071008-发育生物学

胚胎干细胞，多能性

2003-09--2006-07   北京大学   博士

   

干细胞生物学
胚胎工程

   

（1） NSun2-Mediated tsRNAs Alleviate Liver Fibrosis via FAK Dephosphorylation, CELL PROLIFERATION, 2025, 第 13 作者  通讯作者
（2） Discovering human cell-compatible gene therapy virus variants via optimized screening in mouse models, CELL PROLIFERATION, 2024, 第 6 作者
（3） Deciphering the placental abnormalities associated with somatic cell nuclear transfer at single-nucleus resolution, PROTEIN & CELL, 2023, 第 9 作者
（4） tRF-Gln-CTG-026 ameliorates liver injury by alleviating global protein synthesis, SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2023, 第 12 作者  通讯作者
（5） Targeting non-muscle myosin II inhibits proliferative vitreoretinopathy through regulating epithelial-mesenchymal transition, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2023, 第 8 作者  通讯作者
（6） Live-cell imaging reveals redox metabolic reprogramming during zygotic genome activation, JOURNAL OF CELLULAR PHYSIOLOGY, 2023, 第 9 作者
（7） CDetection.v2: One-pot assay for the detection of SARS-CoV-2, FRONTIERS IN MICROBIOLOGY, 2023, 第 16 作者
（8） Influence of feeder cells on transcriptomic analysis of pluripotent stem cells, CELL PROLIFERATION, 2022, 第 7 作者
（9） Generation of immunodeficient pig with hereditary tyrosinemia type 1 and their preliminary application for humanized liver, CELL AND BIOSCIENCE, 2022, 第 10 作者
（10） Rational engineering of adeno-associated virus capsid enhances human hepatocyte tropism and reduces immunogenicity, Cell Proliferation, 2022, 第 8 作者
（11） Pharmacological regulation of tissue fibrosis by targeting the mechanical contraction of myofibroblasts, FUNDAMENTAL RESEARCH, 2022, 第 8 作者  通讯作者
（12） Pharmacological Perturbation of Mechanical Contractility Enables Robust Transdifferentiation of Human Fibroblasts into Neurons, ADVANCED SCIENCE, 2022, 第 8 作者
（13） Enhancing targeted transgene knock-in by donor recruitment, CELL PROLIFERATION, 2021, 第 5 作者  通讯作者
（14） TRANSCRIPTOME AND DNA METHYLATION PROFILES OF MOUSE FETUS AND PLACENTA GENERATED BY ROUND SPERMATID INJECTION, FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2021, 第 7 作者
（15） CONTINUOUS EXPRESSION OF REPROGRAMMING FACTORS INDUCES AND MAINTAINS MOUSE PLURIPOTENCY WITHOUT SPECIFIC GROWTH FACTORS AND SIGNALING INHIBITORS, CELL PROLIFERATION, 2021, 第 9 作者  通讯作者
（16） Transcriptional repression of p21 by EIF1AX promotes the proliferation of breast cancer cells, CELL PROLIFERATION, 2020, 第 5 作者  通讯作者
（17） Domesticated cynomolgus monkey embryonic stem cells allow the generation of neonatal interspecies chimeric pigs, PROTEIN & CELL, 2020, 第 11 作者
（18） IL2RG-deficient minipigs generated via CRISPR/Cas9 technology support the growth of human melanoma-derived tumours, CELL PROLIFERATION, 2020, 第 9 作者
（19） Treating Bietti crystalline dystrophy in a high-fat diet-exacerbated murine model using gene therapy, GENE THERAPY, 2020, 第 10 作者
（20） Rapid construction of a whole-genome mutant library by combining haploid stem cells and inducible self-inactivating PiggyBac transposon, Rapid construction of a whole-genome mutant library by combining haploid stem cells and inducible self-inactivating PiggyBac transposon, PROTEIN & CELL, 2020, 第 5 作者  通讯作者
（21） Rbm14 maintains the integrity of genomic DNA during early mouse embryogenesis via mediating alternative splicing, CELL PROLIFERATION, 2020, 第 8 作者  通讯作者
（22） Generation of qualified clinical-grade functional hepatocytes from human embryonic stem cells in chemically defined conditions, Cell Death and Disease, 2019, 第 8 作者
（23） The effect of clinical-grade retinal pigment epithelium derived from human embryonic stem cells using different transplantation strategies, PROTEIN & CELL, 2019, 第 10 作者
（24） Dynamic methylome of internal mRNA N7-methylguanosine and its regulatory role in translation, Cell Research, 2019, 第 4 作者
（25） Generation of qualified clinical-grade functional hepatocytes from human embryonic stem cells in chemically defined conditions, CELL DEATH & DISEASE, 2019, 第 8 作者
（26） Cyclin B3 is required for metaphase to anaphase transition in oocyte meiosis I, JOURNAL OF CELL BIOLOGY, 2019, 第 15 作者  通讯作者
（27） Mitochondrial Dynamics Is Critical for the Full Pluripotency and Embryonic Developmental Potential of Pluripotent Stem Cells, CELL METABOLISM, 2019, 第 9 作者
（28） Reprogramming of fibroblasts to uterine glandular epithelium by a chemical cocktail induction, CELL DISCOVERY, 2019, 第 8 作者  通讯作者
（29） MeCP2 deficiency promotes cell reprogramming by stimulating IGF1/AKT/mTOR signaling and activating ribosomal protein-mediated cell cycle gene translation, JOURNALOFMOLECULARCELLBIOLOGY, 2018, 第 7 作者  通讯作者
（30） RBM14 is indispensable for pluripotency maintenance and mesoderm development of mouse embryonic stem cells, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2018, 第 8 作者  通讯作者
（31） MicroRNA-494 promotes cancer progression and targets adenomatous polyposis coli in colorectal cancer, MOLECULAR CANCER, 2018, 第 1 作者
（32） A fully defined static suspension culture system for large-scale human embryonic stem cell production, CELL DEATH & DISEASE, 2018, 第 6 作者
（33） Generation of Bimaternal and Bipaternal Mice from Hypomethylated Haploid ESCs with Imprinting Region Deletions, CELL STEM CELL, 2018, 第 10 作者
（34） Generation of clinical-grade functional cardiomyocytes from human embryonic stem cells in chemically defined conditions, JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 2018, 第 9 作者
（35） Mitochondrially produced ATP affects stem cell pluripotency via ActI6a-mediated histone acetylation, FASEB JOURNAL, 2018, 第 1 作者
（36） A single-cell snapshot of cell-fate decisions, JOURNAL OF BIOLOGICAL CHEMISTRY, 2017, 第 1 作者
（37） Generation of Mouse Haploid Somatic Cells by Small Molecules for Genome-Wide Genetic Screening, CELL REPORTS, 2017, 第 14 作者
（38） 单倍体胚胎干细胞的获得与应用前景, The establishment and prospect of haploid embryonic stem cells, 生命科学, 2017, 第 1 作者
（39） EF Hand Protein IBA2 Promotes Cell Proliferation in Breast Cancers via Transcriptional Control of Cyclin D1, CANCER RESEARCH, 2016, 第 1 作者  通讯作者
（40） 人类胚胎基因编辑——科学与伦理, Human Embryo Gene Editing������Science and Ethics, 科学与社会, 2016, 第 2 作者
（41） Ubiquitously Expressed Genes Participate in Cell-Specific Functions via Alternative Promoter Usage, EMBO REPORTS, 2016, 第 8 作者
（42） m(6)A RNA methylation is regulated by microRNAs and promotes reprogramming to pluripotency, CELL STEM CELL, 2015, 第 3 作者
（43） MicroRNA-323-3p Regulates the Activity of Polycomb Repressive Complex 2 (PRC2) via Targeting the mRNA of Embryonic Ectoderm Development (Eed) Gene in Mouse Embryonic Stem Cells, JOURNAL OF BIOLOGICAL CHEMISTRY, 2013, 第 1 作者
（44） Identification of a Small Molecule 1,4-bis-4-(3-Phenoxy-Propoxy)-but-2-Ynyl-Piperazine as a Novel Inhibitor of the Transcription Factor p53, ACTA PHARMACOLOGICA SINICA, 2013, 第 2 作者
（45） iPS cells generated without c-Myc have active Dlk1-Dio3 region and are capable of producing full-term mice through tetraploid complementation, CELL RESEARCH, 2011, 第 4 作者