071009-细胞生物学
100102-免疫学

粘膜免疫，肠道免疫，天然淋巴细胞。

2004-09--2009-04   上海交通大学医学院   博士
1999-09--2004-07   泰山医学院   学士

   

2014-03~现在, 中国科学院上海生命科学研究院健康科学研究所, 研究员
2009-11~2014-02,美国西北大学费恩伯格医学院, 博士后
2009-04~2009-10,爱因斯坦医学院, 博士后

免疫调节

   

[1] 沈蕾, 章晶晶, 邱菊, 邱金馨. 生物标志物NRP1及其在肺纤维化和哮喘诊断、预防和治疗中的应用. CN: CN115521369A, 2022-12-27.

   

[1] Wang, Zhishuo, Yan, Chenghua, Du, Qizhen, Huang, Yuying, Li, Xuezhen, Zeng, Dan, Mao, Ruizhi, Gurram, Rama Krishna, Cheng, Shipeng, Gu, Wangpeng, Zhu, Lin, Fan, Weiguo, Ma, Liyan, Ling, Zhiyang, Qiu, Ju, Li, Dangsheng, Liu, Enmei, Zhang, Yaguang, Fang, Yiru, Zhu, Jinfang, Sun, Bing. HTR2A agonists play a therapeutic role by restricting ILC2 activation in papain-induced lung inflammation. CELLULAR & MOLECULAR IMMUNOLOGY[J]. 2023, 第 15 作者http://dx.doi.org/10.1038/s41423-023-00982-6.
[2] Nature Communications. 2022,   通讯作者  
[3] Ding, Zhaoyun, Cai, Ting, Tang, Jupei, Sun, Hanxiao, Qi, Xinyi, Zhang, Yunpeng, Ji, Yan, Yuan, Liyun, Chang, Huidan, Ma, Yanhui, Zhou, Hong, Li, Li, Sheng, Huiming, Qiu, Ju. Setd2 supports GATA3(+)ST2(+) thymic-derived Treg cells and suppresses intestinal inflammation. NATURE COMMUNICATIONS[J]. 2022, 第 11 作者13(1): http://dx.doi.org/10.1038/s41467-022-35250-0.
[4] Jiali Chang, Xiaojuan Ji, Tian Deng, Jinxin Qiu, Zhaoyun Ding, Zhao Li, Yanhui Ma, Xiaoyu Hu, Li Li, Ju Qiu. Setd2 determines distinct properties of intestinal ILC3 subsets to regulate intestinal immunity. CELL REPORTS. 2022, 第 10 作者38(11): http://dx.doi.org/10.1016/j.celrep.2022.110530.
[5] Qi, Xinyi, Qiu, Jinxin, Chang, Jiali, Ji, Yan, Yang, Qi, Cui, Guoliang, Sun, Liming, Chai, Qian, Qin, Jun, Qiu, Ju. Brg1 restrains the pro-inflammatory properties of ILC3s and modulates intestinal immunity. MUCOSAL IMMUNOLOGY[J]. 2021, 第 10 作者  通讯作者  14(1): 38-52, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7790751/.
[6] Qiu, Jinxin, Zhang, Jingjing, Ji, Yan, Sun, Hanxiao, Gu, Zhitao, Sun, Qiangling, Bai, Meizhu, Gong, Jue, Tang, Jupei, Zhang, Yunpeng, Li, Shiyang, Shao, Zhen, Li, Jinsong, Sheng, Huiming, Shen, Lei, Qiu, Ju. Tissue signals imprint Aiolos expression in ILC2s to modulate type 2 immunity. MUCOSAL IMMUNOLOGY[J]. 2021, 第 16 作者  通讯作者  14(6): 1306-1322, http://dx.doi.org/10.1038/s41385-021-00431-5.
[7] Deng, Tian, Suo, Caixia, Chang, Jiali, Yang, Rui, Li, Jingyu, Cai, Ting, Qiu, Ju. ILC3-derived OX40L is essential for homeostasis of intestinal Tregs in immunodeficient mice. CELLULAR & MOLECULAR IMMUNOLOGY[J]. 2020, 第 7 作者  通讯作者  17(2): 163-177, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000711/.
[8] Pian, Yaya, Chai, Qian, Ren, Boyang, Wang, Yue, Lv, Mengjie, Qiu, Ju, Zhu, Mingzhao. Type 3 Innate Lymphoid Cells Direct Goblet Cell Differentiation via the LT-LT beta R Pathway during Listeria Infection. JOURNAL OF IMMUNOLOGY[J]. 2020, 第 6 作者205(3): 853-863, http://dx.doi.org/10.4049/jimmunol.2000197.
[9] Tian Deng, Caixia Suo, Jiali Chang, Rui Yang, Jingyu Li, Ting Cai, Ju Qiu. ILC3-derived OX40L is essential for homeostasis of intestinal Tregs in immunodeficient mice. CELLULAR AND MOLECULAR IMMUNOLOGY[J]. 2019, 第 7 作者17(2): 163-177, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000711/.
[10] Cai, Ting, Qiu, Jinxin, Ji, Yan, Li, Wenjing, Ding, Zhaoyun, Suo, Caixia, Chang, Jiali, Wang, Jingjing, He, Rui, Qian, Youcun, Guo, Xiaohuan, Zhou, Liang, Sheng, Huiming, Shen, Lei, Qiu, Ju. IL-17-producing ST2(+) group 2 innate lymphoid cells play a pathogenic role in lung inflammation. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY[J]. 2019, 第 15 作者  通讯作者  143(1): 229-+, http://dx.doi.org/10.1016/j.jaci.2018.03.007.
[11] Jingyu Li, Wenli Shi, Hanxiao Sun, Yan Ji, Yuqin Chen, Xiaohuan Guo, Huiming Sheng, Jie Shu, Liang Zhou, Ting Cai, Ju Qiu. Activation of DR3 signaling causes loss of ILC3s and exacerbates intestinal inflammation. NATURE COMMUNICATIONS[J]. 2019, 第 11 作者  通讯作者  10(1): 1-15, https://doaj.org/article/b32e5963fa904384baa13bf39f483e34.
[12] Ting Cai BS, Jinxin Qiu BS, Yan Ji PhD, Wenjing Li MS, Zhaoyun Ding BS, Caixia Suo PhD, Jiali Chang BS, Jingjing Wang BS, Rui He MD PhD, Youcun Qian PhD, Xiaohuan Guo PhD, Liang Zhou MD PhD, Huiming Sheng MD PhD, Lei Shen PhD, Ju Qiu PhD. IL-17–producing ST2+ group 2 innate lymphoid cells play a pathogenic role in lung inflammation. THE JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2019, 143(1): 229-244.e9, http://dx.doi.org/10.1016/j.jaci.2018.03.007.
[13] Caixia Suo, Zhiqin Fan, Liang Zhou, Ju Qiu. Perfluorooctane sulfonate affects intestinal immunity against bacterial infection. SCIENTIFIC REPORTS[J]. 2017, 第 4 作者  通讯作者  7(1): https://doaj.org/article/9a0b6495da0c4a4a8105a707fda58a78.
[14] Yinghui Song, HuaXing Wei, Pamela Stanley, Vivek Kumar, Ju Qiu. Lunatic, Manic, and Radical Fringe Each Promote T and B Cell Development. AMERICAN ASSOCIATION OF IMMUNOLOGISTS. 2016, 第 5 作者http://oa.las.ac.cn/oainone/service/browseall/read1?ptype=JA&workid=JA201902027186750ZK.
[15] Qiu, Ruomeng, Shi, Wenli, Cai, Ting, Pei, Siyu, Tang, Ting, Huang, Yafei, Wang, Huan, Shao, Liming, Qiu, Ju, Wang, Yonghui. Design, synthesis and phenotypic evaluation of N-biaryl amides for IL-17A suppression. MEDCHEMCOMM[J]. 2016, 第 9 作者  通讯作者  7(12): 2344-2348, http://dx.doi.org/10.1039/c6md00427j.
[16] Guo, Xiaohuan, Qiu, Ju, Tu, Tony, Yang, Xuanming, Deng, Liufu, Anders, Robert A, Zhou, Liang, Fu, YangXin. Induction of Innate Lymphoid Cell-Derived Interleukin-22 by the Transcription Factor STAT3 Mediates Protection against Intestinal Infection. IMMUNITY[J]. 2014, 第 2 作者40(1): 25-39, http://dx.doi.org/10.1016/j.immuni.2013.10.021.
[17] Stefka, Andrew T, Feehley, Taylor, Tripathi, Prabhanshu, Qiu, Ju, McCoy, Kathy, Mazmanian, Sarkis K, Tjota, Melissa Y, Seo, GooYoung, Cao, Severine, Theriault, Betty R, Antonopoulos, Dionysios A, Zhou, Liang, Chang, Eugene B, Fu, YangXin, Nagler, Cathryn R. Commensal bacteria protect against food allergen sensitization. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2014, 第 4 作者111(36): 13145-13150, https://www.webofscience.com/wos/woscc/full-record/WOS:000341625600046.
[18] 邱菊. Aryl hydrocarbon receptor promotes RORγt⁺ group 3 ILCs and controls intestinal immunity and inflammation.. Semin Immunopathol.. 2013, 第 1 作者
[19] Qiu, Ju, Guo, Xiaohuan, Chen, Zongming E, He, Lei, Sonnenberg, Gregory F, Artis, David, Fu, YangXin, Zhou, Liang. Group 3 Innate Lymphoid Cells Inhibit T-Cell-Mediated Intestinal Inflammation through Aryl Hydrocarbon Receptor Signaling and Regulation of Microflora. IMMUNITY[J]. 2013, 第 1 作者39(2): 386-399, http://dx.doi.org/10.1016/j.immuni.2013.08.002.

   

（ 1 ） 肠道炎症组织微环境调控3型天然淋巴细胞发育和功能的分子机制研究, 主持, 国家级, 2016-01--2018-12
（ 2 ） Ahr对肠道调节性T细胞作用的分子机制及其在炎症性肠病中的意义, 主持, 国家级, 2016-01--2019-12
（ 3 ） 3型天然淋巴细胞（ILC3）发育的分子调控机制及其与肠道免疫相关疾病的关系, 主持, 国家级, 2015-01--2019-08
（ 4 ） 环境内分泌干扰物对女性生殖功能的影响及分子机制, 参与, 国家级, 2014-01--2019-08
（ 5 ） 淋巴样细胞的可塑性调控, 参与, 部委级, 2017-07--2019-12

（1）TL1A/DR3信号对ILC3的调控作用及在炎症性肠病中的意义   中国细胞生物学学会 第十七次全国会员代表大会   2019-04-09
（2）ST2+IL-17+ILC2在肺部炎症中的致病作用   2018 年度中国细胞生物学学会 免疫细胞生物学分会年会    2018-09-25

已指导学生

索彩霞  博士研究生  071009-细胞生物学  

现指导学生

蔡婷  博士研究生  071009-细胞生物学  

李靖宇  博士研究生  071009-细胞生物学  

石文丽  博士研究生  071009-细胞生物学  

邱金馨  博士研究生  071009-细胞生物学  

丁朝云  硕士研究生  071009-细胞生物学  

畅佳丽  博士研究生  071009-细胞生物学  

李钊  硕士研究生  071009-细胞生物学  

唐聚培  硕士研究生  071009-细胞生物学