Combing the manipulation of Drosophila and the mouse, at present our lab mainly focus on the regulation of intestinal eco-immunological homeostasis including three aims: 1) Innate immune signaling homeostasis: to identify new regulatory factors and to determine network regulations of mucosal innate immunity, especially to decipher the inter-organ communications to coordinate local-systemic immune signal transduction; 2) Cellular homeostasis: to study the damages initiation and stem cell mediated tissue repair of intestinal epithelia during combating pathogens; 3) Commensal flora homeostasis: to learn corporately the change pattern and the immunological regulation mechanisms of gut commensal microflora and the fat/energy metabolism.

2010       Ph.D., Cell Biology, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China

2006-2009  CAS-Stowers joint Ph.D. training programs, Stowers Institute for Medical Research, Kansas City, Missouri, US

                2004           B.S., the College of Life Sciences, Nankai University, Tianjin, China

2018-present  Principal Investigator, The Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences

2014-2018    Professor, The Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences

                          2010-2014    Associate Professor, The Key Laboratory of Infection and Immunity,Institute of Biophysics, Chinese Academy of Sciences 

Xiaomeng He*, Junjing Yu*, Min Wang, Yang Cheng, Yanan Han, Shuo Yang, Lei Sun, Ying Fang, Si-tang Gong, Zhong Wang, Yang-Xin Fu, Lei Pan ^# and Hong Tang^# . Bap180/Baf180 is required to maintain the homeostasis of intestinal innate immune response. Nature Microbiology, 2, 17056 (2017). (#Correspondence author)

Pan L*, Wang S*, Lu T, Weng C, Song X, Park J, Sun J, Yang Z, Yu J, Tang H, McKearin D, Chamovitz D, Ni J, Xie T. Protein competition switches the function of COP9 from self-renewal to differentiation. NATURE, 2014; doi:10.1038/nature13562

Yan D, Neumuller RA, Buckner M, Ayers K, Li H, Hu Y, Yang ZD, Pan L, Wang X, Kelley C, Vinayagam A, Binari R, Randklev S, Perkins LA, Xie T, Cooley L, and Perrimon N. A Regulatory Network of Drosophila Germline Stem Cell Self-Renewal. Developmental Cell 2014, 28, 459–473. (Resource article)

Chen J, Zhao Y, Zhang C, Chen H, Feng J, Chi X, Pan Y, Du J, Guo M, Cao H, Chen H, Wang Z, Pei R, Wang Q, Pan L, Niu J, Chen X, Tang H. Persistent hepatitis C virus infections and hepatopathological manifestations in immune-competent humanized mice. Cell Research, 2014; doi:10.1038/cr.2014.116

Yu J, He X, Chen Y, Hao Y, Yang S, Wang L, Pan L* and Tang H*. Myotubularin-related protein 4 (MTMR4) attenuates BMP/Dpp signaling by dephosphorylation of Smad proteins. J BIOL CHEM 2013, 288 (1): 79-88 (* Correspondence author)

Zhang X, Weng C, Li Y, Wang X, Jiang C, Li X, Xu Y, Chen Q, Pan L* and Tang H*. Human Bop is a novel BH3-only member of the Bcl-2 protein family. Protein & Cell 2012, 3 (10): 790–801 (* Correspondence author)

Wang X*, Pan L*, Wang S*, Zhou J, McDowell W, Park J, Haug J, Staehling K, Tang H, Xie T. Histone H3K9 Trimethylase Eggless Controls Germline Stem Cell Maintenance and Differentiation. PLoS Genet 2011, 7(12): e1002426. doi:10.1371/journal.pgen.1002426 (*co-first author)

Yu J*, Pan L*, Qin X, Chen H, Xu Y, Chen Y and Tang H. MTMR4 attenuates TGFβ signaling by dephosphorylating R-Smads in endosomes. J BIOL CHEM 2010, 285(11):8454-62. Epub 2010 Jan 8 (*co-first author)

Xie T, Song X, Jin Z, Pan L, Weng C, Chen S, Zhang N. Interactions between Stem Cells and Their Niche in the Drosophila Ovary. COLD SPRING HARB SYM.2008, 73:39-47 (Annual review)

Pan L, Chen S, Weng C, Call G, Zhu D, Tang H, Zhang N, Xie T. Stem Cell Aging Is Controlled Both Intrinsically and Extrinsically in the Drosophila Ovary. CELL STEM CELL, 2007, 1:458-469 (Faculty 1000 factor=6, cited 105)

RESEARCH GRANT SUPPORT

2011.1-2013.12 National Natural Science Foundation of China for Young Scholars (Grant No. 31000403) 190,000 RMB

2011.1-2013.12 Key Laboratory of Infection and Immunity (CASKLII), Joint research projects 50,000 RMB

2012.1-2015.12 Ministry of Health (MoH) (Grant No. 2012ZX10001006) 955,800 RMB

2012.1-2016.12 973 Projects, Ministry of Science and Technology ofChina(MoST) (Grant No. 2012CB518900) 827,500 RMB

2012.1-2014.12 Ministry of Science and Technology of China (MoST) (Grant 2011DFG32790) 2,580,000 RMB

2012.1-2013.12 Novo Nordisk – Chinese Academy of Sciences Research Foundation, Joint research projects (Grant No. NNCAS-2011-2) 500,000 RMB

2012.1-2015.12 Chinese Academy of Sciences Young Investigator Fellowship 400,000 RMB        

2013.1-2017.12 Projects of International Cooperation and Exchanges NSFC (Grant No.  81220108018) 2,900,000 RMB

2013.1-2017.12 973 Projects, Ministry of Science and Technology of China (MoST) (Grant No. 2012CB117289) 300,000 RMB (the first two years)

2014.1-2017.12 National Natural Science Foundation of China (31370909) 800,000 RMB

2016.1-2019.12 National Natural Science Foundation of China (31570897) 780,000 RMB

2017.1-2019.12 Outstanding Chinese Academy of Sciences Young Investigator Fellowship 1,800,000 RMB

INVITED PRESENTATIONS

Mar, 2008       49th Annual Drosophila Research Conference, San Diego, California, “Stem cell aging is controlled both intrinsically and extrinsically in the Drosophila ovary.”

May, 2008       Stowers Institute for Medical Research, Kansas City, Missouri, talk on research day “stem cell aging”   

Sep, 2009        Stowers Institute for Medical Research, Kansas City, Missouri, “Genetic networks controlling stem cell aging.”

Dec, 2010       Institute of Biophysics, Chinese Academy of Sciences, “CSN4 competes with BGCN for interacting with BAM to regulate GSCs’ fate.”

Dec, 2014        2014 Young Immune Scholars Annual Meeting, Suzhou, China, “A chromatin remodeling factor contributes to innate immune homeostasis in intestine”

Nov, 2015        2015 Youth Innovation Promotion Association, CAS Annual Meeting, Shanghai, China, “Intestinal innate immune homeostasis”.

Nov, 2015       10th CSI Congress on Immunology, Beijing, China, “Bap180/Baf180 contributes to intestinal innate immune homeostasis”.

Mar,2016         Institute of Genomics, Chinese Academy of Sciences, “The regulation of intestinal immune homeostasis.”

Jun,2016          Institute of Geology and Geophysics, Chinese Academy of Sciences, Popular science lectures “The genetic study in fly.”

Aug,2016         The Inaugural Jiujiang International Drosophila Conference, Jiujiang, Jiangxi, China “A chromatin remodeling factor has a novel role to contribute to the homeostasis of intestinal innate immune response”.

Oct,2016         Second Asian Invertebrate Immunology Symposium, Hangzhou, Zhejiang, China “Bap180/Baf180 is required to maintain the homeostasis of intestinal innate immune response”

                        Session Chair

May,2017        4th Asia-Pacific Drosophila Research Conference, Osaka, Japan “Chemical metabolites contribute to local-systemic innate immune communication”

Oct,2017        4th China Drosophila Research Conference, Shanghai, China “The homeostasis of intestinal innate eco-immunology”

Oct,2017          12th CSI Congress on Immunology, Tianjin, China “Chemical metabolites contribute to local-systemic innate immune communication”

现指导学生

杨烁  博士研究生  071009-细胞生物学  

2006-2009          Predoctoral Fellowship, Stowers Institute for Medical Research, Kansas City,   Missouri, USA

2012               Membership of the Youth Innovation Promotion Association, CAS

2015               Annual Interdisciplinary and Innovation Awards of the Youth Innovation Promotion Association, CAS

                    2016               Outstanding Membership of the Youth Innovation Promotion Association, CAS