基本信息
杨德华  男  硕导  中国科学院上海药物研究所
电子邮件: dhyang@simm.ac.cn
通信地址: 上海市浦东新区金科路3728号5号楼
邮政编码: 201204

招生信息

   
招生专业
100706-药理学
招生方向
G蛋白偶联受体的结构和功能
G蛋白偶联受体的小分子药物筛选

教育背景

2005-09--2009-12   中国科学院上海生命科学研究院   博士研究生/博士
2002-09--2005-07   华南师范大学   硕士研究生/硕士
1997-09--2002-07   烟台师范学院   本科/学士

工作经历

   
工作简历
2017-10~现在, 中国科学院上海药物研究所, 研究员
2012-10~2017-09,中国科学院上海药物研究所, 副研究员
2012-03~2012-09,中国科学院上海药物研究所, 助理研究员
2010-01~2012-02,上海交通大学医学院, 博士后
2005-09~2009-12,中国科学院上海生命科学研究院, 博士研究生/博士
2002-09~2005-07,华南师范大学, 硕士研究生/硕士
1997-09~2002-07,烟台师范学院, 本科/学士

专利与奖励

   
奖励信息
(1) 赛诺菲—中国科学院上海生命科学研究院优秀青年人才奖, 研究所(学校), 2017
(2) 上海市人才发展基金, 省级, 2016
(3) 科技部及盖茨基金会“大挑战·青年科学家”奖, 部委级, 2015
(4) 中华医学科技奖, 二等奖, 部委级, 2008
(5) 上海市科学技术奖, 三等奖, 省级, 2008
(6) 上海市医学科技奖, 二等奖, 其他, 2008
专利成果
( 1 ) 3,4,5-三取代吡唑类化合物、制备方法、药物组合物及用途, 2021, 第 4 作者, 专利号: CN106279023B

出版信息

   
发表论文
(1) Molecular basis of ligand recognition and activation of human V2 vasopressin receptor, Molecular basis of ligand recognition and activation of human V2 vasopressin receptor, CELL RESEARCH, 2021, 
(2) Design, synthesis and pharmacological evaluation of tricyclic derivatives as selective RXFP4 agonists, BIOORGANIC CHEMISTRY, 2021, 第 6 作者
(3) W2476 represses TXNIP transcription via dephosphorylation of FOXO1 at Ser319, CHEMICAL BIOLOGY & DRUG DESIGN, 2021, 第 6 作者
(4) G protein-coupled receptors: structure- and function-based drug discovery, SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2021, 第 1 作者
(5) An in vitro Fo''rster resonance energy transfer-based high-throughput screening assay identifies inhibitors of SUMOylation E2 Ubc9, ACTA PHARMACOLOGICA SINICA, 2020, 第 6 作者
(6) Structural basis for activation of the growth hormone-releasing hormone receptor, NATURE COMMUNICATIONS, 2020, 
(7) High-throughput screening campaign identifies a small molecule agonist of the relaxin family peptide receptor 4, ACTA PHARMACOLOGICA SINICA, 2020, 第 8 作者
(8) Cryo-electron microscopy structure of the glucagon receptor with a dual-agonist peptide, JOURNAL OF BIOLOGICAL CHEMISTRY, 2020, 第 13 作者
(9) Pharmacological characterization of mono-, dual- and tri-peptidic agonists at GIP and GLP-1 receptors, BIOCHEMICAL PHARMACOLOGY, 2020, 第 5 作者
(10) Integrating yeast chemical genomics and mammalian cell pathway analysis (vol 40, pg 1245, 2020), ACTA PHARMACOLOGICA SINICA, 2020, 第 8 作者
(11) Structural basis of G(s) and G(i) recognition by the human glucagon receptor, SCIENCE, 2020, 第 14 作者
(12) Accelerating the Throughput of Affinity Mass Spectrometry-Based Ligand Screening toward a G Protein-Coupled Receptor (vol 91, pg 8162, 2019), ANALYTICAL CHEMISTRY, 2020, 第 8 作者
(13) A Novel G Protein-Biased andSubtype-Selective Agonistfor a G Protein-Coupled Receptor Discovered from Screening HerbalExtracts, ACS CENTRAL SCIENCE, 2020, 
(14) Common activation mechanism of class A GPCRs, ELIFE, 2019, 第 2 作者
(15) Selective activation of TWIK-related acid-sensitive K+ 3 subunit-containing channels is analgesic in rodent models, SCIENCE TRANSLATIONAL MEDICINE, 2019, 第 20 作者
(16) Integrating yeast chemical genomics and mammalian cell pathway analysis, ACTA PHARMACOLOGICA SINICA, 2019, 第 8 作者
(17) Accelerating the Throughput of Affinity Mass Spectrometry-Based Ligand Screening toward a G Protein-Coupled Receptor, ANALYTICAL CHEMISTRY, 2019, 第 8 作者
(18) Structure and dynamics of the active human parathyroid hormone receptor-1, SCIENCE, 2019, 其他(合作组作者)
(19) Identification, structure modification, and characterization of potential small-molecule SGK3 inhibitors with novel scaffolds, ACTA PHARMACOLOGICA SINICA, 2018, 
(20) Adenine derivatives invert high glucose-induced thioredoxin-interacting protein overexpression, CHEMICAL BIOLOGY & DRUG DESIGN, 2018, 第 6 作者
(21) High-throughput screening for small molecule inhibitors of the type-I interferon signaling pathway, High-throughput screening for small molecule inhibitors of the type-I interferon signaling pathway, ACTA PHARMACEUTICA SINICA B, 2018, 第 3 作者
(22) Discovery of thiophene-containing biaryl amide derivatives as novel glucagon receptor antagonists, CHEMICAL BIOLOGY & DRUG DESIGN, 2018, 第 8 作者
(23) Two distinct domains of the glucagon-like peptide-1 receptor control peptide-mediated biased agonism, JOURNAL OF BIOLOGICAL CHEMISTRY, 2018, 第 6 作者
(24) A novel series of 4-methyl substituted pyrazole derivatives as potent glucagon receptor antagonists: Design, synthesis and evaluation of biological activities, BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 第 8 作者
(25) Chemical Diversity in the G Protein-Coupled Receptor Superfamily, TRENDS IN PHARMACOLOGICAL SCIENCES, 2018, 第 3 作者
(26) Extracellular loops 2 and 3 of the calcitonin receptor selectively modify agonist binding and efficacy, BIOCHEMICAL PHARMACOLOGY, 2018, 第 7 作者
(27) Crystal structure of the human 5-HT1B serotonin receptor bound to an inverse agonist, CELL DISCOVERY, 2018, 第 3 作者
(28) Structure of the glucagon receptor in complex with a glucagon analogue, NATURE, 2018, 第 6 作者
(29) W2476 ameliorates beta-cell dysfunction and exerts therapeutic effects in mouse models of diabetes via modulation of the thioredoxin-interacting protein signaling pathway, ACTA PHARMACOLOGICA SINICA, 2017, 第 13 作者
(30) W2476 ameliorates β-cell dysfunction and exerts therapeutic effects in mouse models of diabetes via modulation of the thioredoxin-interacting protein signaling pathway, Acta Pharmacologica Sinica, 2017, 第 13 作者
(31) Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators, NATURE, 2017, 第 2 作者
(32) Structure of the full-length glucagon class B G-protein-coupled receptor, NATURE, 2017, 
(33) Rearrangement of a polar core provides a conserved mechanism for constitutive activation of class B G protein-coupled receptors, JOURNAL OF BIOLOGICAL CHEMISTRY, 2017, 第 5 作者
(34) Genome-wide mapping of miRNAs expressed in embryonic stem cells and pluripotent stem cells generated by different reprogramming strategies, BMC GENOMICS, 2014, 第 2 作者
(35) G蛋白偶联受体别构调节剂, Allosteric modulators of G-protein coupled receptors, 生命的化学, 2013, 第 2 作者

科研活动

   
科研项目
( 1 ) 基于非肽类小分子激动剂Boc5的GLP-1R别构调节剂的功能和应用研究, 负责人, 国家任务, 2014-01--2017-12
( 2 ) GLP-1受体别构调节剂筛选及其在糖尿病中的功能研究, 负责人, 地方任务, 2012-07--2015-06
( 3 ) 针对重要癌基因靶点的个性化抗癌新药开发, 参与, 国家任务, 2014-04--2017-03
( 4 ) 基于促肾上腺皮质激素释放因子1型受体蛋白晶体结构的创新药物发现和成药性研究, 参与, 地方任务, 2014-07--2017-09
( 5 ) 基于B族GPCR蛋白晶体结构阐明GLP-1R跨膜区关键位点的功能, 负责人, 国家任务, 2016-01--2019-12
( 6 ) Functional studies and signal bias exploration on GLP-lR transmembrane domains, 负责人, 中国科学院计划, 2016-01--2017-12
( 7 ) 针对糖尿病新靶标RXFP4的先导化合物发现, 负责人, 中国科学院计划, 2016-01--2017-12
( 8 ) 基于受体蛋白结构信息阐释GLP-1R和GCGR受体选择性的分子机制, 负责人, 国家任务, 2018-01--2021-12