Associate professor, Ph.D, supervisor of postgraduate. Graduated from The University of HongKong, visiting scholar in Johns Hopkins Universityvice director of Shenzhen Key Laboratory of Marine Biomedical MaterialsShenzhen Overseas High-Caliber Personnel.Research interest in biomaterials, drug delivery, stem cell and tissue regeneration. Host NSFC and NSF of Grangdong Provice, Published more than 30 SCI paper in Adv Sci, JBMR, Acta Biomaterialia and so on. Report in national and international conference, got the young investigator travel grant in ASBMR.

Research Areas


Drug delivery

Stem cell 

Tissue regeneration


2007-2011 The University of Hong Kong   Orthopaedic Biomaterials Ph.D

2005-2007 Tianjin University Biomedical Engineering, MS.


Work Experience

2020-now   Professor , Shenzhen Institutes of Advanced Technology , Chinese Academy of Science.

2015-2019 Associate Professor , Shenzhen Institutes of Advanced Technology , Chinese Academy of Science.

2012-2014 Assistant Professor , Shenzhen Institutes of Advanced Technology , Chinese Academy of Science.

2010-2011 Visting scholar, Johns Hopkins University.



1.     Shaoquan Bian, …, Haobo Pan*, Xiaoli Zhao*. A shear-thinning adhesive hydrogel reinforced by photo-initiated crosslinking as a fit-to-shape tissue sealant. Journal of Materials Chemistry B,  2019, 7, 6488-6499  (IF ,5.047)

2.       Qingchang Chen#, Jun Wu#, …, Xiaoli Zhao*, Haobo Pan. Electrospun chitosan/PVA/bioglass Nanofibrous membrane with spatially designed structure for accelerating chronic wound healing. Materials Science and Engineering: C,2019, 105, 110083. (IF 4.959)

3. Fei Gao, …, Xiaoli Zhao, Xu Cui, Changshun Ruan,* and Wenguang Liu*. Osteochondral Regeneration with 3D-Printed Biodegradable High-Strength Supramolecular Polymer Reinforced-Gelatin Hydrogel Scaffolds. Advanced Science, 2019, 1900867. (IF 15.804)

4. Liu Wenlong, …, Zhao Xiaoli, et al. Spatial Distribution of Biomaterial Microenvironment pH and Its Modulatory Effect on Osteoclasts at the Early Stage of Bone Defect Regeneration. ACS Appl. Mater. Interfaces,2019,11(9): 9557-9572 (IF8.456)

5.      Qingchang Chen#, Chuping Zheng# , …, Xiaoli Zhao*, and William W. Lu. Bone Targeted Delivery of SDF‑1 via Alendronate Functionalized Nanoparticles in Guiding Stem Cell Migration. ACS Appl. Mater. Interfaces,2018, 10 (28), pp 23700–23710.

6.      Chen qingchang, Liu Yuan, …, Zhao Xiaoli*. Chitosan-PVA monodisperse millimeter-sized spheres prepared by electrospraying reduce the thromboembolic risk in hemorrhage. Journal of Materials Chemistry B, 2017 ,5, 3686-3696 (IF8.456)

7.  Xinyun Zhai, …, Xiaoli Zhao, Haobo Pan,* and William Weijia Lu. 3D-Bioprinted Osteoblast-Laden Nanocomposite Hydrogel Constructs with Induced Microenvironments Promote Cell Viability, Differentiation, and Osteogenesis both In Vitro and In Vivo, Advanced Science, 2018, 5(3): 1700550. IF15.804

8.  Zhao Y, …, Zhao XL, et al. Plasma Surface Functionalized Polyetheretherketone for Enhanced Osseo-Integration at Bone-Implant Interface. Acs Appl Mater Inter. 2016;8:3901-11.IF8.456

9.      Zheng CP, Pan HB, Zhao XL*.  Alendronate-modified liposome for bone targeting gene delivery regulating mesenchymal stem cell migration. Journal of Orthopaedic Translation, 2016,7,128

10.      Chen QC, Pan HB, Zhao XL*. Chitosan/PVA/Bioglass multilayer films for wound dressing application. Journal of Orthopaedic Translation, 2016,7,117-118

11.      Li YQ, Pan HB, Zhao XL*. Promoting effect of strontium on the division of stem cells in bone formation. Journal of Orthopaedic Translation, 2016,7,129

12.      Wenlong Liu, Ting Wang, Xiaoli Zhao, et al. Akermanite used as an alkaline biodegradable implants for the treatment of osteoporotic bone defect. Bioactive Materials, 2016,1,151-9

13.      Wu Jun#, Zhao Xiaoli#, Yeung KW, To MK. Interfacial Fast Release Layer in Monodisperse Poly (lactic-co-glycolic acid) Microspheres Accelerates the Drug Release. Current Drug Delivery,2016,13(5):720-9

14.   Wu S, Wu J, …, Zhao XL*, Poly(d,l-lacticacid) electrospun fibers with tunable surface nanotopography for modulating drug release profiles. Materials Letters,2015,161:716-19.

15.   Wu S, Huang ZY, …, Zhao XL*. The efficient hemostatic effect of Antarctic krill chitosan is related toits hydration property. Carbohydrate Polymers, 2015,132:295-303. IF6.044

16.   Yue JH, Wu J, Liu D, Zhao XL*, Lu WW. BMP2 gene delivery to bone mesenchymal stem cell by chitosan-g-PEI nonviral vector. Nanoscale Research Letters,2015,10:203.

17.   Wang L, Zhang L, …, Zhao X, Lu WW. Abnormal subchondral bone microstructure following steroid administration is involved in the early pathogenesis of steroid-induced osteonecrosis. Osteoporosis International, 2016;27:153-9.

18.   Zhao XLLi ZY, et al. Enhanced gene delivery by chitosan-disulfide-conjugated LMW-PEI for facilitating osteogenic differentiation. Acta Biomaterialia, 2013, 9(5):6694-6703.

19.   Zhao XL, Li ZY, et al. Octaarginine-modified chitosan as a nonviral gene delivery vector: properties and in vitro transfection efficiency. J nanopart res, 2011,13:693-702.

20.   Zhang JL, Wang N, Liu WG, Zhao XL, Lu William. Intermolecular hydrogen bonding strategy to fabricate mechanically strong hydrogels with high elasticity and fatigue resistance. Soft Matter, 2013,9:6331-6337. (IF:3.909)

21.   Zhao XL, Yu B, et al. Nestin as marker for bone marrow mesenchymal stem cells. J Bone Miner Res, 2011, S2, 1006

22.   Yu B, Zhao XL, Yang CZ, Crane J, Xian LL, Lu WW, Wan M, Cao X. Parathyroid Hormone Induces Differentiation of Mesenchymal Stromal/Stem Cells by Enhancing Bone Morphogenetic Protein Signaling. J Bone Miner Res, 2012,29,2001-2014.

23.   Zhao XL, Liu WG, Chen DY, Lin XZ, Lu WW. Effect of block order of ABA- and BAB-type NIPAAm/HEMA triblock copolymers on thermoresponsive behavior of solutions. Macromol Chem Phys, 2007, 208,1773-1781.

24.   Pan HB, Zhao XL, Darvell WB, Lu WW. Apatite-formation ability – predictor of “bioactivity”? Acta Biomaterialia, 2010,6 4181-4188.

25.   Pan HB, Zhao XL, et al. Strontium borate glass: potential biomaterial for bone regeneration. J R Soc Interface, 2010, 7,1025-1031.(IF:4.097)

26.   Bai T, Zhang P, …, Zhao XL, Lu WW. Construction of an ultrahigh strength hydrogel with excellent fatigue resistance based on strong dipole-dipole interaction. Soft Matter, 2011,7(6):2825-2831.

27.   Dai FY, Tang L, Yang JH, Zhao XL, et al. Fast thermoresponsive BAB-type HEMA/NIPAAm triblock copolymer solutions for embolization of abnormal blood vessels. J Mater Sci Mater Med, 2009, 20, 967-974.

28.   Cao ZQ, Liu WG, Ye GX, Zhao XL, Lin XZ, Gao P, Yao KD. N-isopropylacrylamide/2-Hydroxyethyl Methacrylate Star Diblock Copolymers: Synthesis and Thermo-responsive Behavior. Macromol Chem Phys, 2006, 207, 2329-2335.

29.   Tian F, Zhang BQ, Zhao XL*, Ji WH, Li XW, Cheng GX, Yao KD. In vitro evaluation of embolization effects of thermosensitive N-isopropylacrylamide based copolymer solutions.   Polymer International, 2006, 55, 405-408.


1.      CN201910803050.6 2019.08.28

2.      CN108918493A2018.11.30

3.       CN201811019667.02018.09.03

4.      201610512519.72016.07.04

5.      201610515073.32016.07.04

6.      PCT/CN2016/0872832016.06.27

7.      201610339273.82016.05.23

8.      201610225339.02016.04.13

9.      201610857216.92016.09.28

10.   CN 103030813 B, 2015.08.05.

11.   2016.01.20CN103665191B

12.   2015.11.04CN103736135B

13.   2015.10.28CN103705968B

14.   CN103525851A2014.01.22.

15.   CN103710383A2014.04.09.

16.   CN103690956A2014.04.02

17.   104562436A2015.04.29.

18.   CN1010536812007.10.17.

19.    CN1013071232008.11.19.

Research Interests


Drug delivery

Stem cell

Tissue regeneration


1.      Chinese Orthopaedic AssociationCOA2018.11

2.      29thAnnual Meeting of the European Society for Biomaterials,2018, Netherlands

3.      2017 Chinese Biomaterials Congress

4.      2016 The 11th International Congress of Chinese Orthopaedic Association.

5.      2016 HKU International Symposium for 3D Bio-printing and Biomaterials

6.      2016 International Combined Meeting of Orthopaedic Research Societies

7.      2016 The 26th Interdisciplinary Research Conference on Injectable Osteoarticular Biomaterials and Bone Augmentation Procedures (GRIBOI)

8.      2015 Chinese Biomaterials Congress,

9.      21st Annual conference of ANZORS (Australian & New Zealand Orthopaedic Research Society)

10.   36th SICOT (Science   Innovation   Cooperation   Open   Transition)

11.   China-Europe symposium on Biomaterials in Regenerative Medicine, 2015

12.   7th International conference on osteoporosis and bone research, 2014.

13.   20th Annual conference of Australian & New Zealand Orthopaedic Research Society.

14.   China-Australia Symposium on Orthopaedic Biomaterials.

15.   Annual meeting of Chinese Society for Biomaterials, 2013

16.   9th world biomaterials congress2012

17.   Chinese biomedical Engineering Conference, 2011.

18.   33rd Annual meeting of the American Society for Bone and Mineral Research, 2011.

19.   The 8th Hong Kong International Orthopaedic Forum, 2011.

20.   4th New York Skeletal Biology and Medicine Conference, 2011

21.   3rd Chinese-Europe Symposium on Biomaterials in Regenerative Medicine, 2011.

22.   Biomedical Engineering International Conference, 2010, HongKong

23.   Chinese Biomaterials Congress, 2010, Chengdu

24.   56th Annual meeting of Orthopaedic Research Society, 2010, New Orleans

25.   4th Internation Congress of Chinese Orthopaedic Association, 2009, Xiamen.

26.   International Conference on Natotechnology and Advanced Materials, 2009, HongKong,

27.   The 5th Hong Kong International Orthopaedic Forum, 2008, HongKong

28.   Annual meeting of Polymer Forum, 2007, Chengdu.


The University of Hong Kong

Tianjin University

Johns Hopkins University