083100-生物医学工程
071010-生物化学与分子生物学
070305-高分子化学与物理

分子影像，纳米医学，生物材料
仿生工程
核医学

2005-09--2010-07   华中农业大学   博士研究生
2001-09--2005-07   华中农业大学   本科/学士

   

2018-07~现在, 中科院深圳先进技术研究院, 研究员
2013-07~2018-07,中国科学院深圳先进技术研究院, 副研究员
2011-07~2013-07,中国科学院深圳先进技术研究院, 博士后
2010-07~2011-07,华中农业大学, 教师
2005-09~2010-07,华中农业大学, 博士研究生
2001-09~2005-07,华中农业大学, 本科/学士

   

（1） 广东省自然科学奖, 二等奖, 省级, 2016
（2） 深圳市科学技术奖, 二等奖, 省级, 2015

   

（1） X-ray-activatable Au/Ag nanorods for radio-immuno oncotherapy sensitization and monitoring of the therapeutic response using NIR-II photoacoustic imaging, Advanced Science, 2023, 第 9 作者  通讯作者
（2） Low-dose NIR-II preclinical bioimaging using liposome-encapsulated cyanine dyes, Small, 2023, 第 9 作者  通讯作者
（3） Clinical radiation dose verification by topographic persistent luminescence dosimetry, Nano Today, 2023, 第 7 作者  通讯作者
（4） A Swallowable X-ray Dosimeter for Real-time in vivo Radiotherapy Monitoring, Nature Biomedical Engineering, 2023, 第 11 作者  通讯作者
（5） NIR-II fluorescence visualization of ultrasound-induced blood���brain barrier opening for enhanced photothermal therapy against glioblastoma using indocyanine green microbubbles, Science Bulletin, 2022, 第 8 作者  通讯作者
（6） Self-assembled AIEgen nanoparticles for multiscale NIR-II vascular imaging, BIOMATERIALS, 2021, 第 3 作者
（7） Highly penetrative liposome nanomedicine generated by a biomimetic strategy for enhanced cancer chemotherapy (vol 6, pg 1546, 2018), BIOMATERIALS SCIENCE, 2021, 第 2 作者
（8） Targeted NIR-II emissive nanoprobes for tumor detection in mice and rabbits, CHEMICAL COMMUNICATIONS, 2021, 第 7 作者
（9） Tiny 2D silicon quantum sheets: a brain photonic nanoagent for orthotopic glioma theranostics, SCIENCE BULLETIN, 2021, 第 10 作者  通讯作者
（10） Intravital NIR-II three-dimensional photoacoustic imaging of biomineralized copper sulfide nanoprobes, JOURNAL OF MATERIALS CHEMISTRY B, 2021, 第 13 作者  通讯作者
（11） Metabolizable near-infrared-II nanoprobes for dynamic imaging of deep-seated tumor-associated macrophages in pancreatic cancer, ACS Nano, 2021, 第 9 作者  通讯作者
（12） High���specificity in vivo tumor imaging using bioorthogonal NIR-IIb nanoparticles, Advanced Materials, 2021, 第 6 作者  通讯作者
（13） Centimeter-Deep NIR-II Fluorescence Imaging with Nontoxic AIE Probes in Nonhuman Primates, RESEARCH, 2020, 第 1 作者
（14） Recent Advances in Conjugated Polymer Nanoparticles for NIR-II Imaging and Therapy, ACS APPLIED POLYMER MATERIALS, 2020, 第 6 作者  通讯作者
（15） 功能化纳米探针用于脑胶质瘤精准诊疗研究进展, Recent Advances of Functional Nanoprobes for Precision Diagnosis and Therapy of Glioma, 集成技术, 2020, 第 1 作者
（16） Bright Aggregation-Induced Emission Nanoparticles for Two-Photon Imaging and Localized Compound Therapy of Cancers, ACS NANO, 2020, 第 6 作者
（17） Biomimetic Nanocomposites Cloaked with Bioorthogonally Labeled Glioblastoma Cell Membrane for Targeted Multimodal Imaging of Brain Tumors, ADVANCED FUNCTIONAL MATERIALS, 2020, 第 10 作者  通讯作者
（18） In vivo assessment of inflammation in carotid atherosclerosis by noninvasive photoacoustic imaging, THERANOSTICS, 2020, 第 9 作者
（19） Nanostructural Control Enables Optimized Photoacoustic-Fluorescence-Magnetic Resonance Multimodal Imaging and Photothermal Therapy of Brain Tumor, ADVANCED FUNCTIONAL MATERIALS, 2020, 第 10 作者
（20） A zeolite-based ship-in-a-bottle route to ultrasmall carbon dots for live cell labeling and bioimaging, NANOSCALE ADVANCES, 2020, 第 4 作者
（21） Smart Hydrogel-Based DVDMS/bFGF Nanohybrids for Antibacterial Phototherapy with Multiple Damaging Sites and Accelerated Wound Healing, ACS APPLIED MATERIALS & INTERFACES, 2020, 第 4 作者
（22） Ultrasmall theranostic nanozymes to modulate tumor hypoxia for augmenting photodynamic therapy and radiotherapy, BIOMATERIALS SCIENCE, 2020, 第 12 作者  通讯作者
（23） Activatable NIR-II photoacoustic imaging and photochemical synergistic therapy of MRSA infections using miniature Au/Ag nanorods, BIOMATERIALS, 2020, 第 12 作者  通讯作者
（24） Novel small molecular dye-loaded lipid nanoparticles with efficient near-infrared-II absorption for photoacoustic imaging and photothermal therapy of hepatocellular carcinoma, BIOMATERIALS SCIENCE, 2019, 第 10 作者  通讯作者
（25） Recent advances in functional nanomaterials for photoacoustic imaging of glioma, NANOSCALE HORIZONS, 2019, 第 4 作者  通讯作者
（26） Precise Deciphering of Brain Vasculatures and Microscopic Tumors with Dual NIR-II Fluorescence and Photoacoustic Imaging, ADVANCED MATERIALS, 2019, 第 10 作者  通讯作者
（27） Molecular Engineering of Near-Infrared Light-Responsive BODIPY-Based Nanoparticles with Enhanced Photothermal and Photoacoustic Efficiencies for Cancer Theranostics, THERANOSTICS, 2019, 第 5 作者  通讯作者
（28） Phototheranostics: Active Targeting of Orthotopic Glioma Using Biomimetic Proteolipid Nanoparticles, ACS NANO, 2019, 第 9 作者  通讯作者
（29） pH-sensitive loaded retinal/indocyanine green micelles as an "all-in-one" theranostic agent for multi-modal imaging in vivo guided cellular senescence-photothermal synergistic therapy, CHEMICAL COMMUNICATIONS, 2019, 第 9 作者
（30） Activatable Small-Molecule Photoacoustic Probes that Cross the Blood-Brain Barrier for Visualization of Copper(II) in Mice with Alzheimer's Disease, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2019, 第 2 作者  通讯作者
（31） Ultrasound-Induced Blood-Brain-Barrier Opening Enhances Anticancer Efficacy in the Treatment of Glioblastoma: Current Status and Future Prospects, JOURNAL OF ONCOLOGY, 2019, 第 2 作者
（32） Imaging-guided focused ultrasound-induced thermal and sonodynamic effects of nanosonosensitizers for synergistic enhancement of glioblastoma therapy, BIOMATERIALS SCIENCE, 2019, 第 10 作者
（33） Ultrasmall hybrid protein-copper sulfide nanoparticles for targeted photoacoustic imaging of orthotopic hepatocellular carcinoma with a high signal-to-noise ratio, BIOMATERIALS SCIENCE, 2019, 第 6 作者
（34） Forster Resonance Energy Transfer-Based Dual-Modal Theranostic Nanoprobe for In Situ Visualization of Cancer Photothermal Therapy, THERANOSTICS, 2018, 第 2 作者  通讯作者
（35） Through scalp and skull nir-ii photothermal therapy of deep orthotopic brain tumors with precise photoacoustic imaging guidance, ADVANCED MATERIALS, 2018, 第 2 作者
（36） Enhanced drug delivery using sonoactivatable liposomes with membrane-embedded porphyrins, JOURNAL OF CONTROLLED RELEASE, 2018, 第 7 作者
（37） Highly Sensitive MoS2–Indocyanine Green Hybrid for Photoacoustic Imaging of Orthotopic Brain Glioma at Deep Site, Highly Sensitive MoS2���Indocyanine Green Hybrid for Photoacoustic Imaging of Orthotopic Brain Glioma at Deep Site, 纳微快报：英文版, 2018, 第 11 作者
（38） Enhanced drug delivery using sonoactivatable liposomes with membrane-embedded porphyrins, JOURNAL OF CONTROLLED RELEASE, 2018, 第 7 作者
（39） Hybrid MoSe2-indocyanine green nanosheets as a highly efficient phototheranostic agent for photoacoustic imaging guided photothermal cancer therapy, BIOMATERIALS SCIENCE, 2018, 第 6 作者
（40） Highly Sensitive MoS2-Indocyanine Green Hybrid for Photoacoustic Imaging of Orthotopic Brain Glioma at Deep Site., NANO-MICRO LETTERS, 2018, 第 11 作者  通讯作者
（41） Highly sensitive fluorescence and photoacoustic detection of metastatic breast cancer in mice using dual-modal nanoprobes, ACS APPLIED MATERIALS & INTERFACES, 2018, 第 3 作者
（42） Protein-modified conjugated polymer nanoparticles with strong near-infrared absorption: a novel nanoplatform to design multifunctional nanoprobes for dual-modal photoacoustic and fluorescence imaging, NANOSCALE, 2018, 第 4 作者
（43） Lipid-polymer bilaminar oxygen nanobubbles for enhanced photodynamic therapy of cancer, ACS APPLIED MATERIALS & INTERFACES, 2018, 第 4 作者  通讯作者
（44） Theranostic nanosensitizers for highly efficient MR/fluorescence imaging-guided sonodynamic therapy of gliomas, JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2018, 第 3 作者
（45） Bright aggregation���induced���emission dots for targeted synergetic nir���ii fluorescence and nir���i photoacoustic imaging of orthotopic brain tumors, ADVANCED MATERIALS, 2018, 第 1 作者
（46） Focused Ultrasound-Augmented Delivery of Biodegradable Multifunctional Nanoplatforms for Imaging-Guided Brain Tumor Treatment., ADVANCED SCIENCE, 2018, 第 7 作者
（47） Highly penetrative liposome nanomedicine generated by a biomimetic strategy for enhanced cancer chemotherapy, BIOMATERIALS SCIENCE, 2018, 第 2 作者
（48） A catalase-loaded hierarchical zeolite as an implantable nanocapsule for ultrasound-guided oxygen self-sufficient photodynamic therapy against pancreatic cancer, NANOSCALE, 2018, 第 3 作者
（49） Highly sensitive photoacoustic imaging of orthotopic brain tumor based on the amplified photoacoustic effect of single-layer MoS2 nanosheets, NANOMEDICINE: NANOTECHNOLOGY, BIOLOGY, AND MEDICINE, 2018, 第 4 作者
（50） Protein-Modified CuS Nanotriangles: A Potential Multimodal Nanoplatform for In Vivo Tumor Photoacoustic/Magnetic Resonance Dual-Modal Imaging., ADVANCED HEALTHCARE MATERIALS, 2017, 第 2 作者
（51） Gold Nanoclusters-Indocyanine Green Nanoprobes for Synchronous Cancer Imaging, Treatment and Real-time Monitoring Based on Fluorescence Resonance Energy Transfer, ACS APPLIED MATERIALS & INTERFACES, 2017, 第 8 作者  通讯作者
（52） Redox-responsive dextran based theranostic nanoparticles for near-infrared/magnetic resonance imaging and magnetically targeted photodynamic therapy., BIOMATERIALS SCIENCE, 2017, 第 4 作者
（53） Molecular Engineering of Conjugated Polymers for Biocompatible Organic Nanoparticles with Highly Efficient Photoacoustic and Photothermal Performance in Cancer Theranostics., ACS NANO, 2017, 第 2 作者
（54） Indocyanine green-loaded gold nanostars for sensitive SERS imaging and subcellular monitoring of photothermal therapy., NANOSCALE, 2017, 第 2 作者
（55） Indocyanine Green-holo-Transferrin Nanoassemblies for Tumor-Targeted Dual-Modal Imaging and Photothermal Therapy of Glioma, ACS APPLIED MATERIALS & INTERFACES, 2017, 第 2 作者
（56） Biocompatible conjugated polymer nanoparticles for highly efficient photoacoustic imaging of orthotopic brain tumors in the second near-infrared window., MATERIALS HORIZONS, 2017, 第 2 作者
（57） QDs-virus bioconjugate as potential gene-drug co-delivery system for synergistic tumor therapy, NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2016, 第 7 作者
（58） Indocyanine green-loaded polydopamine coated reduced graphene oxide for theranostic applications, NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2016, 第 5 作者
（59） Translational nanomedicine for imaging-guided photothermal therapy, NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2016, 第 1 作者
（60） Bioorthogonal multifunctional nanoprobes for biomedicine and theranostic applications, NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2016, 第 10 作者
（61） Indocyanine green-loaded polydopamine-iron ions coordination nanoparticles for photoacoustic/magnetic resonance dual-modal imaging-guided cancer photothermal therapy, NANOSCALE, 2016, 第 7 作者  通讯作者
（62） Activatable albumin-photosensitizer nanoassemblies for triple-modal imaging and thermal-modulated photodynamic therapy of cancer, BIOMATERIALS, 2016, 第 2 作者  通讯作者
（63） Smart indocyanine green nanoprobe for imaging-guided cancer phototherapy, NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2016, 第 4 作者
（64） Indocyanine Green-Loaded Polydopamine-Reduced Graphene Oxide Nanocomposites with Amplifying Photoacoustic and Photothermal Effects for Cancer Theranostics, THERANOSTICS, 2016, 第 4 作者  通讯作者
（65） Single-Layer MoS2 Nanosheets with Amplified Photoacoustic Effect for Highly Sensitive Photoacoustic Imaging of Orthotopic Brain Tumors, ADVANCED FUNCTIONAL MATERIALS, 2016, 第 9 作者  通讯作者
（66） Theranostic iron oxide nanoparticles protected by NIR-emitting multidentate-ligands for multimodal imaging-guided photothermal therapy, NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2016, 第 5 作者
（67） Remote and noninvasive NIR-triggered DOX release from DOX/ICG-loaded temperature-responsive nanoparticles to promote anti-tumor effect, NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2016, 第 6 作者
（68） Self-Monitoring Artificial Red Cells with Sufficient Oxygen Supply for Enhanced Photodynamic Therapy, SCIENTIFIC REPORTS, 2016, 第 8 作者
（69） Oxygen Nanocarrier for Combined Cancer Therapy: Oxygen-Boosted ATP-Responsive Chemotherapy with Amplified ROS Lethality, ADVANCED HEALTHCARE MATERIALS, 2016, 第 5 作者
（70） Magneto-Plasmonic Nanocapsules for Multimodal-Imaging and Magnetically Guided Combination Cancer Therapy, CHEMISTRY OF MATERIALS, 2016, 第 5 作者
（71） Smart methylene blue nanoprobe for imaging-guided cancer photodynamic therapy, NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2016, 第 6 作者
（72） 量子点的近红外调控研究进展概述, Review of Research Progress in Near-Infrared-Emitting Quantum Dots, 集成技术, 2015, 第 8 作者
（73） Advances in cancer nanomedicine, CANCER BIOLOGY & MEDICINE, 2015, 第 2 作者
（74） Multifunctional magnetic silica nanotubes for MR imaging and targeted drug delivery, CHEMICAL COMMUNICATIONS, 2015, 第 5 作者
（75） Compact chelator-free Ni-integrated CuS nanoparticles with tunable near-infrared absorption and enhanced relaxivity for in vivo dual-modal photoacoustic/MR imaging, NANOSCALE, 2015, 第 7 作者
（76） NIR-driven Smart Theranostic Nanomedicine for On-demand Drug Release and Synergistic Antitumour Therapy, SCIENTIFIC REPORTS, 2015, 第 6 作者
（77） Advances in cancer nanomedicine, Advances in cancer nanomedicine, CANCER BIOLOGY & MEDICINE, 2015, 第 2 作者
（78） Photosensitizer-conjugated redox-responsive dextran theranostic nanoparticles for near-infrared cancer imaging and photodynamic therapy, POLYMER CHEMISTRY, 2014, 第 3 作者
（79） ZEB1 knockdown mediated using polypeptide cationic micelles inhibits metastasis and effects sensitization to a chemotherapeutic drug for cancer therapy, NANOSCALE, 2014, 第 6 作者
（80） Folate Receptor-Targeting Gold Nanoclusters as Fluorescence Enzyme Mimetic Nanoprobes for Tumor Molecular Colocalization Diagnosis, THERANOSTICS, 2014, 第 2 作者
（81） Smart Human Serum Albumin-Indocyanine Green Nanoparticles Generated by Programmed Assembly for Dual-Modal Imaging-Guided Cancer Synergistic Phototherapy, ACS NANO, 2014, 第 1 作者
（82） Highly Bright and Compact Alloyed Quantum Rods with Near Infrared Emitting: a Potential Multifunctional Nanoplatform for Multimodal Imaging In Vivo, ADVANCED FUNCTIONAL MATERIALS, 2014, 第 3 作者
（83） Polypeptide micelles with dual pH activatable dyes for sensing cells and cancer imaging, NANOSCALE, 2014, 第 6 作者
（84） In vivo photoacoustic molecular imaging of breast carcinoma with folate receptor-targeted indocyanine green nanoprobes, NANOSCALE, 2014, 第 6 作者
（85） Protein-assisted fabrication of nano-reduced graphene oxide for combined invivo photoacoustic imaging and photothermal therapy, BIOMATERIALS, 2013, 第 1 作者
（86） Indocyanine Green Nanoparticles for Theranostic Applications, NANO-MICRO LETTERS, 2013, 第 1 作者
（87） Single-Step Assembly of DOX/ICG Loaded Lipid-Polymer Nanoparticles for Highly Effective Chemo-photothermal Combination Therapy, ACS NANO, 2013, 第 7 作者
（88） 纳米探针在分子影像领域的研究进展, Progress of the nano probes for molecular imaging, 科学通报, 2013, 第 8 作者
（89） Hybrid gold-gadolinium nanoclusters for tumor-targeted NIRF/CT/MRI triple-modal imaging in vivo, NANOSCALE, 2013, 第 2 作者
（90） Ultrasmall paramagnetic near infrared quantum dots as dual modal nanoprobes, RSC ADVANCES, 2013, 第 5 作者
（91） One-step synthesis of peptide-programmed QDs as ready-to-use nanoprobes, CHEMICAL COMMUNICATIONS, 2013, 第 4 作者
（92） PEI protected aptamer molecular probes for contrast-enhanced invivo cancer imaging, BIOMATERIALS, 2012, 第 8 作者
（93） Cation exchange in aptamer-conjugated CdSe nanoclusters: a novel fluorescence signal amplification for cancer cell detection, CHEMICAL COMMUNICATIONS, 2012, 第 1 作者
（94） Indocyanine green-loaded biodegradable tumor targeting nanoprobes for invitro and invivo imaging, BIOMATERIALS, 2012, 第 7 作者
（95） Click-Functionalized Compact Quantum Dots Protected by Multidentate-Imidazole Ligands: Conjugation-Ready Nanotags for Living-Virus Labeling and Imaging, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2012, 第 6 作者

   

（ 1 ） 二区荧光探针标记工程菌可视化治疗脑胶质瘤的方法与机制研究, 负责人, 国家任务, 2024-01--2027-12
（ 2 ） 近红外二区荧光分子探针用于胰管恶性病变的动态可视化, 负责人, 国家任务, 2019-01--2021-12
（ 3 ） 近红外二区光声探针用于成像引导脑胶质瘤精准手术的研究, 负责人, 国家任务, 2019-01--2020-12
（ 4 ） 二级协同靶向吲哚菁绿纳米探针用于脑胶质瘤光学诊疗一体化研究, 负责人, 国家任务, 2016-01--2019-12
（ 5 ） 叶酸受体靶向的石墨烯光声层析分子成像探针的研究, 负责人, 国家任务, 2014-01--2016-12