0710J3-生物信息学
0710Z1-基因组学

癌症基因组学

2010-09--2015-07   中国科学院数学与系统科学研究院   博士
2006-09--2010-07   中国农业大学   学士

   

2020-10~现在, 中国科学院北京基因组研究所（国家生物信息中心）, 研究员
2018-09~2020-08,Columbia University, Associate Research Scientist
2015-09~2018-08,Columbia University, Postdoctoral Researcher
2010-09~2015-07,中国科学院数学与系统科学研究院, 博士
2006-09~2010-07,中国农业大学, 学士

   

（1） SF3B1 mutant-induced missplicing of MAP3K7 causes anemia in myelodysplastic syndromes, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2022, 第 2 作者
（2） SF3B1 mutant-induced missplicing of MAP3K7 causes anemia in myelodysplastic syndromes, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2022, 第 2 作者
（3） Pharmacogenomic landscape of patient-derived tumor cells informs precision oncology therapy, Nature genetics, 2021, 第 2 作者
（4） Mutant SF3B1 promotes AKT- and NF-kappa B driven mammary tumorigenesis, JOURNAL OF CLINICAL INVESTIGATION, 2021, 第 2 作者
（5） Computing the Role of Alternative Splicing in Cancer, Trends in cancer, 2021, 通讯作者
（6） The UVSSA complex alleviates MYC-driven stress, JOURNAL OF CELL BIOLOGY, 2021, 第 3 作者
（7） The UVSSA complex alleviates MYC-driven transcription stress, Journal of Cell Biology, 2021, 第 1 作者
（8） Mutant SF3B1 promotes AKT and NF-kB driven mammary tumorigenesis, The Journal of Clinical Investigation, 2021, 第 1 作者
（9） Pharmacogenomic landscape of patient-derived tumor cells informs precision oncology therapy, Nature genetics, 2021, 第 2 作者
（10） Mutant SF3B1 promotes AKT- and NF-kappa B driven mammary tumorigenesis, JOURNAL OF CLINICAL INVESTIGATION, 2021, 第 2 作者
（11） Computing the Role of Alternative Splicing in Cancer, Trends in cancer, 2021, 通讯作者
（12） The UVSSA complex alleviates MYC-driven stress, JOURNAL OF CELL BIOLOGY, 2021, 第 3 作者
（13） The UVSSA complex alleviates MYC-driven transcription stress, Journal of Cell Biology, 2021, 第 1 作者
（14） Mutant SF3B1 promotes AKT and NF-kB driven mammary tumorigenesis, The Journal of Clinical Investigation, 2021, 第 1 作者
（15） Mutations in the RNA Splicing Factor SF3B1 Promote Tumorigenesis through MYC Stabilization, CANCER DISCOVERY, 2020, 第 1 作者
（16） Genomic Characterization of HIV-Associated Plasmablastic Lymphoma Identifies Pervasive Mutations in the JAK–STAT Pathway, Blood Cancer Discovery, 2020, 第 1 作者
（17） Pan-cancer analysis identifies mutations in SUGP1 that recapitulate mutant SF3B1 splicing dysregulation, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 第 1 作者
（18） A Novel JAK1 Mutant Breast Implant-Associated Anaplastic Large Cell Lymphoma Patient-Derived Xenograft Fostering Pre-Clinical Discoveries, CANCERS, 2020, 第 5 作者
（19） Mutations in the RNA Splicing Factor SF3B1 Promote Tumorigenesis through MYC Stabilization, CANCER DISCOVERY, 2020, 第 1 作者
（20） Genomic Characterization of HIV-Associated Plasmablastic Lymphoma Identifies Pervasive Mutations in the JAK–STAT Pathway, Blood Cancer Discovery, 2020, 第 1 作者
（21） Pan-cancer analysis identifies mutations in SUGP1 that recapitulate mutant SF3B1 splicing dysregulation, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 第 1 作者
（22） A Novel JAK1 Mutant Breast Implant-Associated Anaplastic Large Cell Lymphoma Patient-Derived Xenograft Fostering Pre-Clinical Discoveries, CANCERS, 2020, 第 5 作者
（23） Disease-Causing Mutations in SF3B1 Alter Splicing by Disrupting Interaction with SUGP1, MOLECULAR CELL, 2019, 第 4 作者
（24） Comprehensive characterisation of compartment-specific long non-coding RNAs associated with pancreatic ductal adenocarcinoma, GUT, 2019, 第 2 作者
（25） Secretome analysis of patient-derived GBM tumor spheres identifies midkine as a potent therapeutic target, EXPERIMENTAL AND MOLECULAR MEDICINE, 2019, 第 4 作者
（26） Disease-Causing Mutations in SF3B1 Alter Splicing by Disrupting Interaction with SUGP1, MOLECULAR CELL, 2019, 第 4 作者
（27） Comprehensive characterisation of compartment-specific long non-coding RNAs associated with pancreatic ductal adenocarcinoma, GUT, 2019, 第 2 作者
（28） Secretome analysis of patient-derived GBM tumor spheres identifies midkine as a potent therapeutic target, EXPERIMENTAL AND MOLECULAR MEDICINE, 2019, 第 4 作者
（29） Saa3 is a key mediator of the protumorigenic properties of cancer-associated fibroblasts in pancreatic tumors, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 其他（合作组作者）
（30） Saa3 is a key mediator of the protumorigenic properties of cancer-associated fibroblasts in pancreatic tumors, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 其他（合作组作者）
（31） Clonal Evolution of Glioblastoma under Therapy, NATURE GENETICS, 2016, 第 8 作者
（32） Clonal Evolution of Glioblastoma under Therapy, NATURE GENETICS, 2016, 第 8 作者

   

（ 1 ） 泛癌基因组可变剪切调控关系的深度挖掘, 负责人, 国家任务, 2022-01--2025-12