基本信息
杨其恩  男  博导  中国科学院西北高原生物研究所
电子邮件: yangqien@nwipb.cas.cn
通信地址: 青海西宁市新宁路23号
邮政编码: 810001

招生信息

   
招生专业
071002-动物学
071008-发育生物学
071009-细胞生物学
招生方向
繁殖生物学
发育生物学
功能基因组

教育背景

2006-08--2010-12   佛罗里达大学   博士
2004-09--2006-07   中国农业大学   硕士
2000-09--2004-07   中国农业大学   学士

工作经历

   
工作简历
2014-12~现在, 中国科学院西北高原生物研究所, 研究员
2014-05~2014-11,华盛顿州立大学, 研究助理教授
2011-06~2014-04,华盛顿州立大学, 博士后
2006-08~2010-12,佛罗里达大学, 博士
2004-09~2006-07,中国农业大学, 硕士
2000-09~2004-07,中国农业大学, 学士
社会兼职
2024-03-01-2029-01-01,兽类学报, 责任主编
2023-07-31-2027-07-31,中国动物学会动物生理生态学分会, 副主任委员

出版信息

   
发表论文
(1) Loss of PBX1 function in Leydig cells causes testicular dysgenesis and male sterility, Cellular and Molecular Life Sciences, 2024, 第 6 作者  通讯作者
(2) Single-cell transcriptome analyses reveal critical regulators of spermatogonial stem cell fate transitions, BMC GENOMICS, 2024, 第 11 作者  通讯作者
(3) Single-cell analysis identifies critical regulators of spermatogonial development and differentiation in cattle-yak bulls, Journal of Dairy Science, 2024, 第 5 作者  通讯作者
(4) Integrated ultrasensitive metabolomics and single-cell transcriptomics identify crucial regulators of sheep oocyte maturation and early embryo development in vitro, Journal of Advanced Research, 2024, 第 8 作者  通讯作者
(5) Population structure and breed identification of Chinese indigenous sheep breeds using whole genome SNPs and InDels, Genetics Selection Evolution, 2024, 第 10 作者  通讯作者
(6) Fetal hypoxia exposure induces Hif1a activation and autophagy in adult ovarian granulosa cells, Biology of Reproduction, 2024, 第 8 作者  通讯作者
(7) Single-cell transcriptomic characterization of sheep conceptus elongation and implantation, CELL REPORTS, 2023, 第 12 作者  通讯作者
(8) Elevated Id2 expression causes defective meiosis and spermatogenesis in mice, DEVELOPMENTAL DYNAMICS, 2023, 第 4 作者  通讯作者
(9) Comparative proteomic analysis identifies differentially expressed proteins associated with meiotic arrest in cattle-yak hybrids, PROTEOMICS, 2023, 第 5 作者  通讯作者
(10) ARHGEF15 is expressed in undifferentiated spermatogonia but is not required for spermatogenesis in mice, REPRODUCTIVE BIOLOGY, 2023, 第 6 作者  通讯作者
(11) Transcription factor E4F1 dictates spermatogonial stem cell fate decisions by regulating mitochondrial functions and cell cycle progression, Cell & Bioscience, 2023, 第 6 作者  通讯作者
(12) Pancreatic lipase-related protein 2 is selectively expressed by peritubular myoid cells in the murine testis and sustains long-term spermatogenesis, Cellular and Molecular Life Sciences, 2023, 第 6 作者  通讯作者
(13) Hypobaric hypoxia exposure alters transcriptome in mouse testis and impairs spermatogenesis in offspring, Gene, 2022, 第 2 作者  通讯作者
(14) Long read genome assemblies complemented by single cell RNA-sequencing reveal genetic and cellular mechanisms underlying the adaptive evolution of yak, NATURE COMMUNICATIONS, 2022, 第 13 作者  通讯作者
(15) Ldha-Dependent Metabolic Programs in Sertoli Cells Regulate Spermiogenesis in Mouse Testis, BIOLOGY, 2022, 第 7 作者  通讯作者
(16) Paternal hypoxia exposure impairs fertilization process and preimplantation embryo development, Zygote, 2021, 第 5 作者  通讯作者
(17) Transcriptome analysis revealed key signaling networks regulating ovarian activities in the domestic yak, THERIOGENOLOGY, 2020, 第 6 作者
(18) WTAP Function in Sertoli Cells Is Essential for Sustaining the Spermatogonial Stem Cell Niche, STEM CELL REPORTS, 2020, 第 8 作者  通讯作者
(19) Function and transcriptomic dynamics of Sertoli cells during prospermatogonia development in mouse testis, REPRODUCTIVE BIOLOGY, 2020, 第 3 作者  通讯作者
(20) 青藏高原牦牛遗传资源保护和利用:问题与展望, 生态学报, 2020, 第 6 作者  通讯作者
(21) E4 Transcription Factor 1 (E4F1) Regulates Sertoli Cell Proliferation and Fertility in Mice, ANIMALS, 2020, 第 3 作者  通讯作者
(22) The expression of histone methyltransferases and distribution of selected histone methylations in testes of yak and cattle-yak hybrid, THERIOGENOLOGY, 2020, 第 5 作者  通讯作者
(23) Gene expression dynamics during the gonocyte to spermatogonia transition and spermatogenesis in the domestic yak, JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY, 2019, 第 10 作者  通讯作者
(24) Gene expression dynamics during the gonocyte to spermatogonia transition and spermatogenesis in the domestic yak, JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY, 2019, 第 10 作者  通讯作者
(25) Testosterone-retinoic acid signaling directs spermatogonial differentiation and seasonal spermatogenesis in the Plateau pika (Ochotona curzoniae), THERIOGENOLOGY, 2019, 第 11 作者  通讯作者
(26) The CXCL12-CXCR4 signaling promotes oocyte maturation by regulating cumulus expansion in sheep, THERIOGENOLOGY, 2018, 第 10 作者  通讯作者
(27) ID4 levels dictate the stem cell state in mouse spermatogonia, DEVELOPMENT, 2017, 第 2 作者
(28) Conditions for Long-Term Culture of Cattle Undifferentiated Spermatogonia, BIOLOGY OF REPRODUCTION, 2016, 第 3 作者
(29) The requirement for protein kinase C delta (PRKCD) during preimplantation bovine embryo development, REPRODUCTION, FERTILITY AND DEVELOPMENT, 2016, 第 1 作者
(30) Inactivation of Retinoblastoma Protein (Rb1) in the Oocyte: Evidence That Dysregulated Follicle Growth Drives Ovarian Teratoma Formation in Mice, PLOS GENETICS, 2015, 第 1 作者
(31) Chapter Nine - Spermatogonial Stem Cell Functions in Physiological and Pathological Conditions, CURRENT TOPICS IN DEVELOPMENTAL BIOLOGY, 2014, 第 1 作者
(32) Functional and molecular features of the Id4 + germline stem cell population in mouse testes, GENES & DEVELOPMENT, 2014, 第 4 作者
(33) Retinol dehydrogenase 10 is indispensible for spermatogenesis in juvenile males, PNAS, 2013, 第 2 作者
(34) Retinoblastoma Protein (RB1) Controls Fate Determination in Stem Cells and Progenitors of the Mouse Male Germline, BIOLOGY OF REPRODUCTION, 2013, 第 1 作者
(35) MicroRNAs 221 and 222 regulate the undifferentiated state in mammalian male germ cells, DEVELOPMENT, 2013, 第 1 作者
(36) CXCL12/CXCR4 signaling is essential for the maintenance of mouse spermatogonial stem cells, Journal of Cell Science, 2013, 第 1 作者
(37) Fibroblast growth factors activate mitogen-activated protein kinase pathways to promote migration in ovine trophoblast cells, REPRODUCTION, 2011, 第 1 作者
(38) Fibroblast Growth Factor 2 Promotes Primitive Endoderm Development in Bovine Blastocyst Outgrowths, BIOLOGY OF REPRODUCTION, 2011, 第 1 作者
(39) Protein Kinase C Delta Mediates Fibroblast Growth Factor-2-Induced Interferon-Tau Expression in Bovine Trophoblast, BIOLOGY OF REPRODUCTION, 2011, 第 1 作者
(40) Stepwise in-straw dilution and direct transfer using open pulled straws (OPS) in the mouse: A potential model for field manipulation of vitrified embryos, JOURNAL OF REPRODUCTION AND DEVELOPMENT, 2007, 第 1 作者
发表著作
( 1 ) 动物配子与胚胎冷冻保存原理及应用, 科学出版社, 2016-11, 第 其他 作者
( 2 ) 青海牦牛, 青海民族出版社, 2022-03, 第 3 作者

科研活动

   
科研项目
( 1 ) 青海牦牛遗传多样性评估和极端环境适应关键基因鉴定, 负责人, 国家任务, 2023-01--2026-12
( 2 ) 西北珍稀濒危牛羊抢救性保护研究, 负责人, 国家任务, 2021-10--2025-12
( 3 ) 牛羊生殖发育的关键分子调控机理解析与高效扩繁群建立, 参与, 中国科学院计划, 2020-11--2025-12
( 4 ) 犏牛精母细胞减数分裂前期DNA双链断裂修复障碍的成因解析, 负责人, 国家任务, 2020-01--2023-12
( 5 ) 青海省自然基金团队项目, 负责人, 地方任务, 2020-01--2022-12
参与会议
(1)Germ Cell Fate Decision, Meiosis and Hybrid Sterility   第六届国际牦牛大会   2018-08-27