基本信息
王磊  男  博导  中国科学院生物物理研究所
电子邮件: wanglei@ibp.ac.cn
通信地址: 北京市朝阳区大屯路15号
邮政编码: 100101

招生信息

   
招生专业
071010-生物化学与分子生物学
071009-细胞生物学
071011-生物物理学
招生方向
内质网应激与稳态
氧化还原调控
折叠酶与分子伴侣

教育背景

2004-09--2009-06   中国科学院生物物理研究所   博士
2000-09--2004-06   武汉大学生命科学学院生物学基地班   学士

工作经历

   
工作简历
2020-01~现在, 中国科学院生物物理研究所, 研究员
2012-01~2019-12,中国科学院生物物理研究所, 副研究员
2009-07~2011-12,中国科学院生物物理研究所, 助理研究员
社会兼职
2021-08-01-2025-08-01,中国生物物理学会亚细胞结构与功能分会, 副秘书长
2021-01-01-2023-12-31,中国科学院青年创新促进会, 优秀会员
2015-12-31-2019-12-30,中国科学院青年创新促进会, 会员
2014-12-31-2018-12-30,中国生理学会应激生理学专业委员会, 委员

教授课程

细胞生物学实验
生物物理学实验
生物活性小分子

专利与奖励

   
专利成果
[1] 王磊, 王璐, 王曦, 王志珍. 新型靶向Ero1α/PDI电子传递系统的小分子抑制剂. CN: CN114272379A, 2022-04-05.

出版信息

   
发表论文
[1] Zhu, Yinhua, Wang, Lu, Li, Jing, Zhao, Yuan, Yu, Xuerong, Liu, Ping, Deng, Xiaobing, Liu, Jingjing, Yang, Fan, Zhang, Yini, Yu, Jiaojiao, Lai, Luhua, Wang, Chu, Li, Zhanguo, Wang, Lei, Luo, Tuoping. Photoaffinity labeling coupled with proteomics identify PDI-ADAM17 module is targeted by (-)-vinigrol to induce TNFR1 shedding and ameliorate rheumatoid arthritis in mice. CELL CHEMICAL BIOLOGY[J]. 2024, 第 15 作者  通讯作者  31(3): http://dx.doi.org/10.1016/j.chembiol.2023.10.003.
[2] Cheng, Fang, Wang, Lei. Slowing down the central dogma rate for alleviating aging. The Innovation Life[J]. 2024, 第 2 作者  通讯作者  2(null): 100049, 
[3] Liu, Ping, Hu, Junjie, Wang, Lei. SARS-CoV-2 ORF8 does not function in the nucleus as a histone mimic. PROTEIN & CELL[J]. 2024, 第 3 作者  通讯作者  15(2): 79-82, http://lib.cqvip.com/Qikan/Article/Detail?id=7111862011.
[4] Wang, Lei, Wang, Chihchen. Oxidative protein folding fidelity and redoxtasis in the endoplasmic reticulum. TRENDS IN BIOCHEMICAL SCIENCES. 2023, 第 1 作者  通讯作者  48(1): 40-52, http://dx.doi.org/10.1016/j.tibs.2022.06.011.
[5] Sun, Yiwei, Wang, Xie, Yang, Xiaotong, Wang, Lei, Ding, Jingjin, Wang, Chihchen, Zhang, Hong, Wang, Xi. V-ATPase recruitment to ER exit sites switches COPII-mediated transport to lysosomal degradation. DEVELOPMENTAL CELL[J]. 2023, 第 4 作者58(23): 2761-+, http://dx.doi.org/10.1016/j.devcel.2023.10.007.
[6] Cheng, Fang, Ji, Qianzhao, Wang, Lu, Wang, Chihchen, Liu, GuangHui, Wang, Lei. Reducing oxidative protein folding alleviates senescence by minimizing ER-to-nucleus H2O2 release. EMBO REPORTS[J]. 2023, 第 6 作者  通讯作者  24(8): http://dx.doi.org/10.15252/embr.202256439.
[7] 胡昕炜, 王志珍, 王磊. “后AlphaFold时代”的蛋白质折叠问题. 科学通报[J]. 2023, 第 3 作者  通讯作者  68(22期): 2943-2950, 
[8] Yinhong Niu, Jiale Liao, Haitao Zhou, Chihchen Wang, Lei Wang, Yanli Fan. Flavonoids from Lycium barbarum Leaves Exhibit Anti-Aging Effects through the Redox-Modulation. MOLECULES[J]. 2022, 第 5 作者  通讯作者  27: 4952, https://doaj.org/article/2ec91872f191445e900c6908b4278d3f.
[9] Ping Liu, Xi Wang, Yiwei Sun, Hongyu Zhao, Fang Cheng, Jifeng Wang, Fuquan Yang, Junjie Hu, Hong Zhang, Chihchen Wang, Lei Wang. SARS-CoV-2 ORF8 reshapes the ER through forming mixed disulfides with ER oxidoreductases. REDOX BIOLOGY[J]. 2022, 第 11 作者  通讯作者  54: 102388, https://doaj.org/article/a7b3f20f43aa4354b2c610dd021420e5.
[10] Zhou, Haitao, Ding, Shanshan, Sun, Chuanxin, Fu, Jiahui, Yang, Dong, Wang, Xie, Wang, Chihchen, Wang, Lei. Lycium barbarum Extracts Extend Lifespan and Alleviate Proteotoxicity in Caenorhabditis elegans. FRONTIERS IN NUTRITION[J]. 2022, 第 8 作者  通讯作者  8: 815947, http://dx.doi.org/10.3389/fnut.2021.815947.
[11] Qiao, Xinhua, Zhang, Yingmin, Ye, Aojun, Zhang, Yini, Xie, Ting, Lv, Zhenyu, Shi, Chang, Wu, Dongli, Chu, Boyu, Wu, Xun, Zhang, Weiqi, Wang, Ping, Liu, GuangHui, Wang, Chihchen, Wang, Lei, Chen, Chang. ER reductive stress caused by Ero1 alpha S-nitrosation accelerates senescence. FREE RADICAL BIOLOGY & MEDICINE[J]. 2022, 第 15 作者  通讯作者  180: 165-178, http://dx.doi.org/10.1016/j.freeradbiomed.2022.01.006.
[12] Lu Wang, Xi Wang, Xiying Lv, Qiushuo Jin, Hongcai Shang, Chih-chen Wang, Lei Wang. The extracellular Ero1α/PDI electron transport system regulates platelet function by increasing glutathione reduction potential. Redox Biology[J]. 2022, 第 7 作者  通讯作者  50: 102244, 
[13] Fan Fenggui, Zhang Qiao, Zhang Yini, Huang Guozhong, Liang Xuelian, Wang Chih-chen, Wang Lei, Lu Dongping. Two Arabidopsis Protein Disulfide Isomerase Subgroups Work Synergistically in Catalyzing Oxidative Protein Folding. Plant Physiology[J]. 2022, 第 7 作者  通讯作者  188(1): 241-254, 
[14] Wan, Wang, Zeng, Lianggang, Jin, Wenhan, Chen, Xinxin, Shen, Di, Huang, Yanan, Wang, Mengdie, Bai, Yulong, Lyu, Haochen, Dong, Xuepeng, Gao, Zhenming, Wang, Lei, Liu, Xiaojing, Liu, Yu. A Solvatochromic Fluorescent Probe Reveals Polarity Heterogeneity upon Protein Aggregation in Cells. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2021, 第 12 作者60(49): 25865-25871, 
[15] Wang, Lei, Yu, Jiaojiao, Wang, Chihchen. Protein disulfide isomerase is regulated in multiple ways: Consequences for conformation, activities, and pathophysiological functions. BIOESSAYS[J]. 2021, 第 1 作者  通讯作者  43(3): https://www.webofscience.com/wos/woscc/full-record/WOS:000585977400001.
[16] Xinxin Chen, Jianchao Zhang, Pulan Liu, Yangyang Wei, Xie Wang, Junyu Xiao, Chihchen Wang, Lei Wang. Proteolytic processing of secretory pathway kinase Fam20C by site-1 protease promotes biomineralization. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2021, 第 8 作者  通讯作者  118(32): 
[17] Yu Yan, Xun Wu, Pengcheng Wang, Songyang Zhang, Lulu Sun, Yang Zhao, GuangYi Zeng, Bo Liu, Guoheng Xu, Huiying Liu, Lei Wang, Xian Wang, Changtao Jiang. Homocysteine promotes hepatic steatosis by activating the adipocyte lipolysis in a HIF1α-ERO1α-dependent oxidative stress manner. REDOX BIOLOGY[J]. 2020, 第 11 作者  通讯作者  37: 101742, http://dx.doi.org/10.1016/j.redox.2020.101742.
[18] Yang, Jie, Zhang, Hong, Gong, Weibin, Liu, Zhenyan, Wu, Huiwen, Hu, Wanhui, Chen, Xinxin, Wang, Lei, Wu, Si, Chen, Chang, Perrett, Sarah. S-Glutathionylation of human inducible Hsp70 reveals a regulatory mechanism involving the C-terminal ?-helical lid. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2020, 第 8 作者295(24): 8302-8324, http://dx.doi.org/10.1074/jbc.RA119.012372.
[19] Yu, Jiaojiao, Li, Tao, Liu, Yu, Wang, Xi, Zhang, Jianchao, Wang, Xie, Shi, Guizhi, Lou, Jizhong, Wang, Likun, Wang, Chihchen, VVang, Lei. Phosphorylation switches protein disulfide isomerase activity to maintain proteostasis and attenuate ER stress. EMBO JOURNAL[J]. 2020, 39(10): e103841, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232009/.
[20] Fan, Fenggui, Zhang, Yini, Huang, Guozhong, Zhang, Qiao, Wang, Chihchen, Wang, Lei, Lu, Dongping. AtERO1 and AtERO2 Exhibit Differences in Catalyzing Oxidative Protein Folding in the Endoplasmic Reticulum. PLANT PHYSIOLOGY[J]. 2019, 第 6 作者180(4): 2022-2033, http://dx.doi.org/10.1104/pp.19.00020.
[21] Cheng, Fang, Wang, Si, Song, Moshi, Liu, Zunpeng, Liu, Ping, Wang, Lei, Wang, Yanjiang, Zhao, Qian, Yan, Kaowen, Chan, Piu, Zhang, Weiqi, Qu, Jing, Liu, GuangHui. DJ-1 is dispensable for human stem cell homeostasis. PROTEIN & CELL. 2019, 第 6 作者10(11): 846-853, https://journal.hep.com.cn/pac/EN/10.1007/s13238-019-00659-9.
[22] Wang Lei. AtERO1 and AtERO2 exhibit differences in catalyzing oxidative protein folding in the ER. Plant Physiology. 2019, 第 1 作者  通讯作者  
[23] Wang, Lu, Zhou, Junsong, Wang, Lei, Wang, Chihchen, Essex, David W. The b ' domain of protein disulfide isomerase cooperates with the a and a ' domains to functionally interact with platelets. JOURNAL OF THROMBOSIS AND HAEMOSTASIS[J]. 2019, 第 3 作者17(2): 371-382, https://www.webofscience.com/wos/woscc/full-record/WOS:000458294900015.
[24] Wu, Xun, Zhang, Lihui, Miao, Yutong, Yang, Juan, Wang, Xian, Wang, Chihchen, Feng, Juan, Wang, Lei. Homocysteine causes vascular endothelial dysfunction by disrupting endoplasmic reticulum redox homeostasis. REDOX BIOLOGY[J]. 2019, 第 8 作者  通讯作者  20: 46-59, http://dx.doi.org/10.1016/j.redox.2018.09.021.
[25] Yini Zhang, Tao Li, Lihui Zhang, Fugen Shangguan, Guizhi Shi, Xun Wu, Ya Cui, Xie Wang, Xi Wang, Yongzhang Liu, Bin Lu, Taotao Wei, Chihchen Wang, Lei Wang. Targeting the functional interplay between endoplasmic reticulum oxidoreductin-1α and protein disulfide isomerase suppresses the progression of cervical cancer. EBIOMEDICINE[J]. 2019, 第 14 作者  通讯作者  41: 408-419, 
[26] Xu, WenChang, Liang, JinZhao, Li, Cheng, He, ZhiXin, Yuan, HanYe, Huang, BenYan, Liu, XiaoLing, Tang, Bo, Pang, DaiWen, Du, HaiNing, Yang, Yi, Chen, Jie, Wang, Lei, Zhang, Min, Liang, Yi. Pathological hydrogen peroxide triggers the fibrillization of wild-type SOD1 via sulfenic acid modification of Cys-111. CELL DEATH & DISEASE[J]. 2018, 第 13 作者9(2): https://doaj.org/article/748fad2992e74a63af60208f55377e90.
[27] Fang, Jingqi, Yang, Jiping, Wu, Xun, Zhang, Gangming, Li, Tao, Wang, Xie, Zhang, Hong, Wang, Chihchen, Liu, GuangHui, Wang, Lei. Metformin alleviates human cellular aging by upregulating the endoplasmic reticulum glutathione peroxidase 7. AGING CELL[J]. 2018, 第 10 作者  通讯作者  17(4): http://dx.doi.org/10.1111/acel.12765.
[28] Li, Huanhuan, Yang, Kai, Wang, Wenjia, Niu, Yingbo, Li, Jun, Dong, Yuhui, Liu, Yingfang, Wang, Chihchen, Wang, Lei, Liang, Huanhuan. Crystal and solution structures of human protein-disulfide isomerase-like protein of the testis (PDILT) provide insight into its chaperone activity. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2018, 第 9 作者  通讯作者  293(4): 1192-1202, http://dx.doi.org/10.1074/jbc.M117.797290.
[29] Fan, Fenggui, Zhang, Yini, Wang, Shen, Han, Yongfeng, Wang, Lei, Lu, Dongping. Characterization of the oxidative protein folding activity of a unique plant oxidoreductase, Arabidopsis protein disulfide isomerase-11. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2018, 第 5 作者  通讯作者  495(1): 1041-1047, http://dx.doi.org/10.1016/j.bbrc.2017.11.111.
[30] Zhang, Jianchao, Zhu, Qinyu, Wang, Xie, Yu, Jiaojiao, Chen, Xinxin, Wang, Jifeng, Wang, Xi, Xiao, Junyu, Wang, Chihchen, Wang, Lei. Secretory kinase Fam20C tunes endoplasmic reticulum redox state via phosphorylation of Ero1 alpha. EMBO JOURNAL[J]. 2018, 第 10 作者  通讯作者  37(14): e98699, https://www.webofscience.com/wos/woscc/full-record/WOS:000438517100008.
[31] Li, Yazi, Zhang, Yuying, Wang, Lei, Wang, Ping, Xue, Yanhong, Li, Xiaopeng, Qiao, Xinhua, Zhang, Xu, Xu, Tao, Liu, Guanghui, Li, Peng, Chen, Chang. Autophagy impairment mediated by S-nitrosation of ATG4B leads to neurotoxicity in response to hyperglycemia. AUTOPHAGY[J]. 2017, 第 3 作者13(7): 1145-1160, https://dx.doi.org/10.1080/15548627.2017.1320467.
[32] Niu, Yingbo, Zhang, Lihui, Yu, Jiaojiao, Wang, Chihchen, Wang, Lei. Novel Roles of the Non-catalytic Elements of Yeast Protein-disulfide Isomerase in Its Interplay with Endoplasmic Reticulum Oxidoreductin 1. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2016, 第 5 作者  通讯作者  291(15): 8283-8294, http://dx.doi.org/10.1074/jbc.M115.694257.
[33] Wang, Lei, Wang, Xi, Wang, Chihchen. Protein disulfide-isomerase, a folding catalyst and a redox-regulated chaperone. FREE RADICAL BIOLOGY AND MEDICINE[J]. 2015, 第 1 作者83: 305-313, http://dx.doi.org/10.1016/j.freeradbiomed.2015.02.007.
[34] 王曦, 王磊, 陈畅, 王志珍. 未折叠蛋白响应:2014年拉斯克基础医学研究奖解读. 科学通报[J]. 2014, 第 2 作者59(36): 3533-3534, https://d.wanfangdata.com.cn/periodical/kxtb201436001.
[35] Zhang, Lihui, Niu, Yingbo, Zhu, Li, Fang, Jingqi, Wang, Xie, Wang, Lei, Wang, Chihchen. Different Interaction Modes for Protein-disulfide Isomerase (PDI) as an Efficient Regulator and a Specific Substrate of Endoplasmic Reticulum Oxidoreductin-1 alpha (Ero1 alpha). JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2014, 第 6 作者  通讯作者  289(45): 31188-31199, http://dx.doi.org/10.1074/jbc.M114.602961.
[36] Wang, Lei, Zhang, Lihui, Niu, Yingbo, Sitia, Roberto, Wang, Chihchen. Glutathione Peroxidase 7 Utilizes Hydrogen Peroxide Generated by Ero1 alpha to Promote Oxidative Protein Folding. ANTIOXIDANTS & REDOX SIGNALING[J]. 2014, 第 1 作者  通讯作者  20(4): 545-556, http://dx.doi.org/10.1089/ars.2013.5236.
[37] Lihui Zhang, Yingbo Niu, Li Zhu, Jingqi Fang, Xie Wang, Lei Wang, Chihchen Wang. Different Interaction Modes for Protein-disulfide Isomerase (PDI) as an Efficient Regulator and a Specific Substrate of Endoplasmic Reticulum Oxidoreductin-1α (Ero1α) *. THE JOURNAL OF BIOLOGICAL CHEMISTRY. 2014, 第 6 作者289(45): 31188-31199, http://dx.doi.org/10.1074/jbc.M114.602961.
[38] Wang, Chao, Yu, Jiang, Huo, Lin, Wang, Lei, Feng, Wei, Wang, Chihchen. Human Protein-disulfide Isomerase Is a Redox-regulated Chaperone Activated by Oxidation of Domain a '. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2012, 第 4 作者287(2): 1139-1149, http://dx.doi.org/10.1074/jbc.M111.303149.
[39] Wang, Lei, Zhu, Li, Wang, Chihchen. The endoplasmic reticulum sulfhydryl oxidase Ero1 beta drives efficient oxidative protein folding with loose regulation. BIOCHEMICAL JOURNAL[J]. 2011, 第 1 作者434: 113-121, http://dx.doi.org/10.1042/BJ20101357.
[40] Nguyen, Van Dat, Saaranen, Mirva J, Karala, AnnaRiikka, Lappi, AnnaKaisa, Wang, Lei, Raykhel, Irina B, Alanen, Heli I, Salo, Kirsi E H, Wang, Chihchen, Ruddock, Lloyd W. Two Endoplasmic Reticulum PDI Peroxidases Increase the Efficiency of the Use of Peroxide during Disulfide Bond Formation. JOURNAL OF MOLECULAR BIOLOGY[J]. 2011, 第 5 作者406(3): 503-515, http://dx.doi.org/10.1016/j.jmb.2010.12.039.
[41] Cheng, Han, Wang, Lei, Wang, Chihchen. Domain a' of protein disulfide isomerase plays key role in inhibiting alpha-synuclein fibril formation. CELL STRESS & CHAPERONES[J]. 2010, 第 2 作者15(4): 415-421, http://dx.doi.org/10.1007/s12192-009-0157-2.
[42] Wang, Lei, Li, Shengjian, Sidhu, Ateesh, Zhu, Li, Liang, Yi, Freedman, Robert B, Wang, Chihchen. Reconstitution of Human Ero1-L alpha/Protein-Disulfide Isomerase Oxidative Folding Pathway in Vitro POSITION-DEPENDENT DIFFERENCES IN ROLE BETWEEN THE a AND a ' DOMAINS OF PROTEIN-DISULFIDE ISOMERASE. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2009, 第 1 作者284(1): 199-206, http://dx.doi.org/10.1074/jbc.M806645200.
[43] Wang, Likun, Wang, Lei, Vavassori, Stefano, Li, Shengjian, Ke, Huimin, Anelli, Tiziana, Degano, Massimo, Ronzoni, Riccardo, Sitia, Roberto, Sun, Fei, Wang, Chihchen. Crystal structure of human ERp44 shows a dynamic functional modulation by its carboxy-terminal tail. EMBO REPORTS[J]. 2008, 第 2 作者9(7): 642-647, http://www.irgrid.ac.cn/handle/1471x/757645.

科研活动

   
科研项目
( 1 ) 内质网氧化还原稳态在高同型半胱氨酸血症引起血管内皮细胞功能损伤中的作用, 主持, 国家级, 2018-01--2021-12
( 2 ) Ero1α翻译后修饰介导的内质网氧化应激及抗氧化应答, 主持, 国家级, 2016-01--2019-12
( 3 ) 细胞器动态互作的蛋白质机器, 参与, 国家级, 2016-07--2021-06
( 4 ) 基于糖尿病发生进程关键信号通路的分子靶标的发现与确认, 参与, 部委级, 2016-01--2017-12
( 5 ) 细胞分泌途径关键大分子复合体的跨尺度研究, 主持, 部委级, 2020-01--2024-12
( 6 ) 内质网中蛋白质氧化折叠及其调控的新机制, 主持, 国家级, 2014-01--2017-12
( 7 ) 人细胞内质网中巯基氧化酶Ero1β驱动的电子传递系统的工作机制, 主持, 国家级, 2011-01--2013-12
( 8 ) 内质网稳态调节, 主持, 国家级, 2021-01--2023-12