境化学学术大会, 2013, 第 2 作者
(67) 细胞色素c在氧化石墨烯上的吸附研究, Study on the Adsorption of Cytochrome c on Graphene Oxide, 分析测试学报, 2012, 第 2 作者
(68) 纳米银的脑神经细胞毒理学研究, 第六届全国环境化学学术大会论文集, 2011, 第 1 作者

科研活动

   
科研项目
( 1 ) 基于人胚胎干细胞分化模型研究全氟类化合物的心脏毒性, 负责人, 国家任务, 2020-01--2023-12
( 2 ) 基于胚胎干细胞研究双酚A及其替代物在神经发育过程中对轴突导向的影响, 负责人, 国家任务, 2018-01--2020-12