基本信息
张馨欣  女  博导  中国科学院上海药物研究所
电子邮件: xinxinzhang@simm.ac.cn
通信地址: 上海浦东张江海科路501号
邮政编码:

招生信息

   
招生专业
100702-药剂学
100800-中药学
招生方向
新型药物制剂的研发以及注射用脂质载体制剂的研究
中药制剂学

教育背景

2004-09--2008-06   沈阳药科大学   博士
2000-09--2004-06   沈阳药科大学   本科

工作经历

   
工作简历
2016-10~现在, 中国科学院上海药物研究所, 研究员
2016-10~2017-10,美国加州大学圣地亚哥分校, 访问学者
2011-11~2016-10,中国科学院上海药物研究所, 副研究员
2010-08~2011-10,中国科学院上海药物研究所, 助理研究员
2008-07~2010-07,中国科学院上海药物研究所, 博士后
2004-09~2008-06,沈阳药科大学, 博士
2000-09~2004-06,沈阳药科大学, 本科
社会兼职
2023-01-01-2025-12-31,中国药学会儿童药物专业委员会委员,
2016-01-01-2017-12-31,上海市药理学会皮肤药理学专业委员会, 委员

教授课程

中药药剂学
药物制剂工艺与工程

专利与奖励

   
奖励信息
(1) 中科院青年创新促进会, , 院级, 2015
(2) 青年药剂学奖, 其他, 2015
(3) 赛诺菲-中国科学院上海生命科学研究院优秀青年人才奖励基金, , 院级, 2014
专利成果
( 1 ) 一种Talazoparib药物组合物及其应用, 2019, 第 5 作者, 专利号: CN110035743A

( 2 ) 一种包含灵芝孢子油和灵芝多糖的口服乳剂及其制备方法和用途, 2019, 第 2 作者, 专利号: CN109646399A

( 3 ) 一种包含灵芝孢子油和灵芝多糖的组合物及其用途, 2019, 第 2 作者, 专利号: CN109568354A

( 4 ) 一种Talazoparib药物组合物及其应用, 2018, 第 5 作者, 专利号: CN108210461A

( 5 ) PEG修饰的多粘菌素及其制备方法和应用, 2016, 第 2 作者, 专利号: CN105885027A

( 6 ) 高频超声雾化微粒制备系统, 2016, 第 3 作者, 专利号: CN105581983A

( 7 ) 动态监控的高频超声雾化微粒制备系统, 2016, 第 2 作者, 专利号: CN105582683A

( 8 ) 一种具有抗炎和抗血栓形成作用的静脉注射用脂肪乳剂及其制备方法和用途, 2015, 第 3 作者, 专利号: CN104739763A

( 9 ) 氨甲环酸皮肤外用纳米制剂及其制备方法和用途, 2014, 第 5 作者, 专利号: CN103565743A

( 10 ) 石杉碱甲眼用微乳制剂及其制备方法, 2012, 第 7 作者, 专利号: CN102370617A

( 11 ) 石杉碱甲在制备治疗青光眼和/或缺血诱发的视神经损伤的药物中的用途, 2011, 第 7 作者, 专利号: CN102258518A

( 12 ) 扎那米韦鼻用纳米混悬剂及其制备方法, 2010, 第 2 作者, 专利号: CN101773468A

( 13 ) 具有相转变性质的扎那米韦鼻用原位凝胶剂及其制备方法, 2010, 第 4 作者, 专利号: CN101229122B

( 14 ) 具有相转变性质的扎那米韦鼻用原位凝胶剂及其制备方法, 2010, 第 4 作者, 专利号: CN101229122B

( 15 ) 一种苯并异噁唑类衍生物的控释制剂及其制备方法, 2010, 第 7 作者, 专利号: CN101711752A

( 16 ) 一种羟基喜树碱长循环纳米脂质载体及其制备方法, 2009, 第 3 作者, 专利号: CN100531720C

( 17 ) 一种羟基喜树碱长循环纳米脂质载体及其制备方法, 2009, 第 3 作者, 专利号: CN100531720C

( 18 ) 皮肤用表皮生长因子纳米脂质载体制剂及其制备方法, 2009, 第 2 作者, 专利号: CN101474153A

( 19 ) 皮肤用表皮生长因子纳米脂质载体制剂及其制备方法, 2009, 第 2 作者, 专利号: CN101474153A

( 20 ) 具有降低喜树碱类药物胃肠毒性的新型纳米微粒制剂, 2008, 第 2 作者, 专利号: CN101229131A

( 21 ) 具有降低喜树碱类药物胃肠毒性的新型纳米微粒制剂, 2008, 第 2 作者, 专利号: CN101229131A

( 22 ) 一种聚乙二醇修饰的羟基喜树碱隐形脂质纳米球及其制备方法, 2006, 第 2 作者, 专利号: CN1875944A

( 23 ) 一种聚乙二醇修饰的羟基喜树碱隐形脂质纳米球及其制备方法, 2006, 第 2 作者, 专利号: CN1875944A

出版信息

   
发表论文
(1) Effect of phosphatidylcholine on the stability and lipolysis of nanoemulsion drug delivery systems, INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2020, 通讯作者
(2) Enhanced oral bioavailability and bioefficacy of phloretin using mixed polymeric modified self‐nanoemulsions, FOOD SCIENCE & NUTRITION, 2020, 第 10 作者
(3) Delivery of acetylthevetin B, an antitumor cardiac glycoside, using polymeric micelles for enhanced therapeutic efficacy against lung cancer cells (vol 38, pg 290, 2020), ACTA PHARMACOLOGICA SINICA, 2020, 通讯作者
(4) MT1‐MMP‐Activated Liposomes to Improve Tumor Blood Perfusion and Drug Delivery for Enhanced Pancreatic Cancer Therapy, ADVANCED SCIENCE, 2020, 第 10 作者
(5) Stepwise targeting and responsive lipid-coated nanoparticles for enhanced tumor cell sensitivity and hepatocellular carcinoma therapy, THERANOSTICS, 2020, 通讯作者
(6) NPC1L1-Targeted Cholesterol-Grafted Poly(beta-Amino Ester)/pDNA Complexes for Oral Gene Delivery, ADVANCED HEALTHCARE MATERIALS, 2019, 第 7 作者
(7) Chain-Length- and Saturation-Tuned Mechanics of Fluid Nanovesicles Direct Tumor Delivery, ACS NANO, 2019, 其他(合作组作者)
(8) Naturally occurring cassane diterpenoids (CAs) of Caesalpinia: A systematic review of its biosynthesis, chemistry and pharmacology, FITOTERAPIA, 2019, 第 2 作者
(9) 16-Tigloyl linked barrigenol-like triterpenoid from Semen Aesculi and its anti-tumor activity in vivo and in vitro, RSC ADVANCES, 2019, 第 3 作者
(10) The dietary freeze-dried fruit powder of Actinidia arguta ameliorates dextran sulphate sodium-induced ulcerative colitis in mice by inhibiting the activation of MAPKs, FOOD & FUNCTION, 2019, 第 6 作者
(11) Lipid-Based Liquid Crystalline Nanoparticles Facilitate Cytosolic Delivery of siRNA via Structural Transformation, NANO LETTERS, 2018, 通讯作者
(12) Rapid transport of deformation-tuned nanoparticles across biological hydrogels and cellular barriers, NATURE COMMUNICATIONS, 2018, 第11作者
(13) Sphk2 RNAi nanoparticles suppress tumor growth via downregulating cancer cell derived exosomal microRNA, JOURNAL OF CONTROLLED RELEASE, 2018, 第 2 作者
(14) Sphk2 RNAi nanoparticles suppress tumor growth via downregulating cancer cell derived exosomal microRNA, JOURNAL OF CONTROLLED RELEASE, 2018, 第 2 作者
(15) Liquid crystalline nanoparticles for siRNA delivery, JOURNAL OF CONTROLLED RELEASE, 2017, 第 7 作者
(16) Lipid-coated iron oxide nanoparticles for dual-modal imaging of hepatocellular carcinoma, INTERNATIONAL JOURNAL OF NANOMEDICINE, 2017, 
(17) Delivery of acetylthevetin B,an antitumor cardiac glycoside, using polymeric micelles for enhanced therapeutic efficacy against lung cancer cells, ACTA PHARMACOLOGICA SINICA, 2017, 通讯作者
(18) Remote Loading of Small-Molecule Therapeutics into Cholesterol-Enriched Cell-Membrane-Derived Vesicles, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2017, 第 1 作者
(19) 功能性磷脂的合成及剪切力敏感型脂质体的制备, 药学学报, 2017, 第 6 作者
(20) Dual-tail approach to discovery of novel carbonic anhydrase IX inhibitors by simultaneously matching the hydrophobic and hydrophilic halves of the active site, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 第 7 作者
(21) Synthesis of glucuronic acid derivatives via the efficient and selective removal of a C6 methyl group, TETRAHEDRON LETTERS, 2017, 第 3 作者
(22) Thermosensitive Liposomal Codelivery of HSA-Paclitaxel and HSA-Ellagic Acid Complexes for Enhanced Drug Perfusion and Efficacy Against Pancreatic Cancer, ACS APPLIED MATERIALS & INTERFACES, 2017, 第 6 作者
(23) 超声喷雾冷冻干燥技术制备脂质体微球用于人上皮生长因子透皮给药的研究, 2016, 第 3 作者
(24) Spray-dried powders enhance vaginal siRNA delivery by potentially modulating the mucus molecular sieve structure, INTERNATIONAL JOURNAL OF NANOMEDICINE, 2015, 第 2 作者
(25) Smart lipid capped mesoporous silica nanoparticles with tumor extrcellular pH activated charge-conversion property for deep hepatocellular carcinoma penetration, Journal of Controlled Release, 2015, 第 1 作者
(26) 脂质材料改性修饰及药物递送的研究(英文), 2015, 第 1 作者
(27) Targeting exosomal miRNA with pH-sensitive liposome coated chitosan–siRNA nanoparticles for inhibition of hepatocellular carcinoma metastasis, JOURNAL OF CONTROLLED RELEASE, 2015, 第 2 作者
(28) Biodegradable mesoporous calcium–magnesium silicate-polybutylene succinate scaffolds for osseous tissue engineering, INTERNATIONAL JOURNAL OF NANOMEDICINE, 2015, 第 1 作者
(29) Intracellular delivery and antitumor effects of a redox-responsive polymeric paclitaxel conjugate based on hyaluronic acid, ACTA BIOMATERIALIA, 2015, 第 5 作者
(30) 聚乙二醇化多粘菌素E对革兰阴性菌感染的治疗效果及降低肾毒性的作用, Therapeutic efficacy of pegylated polymyxin E in the treatment of infection induced by gramnegative bacteria and the effect of reducing nephrotoxicity, 药学学报, 2015, 第 2 作者
(31) Smart lipid capped mesoporous silica nanoparticles with tumor extracellular pH activated charge-conversion property for deep hepatocellular carcinoma penetration, JOURNAL OF CONTROLLED RELEASE, 2015, 第 1 作者
(32) Preparation of redispersible liposomal dry powder using an ultrasonic spray freeze-drying technique for transdermal delivery of human epithelial growth factor, INTERNATIONAL JOURNAL OF NANOMEDICINE, 2014, 通讯作者
(33) 载盐酸伊立替康的半乳糖修饰脂质介孔硅核壳纳米粒对肝癌细胞的抑制效果, 药学学报, 2014, 第 2 作者
(34) Biofunctionalized polymer-lipid supported mesoporous silica nanoparticles for release of chemotherapeutics in multidrug resistant cancer cells, BIOMATERIALS, 2014, 第 1 作者
(35) Role of phospholipids and copolymers in enhancing stability and controlling degradation of intravenous lipid emulsions, COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 2013, 第 2 作者
(36) Novel pH-Sensitive Lipid-Polymer Composite Microspheres of 10-Hydroxycamptothecin Exhibiting Colon-Specific Biodistribution and Reduced Systemic Absorption, JOURNAL OF PHARMACEUTICAL SCIENCES, 2013, 第 4 作者
(37) Biofunctionalized polymer- lipid supported mesoporous silica nanoparticles for release of chemotherapeutics in multidrug resistant cancer cells, Biomaterials, 2012, 第 1 作者
(38) Dual-functional liposome for tumor targeting and overcoming multidrug resistance in hepatocellular carcinoma cells, BIOMATERIALS, 2012, 第 1 作者
(39) 基于转运蛋白BCRP的PEO-PPO-PEO胶束制备及其降低伊立替康消化道毒性的研究, 2012, 第 1 作者
(40) 伊立替康PEO-PPO-PEO胶束的制备和表征及其降低药物消化道毒性的机制研究, 药学学报, 2012, 第 1 作者
(41) Novel NSAIDs ophthalmic formulation: Flurbiprofen axetil emulsion with low irritancy and improved anti-inflammation effect, INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2011, 第 4 作者
(42) Lipid-polymer composite microspheres for colon-specific drug delivery prepared using an ultrasonic spray freeze-drying technique, JOURNAL OF MICROENCAPSULATION, 2011, 第 3 作者
(43) An examination of the potential effect of lipids on the first‐pass metabolism of the lipophilic drug anethol trithione, JOURNAL OF PHARMACEUTICAL SCIENCES, 2011, 第 5 作者
(44) Novel gastroretentive sustained-release tablet of tacrolimus based on self-microemulsifying mixture: in vitro evaluation and in vivo bioavailability test, Novel gastroretentive sustained-release tablet of tacrolimus based on self-microemulsifying mixture: in vitro evaluation and in vivo bioavailability test, 中国药理学报:英文版, 2011, 
(45) Novel gastroretentive sustained-release tablet of tacrolimus based on self-microemulsifying mixture: in vitro evaluation and in vivo bioavailability test, ACTA PHARMACOLOGICA SINICA, 2011, 通讯作者
(46) Self-assembled liquid crystalline nanoparticles as a novel ophthalmic delivery system for dexamethasone: Improving preocular retention and ocular bioavailability, INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2010, 第 6 作者
(47) Absorption enhancement of adefovir dipivoxil by incorporating MCT and ethyl oleate complex oil phase in emulsion, ACTA PHARMACOLOGICA SINICA, 2010, 第 3 作者
(48) Novel vehicle based on cubosomes for ophthalmic delivery of flurbiprofen with low irritancy and high bioavailability, ACTA PHARMACOLOGICA SINICA, 2010, 第 5 作者
(49) Effect of poly (ethylene oxide)-poly (propylene oxide)-poly (ethylene oxide) micelles on pharmacokinetics and intestinal toxicity of irinotecan hydrochloride: potential involvement of breast cancer resistance protein (ABCG2), JOURNAL OF PHARMACY AND PHARMACOLOGY, 2010, 第 2 作者
(50) Reversible Inhibitory Effects of Saturated and Unsaturated Alkyl Esters on the Carboxylesterases Activity in Rat Intestine, LIPIDS, 2010, 第 3 作者
(51) 羟喜树碱注射乳剂的制备及其灭菌稳定性研究, Preparation of Hydroxycamptothecin Emulsion for Inject and Its Stability After Sterilization, 中国药师, 2009, 第 2 作者
(52) Novel microemulsion in situ electrolyte-triggered gelling system for ophthalmic delivery of lipophilic cyclosporine A: In vitro and in vivo results, INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2009, 第 4 作者
(53) 利巴韦林温度-离子敏感型鼻用原位凝胶喷雾剂的制备及体外性质考察, Preparation and in vitro evaluation of thermo-and ion-sensitive in situ gels of vibavirin via intranasal administration, 沈阳药科大学学报, 2009, 第 3 作者
(54) Lipid-based formulations to enhance oral bioavailability of the poorly water-soluble drug anethol trithione: Effects of lipid composition and formulation, INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2009, 第 3 作者
(55) PEGylated nanostructured lipid carriers loaded with 10-hydroxycamptothecin: an efficient carrier with enhanced anti-tumour effects against lung cancer, JOURNAL OF PHARMACY AND PHARMACOLOGY, 2008, 第 1 作者
(56) 聚乙二醇修饰的羟基喜树碱纳米脂质载体的制备及其小鼠组织分布, Preparation of PEG-modified nanostructured lipid carriers loaded with hydroxycamptothecin and tissue distribution in mice, 药学学报, 2008, 第 1 作者
(57) Redispersible, dry emulsion of lovastatin protects against intestinal metabolism and improves bioavailability1, ACTA PHARMACOLOGICA SINICA, 2008, 第 2 作者
(58) Redispersible, dry emulsion of lovastatin protects against intestinal metabolism and improves bioavailability, ACTA PHARMACOLOGICA SINICA, 2008, 第 2 作者
(59) Preparation of a Dispersible PEGylate Nanostructured Lipid Carriers (NLC) Loaded with 10-Hydroxycamptothecin by Spray-Drying, CHEMICAL & PHARMACEUTICAL BULLETIN, 2008, 第 1 作者
(60) Effects of breast cancer resistance protein inhibitors and pharmaceutical excipients on decreasing gastrointestinal toxicity of camptothecin analogs, ACTA PHARMACOLOGICA SINICA, 2008, 第 1 作者
(61) 灯盏花素亲水凝胶骨架缓释片的研究, Study on Breviscapin Hydrophilic Matrics Sustained Release Tablets, 中国药学杂志, 2006, 第 2 作者
(62) 羟基喜树碱纳米脂质载体的制备及体外释放, 中国医药工业杂志, 2006, 第 1 作者
发表著作
New Nanomaterials and Techniques for Tumor-targeted Systems, Springer, 2020-01, 第 其他 作者

科研活动

   
科研项目
( 1 ) 基于肝脏转运蛋白BCRP/ MRP2的纳米载体设计及其降低药物肝胆转运的研究, 负责人, 国家任务, 2010-01--2012-12
( 2 ) 高效低毒的功能性高分子脂质体设计及其降低拓扑异构酶Ⅰ抑制剂消化道毒性机制的研究, 负责人, 地方任务, 2011-01--2013-12
( 3 ) 抗感染药物多黏菌素E脂质体技术开发及安全性评价, 负责人, 地方任务, 2012-09--2015-09
( 4 ) 纳米药物的产业化技术, 参与, 中国科学院计划, 2013-01--2015-12
( 5 ) 基于系统科学的细胞多维信息实时自动获取与分析方法研究, 参与, 国家任务, 2015-01--2019-12
( 6 ) 多点动态监控的高频超声雾化微粒制备系统的设计和研制, 参与, 中国科学院计划, 2012-11--2014-11
( 7 ) 基于合成致死新策略的siRNA传递系统构建及其肝肿瘤穿透效应的机制研究, 负责人, 国家任务, 2016-01--2019-12
( 8 ) 注射用功能性脂质制剂的研究, 负责人, 中国科学院计划, 2015-01--2018-12
( 9 ) 新型注射脂质辅料的产业化及应用的共性关键技术研发和国际化注册, 参与, 国家任务, 2018-01--2020-12
( 10 ) 脂质递药系统, 负责人, 国家任务, 2023-01--2025-12
参与会议
(1)Lipid-based nanoparticles facilitate cytosolic delivery of siRNA   2018-10-12
(2)Transformable Liquid Crystals for Efficient Cytosolic Delivery of siRNA    2016-07-16
(3)脂质材料改性修饰及药物递送的研究   2015年中国药物制剂大会   2015-09-25
(4)Biofunctional lipid materials for nanoparticle preparation and antitumor drug delivery   Xinxin Zhang   2014-10-19
(5)Delivery of smart lipid capped mesoporous silica nanoparticles along tumor extracellular pH gradients for Hepatocellular Carcinoma Therapy   Xinxin Zhang   2014-09-19
(6)Preparation of Redispersible Liposomal Dry Powder by an Ultrasonic Spray Freeze Drying Technique for Transdermal Delivery of Human Epithelial Growth Factor   Xinxin Zhang   2014-07-18
(7)Triggered release of CPT-11 in multidrug resistant cancer cells by biofunctionalized lipid bilayer supported mesoporous silica nanoparticles   Xinxin Zhang   2013-07-19