基本信息
张映  女  硕导  中国科学院动物研究所
电子邮件: yingzhang@ioz.ac.cn
通信地址: 中科院动物所西区725
邮政编码:

招生信息

   
招生专业
071008-发育生物学
招生方向
胚胎干细胞,多能性

教育背景

2003-09--2006-07   北京大学   博士

工作经历

   
工作简历
2019-02~现在, 中国科学院动物研究所, 副研究员
2010-08~2019-02,中国科学院动物研究所, 助理研究员
2008-04~2010-08,北京大学, 博士后
2003-09~2006-07,北京大学, 博士

教授课程

干细胞生物学
胚胎工程

专利与奖励

   
奖励信息
(1) 干细胞多能性调控机理与转化研究集体奖, 院级, 2013
专利成果
( 1 ) 一种将成纤维细胞转分化为腺上皮细胞的方法及其培养体系和应用, 2020, 第 5 作者, 专利号: CN111718890A

( 2 ) miRNA对m 6 A修饰水平的调控方法及其应用, 2017, 第 5 作者, 专利号: CN107207557A

( 3 ) 无损检测细胞miRNA的表达量及确定细胞类型与状态的方法, 2014, 第 3 作者, 专利号: CN103571929A

出版信息

   
发表论文
(1) Influence of feeder cells on transcriptomic analysis of pluripotent stem cells, CELL PROLIFERATION, 2022, 第 7 作者
(2) Generation of immunodeficient pig with hereditary tyrosinemia type 1 and their preliminary application for humanized liver, CELL AND BIOSCIENCE, 2022, 第 10 作者
(3) Pharmacological regulation of tissue fibrosis by targeting the mechanical contraction of myofibroblasts, Fundamental Research, 2022, 通讯作者
(4) Pharmacological Perturbation of Mechanical Contractility Enables Robust Transdifferentiation of Human Fibroblasts into Neurons, ADVANCED SCIENCE, 2022, 第 8 作者
(5) Enhancing targeted transgene knock-in by donor recruitment, CELL PROLIFERATION, 2021, 通讯作者
(6) Transcriptome and DNA Methylation Profiles of Mouse Fetus and Placenta Generated by Round Spermatid Injection, FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2021, 第 7 作者
(7) Continuous expression of reprogramming factors induces and maintains mouse pluripotency without specific growth factors and signaling inhibitors, CELL PROLIFERATION, 2021, 通讯作者
(8) Rbm14 maintains the integrity of genomic DNA during early mouse embryogenesis via mediating alternative splicing, CELL PROLIFERATION, 2020, 通讯作者
(9) Rapid construction of a whole-genome mutant library by combining haploid stem cells and inducible self-inactivating PiggyBac transposon, Rapid construction of a whole-genome mutant library by combining haploid stem cells and inducible self-inactivating PiggyBac transposon, PROTEIN & CELL, 2020, 通讯作者
(10) Transcriptional repression of p21 by EIF1AX promotes the proliferation of breast cancer cells, CELL PROLIFERATION, 2020, 通讯作者
(11) Domesticated cynomolgus monkey embryonic stem cells allow the generation of neonatal interspecies chimeric pigs, PROTEIN & CELL, 2020, 第11作者
(12) IL2RG-deficient minipigs generated via CRISPR/Cas9 technology support the growth of human melanoma-derived tumours, CELL PROLIFERATION, 2020, 第 9 作者
(13) Treating Bietti crystalline dystrophy in a high-fat diet-exacerbated murine model using gene therapy, GENE THERAPY, 2020, 第 10 作者
(14) The effect of clinical-grade retinal pigment epithelium derived from human embryonic stem cells using different transplantation strategies, PROTEIN & CELL, 2019, 第 10 作者
(15) Dynamic methylome of internal mRNA N-7-methylguanosine and its regulatory role in translation, CELL RESEARCH, 2019, 第 4 作者
(16) Generation of qualified clinical-grade functional hepatocytes from human embryonic stem cells in chemically defined conditions, CELL DEATH & DISEASE, 2019, 第 8 作者
(17) Cyclin B3 is required for metaphase to anaphase transition in oocyte meiosis I, JOURNAL OF CELL BIOLOGY, 2019, 通讯作者
(18) The effect of clinical-grade retinal pigment epithelium derived from human embryonic stem cells using different transplantation strategies, The effect of clinical-grade retinal pigment epithelium derived from human embryonic stem cells using different transplantation strategies, 蛋白质与细胞:英文版, 2019, 第 10 作者
(19) Mitochondrial Dynamics Is Critical for the Full Pluripotency and Embryonic Developmental Potential of Pluripotent Stem Cells, CELL METABOLISM, 2019, 第 9 作者
(20) Reprogramming of fibroblasts to uterine glandular epithelium by a chemical cocktail induction, CELL DISCOVERY, 2019, 通讯作者
(21) Cyclin B3 is required for metaphase to anaphase transition in oocyte meiosis I, The Journal of Cell Biology, 2019, 通讯作者
(22) Mitochondrially produced ATP affects stem cell pluripotency via Actl6a-mediated histone acetylation, FASEB J, 2018, 
(23) MeCP2 deficiency promotes cell reprogramming by stimulating IGF1/AKT/mTOR signaling and activating ribosomal protein-mediated cell cycle gene translation, JOURNAL OF MOLECULAR CELL BIOLOGY, 2018, 通讯作者
(24) RBM14 is indispensable for pluripotency maintenance and mesoderm development of mouse embryonic stem cells, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2018, 通讯作者
(25) MicroRNA-494 promotes cancer progression and targets adenomatous polyposis coli in colorectal cancer, MOLECULAR CANCER, 2018, 第 1 作者
(26) A fully defined static suspension culture system for large-scale human embryonic stem cell production, CELL DEATH & DISEASE, 2018, 第 6 作者
(27) Generation of Bimaternal and Bipaternal Mice from Hypomethylated Haploid ESCs with Imprinting Region Deletions, CELL STEM CELL, 2018, 第 10 作者
(28) Generation of clinical-grade functional cardiomyocytes from human embryonic stem cells in chemically defined conditions, JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 2018, 第 9 作者
(29) Mitochondrially produced ATP affects stem cell pluripotency via ActI6a-mediated histone acetylation, FASEB JOURNAL, 2018, 第 1 作者
(30) A single-cell snapshot of cell-fate decisions, JOURNAL OF BIOLOGICAL CHEMISTRY, 2017, 第 1 作者
(31) Generation of Mouse Haploid Somatic Cells by Small Molecules for Genome-Wide Genetic Screening, CELL REPORTS, 2017, 第 14 作者
(32) 单倍体胚胎干细胞的获得与应用前景, The establishment and prospect of haploid embryonic stem cells, 生命科学, 2017, 第 1 作者
(33) EF Hand Protein IBA2 Promotes Cell Proliferation in Breast Cancers via Transcriptional Control of Cyclin D1, CANCER RESEARCH, 2016, 通讯作者
(34) m6A RNA甲基化由microRNA调控并且促进细胞向多能性状态的重编程转变, 科学新闻, 2016, 第 3 作者
(35) 人类胚胎基因编辑——科学与伦理, Human Embryo Gene Editing——Science and Ethics, 科学与社会, 2016, 第 2 作者
(36) Ubiquitously Expressed Genes Participate in Cell-Specific Functions via Alternative Promoter Usage, EMBO REPORTS, 2016, 第 8 作者
(37) MicroRNA-323-3p Regulates the Activity of Polycomb Repressive Complex 2 (PRC2) via Targeting the mRNA of Embryonic Ectoderm Development (Eed) Gene in Mouse Embryonic Stem Cells, JOURNAL OF BIOLOGICAL CHEMISTRY, 2013, 第 1 作者
(38) Identification of a Small Molecule 1,4-bis-4-(3-Phenoxy-Propoxy)-but-2-Ynyl-Piperazine as a Novel Inhibitor of the Transcription Factor p53, ACTA PHARMACOLOGICA SINICA, 2013, 第 2 作者
(39) iPS cells generated without c-Myc have active Dlk1-Dio3 region and are capable of producing full-term mice through tetraploid complementation, iPS cells generated without c-Myc have active Dlk1-Dio3 region and are capable of producing full-term mice through tetraploid complementation, 细胞研究:英文版, 2011, 第 4 作者
(40) iPS cells generated without c-Myc have active Dlkl-Dio3 region and are capable of producing full-term mice through tetraploid complementation, Cell Research, 2011, 第 4 作者
(41) iPS cells generated without c-Myc have active Dlk1-Dio3 region and are capable of producing full-term mice through tetraploid complementation, CELL RESEARCH, 2011, 第 4 作者

科研活动

   
科研项目
( 1 ) EIF1AX在乳腺癌中的作用及机制研究, 负责人, 国家任务, 2020-01--2023-12
( 2 ) 单基因遗传病的基因治疗研究, 参与, 国家任务, 2019-10--2023-12
( 3 ) 获得性性状的生殖传递机制, 参与, 国家任务, 2018-12--2021-12
参与会议
(1)m6A RNA Methylation Is Regulated by MicroRNAs and Promotes Reprogramming to Pluripotency    2015-06-24