071010-生物化学与分子生物学
071005-微生物学

嗜热木质纤维素降解酶的筛选和优化
降解木质纤维素的嗜热微生物的生理生化研究
生物能源与生物转化

2007-03--2010-02   韩国釜山国立大学   博士
2004-09--2007-02   韩国釜山国立大学   硕士
2000-09--2004-06   烟台大学   学士

   

2013-05~2013-11,美国堪萨斯州立大学, 博士后研究员
2011-05~2013-05,韩国釜山国立大学, 博士后研究员
2010-07~2011-04,美国纽约大学, 博士后研究员

   

（1） 青岛市崂山区“山海英才”, 市地级, 2015
（2） 釜山大学优秀学术奖, , 研究所（学校）, 2009
（3） 釜山大学自然科学院优秀学术奖, , 研究所（学校）, 2009

[1] 李福利, 顾阳, 刘自勇, 贾德臣, 查孝胜, 马小清, 吕明, 姜卫红. 一种提高合成气发酵产乙醇含量的突变株和利用突变株的应用. CN: CN113234653A, 2021-08-10.
[2] 李福利, 苏航, 吕明. 一种特异性识别底物的褐藻胶裂解酶突变体及其应用. CN: CN112980821A, 2021-06-18.
[3] 李福利, 苏航, 冀世奇, 吕明. 褐藻胶裂解酶的编码基因及其应用. CN: CN108929878B, 2021-04-06.
[4] 吕明, 李福利, 韩文杰, 阿布萨利赫. β‑木糖苷酶及其应用. CN: CN107189994A, 2017-09-22.
[5] 李福利, 孟冬冬, 吕明, 张坤迪. 一种耐热木聚糖酶及其应用. CN: CN105671019A, 2016-06-15.
[6] 李亮, 吕明, 王海超, 张启梁. 采用生物制剂浮选含金矿石的方法. CN: CN105537006A, 2016-05-04.

   

[1] Bai, Xue, Lan, Jing, He, Shanru, Bu, Tingting, Zhang, Jie, Wang, Lulu, Jin, Xiaoling, Mao, Yuanchao, Guan, Wanting, Zhang, Liying, Lu, Ming, Piao, Hailong, Jo, Inseong, Quan, Chunshan, Nam, Ki Hyun, Xu, Yongbin. Structural and Biochemical Analyses of the Butanol Dehydrogenase from Fusobacterium nucleatum. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES[J]. 2023, 24(3): http://dx.doi.org/10.3390/ijms24032994.
[2] Hamouda, Hamed I, Fan, YiXuan, Abdalla, Mohnad, Su, Hang, Lu, Ming, Li, FuLi. Distinct roles of carbohydrate-binding modules in multidomain beta-1,3-1,4-glucanase on polysaccharide degradation. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2023, 107(5-6): 1751-1764, http://dx.doi.org/10.1007/s00253-023-12416-4.
[3] Hamouda, Hamed I, Fan, YiXuan, Abdalla, Mohnad, Su, Hang, Lu, Ming, Li, FuLi. Distinct roles of carbohydrate-binding modules in multidomain β-1,3-1,4-glucanase on polysaccharide degradation. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2023, 107(5-6): 1751-1764, http://dx.doi.org/10.1007/s00253-023-12416-4.
[4] Ma, Xin, Zhang, Guoqiang, Li, Fengting, Jiao, Mingyang, Yao, Shunyu, Chen, Zhipeng, Liu, Ziyong, Zhang, Yongyu, Lv, Ming, Liu, Licheng. Boosting the Microbial Electrosynthesis of Acetate from CO2 by Hydrogen Evolution Catalysts of Pt Nanoparticles/rGO. CATALYSIS LETTERS[J]. 2021, 第 9 作者151(10): 2939-2949, http://dx.doi.org/10.1007/s10562-021-03537-4.
[5] Ali, Nasir, Hamouda, Hamed, I, Su, Hang, Li, FuLi, Lu, Ming. Combinations of alkaline hydrogen peroxide and lithium chloride/N,N-dimethylacetamide pretreatments of corn stalk for improved biomethanation. ENVIRONMENTAL RESEARCH[J]. 2020, 186: http://dx.doi.org/10.1016/j.envres.2020.109563.
[6] Hamouda, Hamed, I, Ali, Nasir, Su, Hang, Feng, Jie, Lu, Ming, Li, FuLi. Exploration of Two Pectate Lyases from Caldicellulosiruptor bescii Reveals that the CBM66 Module Has a Crucial Role in Pectic Biomass Degradation. APPLIED AND ENVIRONMENTAL MICROBIOLOGY[J]. 2020, 86(16): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7414952/.
[7] Ali, Nasir, Zhang, Quan, Liu, ZiYong, Li, FuLi, Lu, Ming, Fang, XiangChen. Emerging technologies for the pretreatment of lignocellulosic materials for bio-based products. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY. 2020, 104(2): 455-473, http://dx.doi.org/10.1007/s00253-019-10158-w.
[8] 冯杰, HamedIHamouda, NaisrAli, 王雨铭, 张培玉, 吕明. 嗜热厌氧菌Caldicellulosiruptor sp.F32中降解β-1，3-1，4葡聚糖水解酶的协同性分析及糖基化对F32EG5热稳定性影响. 微生物学报[J]. 2019, 第 6 作者59(11): 2144-2154, https://actamicro.ijournals.cn/actamicrocn/article/abstract/20191109?st=article_issue.
[9] Wang, Bing, Ji, ShiQi, Ma, XiaoQing, Lu, Ming, Wang, LuShan, Li, FuLi. Substitution of one calcium-binding amino acid strengthens substrate binding in a thermophilic alginate lyase. FEBS LETTERS[J]. 2018, 592(3): 369-379, https://www.webofscience.com/wos/woscc/full-record/WOS:000424875300008.
[10] 吕明. 热解纤维素菌属F32中乙酰木聚糖酯酶Axe7的表征. 微生物学通报. 2017, 第 1 作者  通讯作者  
[11] Saleh Mohammad Abu, Han WenJie, Lu Ming, Wang Bing, Li Huayue, Kelly Robert M, Li FuLi. Two Distinct α- l -Arabinofuranosidases in Caldicellulosiruptor Species Drive Degradation of Arabinose-Based Polysaccharides. APPLIED AND ENVIRONMENTAL MICROBIOLOGY[J]. 2017, 
[12] 吕明. 难处理金银精矿生物氧化—氰化浸金试验研究. 黄金. 2016, 第 1 作者  通讯作者  
[13] 王灵, 韩文杰, 孟冬冬, 朱静, 李福利, 吕明. 糖基化对Caldicellulosiruptor sp. F32中内切型木聚糖酶热稳定性的影响. 生物技术[J]. 2016, 第 6 作者26(3): 300-306, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=5739201&detailType=1.
[14] 韩文杰, 吕明, 周同, 张培玉. 微生物技术在金矿提金中的应用与展望. 生物技术通讯[J]. 2016, 第 2 作者27(5): 738-742, http://lib.cqvip.com/Qikan/Article/Detail?id=670394522.
[15] Ji, ShiQi, Wang, Bing, Lu, Ming, Li, FuLi. Direct bioconversion of brown algae into ethanol by thermophilic bacterium Defluviitalea phaphyphila. BIOTECHNOLOGY FOR BIOFUELS[J]. 2016, 9(1): http://ir.qibebt.ac.cn/handle/337004/12616.
[16] Meng, DongDong, Ying, Yu, Zhang, KunDi, Lu, Ming, Li, FuLi. Depiction of carbohydrate-active enzyme diversity in Caldicellulosiruptor sp F32 at the genome level reveals insights into distinct polysaccharide degradation features. MOLECULAR BIOSYSTEMS[J]. 2015, 11(11): 3164-3173, http://dx.doi.org/10.1039/c5mb00409h.
[17] 吕明. Defluviitalea phaphyphila sp. nov., a Novel Thermophilic Bacterium That Degrades Brown Algae.. Appl Environ Microbiol.. 2015, 第 1 作者
[18] Chang, Ziwei, Lu, Ming, Ma, Yunqi, Kwag, DongGeon, Kim, SeoHyun, Park, JiMin, Nam, BoHye, Kim, YoungOk, An, CheulMin, Li, Huayue, Jung, Jee H, Park, JangSu. Production of disulfide bond-rich peptides by fusion expression using small transmembrane proteins of Escherichia coli. AMINO ACIDS[J]. 2015, 47(3): 579-587, http://dx.doi.org/10.1007/s00726-014-1892-y.
[19] Meng, D. D., Ying, Y., Chen, X. H., Lu, M., Ning, K., Wang, L. S., Li, F. L.. Distinct roles for carbohydrate-binding modules of glycoside hydrolase 10 (GH10) and GH11 xylanases from Caldicellulosiruptor sp. strain F32 in thermostability and catalytic efficiency. APPL ENVIRON MICROB[J]. 2015, 81(6): 2006-2014, http://ir.qibebt.ac.cn/handle/337004/8625.
[20] Lu, Ming, Park, JangSu. Protonation Behavior of Histidine during HSF1 Activation by Physiological Acidification. JOURNAL OF CELLULAR BIOCHEMISTRY[J]. 2015, 116(6): 977-984, http://dx.doi.org/10.1002/jcb.25051.
[21] Chang, Ziwei, Lu, Ming, Kim, SoSun, Park, JangSu. Potential role of HSP90 in mediating the interactions between estrogen receptor (ER) and aryl hydrocarbon receptor (AhR) signaling pathways. TOXICOLOGY LETTERS[J]. 2014, 226(1): 6-13, http://dx.doi.org/10.1016/j.toxlet.2014.01.032.
[22] Chang, Ziwei, Lu, Ming, Shon, KwangJae, Park, JangSu. Functional expression of Carassius auratus cytochrome P4501A in a novel Shewanella oneidensis expression system and application for the degradation of benzoa pyrene. JOURNAL OF BIOTECHNOLOGY[J]. 2014, 179: 1-7, http://dx.doi.org/10.1016/j.jbiotec.2014.03.008.
[23] Lu, Ming, Chang, Ziwei, Bae, MinJi, Oh, Seung Min, Chung, KyuHyuck, Park, JangSu. Molecular characterization of the aryl hydrocarbon receptor (AhR) pathway in goldfish (Carassius auratus) exposure to TCDD: The mRNA and protein levels. FISH & SHELLFISH IMMUNOLOGY[J]. 2013, 35(2): 469-475, http://dx.doi.org/10.1016/j.fsi.2013.05.002.
[24] Lu, Ming, Chang, Ziwei, Park, JangSu. Histidine (His83) is Essential for Heat Shock Factor 1 (HSF1) Activation in Protecting against Acid pH Stress. BULLETIN OF THE KOREAN CHEMICAL SOCIETY[J]. 2013, 34(11): 3405-3409, https://www.webofscience.com/wos/woscc/full-record/WOS:000327689400050.
[25] Lu, Ming, Kwon, Bobae, Chang, Ziwei, Park, HyeonGyeong, Park, JangSu. Roles of His(101) in DNA-Binding Domain of Human Heat Shock Factor 1 Under Acid pH Environment. BULLETIN OF THE KOREAN CHEMICAL SOCIETY[J]. 2012, 33(12): 4201-4203, https://www.webofscience.com/wos/woscc/full-record/WOS:000313154400055.
[26] Chang, Ziwei, Lu, Ming, Park, SungMin, Park, HyunKyung, Kang, Ho Sung, Pak, Youngshang, Park, JangSu. Functional HSF1 requires aromatic-participant interactions in protecting mouse embryonic fibroblasts against apoptosis via G2 cell cycle arrest. MOLECULES AND CELLS[J]. 2012, 33(5): 465-470, http://dx.doi.org/10.1007/s10059-012-2246-9.
[27] Chang, Ziwei, Lu, Ming, Lee, Keun Woo, Oh, BeomSeok, Bae, MinJi, Park, JangSu. Influence of divalent metal ions on E2-induced ER pathway in goldfish (Carassius auratus) hepatocytes. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY[J]. 2011, 74(8): 2233-2239, http://dx.doi.org/10.1016/j.ecoenv.2011.07.024.
[28] Lee, Keun Woo, Chang, Ziwei, Oh, BeomSeok, Lu, Ming, Park, JangSu. Estrogenic Response in Male Bullfrog (Rana catesbeiana) Hepatocytes After Single or Combined Exposure to Cadmium (Cd) and 17beta-Estradiol (E2). BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY[J]. 2010, 85(5): 452-456, http://dx.doi.org/10.1007/s00128-010-0119-5.
[29] 吕明. Zn2+ in Replication Protein A Is Required for Its Full Activities of Single-Stranded DNA-Binding and DNA Replication. Bulletin of the Korean Chemical Society. 2009, 第 1 作者
[30] Li, ChunRi, Lee, SangHoon, Kim, SoSun, Kim, Andre, Lee, Keun Woo, Lu, Ming, Kim, HeeEun, Kwak, ImJung, Lee, YunJu, Kim, DongKyoo, Lee, JungSick, Kang, ShinWon, Huh, MinDo, Chung, KyuHyuck, Park, JangSu. Environmental estrogenic effects and gonadal development in wild goldfish (Carassius auratus). ENVIRONMENTAL MONITORING AND ASSESSMENT[J]. 2009, 150(1-4): 397-404, https://www.webofscience.com/wos/woscc/full-record/WOS:000263159900032.
[31] Lu, Ming, Sohn, KwangJea, Kim, SiWon, Li, ChunRi, Kim, Suhkmann, Kim, DongKyoo, Park, JangSu. Alpha-helix 1 in the DNA-binding domain of heat shock factor 1 regulates its heat-induced trimerization and DNA-binding. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2009, 385(4): 612-617, https://www.webofscience.com/wos/woscc/full-record/WOS:000267396500024.
[32] Lu, Ming, Lee, YunJu, Park, SungMin, Kang, Ho Sung, Kang, Shin Won, Kim, Suhkmann, Park, JangSu. Aromatic-Participant Interactions Are Essential for Disulfide-Bond-Based Trimerization in Human Heat Shock Transcription Factor 1. BIOCHEMISTRY[J]. 2009, 48(18): 3795-3797, https://www.webofscience.com/wos/woscc/full-record/WOS:000265780800001.
[33] Lu, Ming, Kim, HeeEun, Li, ChunRi, Kim, Sol, Kwak, ImJung, Lee, YunJu, Kim, SoSun, Moon, JiYoung, Kim, Cho Hee, Kim, DongKyoo, Kang, Ho Sung, Park, JangSu. Two distinct disulfide bonds formed in human heat shock transcription factor 1 act in opposition to regulate its DNA binding activity. BIOCHEMISTRY[J]. 2008, 47(22): 6007-6015, https://www.webofscience.com/wos/woscc/full-record/WOS:000256256200012.
[34] Lu, Ming, Kim, HeeEun, Li, ChunRi, Hwang, YunJeong, Kim, Sol, Kwak, ImJung, Lee, YunJu, Kim, SoSun, Kang, ShinWon, Park, NamGyu, Kim, DongKyoo, Kang, Ho Sung, Park, JangSu. Two functional domains of human heat shock factor 1 have different effects on its DNA-binding activity through redox changes. BULLETINOFTHEKOREANCHEMICALSOCIETY[J]. 2007, 28(9): 1455-1456, https://www.webofscience.com/wos/woscc/full-record/WOS:000251301400001.

   

（ 1 ） 极端嗜热细菌Caldicellulosiruptor中双功能纤维素水解酶作用机制的研究, 主持, 国家级, 2015-01--2017-12
（ 2 ） 极端嗜热厌氧细菌Caldicellulosiruptor sp. F32水解秸秆产糖机制的研究, 主持, 国家级, 2014-01--2014-12
（ 3 ） 新型高温高效褐藻胶酶工具酶的开发及应用, 主持, 省级, 2014-01--2015-12
（ 4 ） 工业微生物与蛋白复配黄金浸出技术的引进应用, 主持, 国家级, 2015-04--2018-03
（ 5 ） 海洋牙鲆鱼来源的β型生物防御素：其异源表达与结构功能的研究, 主持, 省级, 2015-09--2017-08

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