071007-遗传学

蓝藻（蓝细菌）分子生物学及应用，合成生物学

1986-08--1989-06   法国埃克斯-马赛大学   博士
1985-08--1986-07   法国埃克斯-马赛大学   硕士
1980-09--1984-06   山东师范大学   学士

   

2015-06~现在, 中国科学院水生生物学研究所, 教授
2012-01~2015-05,埃克斯-马赛大学理学院（合并后）, 副院长
2010-06~2011-12,埃克斯-马赛第二大学理学院, 院长
2008-05~2010-05,埃克斯-马赛第二大学理学院, 副院长
1999-07~2015-05,法国埃克斯-马赛大学, 教授
1990-08~1999-06,法国路易巴斯德大学, 讲师
1989-07~1990-07,瑞士苏黎世大学, 博士后
1986-08~1989-06,法国埃克斯-马赛大学, 博士
1985-08~1986-07,法国埃克斯-马赛大学, 硕士
1980-09~1984-06,山东师范大学, 学士

2022-12-31-2024-05-24,Anual Review of Microbiology, 编辑
2022-01-01-今,mLife期刊, 副主编
2020-01-01-今,武汉理工大学艾克斯马赛学院, 执行院长
2019-12-31-今,国际光合原核微生物研讨会（ISPP）国际学术委员会, 会员
2019-12-31-今,American Society for Microbiology, 会员
2007-12-30-2019-12-31,美国微生物学协会期刊Journal of Bacteriology, ASM, 编委

   

（1） Global translational control by the transcriptional repressor TrcR in the filamentous cyanobacterium Anabaena sp. PCC 7120, Communications Biology, 2023, 第 5 作者  通讯作者
（2） A c-di-GMP binding effector controls cell size in a cyanobacterium, Proceedings of the National Academy of Sciences of the United States of America, 2023, 第 9 作者  通讯作者
（3） Control of Cell Size by c-di-GMP Requires a Two-Component Signaling System in the Cyanobacterium Anabaena sp. Strain PCC 7120, MICROBIOLOGY SPECTRUM, 2023, 第 5 作者  通讯作者
（4） Global translational control by the transcriptional repressor TrcR in the filamentous cyanobacterium Anabaena sp. PCC 7120, COMMUNICATIONS BIOLOGY, 2023, 第 5 作者  通讯作者
（5） Global translational control by the transcriptional repressor TrcR in the filamentous cyanobacterium Anabaena sp. PCC 7120, COMMUNICATIONS BIOLOGY, 2023, 第 5 作者  通讯作者
（6） 铁胁迫对微囊藻毒素合成酶McyC和McyI表达的影响, IRON STRESS ON THE EXPRESSION OF MICROCYSTIN SYNTHETASE MCYC AND MCYI, 水生生物学报, 2023, 第 3 作者
（7） Carbon cycle in the microbial ecosystems of biological soil crusts, SOIL BIOLOGY & BIOCHEMISTRY, 2022, 第 5 作者
（8） The Making of a Heterocyst in Cyanobacteria Annual Review of Microbiology, ANNUAL REVIEW OF MICROBIOLOGY, 2022, 第 2 作者  通讯作者
（9） A tRNA t6A modification system contributes to the sensitivity towards the toxin ��-N-methylamino-L-alanine (BMAA) in the cyanobacterium Anabaena sp. PCC 7120, Aquatic Toxicology, 2022, 第 2 作者  通讯作者
（10） "Life is short,and art is long":RNA degradation in cyanobacteria and model bacteria, "Life is short,and art is long":RNA degradation in cyanobacteria and model bacteria, mLife, 2022, 第 3 作者  通讯作者
（11） Three-dimensional coordination of cell-division site positioning in a filamentous cyanobacterium, PNAS NEXUS, 2022, 第 4 作者  通讯作者
（12） A proteolytic pathway coordinates cell division and heterocyst differentiation in the cyanobacterium Anabaena sp. PCC 7120, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2022, 第 5 作者  通讯作者
（13） HetF Protein Is a New Divisome Component in a Filamentous and Developmental Cyanobacterium, MBIO, 2021, 第 7 作者  通讯作者
（14） The developmental regulator PatD modulates assembly of the cell-division protein FtsZ in the cyanobacterium Anabaena sp. PCC 7120, ENVIRONMENTAL MICROBIOLOGY, 2021, 第 8 作者  通讯作者
（15） c-di-GMP Homeostasis Is Critical for Heterocyst Development in Anabaena sp. PCC 7120, FRONTIERS IN MICROBIOLOGY, 2021, 第 4 作者
（16） Functions of the Essential Gene mraY in Cellular Morphogenesis and Development of the Filamentous Cyanobacterium Anabaena PCC 7120, FRONTIERS IN MICROBIOLOGY,12,(2021-10-21), 2021, 第 6 作者  通讯作者
（17） RNA Interference by Cyanobacterial Feeding Demonstrates the SCSG1 Gene Is Essential for Ciliogenesis during Oral Apparatus Regeneration in Stentor, MICROORGANISMS, 2021, 第 5 作者
（18） Functions of the Essential Gene mraY in Cellular Morphogenesis and Development of the Filamentous Cyanobacterium Anabaena PCC 7120, FRONTIERS IN MICROBIOLOGY, 2021, 第 6 作者  通讯作者
（19） The Proposed Neurotoxin ��- N -Methylamino- l -Alanine (BMAA) Is Taken up through Amino-Acid Transport Systems in the Cyanobacterium Anabaena PCC 7120, TOXINS, 2020, 第 8 作者
（20） Functional Dissection of Genes Encoding DNA Polymerases Based on Conditional Mutants in the Heterocyst-Forming Cyanobacterium Anabaena PCC 7120, FRONTIERS IN MICROBIOLOGY, 2020, 第 5 作者  通讯作者
（21） The Proposed Neurotoxin beta-N-Methylamino-l-Alanine (BMAA) Is Taken up through Amino-Acid Transport Systems in the CyanobacteriumAnabaenaPCC 7120, TOXINS, 2020, 第 8 作者  通讯作者
（22） Expanding the potential of crispr-cpf1-based genome editing technology in the cyanobacterium anabaena pcc 7120, ACS SYNTHETIC BIOLOGY, 2019, 第 7 作者  通讯作者
（23） patD , a Gene Regulated by NtcA, Is Involved in the Optimization of Heterocyst Frequency in the Cyanobacterium Anabaena sp. Strain PCC 7120, JOURNAL OF BACTERIOLOGY, 2019, 第 8 作者  通讯作者
（24） Preventing Accidental Heterocyst Development in Cyanobacteria, JOURNAL OF BACTERIOLOGY, 2019, 第 2 作者  通讯作者
（25） Coordinating carbon and nitrogen metabolic signaling through the cyanobacterial global repressor NdhR, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 第 12 作者  通讯作者
（26） Carbon/Nitrogen Metabolic Balance: Lessons from Cyanobacteria, TRENDS IN PLANT SCIENCE, 2018, 第 1 作者  通讯作者
（27） Three Substrains of the Cyanobacterium Anabaena sp Strain PCC 7120 Display Divergence in Genomic Sequences and hetC Function, JOURNAL OF BACTERIOLOGY, 2018, 第 5 作者
（28） Diversity of Growth Patterns Probed in Live Cyanobacterial Cells Using a Fluorescent Analog of a Peptidoglycan Precursor, FRONTIERS IN MICROBIOLOGY, 2018, 第 4 作者  通讯作者
（29） Protein Kinase Inhibitors as Potential Antimicrobial Drugs Against Tuberculosis, Malaria and HIV, CURRENT PHARMACEUTICAL DESIGN, 2017, 第 3 作者
（30） Structural insights into HetR���PatS interaction involved in cyanobacterial pattern formation, SCIENTIFIC REPORTS, 2015, 第 17 作者  通讯作者
（31） Fluorescence Resonance Energy Transfer Based on Interaction of PII and PipX Proteins Provides a Robust and Specific Biosensor for 2-Oxoglutarate, a Central Metabolite and a Signaling Molecule., FEBS J., 2014, 第 1 作者  通讯作者
（32） ATPase as a switch in P II signal transduction, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 第 1 作者  通讯作者
（33） Exploring the size limit of protein diffusion through the periplasm in the cyanobacterium Anabaena sp. PCC 7120 using the 13 kDa iLOV fluorescent protein, Res. Microbiol., 2013, 第 1 作者  通讯作者
（34） The inositol monophosphatase All2917 (IMPA1) is involved in osmotic adaptation in Anabaena sp PCC7120, ENVIRONMENTAL MICROBIOLOGY REPORTS, 2012, 第 4 作者
（35） Characterization of Two Critical Residues in the Effector-Binding Domain of NtcA in the Cyanobacterium Anabaena sp Strain PCC 7120, CURRENT MICROBIOLOGY, 2011, 第 5 作者  通讯作者
（36） Identification of the oriC region and its influence on heterocyst development in the filamentous cyanobacterium Anabaena sp strain PCC 71 20, MICROBIOLOGY-SGM, 2011, 第 4 作者  通讯作者
（37） NtcA Regulates patA Expression in Anabaena sp. Strain PCC 7120 ���, JOURNAL OF BACTERIOLOGY, 2010, 第 6 作者
（38） Structural basis for the allosteric control of the global nitrogen-regulating transcription factor NtcA by the nitrogen starvation signal 2-oxoglutarate., PNAS, USA, 2010, 第 1 作者  通讯作者
（39） hetR and patS, two genes necessary for heterocyst pattern formation, are widespread in filamentous non heterocyst-forming cyanobacteria, MICROBIOLOGY-SGM, 2009, 第 3 作者
（40） Mutual Regulation of ntcA and hetR during Heterocyst Differentiation Requires Two Similar PP2C-Type Protein Phosphatases, PrpJ1 and PrpJ2, in Anabaena sp. Strain PCC 7120 ���, JOURNAL OF BACTERIOLOGY, 2009, 第 5 作者  通讯作者
（41） Cloning and characterization of the fecC gene necessary for optimal growth under iron-deficiency conditions in the cyanobacterium Anabaena sp. PCC 7120, WUHAN UNIVERSITY JOURNAL OF NATURAL SCIENCES, 2004, 第 3 作者
（42） 蓝藻信号传导系统研究进展, 自然科学进展, 2003, 第 3 作者
（43） "Life is short, and art is long": RNA degradation in cyanobacteria and model bacteria, mLife, 第 3 作者

   

（ 1 ） 多细胞蓝细菌（蓝藻）细胞分裂三维调控机制及其与形态多样性和肽聚糖代谢的关系, 负责人, 国家任务, 2024-01--2028-12
（ 2 ） 水圈微生物驱动碳氮硫循环的代谢新机制, 负责人, 国家任务, 2024-01--2024-12
（ 3 ） 生物大分子合成单细胞生命, 参与, 国家任务, 2023-01--2027-12
（ 4 ） 水华蓝藻合成微生物控制系统构建与应用, 负责人, 国家任务, 2019-07--2024-06

（1）Cell division and regulation in cyanobacteria   首届“细菌和全球健康”研讨会   2024-01-17
（2）多细胞蓝细菌的细胞形态发生机制   全国海洋微生物学学术研讨会   2023-11-24
（3）Cell Size Matters   第十届全国微生物遗传学学术研讨会   2023-08-11
（4）Cell morphogenesis in multicellular cyanobacteria   2023年微生物学者前沿论坛   2023-06-05
（5）To divide AND to differentiate, that is the question   第十七届光合作用原核生物国际研讨会   2022-08-21
（6）环境合成生物学   第66届鳌山论坛“藻类：合成生物学、绿色生物制造与碳中和”   2021-10-19
（7）蓝细菌自养与碳固定   第一届全国碳中和与绿色发展大会   2021-05-29
（8）Cell-cycle control of developmental fate in Anabaena   第七届全国蓝藻水华论坛   2021-05-28
（9）Single filament analysis and genetic noise in the cyanobacterium Anabaena   第三届微生物功能单细胞分离研讨会    2021-05-24
（10）Coupling cell division to heterocyst development in Anabaena   2020-09-07
（11）From nutrional sensing to altruistic development in cyanobacteria   2019-10-10
（12）Functional dissection of hetF in Anabaena development   第一届中德蓝细菌双边会议   2019-09-25
（13）Metabolic control of cyanobacteria   2019-09-21
（14）From nutrional sensing to altruistic development in cyanobacteria   第二十二次全国环境微生物学学术研讨会   2019-08-12
（15）Controversy on the connection between Cyanobacteria and Neurodegenerative Diseases   2019国际环境和健康微生物学会议暨海外华人微生物学会年会   2019-07-12