基本信息
张延平 女 博导 中国科学院微生物研究所
电子邮件: zhangyp@im.ac.cn
通信地址: 北京市朝阳区北辰西路一号院3号
邮政编码: 100101
电子邮件: zhangyp@im.ac.cn
通信地址: 北京市朝阳区北辰西路一号院3号
邮政编码: 100101
研究领域
微生物系统代谢工程,合成生物学,微生物组工程
招生信息
招生专业
071010-生物化学与分子生物学071005-微生物学
招生方向
微生物生理与代谢工程;合成生物学;微生物组工程
教育背景
2000-09--2006-06 清华大学 博士学位1996-09--2000-06 清华大学 学士学位
工作经历
工作简历
2022-10~现在, 中国科学院微生物研究所, 研究员2016-10~2022-10,中国科学院微生物研究所, 项目研究员2010-09~2016-09,中国科学院微生物研究所, 副研究员2006-07~2010-08,中国科学院微生物研究所, 助理研究员
社会兼职
2022-12-01-今,中国生物工程学会一碳生物技术专业委员会, 副主任
2018-04-01-今,北京微生物学会, 理事
2018-04-01-今,北京微生物学会, 理事
教授课程
代谢工程合成生物学与生物技术
专利与奖励
专利成果
[1] 赵春华, 张延平, 李寅, 珍保罗西努瓦, 张天瑞, 董红军. 利用木糖生产丁醇的工程菌株及其构建方法和应用. CN: CN111826372B, 2022-03-01.[2] 董红军, 赵春华, 张天瑞, 朱华伟, 林兆, 张延平, 李寅. 高产丁醇的大肠杆菌基因工程菌及其构建方法与应用. CN: CN107287143A, 2017-10-24.[3] 赵春华, 董红军, 张延平, 李寅. 一种丁酸产量低且丁醇产量高的工程菌及其构建方法与应用. CN: CN105567722A, 2016-05-11.[4] 董红军, 赵春华, 张延平, 李寅. 一种提高大肠杆菌生产丁醇的方法. CN: CN105505971A, 2016-04-20.[5] 董红军, 赵春华, 林兆, 张延平, 李寅. 一种构建高产丁醇菌株的方法与应用. CN: CN105368863A, 2016-03-02.[6] 张延平, 杨帆, 孙雷, 李兴华, 朱泰承, 李寅. 1,2,4-丁三醇相关蛋白在生物法制备1,2,4-丁三醇中的应用. CN: CN105567716A, 2016-05-11.[7] 蔡真, 李兴华, 张延平, 李寅. 1,2,4-丁三醇的生物合成方法. CN: CN102965401A, 2013-03-13.[8] 张延平, 张博, 张海峰, 孙红兵, 李寅, 马延和. 一种酿酒酵母工程菌及其在生产乙醇中的应用. CN: CN102732437A, 2012-10-17.[9] 工程菌株及其在利用葡萄糖和乙酸制备丁酸丁酯中的应用. 2023-11-13.[10] 醇酰基转移酶、工程菌株及其应用. 2023-09-19.[11] 醇酰基转移酶、工程菌株及其应用. 2023-09-19.[12] 导电水凝胶和一体化生物光伏系统及其制备方法. 2021-11-22.[13] 董红军, 戴宗杰, 张延平, 李寅. 一种稳定联产异丙醇和丁醇的工程菌及其构建方法与应用. CN: CN102199614A, 2011-09-28.
出版信息
发表论文
[1] Jiayu Fang, Yanping Zhang, Taicheng Zhu, Yin Li. Scramblase activity of proteorhodopsin confers physiological advantages to Escherichia coli in the absence of light. ISCIENCE[J]. 2023, 第 2 作者26(12): 108551, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10730872/.[2] Lei Zhao, Zhen Cai, Yin Li, Yanping Zhang. Engineering Rubisco to enhance CO2 utilization. SYNTHETIC AND SYSTEMS BIOTECHNOLOGY[J]. 2023, 第 4 作者 通讯作者 9(1): 55-68, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10809010/.[3] 赵雪桐, 朱华伟, 张延平, 李寅. 基于类囊体膜的光能利用和光动力学治疗. 科学通报[J]. 2023, 第 3 作者68(10): 1203-1216, http://lib.cqvip.com/Qikan/Article/Detail?id=7109523667.[4] 张延平, 张天瑞, 赵同心, 赵秋伟, 朱泰承, 李寅. 氧化还原调控促进低碳生物合成. 科学通报[J]. 2023, 第 1 作者68(19): 2435-2445, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=7515055&detailType=1.[5] Zhu, Huawei, Wang, Haowei, Zhang, Yanping, Li, Yin. Biophotovoltaics: Recent advances and perspectives. BIOTECHNOLOGY ADVANCES. 2023, 第 3 作者64: http://dx.doi.org/10.1016/j.biotechadv.2023.108101.[6] 赵同心, 赵磊, 张延平, 李寅. 甲酸微生物转化研究进展. 化工进展[J]. 2023, 第 3 作者 通讯作者 42(1): 67-72, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=7409211&detailType=1.[7] Wu, Ranran, Li, Fei, Cui, Xinyu, Li, Zehua, Ma, Chunling, Jiang, Huifeng, Zhang, Lingling, Zhang, YiHeng P Job, Zhao, Tongxin, Zhang, Yanping, Li, Yin, Chen, Hui, Zhu, Zhiguang. Enzymatic Electrosynthesis of Glycine from CO2 and NH3. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2023, 第 10 作者http://dx.doi.org/10.1002/anie.202218387.[8] Huawei Zhu, Liru Xu, Guodong Luan, Tao Zhan, Zepeng Kang, Chunli Li, Xuefeng Lu, Xueli Zhang, Zhiguang Zhu, Yanping Zhang, Yin Li. A miniaturized bionic ocean-battery mimicking the structure of marine microbial ecosystems. NATURE COMMUNICATIONS[J]. 2022, 第 10 作者 通讯作者 13(1): 1-14, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9509365/.[9] Xiao, Lu, Liu, Guoxia, Gong, Fuyu, Zhu, Huawei, Zhang, Yanping, Cai, Zhen, Li, Yin. A Minimized Synthetic Carbon Fixation Cycle. ACS CATALYSIS[J]. 2022, 第 5 作者12(1): 799-808, http://dx.doi.org/10.1021/acscatal.1c04151.[10] Dai, Zongjie, Zhu, Yan, Dong, Hongjun, Zhao, Chunhua, Zhang, Yanping, Li, Yin. Enforcing ATP hydrolysis enhanced anaerobic glycolysis and promoted solvent production in Clostridium acetobutylicum. MICROBIAL CELL FACTORIES[J]. 2021, 第 5 作者 通讯作者 20(1): http://dx.doi.org/10.1186/s12934-021-01639-7.[11] Meng, Hengkai, Zhang, Wei, Zhu, Huawei, Yang, Fan, Zhang, Yanping, Zhou, Jie, Li, Yin. Over-expression of an electron transport protein OmcS provides sufficient NADH for d-lactate production in cyanobacterium. BIOTECHNOLOGY FOR BIOFUELS[J]. 2021, 第 5 作者14(1): https://doaj.org/article/75c474d0b7ed40299611510c4e124ce5.[12] Sinumvayo, Jean Paul, Li, Yin, Zhang, Yanping. Microbial production of butyl butyrate: from single strain to cognate consortium. BIORESOURCES AND BIOPROCESSING[J]. 2021, 第 3 作者 通讯作者 8(1): 1-11, https://doaj.org/article/fdbd7008e9f047818df4166e4a69e245.[13] Zhou, Jie, Yang, Fan, Zhang, Fuliang, Meng, Hengkai, Zhang, Yanping, Li, Yin. Impairing photorespiration increases photosynthetic conversion of CO2 to isoprene in engineered cyanobacteria. BIORESOURCES AND BIOPROCESSING[J]. 2021, 第 5 作者8(1): https://doaj.org/article/8c58836911c64c2986fee3541c4549b4.[14] Sinumvayo, Jean Paul, Zhao, Chunhua, Liu, Guoxia, Li, Yin, Zhang, Yanping. One-pot production of butyl butyrate from glucose using a cognate "diamond-shaped" E. coli consortium. BIORESOURCES AND BIOPROCESSING[J]. 2021, 第 5 作者 通讯作者 8(1): http://dx.doi.org/10.1186/s40643-021-00372-8.[15] Zhao, Tongxing, Xu, Liru, Zhao, Lei, Zhang, Hongjie, Li, Yin, Zhang, Yanping. BtsT/BtsS is involved in glyoxylate transport in E. coli and its mutations facilitated glyoxylate utilization. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2021, 第 6 作者 通讯作者 551: 71-77, http://dx.doi.org/10.1016/j.bbrc.2021.03.002.[16] Zhao, Tongxing, Li, Yin, Zhang, Yanping. Biological carbon fixation: a thermodynamic perspective. GREEN CHEMISTRY. 2021, 第 3 作者 通讯作者 23(20): 7852-7864, http://dx.doi.org/10.1039/d0gc03493b.[17] 方嘉煜, 朱泰承, 张延平, 李寅. Gloeobacter violaceus视紫红质在大肠杆菌中的异源表达与功能评价. 生物工程学报[J]. 2020, 第 3 作者 通讯作者 37(2): 604-614, https://kns.cnki.net/KCMS/detail/detail.aspx?dbcode=CJFQ&dbname=CJFDLAST2021&filename=SHWU202102021&v=MTgxMTZVYnJNTmlYY2U3RzRITkRNclk5SFpZUjhlWDFMdXhZUzdEaDFUM3FUcldNMUZyQ1VSN3VmWWVkbUZpamc=.[18] Zhao, Chunhua, Zhang, Yanping, Li, Yin. Metabolic engineering for the production of butanol, a potential advanced biofuel, from renewable resources. BIOCHEMICAL SOCIETY TRANSACTIONS. 2020, 第 2 作者 通讯作者 48(5): 2283-2293, https://www.webofscience.com/wos/woscc/full-record/WOS:000583065000038.[19] Zhao, Chunhua, Zhang, Yanping, Li, Yin. Production of fuels and chemicals from renewable resources using engineered Escherichia coli. BIOTECHNOLOGY ADVANCES. 2019, 第 2 作者 通讯作者 37(7): http://dx.doi.org/10.1016/j.biotechadv.2019.06.001.[20] Huawei Zhu, Hengkai Meng, Wei Zhang, Haichun Gao, Jie Zhou, Yanping Zhang, Yin Li. Development of a longevous two-species biophotovoltaics with constrained electron flow. NATURE COMMUNICATIONS[J]. 2019, 第 6 作者 通讯作者 10(1): 1-12, [21] Zhao, Chunhua, Dong, Hongjun, Zhang, Yanping, Li, Yin. Discovery of potential genes contributing to the biosynthesis of short-chain fatty acids and lactate in gut microbiota from systematic investigation in E. coli. NPJ BIOFILMS AND MICROBIOMES[J]. 2019, 第 3 作者 通讯作者 5(1): http://dx.doi.org/10.1038/s41522-019-0092-7.[22] Zhao, Chunhua, Sinumvayo, Jean Paul, Zhang, Yanping, Li, Yin. Design and development of a "Y-shaped" microbial consortium capable of simultaneously utilizing biomass sugars for efficient production of butanol. METABOLICENGINEERING[J]. 2019, 第 3 作者 通讯作者 55: 111-119, http://dx.doi.org/10.1016/j.ymben.2019.06.012.[23] Gong, Fuyu, Zhu, Huawei, Zhang, Yanping, Li, Yin. Biological carbon fixation: From natural to synthetic. JOURNAL OF CO2 UTILIZATION[J]. 2018, 第 3 作者 通讯作者 28: 221-227, http://dx.doi.org/10.1016/j.jcou.2018.09.014.[24] 张天瑞, 赵秋伟, 李正华, 李寅, 张延平. 新一代糖化酶高产菌株的选育及其工业应用. 微生物学报[J]. 2017, 第 5 作者57(8): 1293-1300, https://actamicro.ijournals.cn/actamicrocn/article/abstract/20170816?st=article_issue.[25] Zhao, Chunhua, Lin, Zhao, Dong, Hongjun, Zhang, Yanping, Li, Yin. Reexamination of the Physiological Role of PykA in Escherichia coli Revealed that It Negatively Regulates the Intracellular ATP Levels under Anaerobic Conditions. APPLIED AND ENVIRONMENTAL MICROBIOLOGY[J]. 2017, 第 4 作者83(11): https://www.webofscience.com/wos/woscc/full-record/WOS:000401471600011.[26] Dong, Hongjun, Zhao, Chunhua, Zhang, Tianrui, Zhu, Huawei, Lin, Zhao, Tao, Wenwen, Zhang, Yanping, Li, Yin. A systematically chromosomally engineered Escherichia coli efficiently produces butanol. METABOLIC ENGINEERING[J]. 2017, 第 7 作者44: 284-292, http://dx.doi.org/10.1016/j.ymben.2017.10.014.[27] Zhao, Chunhua, Zhao, Qiuwei, Li, Yin, Zhang, Yanping. Engineering redox homeostasis to develop efficient alcohol-producing microbial cell factories. MICROBIAL CELL FACTORIES[J]. 2017, 第 4 作者 通讯作者 16(1): https://doaj.org/article/135d206e67dc4134bbdd76478a2080c6.[28] Dong Hongjun, Zhao Chunhua, Zhang Tianrui, Zhu Huawei, Lin Zhao, Tao Wenwen, Zhang Yanping, Li Yin. A systematically chromosomally engineered Escherichia coli efficiently produces butanol. METABOLIC ENGINEERING[J]. 2017, 第 7 作者[29] Zhou, Jie, Zhang, Fuliang, Meng, Hengkai, Zhang, Yanping, Li, Yin. Introducing extra NADPH consumption ability significantly increases the photosynthetic efficiency and biomass production of cyanobacteria. METABOLIC ENGINEERING[J]. 2016, 第 4 作者38: 217-227, http://dx.doi.org/10.1016/j.ymben.2016.08.002.[30] Dai, Zongjie, Dong, Hongjun, Zhang, Yanping, Li, Yin. Elucidating the contributions of multiple aldehyde/alcohol dehydrogenases to butanol and ethanol production in Clostridium acetobutylicum. SCIENTIFIC REPORTS[J]. 2016, 第 3 作者 通讯作者 6: https://www.webofscience.com/wos/woscc/full-record/WOS:000378231700001.[31] Sun, Lei, Yang, Fan, Sun, Hongbing, Zhu, Taicheng, Li, Xinghua, Li, Yin, Xu, Zhenghong, Zhang, Yanping. Synthetic pathway optimization for improved 1,2,4-butanetriol production. JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY[J]. 2016, 第 8 作者43(1): 67-78, http://www.irgrid.ac.cn/handle/1471x/1111547.[32] Zhang, Bo, Sun, Hongbing, Li, Jing, Wan, Yinhua, Li, Yin, Zhang, Yanping. High-titer-ethanol production from cellulosic hydrolysate by an engineered strain of Saccharomyces cerevisiae during an in situ removal process reducing the inhibition of ethanol on xylose metabolism. PROCESS BIOCHEMISTRY[J]. 2016, 第 6 作者 通讯作者 51(8): 967-972, http://dx.doi.org/10.1016/j.procbio.2016.04.019.[33] Dong, Hongjun, Zhao, Chunhua, Zhang, Tianrui, Lin, Zhao, Li, Yin, Zhang, Yanping, Ye, Q, Bao, J, Zhong, JJ. Engineering Escherichia coli Cell Factories for n-Butanol Production. BIOREACTOR ENGINEERING RESEARCH AND INDUSTRIAL APPLICATIONS I: CELL FACTORIES[J]. 2016, 第 11 作者155: 141-163, https://www.webofscience.com/wos/woscc/full-record/WOS:000395375800005.[34] 孙雷, 杨帆, 朱泰承, 李兴华, 孙红兵, 李寅, 许正宏, 张延平. 大肠杆菌合成1,2,4-丁三醇的途径优化. 生物工程学报[J]. 2016, 第 8 作者32(1): 51-63, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=5615523&detailType=1.[35] Yin Li. Engineering Saccharomyces cerevisiae to produce a high ethanol-titer-ethanol from a cellulosic hydrolysate by in situ reducing the ethanol-mediated inhibition on of xylose metabolismin situ. Process Biochemistry. 2016, [36] Yin Li. Elucidating the contribution of multiple aldehyde/alcohol dehydrogenases to butanol and ethanol production in Clostridium acetobutylicum. Scientific reports. 2016, [37] Gong, Fuyu, Bao, Guanhui, Zhao, Chunhua, Zhang, Yanping, Li, Yin, Dong, Hongjun. Fermentation and genomic analysis of acetone-uncoupled butanol production by Clostridium tetanomorphum. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2016, 第 4 作者 通讯作者 100(3): 1523-1529, https://www.webofscience.com/wos/woscc/full-record/WOS:000369308900041.[38] 朱华伟, 张延平, 李寅. 微生物电合成-电能驱动的CO2固定. 中国科学:生命科学[J]. 2016, 第 2 作者46(12): 1388-1399, http://lib.cqvip.com/Qikan/Article/Detail?id=670876747.[39] Tao, Wenwen, Dong, Hongjun, Zhang, Yanping, Cai, Zhen, Li, Yin. Introducing transglutaminase with its precursor region into Clostridium acetobutylicum improves its tolerance to oxidative stress and solvent production. PROCESS BIOCHEMISTRY[J]. 2015, 第 3 作者50(1): 111-118, http://dx.doi.org/10.1016/j.procbio.2014.10.016.[40] Zhou, Jie, Zhang, Haifeng, Meng, Hengkai, Zhang, Yanping, Li, Yin. Production of optically pure D-lactate from CO2 by blocking the PHB and acetate pathways and expressing D-lactate dehydrogenase in cyanobacterium Synechocystis sp PCC 6803. PROCESS BIOCHEMISTRY[J]. 2014, 第 4 作者49(12): 2071-2077, http://dx.doi.org/10.1016/j.procbio.2014.09.007.[41] Zhu, Linjiang, Xu, Hongtao, Zhang, Yanping, Fu, Guoliang, Wu, Paul Q, Li, Yin. BOX-PCR and PCR-DGGE analysis for bacterial diversity of a naturally fermented functional food (Enzyme (R)). FOOD BIOSCIENCE[J]. 2014, 第 3 作者5: 115-122, https://www.webofscience.com/wos/woscc/full-record/WOS:000209885100015.[42] Zhu, Yan, Li, Dan, Bao, Guanhui, Wang, Shaohua, Mao, Shaoming, Song, Jiangning, Li, Yin, Zhang, Yanping. Metabolic Changes in Klebsiella oxytoca in Response to Low Oxidoreduction Potential, as Revealed by Comparative Proteomic Profiling Integrated with Flux Balance Analysis. APPLIED AND ENVIRONMENTAL MICROBIOLOGY[J]. 2014, 第 8 作者 通讯作者 80(9): 2833-2841, http://www.irgrid.ac.cn/handle/1471x/1111451.[43] Zhou, Jie, Zhang, Haifeng, Meng, Hengkai, Zhu, Yan, Bao, Guanhui, Zhang, Yanping, Li, Yin, Ma, Yanhe. Discovery of a super-strong promoter enables efficient production of heterologous proteins in cyanobacteria. SCIENTIFIC REPORTS[J]. 2014, 第 6 作者4: https://www.webofscience.com/wos/woscc/full-record/WOS:000333515700007.[44] Zhu, Linjiang, Cai, Zhen, Zhang, Yanping, Li, Yin. Engineering stress tolerance of Escherichia coli by stress-induced mutagenesis (SIM)-based adaptive evolution. BIOTECHNOLOGY JOURNAL[J]. 2014, 第 3 作者9(1): 120-127, https://www.webofscience.com/wos/woscc/full-record/WOS:000337540100012.[45] Li, Xinghua, Cai, Zhen, Li, Yin, Zhang, Yanping. Design and Construction of a Non-Natural Malate to 1,2,4-Butanetriol Pathway Creates Possibility to Produce 1,2,4-Butanetriol from Glucose. SCIENTIFIC REPORTS[J]. 2014, 第 4 作者4: https://www.webofscience.com/wos/woscc/full-record/WOS:000338762600001.[46] Dong, Hongjun, Tao, Wenwen, Gong, Fuyu, Li, Yin, Zhang, Yanping. A functional recT gene for recombineering of Clostridium. JOURNAL OF BIOTECHNOLOGY[J]. 2014, 第 5 作者 通讯作者 173: 65-67, http://dx.doi.org/10.1016/j.jbiotec.2013.12.011.[47] Bao, Guanhui, Dong, Hongjun, Zhu, Yan, Mao, Shaoming, Zhang, Tianrui, Zhang, Yanping, Chen, Zugen, Li, Yin. Comparative genomic and proteomic analyses of Clostridium acetobutylicum Rh8 and its parent strain DSM 1731 revealed new understandings on butanol tolerance. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2014, 第 6 作者450(4): 1612-1618, http://www.irgrid.ac.cn/handle/1471x/1111522.[48] Zhou, Jie, Zhang, Fuliang, Meng, Hengkai, Bao, Guanhui, Zhang, Yanping, Li, Yin. Development of a silicon carbide disruption method enables efficient extraction of proteins from cyanobacterium Synechocystis sp PCC 6803. PROCESS BIOCHEMISTRY[J]. 2014, 第 5 作者49(12): 2199-2202, http://dx.doi.org/10.1016/j.procbio.2014.09.012.[49] Luan, Guodong, Dong, Hongjun, Zhang, Tianrui, Lin, Zhao, Zhang, Yanping, Li, Yin, Cai, Zhen. Engineering cellular robustness of microbes by introducing the GroESL chaperonins from extremophilic bacteria. JOURNAL OF BIOTECHNOLOGY[J]. 2014, 第 5 作者178: 38-40, http://dx.doi.org/10.1016/j.jbiotec.2014.03.010.[50] Luan, Guodong, Cai, Zhen, Gong, Fuyu, Dong, Hongjun, Lin, Zhao, Zhang, Yanping, Li, Yin. Developing controllable hypermutable Clostridium cells through manipulating its methyl-directed mismatch repair system. PROTEIN & CELL[J]. 2013, 第 6 作者4(11): 854-862, https://www.webofscience.com/wos/woscc/full-record/WOS:000326939900007.[51] 戴宗杰, 董红军, 朱岩, 张延平, 李寅. 生物丁醇代谢工程的研究进展. 生物加工过程[J]. 2013, 第 4 作者11(2): 58-64, http://lib.cqvip.com/Qikan/Article/Detail?id=45512423.[52] Zhu, Yan, Song, Jiangning, Xu, Zixiang, Sun, Jibin, Zhang, Yanping, Li, Yin, Ma, Yanhe. Development of thermodynamic optimum searching (TOS) to improve the prediction accuracy of flux balance analysis. BIOTECHNOLOGY AND BIOENGINEERING[J]. 2013, 第 5 作者110(3): 914-923, http://www.irgrid.ac.cn/handle/1471x/533833.[53] Guanhui Bao, Yanping Zhang, Chenyu Du, Zugen Chen, Yin Li, Zhuan Cao, Yanhe Ma. Genome Sequence of Klebsiella oxytoca M5al, a Promising Strain for Nitrogen Fixation and Chemical Production. GENOME ANNOUNCEMENTS. 2013, 第 2 作者1(1): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3569362/.[54] Yang, Liejian, Bao, Guanhui, Zhu, Yan, Dong, Hongjun, Zhang, Yanping, Li, Yin. Discovery of a novel gene involved in autolysis of Clostridium cells. PROTEIN & CELL[J]. 2013, 第 5 作者4(6): 467-474, https://www.webofscience.com/wos/woscc/full-record/WOS:000320329700007.[55] Zhang, Yanping, Li, Yin. Engineering the antioxidative properties of lactic acid bacteria for improving its robustness. CURRENT OPINION IN BIOTECHNOLOGY. 2013, 第 1 作者24(2): 142-147, http://dx.doi.org/10.1016/j.copbio.2012.08.013.[56] Jia, Kaizhi, Zhang, Yanping, Li, Yin. Identification and Characterization of Two Functionally Unknown Genes Involved in Butanol Tolerance of Clostridium acetobutylicum. PLOS ONE[J]. 2012, 第 2 作者7(6): https://doaj.org/article/5fc30e0bf947464fa3c2c169b222ee8a.[57] Dong, Hongjun, Tao, Wenwen, Zhang, Yanping, Li, Yin. Development of an anhydrotetracycline-inducible gene expression system for solvent-producing Clostridium acetobutylicum: A useful tool for strain engineering. METABOLIC ENGINEERING[J]. 2012, 第 3 作者14(1): 59-67, http://dx.doi.org/10.1016/j.ymben.2011.10.004.[58] Wang, Shaohua, Zhu, Yan, Zhang, Yanping, Li, Yin. Controlling the oxidoreduction potential of the culture of Clostridium acetobutylicum leads to an earlier initiation of solventogenesis, thus increasing solvent productivity. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2012, 第 3 作者 通讯作者 93(3): 1021-1030, https://www.webofscience.com/wos/woscc/full-record/WOS:000300282500010.[59] Dai Zongjie, Dong Hongjun, Zhu Yan, Zhang Yanping, Li Yin, Ma Yanhe. Introducing a single secondary alcohol dehydrogenase into butanol-tolerant Clostridium acetobutylicum Rh8 switches ABE fermentation to high level IBE fermentation. BIOTECHNOLOGY FOR BIOFUELS[J]. 2012, 第 4 作者5(1): https://doaj.org/article/c7bb32af715f46978e6cb06cc0f45d84.[60] Zhu, Linjiang, Zhu, Yan, Zhang, Yanping, Li, Yin. Engineering the robustness of industrial microbes through synthetic biology. TRENDS IN MICROBIOLOGY[J]. 2012, 第 3 作者20(2): 94-101, http://dx.doi.org/10.1016/j.tim.2011.12.003.[61] Zhou, Jie, Zhang, Haifeng, Zhang, Yanping, Li, Yin, Ma, Yanhe. Designing and creating a modularized synthetic pathway in cyanobacterium Synechocystis enables production of acetone from carbon dioxide. METABOLIC ENGINEERING[J]. 2012, 第 3 作者14(4): 394-400, http://dx.doi.org/10.1016/j.ymben.2012.03.005.[62] Dai, Zongjie, Dong, Hongjun, Zhu, Yan, Zhang, Yanping, Li, Yin, Ma, Yanhe. Introducing a single secondary alcohol dehydrogenase into butanol-tolerant Clostridium acetobutylicum Rh8 switches ABE fermentation to high level IBE fermentation. BIOTECHNOLOGY FOR BIOFUELS[J]. 2012, 第 4 作者5(1): 44-44, http://dx.doi.org/10.1186/1754-6834-5-44.[63] Dong, Hongjun, Tao, Wenwen, Dai, Zongjie, Yang, Liejian, Gong, Fuyu, Zhang, Yanping, Li, Yin, Bai, FW, Liu, CG, Huang, H, Tsao, GT. Biobutanol. BIOTECHNOLOGY IN CHINA III: BIOFUELS AND BIOENERGY[J]. 2012, 第 6 作者128: 85-100, https://www.webofscience.com/wos/woscc/full-record/WOS:000321104200006.[64] Bao, Guanhui, Wang, Runjiang, Zhu, Yan, Dong, Hongjun, Mao, Shaoming, Zhang, Yanping, Chen, Zugen, Li, Yin, Ma, Yanhe. Complete Genome Sequence of Clostridium acetobutylicum DSM 1731, a Solvent-Producing Strain with Multireplicon Genome Architecture. JOURNAL OF BACTERIOLOGY[J]. 2011, 第 6 作者193(18): 5007-5008, https://www.webofscience.com/wos/woscc/full-record/WOS:000294261700049.[65] Zhu, Linjiang, Dong, Hongjun, Zhang, Yanping, Li, Yin. Engineering the robustness of Clostridium acetobutylicum by introducing glutathione biosynthetic capability. METABOLIC ENGINEERING[J]. 2011, 第 3 作者 通讯作者 13(4): 426-434, http://dx.doi.org/10.1016/j.ymben.2011.01.009.[66] Wang, Shaohua, Zhang, Yanping, Dong, Hongjun, Mao, Shaoming, Zhu, Yan, Wang, Runjiang, Luan, Guodong, Li, Yin. Formic Acid Triggers the "Acid Crash" of Acetone-Butanol-Ethanol Fermentation by Clostridium acetobutylicum. APPLIED AND ENVIRONMENTAL MICROBIOLOGY[J]. 2011, 第 2 作者77(5): 1674-1680, http://124.16.144.217/handle/311023/1514.[67] Jia, Kaizhi, Zhu, Yan, Zhang, Yanping, Li, Yin. Group II Intron-Anchored Gene Deletion in Clostridium. PLOS ONE[J]. 2011, 第 3 作者6(1): http://124.16.144.217/handle/311023/2376.[68] Mao, Shaoming, Luo, Yuanming, Bao, Guanhui, Zhang, Yanping, Li, Yin, Ma, Yanhe. Comparative analysis on the membrane proteome of Clostridium acetobutylicum wild type strain and its butanol-tolerant mutant. MOLECULAR BIOSYSTEMS[J]. 2011, 第 4 作者7(5): 1660-1677, https://www.webofscience.com/wos/woscc/full-record/WOS:000289367200027.[69] Dong, Hongjun, Zhang, Yanping, Dai, Zongjie, Li, Yin. Engineering Clostridium Strain to Accept Unmethylated DNA. PLOS ONE[J]. 2010, 第 2 作者5(2): https://doaj.org/article/5b6f7c67e97541a4ae449a5b3700d3c1.[70] Jia, Kaizhi, Zhang, Yanping, Li, Yin. Systematic engineering of microorganisms to improve alcohol tolerance. ENGINEERING IN LIFE SCIENCES[J]. 2010, 第 2 作者10(5): 422-429, http://124.16.144.217/handle/311023/2306.[71] 张延平, 李寅. 后基因组时代的工业生物技术. 生物工程学报[J]. 2010, 第 1 作者1171-1175, http://lib.cqvip.com/Qikan/Article/Detail?id=35390642.[72] Yanping Zhang. Proteomic analyses to reveal the protective role of glutathione in stress resistance of Lactococcus lactis.. Applied and Environmental Microbiology. 2010, 第 1 作者[73] 董红军, 张延平, 李寅. 丙酮丁醇梭菌的遗传操作系统. 生物工程学报[J]. 2010, 第 2 作者1372-1378, http://lib.cqvip.com/Qikan/Article/Detail?id=35657151.[74] Zhang, Yanhe, Zhang, Yanping, Zhu, Yan, Mao, Shaoming, Li, Yin. Proteomic Analyses To Reveal the Protective Role of Glutathione in Resistance of Lactococcus lactis to Osmotic Stress. APPLIED AND ENVIRONMENTAL MICROBIOLOGY[J]. 2010, 第 2 作者76(10): 3177-3186, http://124.16.144.217/handle/311023/1498.[75] Zhang, Juan, Du, GuoCheng, Zhang, Yanping, Liao, XianYan, Wang, Miao, Li, Yin, Chen, Jian. Glutathione Protects Lactobacillus sanfranciscensis against Freeze-Thawing, Freeze-Drying, and Cold Treatment. APPLIED AND ENVIRONMENTAL MICROBIOLOGY[J]. 2010, 第 3 作者76(9): 2989-2996, http://124.16.144.217/handle/311023/1507.[76] 王鑫昕, 王少华, 李维, 李寅, 张延平. 细菌的有机溶剂耐受机制. 生物工程学报[J]. 2009, 第 5 作者641-649, http://lib.cqvip.com/Qikan/Article/Detail?id=30566720.[77] Zhang, Yanping, Huang, Zhihua, Du, Chenyu, Li, Yin, Cao, Zhuan. Introduction of an NADH regeneration system into Klebsiella oxytoca leads to an enhanced oxidative and reductive metabolism of glycerol. METABOLIC ENGINEERING[J]. 2009, 第 1 作者11(2): 101-106, http://dx.doi.org/10.1016/j.ymben.2008.11.001.[78] Zhang, Yanping, Zhu, Yan, Zhu, Yang, Li, Yin. The importance of engineering physiological functionality into microbes. TRENDS IN BIOTECHNOLOGY[J]. 2009, 第 1 作者27(12): 664-672, http://dx.doi.org/10.1016/j.tibtech.2009.08.006.[79] 郑学瑞, 王兴华, 李寅, 张延平. 在Klebsiella oxytoca表达不依赖辅酶B12的甘油脱水酶以促进1,3-丙二醇合成. 山西大学学报自然科学版[J]. 2009, 第 4 作者32(A01): 132-136, http://lib.cqvip.com/Qikan/Article/Detail?id=30549177.[80] Zhu, Yan, Zhang, Yanping, Li, Yin. Understanding the industrial application potential of lactic acid bacteria through genomics. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2009, 第 2 作者83(4): 597-610, http://124.16.144.217/handle/311023/2698.[81] 杨明刘力强牛昆贾娟娟李寅张延平王正品. 丙酮丁醇发酵菌的分子遗传改造. 中国生物工程杂志[J]. 2009, 29(10): 109-114, https://manu60.magtech.com.cn/biotech/CN/Y2009/V29/I10/109.[82] 黄星, 李寅, 杨光, 张延平, 曹竹安. 生物产业发展中的系统论. 化工学报[J]. 2008, 第 4 作者59(8): 1884-1893, http://lib.cqvip.com/Qikan/Article/Detail?id=28125899.[83] 张延平, 李寅, 马延和. 细胞工厂与生物炼制. 化学进展[J]. 2007, 第 1 作者1076-1083, http://lib.cqvip.com/Qikan/Article/Detail?id=1000115863.[84] 黄志华, 刘铭, 张延平, 曹竹安. 重组甲酸脱氢酶对合成1,3-丙二醇的促进作用. 化工学报[J]. 2007, 第 3 作者58(4): 919-924, http://lib.cqvip.com/Qikan/Article/Detail?id=24174439.[85] 黄志华, 张延平, 杜晨宇, 黄星, 曹竹安. 利用氧化还原电位调控基因工程菌株Klebsiella pneumoniae F-1合成1,3-丙二醇. 过程工程学报[J]. 2007, 第 2 作者7(5): 1014-1017, https://www.jproeng.com/CN/Y2007/V7/I5/1014.[86] Zhang Yanping, Li Yin, Ma Yanhe. Nficrobial CeR factories and biorefinery. PROGRESS IN CHEMISTRY[J]. 2007, 第 1 作者 通讯作者 19(7-8): 1076-1083, https://www.webofscience.com/wos/woscc/full-record/WOS:000248841600005.[87] 张延平, 李寅, 马延和. 生物炼制中的微生物细胞工厂. 前沿科学[J]. 2007, 第 1 作者http://lib.cqvip.com/Qikan/Article/Detail?id=1001964498.[88] 黄志华, 张延平, 刘铭, 王宝光, 曹竹安. 甲酸脱氢酶在Klebsiella pneumoniae中的表达和功能分析. 微生物学报[J]. 2007, 第 2 作者47(1): 64-68, http://lib.cqvip.com/Qikan/Article/Detail?id=23766155.[89] 张延平, 杜晨宇, 黄志华, 刘铭, 曹竹安. 醛脱氢酶基因敲除对克氏肺炎杆菌合成1,3-丙二醇的影响. 化工学报[J]. 2006, 第 1 作者57(11): 2686-2692, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=2618348&detailType=1.[90] 黄志华, 刘铭, 王宝光, 张延平, 曹竹安. 甲酸脱氢酶用于辅酶NADH再生的研究进展. 过程工程学报[J]. 2006, 第 4 作者6(6): 1011-1016, https://www.jproeng.com/CN/Y2006/V6/I6/1011.[91] 张延平, 刘铭, 杜晨宇, 沈金玉, 曹竹安. 代谢副产物对Klebsiella pneumoniae生长及合成1,3-丙二醇的影响. 过程工程学报[J]. 2006, 第 1 作者6(5): 804-808, https://www.jproeng.com/CN/Y2006/V6/I5/804.[92] 黄志华, 张延平, 黄兴, 王宝光, 曹竹安. 在Klebsiella pneumoniae醛脱氢酶失活菌中构建NADH再生系统. 中国生物工程杂志[J]. 2006, 第 2 作者26(12): 75-80, https://manu60.magtech.com.cn/biotech/CN/Y2006/V26/I12/75.[93] 张延平, 杜晨宇, 饶治, 曹竹安. 维生素C和E对Klebsiella pneumoniae合成1,3-丙二醇的调控. 过程工程学报[J]. 2005, 第 1 作者5(2): 197-200, https://www.jproeng.com/CN/Y2005/V5/I2/197.[94] 张延平, 刘铭, 曹竹安. 醛脱氢酶基因敲除的K.pneumoniae重组菌的构建. 中国生物工程杂志[J]. 2005, 第 1 作者25(12): 34-38, https://manu60.magtech.com.cn/biotech/CN/Y2005/V25/I12/34.[95] 李春, 曹竹安, 张延平, 饶治, 杜晨宇. 能量驱动对Klebsiella pneumoniae发酵甘油合成1,3-丙二醇的影响. 过程工程学报[J]. 2004, 第 3 作者4(6): 567-571, http://lib.cqvip.com/Qikan/Article/Detail?id=11243898.[96] 朱慧铭, 李春, 杨东, 张延平, 曹竹安. Klebsiella pneumoniae合成1,3-丙二醇过程中的生长与催化耦联. 化工学报[J]. 2004, 第 4 作者505-508, http://lib.cqvip.com/Qikan/Article/Detail?id=1000025411.[97] 杜晨宇, 李春, 杨东, 张延平, 曹竹安. Klebsiella pneumoniae合成1,3—丙二醇过程中的生长与催化耦联. 磁流体发电情报[J]. 2004, 第 4 作者55(3): 505-508, http://lib.cqvip.com/Qikan/Article/Detail?id=9550317.[98] 沈金玉, 饶治, 张延平, 李春, 曹竹安. 外源添加ATP对K.pneumoniae菌体生长和产物合成的影响. 精细化工[J]. 2004, 第 3 作者21(6): 413-417, http://lib.cqvip.com/Qikan/Article/Detail?id=9857774.[99] 李春, 杜晨宇, 张延平, 曹竹安, 杨东. 两段双底物发酵生产1,3-丙二醇. 过程工程学报[J]. 2003, 第 3 作者3(3): 269-273, http://lib.cqvip.com/Qikan/Article/Detail?id=8373530.[100] 于慧敏, 张延平, 史悦, 杨胜利, 沈忠耀. 重组大肠杆菌VG1(PTU14)产PHB的补实分批培养. 化工学报[J]. 2002, 第 2 作者53(7): 742-746, http://lib.cqvip.com/Qikan/Article/Detail?id=6544500.[101] 张延平, 史悦, 杨胜利, 于慧敏, 沈忠耀. 透明颤菌血红蛋白基因在产PHB重组大肠杆菌中的引入. 微生物学报[J]. 2001, 第 1 作者41(5): 548, http://lib.cqvip.com/Qikan/Article/Detail?id=5736117.
科研活动
科研项目
( 1 ) 王宽诚人才奖-卢嘉锡青年人才奖青年创新促进会会员及优秀会员创新交叉团队, 负责人, 中国科学院计划, 2014-01--2017-12( 2 ) 工业酵母菌种的基因组全局扰动, 负责人, 国家任务, 2012-01--2015-12( 3 ) beta-丙氨酸的生物催化转化工艺, 参与, 中国科学院计划, 2016-01--2018-12( 4 ) 细胞氧化还原水平对黄原胶合成影响研究, 负责人, 中国科学院计划, 2018-01--2019-12( 5 ) 青年创新促进会人才项目, 负责人, 中国科学院计划, 2014-01--2017-12( 6 ) 广西特色非粮生物质资源化利用技术开发, 参与, 中国科学院计划, 2019-01--2020-12( 7 ) 阻止氧争夺电子创建第二代双菌生物光伏的研究, 负责人, 国家任务, 2021-01--2024-12( 8 ) 第二代微生物组生物光伏关键技术研究, 负责人, 其他国际合作项目, 2021-01--2023-12( 9 ) 原位腐解菌群设计构建与原位促腐技术集成, 负责人, 中国科学院计划, 2021-07--2026-06( 10 ) 生物转化甲酸合成能源及精细化学品, 负责人, 国家任务, 2021-12--2024-11( 11 ) 构建甲酸同化旁路降低生物合成丁酸氧需求的研究, 负责人, 国家任务, 2023-01--2026-12
参与会议
(1)低碳生物合成:糖基发酵到生物固碳 首届中国一碳生物技术和低碳产业发展大会 张延平 2023-04-08(2)低碳生物合成中的氧化还原问题 香山科学会议,第715次学术讨论会 张延平 2022-07-21