基本信息
滕兆乾  男  博导  中国科学院动物研究所
电子邮件: tengzq@ioz.ac.cn
通信地址: 北京市朝阳区大屯路甲3号621室
邮政编码: 100101

招生信息

   
招生专业
0710J6-再生医学
071006-神经生物学
招生方向
再生医学
干细胞与脑损伤修复
神经再生

教育背景

2002-09--2005-07   中国科学院动物研究所   博士
1999-09--2002-07   山东师范大学生命科学学院   硕士

工作经历

   
工作简历
2014-09~现在, 中国科学院动物研究所, 研究员
2014-01~2014-08,Johns Hopkins University School of Medicine, Research Associate
2011-03~2013-12,Louisiana State University School of Medicine, 博士后
2008-08~2011-02,University of New Mexico School of Medicine, 博士后
2005-09~2008-03,中国农业大学农学与生物技术学院, 博士后
2002-09~2005-07,中国科学院动物研究所, 博士
1999-09~2002-07,山东师范大学生命科学学院, 硕士
社会兼职
2021-10-05-今,Genes, Editorial Board member
2020-09-23-今,Frontiers in Cell and Developmental Biology, Guest Associate Editor
2018-03-09-今,Frontiers in Genetics, Guest Associate Editor
2017-05-04-今,Frontiers in Stem Cell Research, Review Editor
2015-12-28-今,International Society for Stem Cell Research, Member
2009-09-30-今,Society for Neuroscience, USA, Member

教授课程

再生医学导论

专利与奖励

   
专利成果
( 1 ) 一种高效感染原代小胶质细胞的重组突变腺相关病毒及其相关生物材料, 2022, 第 1 作者, 专利号: ZL202110021870.7

( 2 ) 一种多能干细胞诱导产生小胶质细胞的方法及试剂盒, 2021, 第 1 作者, 专利号: ZL201910558177.6

( 3 ) 敲低ARID1A在损伤后抑制视网膜神经节细胞凋亡中的应用, 2021, 第 6 作者, 专利号: CN113209293A

出版信息

   
发表论文
(1) Mouse model of voluntary movement deficits induced by needlestick injuries to the primary motor cortex, JOURNAL OF NEUROSCIENCE METHODS, 2022, 通讯作者
(2) Intranasal Administration of Agomir-let-7i Improves Cognitive Function in Mice with Traumatic Brain Injury, Cells, 2022, 通讯作者
(3) Loss of microglial EED impairs synapse density, learning, and memory, Molecular Psychiatry, 2022, 通讯作者
(4) miR-26a promotes axon regeneration in the mammalian central nervous system by suppressing PTEN expression, ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2021, 第 5 作者
(5) Transcriptional profiling of microglia in the injured brain reveals distinct molecular features underlying neurodegeneration, GLIA, 2021, 通讯作者
(6) TREM2, microglia, and Alzheimer’s disease, MECHANISMS OF AGEING AND DEVELOPMENT, 2021, 第 2 作者
(7) Histone crotonylation regulates neural stem cell fate decisions by activating bivalent promoters, EMBO REPORTS, 2021, 通讯作者
(8) Strategies to Promote Long-Distance Optic Nerve Regeneration, FRONTIERS IN CELLULAR NEUROSCIENCE, 2020, 第 4 作者
(9) Editorial: Non-Coding RNAs and Human Diseases, FRONTIERS IN GENETICS, 2020, 第 3 作者
(10) Loss of MicroRNA-137 Impairs the Homeostasis of Potassium in Neurons via KCC2, EXPERIMENTAL NEUROBIOLOGY, 2020, 通讯作者
(11) Loss of Arid1a Promotes Neuronal Survival Following Optic Nerve Injury, FRONTIERS IN CELLULAR NEUROSCIENCE, 2020, 第 7 作者
(12) Regulatory networks between Polycomb complexes and non-coding RNAs in the central nervous system, Regulatory networks between Polycomb complexes and non-coding RNAs in the central nervous system, JOURNAL OF MOLECULAR CELL BIOLOGY, 2020, 第 4 作者
(13) UTX Regulates Human Neural Differentiation and Dendritic Morphology by Resolving Bivalent Promoters, STEM CELL REPORTS, 2020, 通讯作者
(14) SerpinA3N deficiency deteriorates impairments of learning and memory in mice following hippocampal stab injury, CELL DEATH DISCOVERY, 2020, 通讯作者
(15) Prostaglandin E1 Inhibits GLI2 Amplification-Associated Activation of the Hedgehog Pathway and Drug Refractory Tumor Growth, CANCER RESEARCH, 2020, 第 5 作者
(16) Overexpression of serotonin receptor 5b expression rescues neuronal and behavioral deficits in a mouse model of Kabuki syndrome, IBRO REPORTS, 2020, 第 8 作者
(17) Polycomb Protein EED Regulates Neuronal Differentiation through Targeting SOX11 in Hippocampal Dentate Gyrus, STEM CELL REPORTS, 2019, 第 7 作者
(18) GA-binding protein GABP beta 1 is required for the proliferation of neural stem/progenitor cells, STEM CELL RESEARCH, 2019, 通讯作者
(19) Precisely controlling endogenous protein dosage in hPSCs and derivatives to model FOXG1 syndrome, Nature Communications, 2019, 第 7 作者
(20) Regulatory networks between Polycomb complexes and non-coding RNAs in the central nervous system, Journal of Molecular Cell Biology, 2019, 
(21) MiR-137 Deficiency Causes Anxiety-Like Behaviors in Mice, FRONTIERS IN MOLECULAR NEUROSCIENCE, 2019, 通讯作者
(22) Commentary: Multiscale Analysis of Independent Alzheimer’s Cohorts Finds Disruption of Molecular, Genetic, and Clinical Networks by Human Herpesvirus., FRONTIERS IN MOLECULAR NEUROSCIENCE, 2018, 通讯作者
(23) A Chemical Recipe for Generation of Clinical-Grade Striatal Neurons from hESCs, STEM CELL REPORTS, 2018, 第 7 作者
(24) miR-9 regulates basal ganglia-dependent developmental vocal learning and adult vocal performance in songbirds, ELIFE, 2018, 第 7 作者
(25) Polycomb protein family member CBX7 regulates intrinsic axon growth and regeneration., CELL DEATH AND DIFFERENTIATION, 2018, 第 10 作者
(26) Partial loss of psychiatric risk gene miR-137 in mice causes repetitive behavior and impairs sociability and learning via increased Pde10a, NATURE NEUROSCIENCE, 2018, 通讯作者
(27) Polycomb Repressive Complex 2: Emerging Roles in the Central Nervous System, NEUROSCIENTIST, 2018, 第 3 作者
(28) MiR-203 Interplays with Polycomb Repressive Complexes to Regulate the Proliferation of Neural Stem/Progenitor Cells, STEM CELL REPORTS, 2017, 通讯作者
(29) The Histone H3K27 Demethylase UTX Regulates Synaptic Plasticity and Cognitive Behaviors in Mice., FRONTIERS IN MOLECULAR NEUROSCIENCE, 2017, 通讯作者
(30) Extrinsic and Intrinsic Regulation of Axon Regeneration by MicroRNAs after Spinal Cord Injury, NEURAL PLASTICITY, 2016, 第 2 作者
(31) Inhibition of monoacylglycerol lipase prevents chronic traumatic encephalopathy-like neuropathology in a mouse model of repetitive mild closed head injury, Journal of Cerebral Blood Flow & Metabolism, 2014, 
(32) Δ 9 -THC-caused synaptic and memory impairments are mediated through COX-2 signaling, Cell, 2013, 
(33) Epigenetic Regulation of miR-184 by MBD1 Governs Neural Stem Cell Proliferation and Differentiation, CELL STEM CELL, 2010, 第 2 作者
(34) Synaptic and Cognitive Improvements by Inhibition of 2-AG Metabolism Are through Upregulation of MicroRNA-188-3p in a Mouse Model of Alzheimer's Disease, The Journal of Neuroscience, 

科研活动

   
科研项目
( 1 ) 引进人才科研启动费, 负责人, 研究所自选, 2014-09--2018-12
( 2 ) 多重性脑创伤后miRNAs对海马神经发生与胶质细胞发生的调控机制, 负责人, 国家任务, 2016-01--2019-12
( 3 ) 中国科学院“****”, 负责人, 其他任务, 2015-01--2018-12
( 4 ) '干细胞与脑损伤修复, 负责人, 研究所自选, 2015-01--2017-12
( 5 ) 免疫球蛋白E受体在脑损伤修复中的功能与分子调控机制研究, 负责人, 地方任务, 2018-01--2020-12
( 6 ) 脑创伤大脑皮层的神经再生机制与修复, 负责人, 中国科学院计划, 2018-08--2022-12
( 7 ) 疾病相关神经前体细胞的分子标记物鉴定与质控标准, 负责人, 国家任务, 2018-07--2022-12
( 8 ) MicroRNA-137在人源胚胎干细胞神经分化中的功能与调控机制, 负责人, 国家任务, 2022-01--2025-12