基本信息
蔡潭溪  男    中国科学院生物物理研究所
电子邮件: txcai@moon.ibp.ac.cn
通信地址: 北京市朝阳区大屯路15号8115室
邮政编码: 100101

招生信息

   
招生专业
071010-生物化学与分子生物学
招生方向
蛋白质组学、脂质组学

教育背景

2011-09--2015-01   中国科学院大学   博士学位
1999-09--2006-06   南京农业大学   学士,硕士学位

工作经历

   
工作简历
2015-01~现在, 中国科学院生物物理研究所, 副研究员
2011-09~2015-01,中国科学院大学, 博士学位
2006-07~2014-12,中国科学生物物理研究所, 助理研究员
1999-09~2006-06,南京农业大学, 学士,硕士学位

教授课程

生物技术药物
分析生物化学及样品制备
生命科学研究中的色谱、质谱和组学技术
ABSP lab exercise
生物样品分离与质谱鉴定技术

专利与奖励

   
奖励信息
(1) 中国科学院宝洁优秀研究生奖学金, 一等奖, 院级, 2015
(2) 第12届全国脂质与脂蛋白学术会议“阳普”优秀论文奖, 二等奖, 专项, 2014
(3) 生物物理研究所2014年度所长论文奖, 一等奖, 研究所(学校), 2014
(4) 中国科学院三好学生, 一等奖, 院级, 2013
(5) 中国分析测试协会科学技术奖, 一等奖, 专项, 2011
专利成果
( 1 ) 一种用于富集内源性低分子量蛋白和多肽的试剂盒及方法, 2021, 第 3 作者, 专利号: CN112014198B

( 2 ) 一种脑胶质瘤的生物标志物及其应用, 2021, 第 2 作者, 专利号: CN113533728A

( 3 ) 一种基于稳定同位素标记的磷脂分类检测和定量方法, 2015, 第 1 作者, 专利号: CN105067697A

( 4 ) 一种基于化学衍生的磷脂分类检测和定量方法, 2015, 第 1 作者, 专利号: CN105021758A

( 5 ) 一种逆流色谱仪及其专用逆流色谱柱, 2012, 第 2 作者, 专利号: CN202166634U

( 6 ) 逆流色谱仪及其专用逆流色谱柱, 2011, 第 2 作者, 专利号: CN102175803A

出版信息

   
发表论文
(1) CrrAB regulates PagP-mediated glycerophosphoglycerol palmitoylation in the outer membrane of Klebsiella pneumoniae, Journal of Lipid Research, 2022, 第 3 作者
(2) Plasma proteome profiling combined with clinical and genetic features reveals the pathophysiological characteristics of β-thalassemia, iScience, 2022, 第 14 作者
(3) 血浆低分子量蛋白与多肽的研究进展, Advances in Plasma Low Molecular Weight Proteins and Peptides, 生物化学与生物物理进展, 2022, 第 2 作者
(4) Proteomics reveals the function reverse of MPSSS-treated prostate cancer-associated fibroblasts to suppress PC-3 cell viability via the FoxO pathway, CANCER MEDICINE, 2021, 第 5 作者
(5) Deeply Mining a Universe of Peptides Encoded by Long Noncoding RNAs, MOLECULAR & CELLULAR PROTEOMICS, 2021, 第 4 作者
(6) LncRNA-encoded microproteins: A new form of cargo in cell culture-derived and circulating extracellular vesicles, JOURNAL OF EXTRACELLULAR VESICLES, 2021, 通讯作者
(7) Identification of histone malonylation in the human fetal brain and implications for diabetes‐induced neural tube defects, MOLECULAR GENETICS & GENOMIC MEDICINE, 2020, 第 2 作者
(8) Large-scale Identification of N-linked Intact Glycopeptides in Human Serum using HILIC Enrichment and Spectral Library Search *, MOLECULAR & CELLULAR PROTEOMICS, 2020, 第 8 作者
(9) Sequential Precipitation and Delipidation Enables Efficient Enrichment of Low-Molecular Weight Proteins and Peptides from Human Plasma, JOURNAL OF PROTEOME RESEARCH, 2020, 通讯作者
(10) Proteomic Changes of Klebsiella pneumoniae in Response to Colistin Treatment and crrB Mutation-Mediated Colistin Resistance, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2020, 第 5 作者
(11) Separation and characterization of extracellular vesicles from human plasma by asymmetrical flow field-flow fractionation, ANALYTICA CHIMICA ACTA, 2020, 第 10 作者
(12) Comprehensive characterization and proteoform analysis of the hydrophobic surfactant proteins B and C in calf pulmonary surfactant, JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2019, 第 5 作者
(13) Phospholipid and Phospholipidomics in Health and Diseases, Phospholipid and Phospholipidomics in Health and Diseases, 2018, 第 1 作者
(14) SmProt: a database of small proteins encoded by annotated coding and non-coding RNA loci, BRIEFINGS IN BIOINFORMATICS, 2018, 第 4 作者
(15) Strategies for Characterization of Low-Abundant Intact or Truncated Low-Molecular-Weight Proteins From Human Plasma, The Enzymes, 2017, 第 1 作者
(16) SmProt: a database of small proteins encoded by annotated coding and non-coding RNA loci., Brief Bioinform., 2017, 
(17) CD146 coordinates brain endothelial cell-pericyte communication for blood-brain barrier development, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, 第 4 作者
(18) MicroRNA-202 maintains spermatogonial stem cells by inhibiting cell cycle regulators and RNA binding proteins, NUCLEIC ACIDS RESEARCH, 2017, 第 2 作者
(19) Macrophage Foam Cell-Derived Extracellular Vesicles Promote Vascular Smooth Muscle Cell Migration and Adhesion, JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2016, 第 4 作者
(20) Prediction of Protein Lysine Acylation by Integrating Primary Sequence Information with Multiple Functional Features, JOURNAL OF PROTEOME RESEARCH, 2016, 第 5 作者
(21) Characterization and relative quantification of phospholipids based on methylation and stable isotopic labeling, JOURNAL OF LIPID RESEARCH, 2016, 第 1 作者
(22) Pore architecture of TRIC channels and insights into their gating mechanism, NATURE, 2016, 第 5 作者
(23) Rapid Profiling and Relative Quantitation of Phosphoinositides by Multiple Precursor Ion Scanning Based on Phosphate Methylation and Isotopic Labeling, Anal. Chem, 2015, 第 1 作者
(24) Profiling and Relative Quantitation of Phosphoinositides by Multiple Precursor Ion Scanning Based on Phosphate Methylation and Isotopic Labeling, ANALYTICAL CHEMISTRY, 2015, 第 1 作者
(25) Proteomic Comparison and MRM-Based Comparative Analysis of Metabolites Reveal Metabolic Shift in Human Prostate Cancer Cell Lines, JOURNAL OF PROTEOME RESEARCH, 2015, 第 2 作者
(26) Lysine Malonylation Is Elevated in Type 2 Diabetic Mouse Models and Enriched in Metabolic Associated Proteins, MOLECULAR & CELLULAR PROTEOMICS, 2015, 第 2 作者
(27) Analysis of age and gender associated N -glycoproteome in human whole saliva, CLINICAL PROTEOMICS, 2014, 第 5 作者
(28) 脂蛋白质组学研究进展, The Research Advances in Lipoproteomics, PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2014, 第 3 作者
(29) Inactivation of Caenorhabditis elegans aminopeptidase DNPP-1 restores endocytic sorting and recycling in tat-1 mutants, MOLECULAR BIOLOGY OF THE CELL, 2013, 第 4 作者
(30) Chronic high glucose induced INS-1 beta cell mitochondrial dysfunction: A comparative mitochondrial proteome with SILAC, PROTEOMICS, 2013, 第 8 作者
(31) Integrative Proteomic and Transcriptomic Analyses Reveal Multiple Post-Transcriptional Regulatory Mechanisms of Mouse Spermatogenesis, MOLECULAR & CELLULAR PROTEOMICS, 2013, 第 2 作者
(32) Chronic high glucose-induced INS-1β cell mitochondrial dysfunction: a comparative mitochondrial proteome with SILAC, Proteomics, 2013, 第 7 作者
(33) Isolation and identification of mannose-binding proteins and estimation of their abundance in sera from hepatocellular carcinoma patients, PROTEOMICS, 2013, 
(34) Structural and functional insights into lipid-bound nerve growth factors, FASEB JOURNAL, 2012, 第 9 作者
(35) Purification, identification and profiling of serum amyloid A proteins from sera of advanced-stage cancer patients, Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences, 2012, 第 9 作者
(36) Preparative isolation of alkaloids from Corydalis bungeana Turcz. by high-speed counter-current chromatography using stepwise elution, JOURNAL OF SEPARATION SCIENCE, 2011, 第 3 作者
(37) Phosphoproteome Analysis of Rat L6 Myotubes Using Reversed-Phase C18 Prefractionation and Titanium Dioxide Enrichment, Journal of Proteome Research, 2010, 第 7 作者
(38) The Research Advances in The Field of Lipidomics, Progress in Biochemistry and Biophysics, 2010, 
(39) The Profile of Mitochondrial Proteins and Their Phosphorylation Signaling Network in INS-1 beta Cells, Journal of Proteome Research, 2010, 
(40) 脂质组学研究进展, The Research Advances in The Field of Lipidomics, 生物化学与生物物理进展, 2010, 第 1 作者
(41) Beta Cell Mitochondrial proteomics: from protein profile to protein phosphorylation, J Proteome Res,, 2010, 第 7 作者
(42) Enhanced MALDI-TOF MS Analysis of Phosphopeptides Using an Optimized DHAP DAHC Matrix, Journal of Biomedicine and Biotechnology, 2010, 第 7 作者
(43) Proteomic analysis of the mitochondria from C. elegans, Proteomics, Proteomics, 2009, 第 2 作者
(44) Proteomic analysis of mitochondria from Caenorhabditis elegans, Proteomics, 2009, 
(45) Discovery and identification of potential biomarkers of pediatric Acute Lymphoblastic Leukemia, Proteome Science, 2009, 第 8 作者

科研活动

   
科研项目
( 1 ) 高密度脂蛋白主要组成成分及其修饰的动态变化与糖尿病和冠心病之间的关联性研究, 负责人, 国家任务, 2017-01--2020-12
( 2 ) 基于中药复方抗糖尿病新靶标的发现, 参与, 中国科学院计划, 2016-01--2018-12
( 3 ) Study on the pathogenesis of obesity and type 2 diabetes mellitus (T2DM) using comparative lipoproteomics approach, 参与, 中国科学院计划, 2016-01--2016-12
参与会议
(1)Characterization and relative quantification of phospholipids based on methylation and stable isotopic labeling   2016-06-05
(2)Lysine malonylation is elevated in type 2 diabetic mouse models and enriched in metabolic associated proteins.   2015-07-06
(3)Comparative proteomics-based in silico analyzes further our understanding of mouse spermatogenesis and fertility   2014-06-04