基本信息

康禹 女 硕导 中国科学院北京基因组研究所(国家生物信息中心)
电子邮件: kangy@big.ac.cn
通信地址: 北京市朝阳区北辰西路一号院104楼
邮政编码: 100101
电子邮件: kangy@big.ac.cn
通信地址: 北京市朝阳区北辰西路一号院104楼
邮政编码: 100101
招生信息
招生专业
0710Z1-基因组学0710J3-生物信息学071007-遗传学
招生方向
医学基因组测序技术生物信息学
教育背景
1999-09--2002-07 北京大学 博士1991-09--1996-07 北京医科大学 本科
工作经历
工作简历
2023-05~2024-05,中国科学院北京基因组研究所(国家生物信息中心), 研究员2016-01~2023-05,中国科学院北京基因组研究所(国家生物信息中心), 副研究员2012-06~2015-12,中国科学院北京基因组研究所, 助理研究员2010-03~2012-05,中国科学院北京基因组研究所, 博后2002-08~2010-02,本元正阳基因技术有限责任公司, 经理1996-09~1999-08,北京大学人民医院, 住院医师
专利与奖励
专利成果
( 1 ) 用于类风湿关节炎炎症状态评估及预后评价的肠道微生物菌群, 专利授权, 2021, 第 2 作者, 专利号: CN110283754B( 2 ) 一种痰液微生物的快速提纯试剂及其应用, 专利授权, 2020, 第 2 作者, 专利号: CN108795931B( 3 ) 与自闭症相关的肠道菌群生物标志物及其应用, 发明专利, 2020, 第 2 作者, 专利号: CN111197085A( 4 ) 用于体液细菌与细胞分离的芯片、制作方法及其使用方法, 发明专利, 2019, 第 2 作者, 专利号: CN110551617A( 5 ) 痰液样品中病原菌的快速提纯装置及快速提纯方法, 专利授权, 2019, 第 1 作者, 专利号: CN107090399B( 6 ) 一种痰液液化试剂、含有其的试剂盒及其应用, 发明专利, 2018, 第 2 作者, 专利号: CN108414313A( 7 ) 宏基因组提取方法, 发明专利, 2013, 第 7 作者, 专利号: CN103060309A
出版信息
发表论文
[1] Genomics, Proteomics & Bioinformatics. 2023, 通讯作者 [2] Liang, Ying, Shi, Xing, Shen, Yang, Huang, Zhuoran, Wang, Jian, Shao, Changjun, Chu, Yanan, Chen, Jing, Yu, Jun, Kang, Yu. Enhanced intestinal protein fermentation in schizophrenia. BMC MEDICINE[J]. 2022, 第 10 作者 通讯作者 20(1): http://dx.doi.org/10.1186/s12916-022-02261-z.[3] 康禹. Intestinal butyrate-metabolizing species contribute to autoantibody production and bone erosion in rheumatoid arthritis.. Science Advances[J]. 2022, 第 1 作者[4] Lyu, Wei, Meng, Qingren, Xiao, Jingfa, Li, Jing, Wang, Jian, Qiu, Zhifeng, Song, Xiaojing, Zhu, Hua, Shao, Changjun, Chu, Yanan, Zhou, Qian, Li, Taisheng, JeanPierre, Routy, Yu, Jun, Han, Yang, Kang, Yu. Gut lactate-producing bacteria promote CD4 T cell recovery on Anti-retroviral therapy in HIV-infected patients. COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL[J]. 2021, 第 16 作者 通讯作者 19: 2928-2937, http://dx.doi.org/10.1016/j.csbj.2021.05.021.[5] Zhai, Yao, Li, Daixi, Du, Pengcheng, Zhang, Zhao, He, Zilong, Guo, Yatao, Chen, Yusheng, Kang, Yu, Hu, Songnian, Gao, Zhancheng. Complete sequences of two new KPC-harbouring plasmids in Klebsiella pneumoniae ST11 strains in China. JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE[J]. 2021, 第 8 作者24: 114-120, http://dx.doi.org/10.1016/j.jgar.2020.11.023.[6] Kang, Yu, Yuan, Lina, Shi, Xing, Chu, Yanan, He, Zilong, Jia, Xinmiao, Lin, Qiang, Ma, Qin, Wang, Jian, Xiao, Jingfa, Hu, Songnian, Gao, Zhancheng, Chen, Fei, Yu, Jun. A fine-scale map of genome-wide recombination in divergent Escherichia coli population. Briefings in Bioinformatics[J]. 2021, 第 1 作者22(4): [7] Li, DaiXi, Zhai, Yao, Zhang, Zhao, Guo, YaTao, Wang, ZhanWei, He, ZiLong, Hu, SongNian, Chen, YuSheng, Kang, Yu, Gao, ZhanCheng. Genetic factors related to the widespread dissemination of ST11 extensively drug-resistant carbapenemase-producing Klebsiella pneumoniae strains within hospital. CHINESE MEDICAL JOURNAL[J]. 2020, 第 9 作者133(21): 2573-2585, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7722564/.[8] Xing Shi, Zhancheng Gao, Qiang Lin, Liping Zhao, Qin Ma, Yu Kang, Jun Yu. Meta-analysis Reveals Potential Influence of Oxidative Stress on the Airway Microbiomes of Cystic Fibrosis Patients. GENOMICS, PROTEOMICS & BIOINFORMATICS. 2020, 第 6 作者17(6): 590-602, [9] Manwar Muhammad Ramzan, Shao Changjun, Shi Xing, Wang Jian, Lin Qiang, Tong Yigang, Kang Yu, Yu Jun. The bacterial RNA ligase RtcB accelerates the repair process of fragmented rRNA upon releasing the antibiotic stress. SCIENCE CHINA. LIFE SCIENCES[J]. 2020, 第 7 作者 通讯作者 63(2): 251-258, https://www.sciengine.com/doi/10.1007/s11427-018-9405-y.[10] Zhang, Zhao, Li, Daixi, Shi, Xing, Zhai, Yao, Guo, Yatao, Zheng, Yali, Zhao, Lili, He, Yukun, Chen, Yusheng, Wang, Zhanwei, Su, Jianrong, Kang, Yu, Gao, Zhancheng. Genomic characterization of an emerging Enterobacteriaceae species: the first case of co-infection with a typical pathogen in a human patient. BMC GENOMICS[J]. 2020, 第 12 作者 通讯作者 21(1): http://dx.doi.org/10.1186/s12864-020-6720-z.[11] 康禹. Genomic characterization of an emerging Enterobacteriaceae species for the first case of human infection in cooperation with a typical pathogen.. BMC Genomics[J]. 2020, 第 1 作者 通讯作者 [12] Zhang, Mengxiang, Chu, Yanan, Meng, Qingren, Ding, Rui, Shi, Xing, Wang, Zuqun, He, Yi, Zhang, Juan, Liu, Jing, Zhang, Jie, Yu, Jun, Kang, Yu, Wang, Juan. A quasi-paired cohort strategy reveals the impaired detoxifying function of microbes in the gut of autistic children. SCIENCE ADVANCES[J]. 2020, 第 12 作者 通讯作者 6(43): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7577716/.[13] Xing Shi, Changjun Shao, Chunxiong Luo, Yanan Chu, Jian Wang, Qingren Meng, Jun Yu, Zhancheng Gao, Yu Kang. Microfluidics-Based Enrichment and Whole-Genome Amplification Enable Strain-Level Resolution for Airway Metagenomics. MSYSTEMS[J]. 2019, 第 9 作者 通讯作者 4(4): https://www.webofscience.com/wos/woscc/full-record/WOS:000482629400038.[14] Zheng, Yali, Ning, Pu, Luo, Qiongzhen, He, Yukun, Yu, Xu, Liu, Xiaohui, Chen, Yusheng, Wang, Xiaorong, Kang, Yu, Gao, Zhancheng. Inflammatory responses relate to distinct bronchoalveolar lavage lipidome in community-acquired pneumonia patients: a pilot study. RESPIRATORY RESEARCH[J]. 2019, 第 9 作者 通讯作者 20(1): https://doaj.org/article/3be8c8b9b12a43fe9d94c29f1e5624fa.[15] Shi, Xing, Gao, Zhancheng, Lin, Qiang, Zhao, Liping, Ma, Qin, Kang, Yu, Yu, Jun. Meta -analysis Reveals Potential Influence of Oxidative Stress on the Airway Microbiomes of Cystic Fibrosis Patients. GENOMICS PROTEOMICS & BIOINFORMATICS[J]. 2019, 第 6 作者 通讯作者 17(6): 590-602, http://lib.cqvip.com/Qikan/Article/Detail?id=00002HUHLL7G7JP167DO3JP1MDR.[16] Li, Lingjun, Wu, Tian, Wang, Ying, Ran, Min, Kang, Yu, Ouyang, Qi, Luo, Chunxiong. Spatial coordination in a mutually beneficial bacterial community enhances its antibiotic resistance. COMMUNICATIONS BIOLOGY[J]. 2019, 第 5 作者2(1): http://dx.doi.org/10.1038/s42003-019-0533-0.[17] Niu, ShengYong, Yang, Jinyu, McDermaid, Adam, Zhao, Jing, Kang, Yu, Ma, Qin. Bioinformatics tools for quantitative and functional metagenome and metatranscriptome data analysis in microbes. BRIEFINGS IN BIOINFORMATICS. 2018, 第 5 作者19(6): 1415-1429, http://dx.doi.org/10.1093/bib/bbx051.[18] Guo, Yatao, Zhai, Yao, Zhang, Zhao, Li, Daixi, Wang, Zhanwei, Li, Jingquan, He, Zilong, Hu, Songnian, Kang, Yu, Gao, Zhancheng. Complete Genomic Analysis of a Kingdom-Crossing Klebsiella variicola Isolate. FRONTIERS IN MICROBIOLOGY[J]. 2018, 第 9 作者 通讯作者 9: https://doaj.org/article/a29086efd6d34b4bb198992f8babbb0b.[19] Ning, Pu, Zheng, Yali, Luo, Qiongzhen, Liu, Xiaohui, Kang, Yu, Zhang, Yan, Zhang, Rongbao, Xu, Yu, Yang, Donghong, Xi, Wen, Wang, Keqiang, Chen, Yusheng, An, Shuchang, Gao, Zhancheng. Metabolic profiles in community-acquired pneumonia: developing assessment tools for disease severity. CRITICAL CARE[J]. 2018, 第 5 作者22(1): https://doaj.org/article/79dc822a9846404192025bf944e2b859.[20] Rajwani, Rahim, Yam, Wing Cheong, Zhang, Ying, Kang, Yu, Wong, Barry Kin Chung, Leung, Kenneth Siu Sing, Tam, Kingsley King Gee, Tulu, Ketema Tafess, Zhu, Li, Siu, Gilman Kit Hang. Comparative Whole-Genomic Analysis of an Ancient L2 Lineage Mycobacterium tuberculosis Reveals a Novel Phylogenetic Clade and Common Genetic Determinants of Hypervirulent Strains. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY[J]. 2018, 第 4 作者7: https://doaj.org/article/91c26317b64b448daf44eb8b1657ab47.[21] Huang YC, Shi X, Li ZY, Shen Y, Shi XX, Wang LY, Li GF, Yuan Y, Wang JX, Zhang YC, Zhao L, Zhang M, Kang Y, Liang Y. Possible association of Firmicutes in the gut microbiota of patients with major depressive disorder. NEUROPSYCHIATRIC DISEASE AND TREATMENT[J]. 2018, 14: 3329-3337, https://doaj.org/article/83d1f3c6f057478eae9fc4578bc75905.[22] Zhao, Yongbing, Sun, Chen, Zhao, Dongyu, Zhang, Yadong, You, Yang, Jia, Xinmiao, Yang, Junhui, Wang, Lingping, Wang, Jinyue, Fu, Haohuan, Kang, Yu, Chen, Fei, Yu, Jun, Wu, Jiayan, Xiao, Jingfa. PGAP-X: extension on pan-genome analysis pipeline. BMC Genomics[J]. 2018, 第 11 作者19(S1): https://doaj.org/article/778dfe46a6174e30abed0aee35dafbc8.[23] Wu, Tian, Shao, Changjun, Li, Lingjun, Wang, Shujing, Ouyang, Qi, Kang, Yu, Luo, Chunxiong. Streamline-based purification of bacterial samples from liquefied sputum utilizing microfluidics. LAB ON A CHIP[J]. 2017, 第 6 作者 通讯作者 17(21): 3601-3608, https://www.webofscience.com/wos/woscc/full-record/WOS:000413868700005.[24] Yuan, Lina, Yu, Yang, Zhu, Yanmin, Li, Yulai, Li, Changqing, Li, Rujiao, Ma, Qin, Siu, Gilman KitHang, Yu, Jun, Jiang, Taijiao, Xiao, Jingfa, Kang, Yu. GAAP: Genome-organization-framework-Assisted Assembly Pipeline for prokaryotic genomes. BMC GENOMICS[J]. 2017, 第 12 作者 通讯作者 18(Suppl 1): http://dx.doi.org/10.1186/s12864-016-3267-0.[25] Zhai, Yao, He, Zilong, Kang, Yu, Yu, Haiying, Wang, Jianfeng, Du, Pengcheng, Zhang, Zhao, Hu, Songnian, Gao, Zhancheng. Complete nucleotide sequence of pH11, an IncHI2 plasmid conferring multi-antibiotic resistance and multi-heavy metal resistance genes in a clinical Klebsiella pneumoniae isolate. PLASMID[J]. 2016, 第 3 作者86: 26-31, http://www.corc.org.cn/handle/1471x/2374459.[26] Fang Wang, Ran Li, Ying Shang, Can Wang, Guo-Qing Wang, DeXun Zhou, Dong-Hong Yang, Wen Xi, Ke-QiangWang, Jing Bao, Yu Kang, Zhan-Cheng Gao. A Pilot Study of Quantitative Loop-mediated Isothermal Amplification-guided Target Therapies for Hospital-acquired Pneumonia. 中华医学杂志:英文版[J]. 2016, 第 11 作者181-186, http://lib.cqvip.com/Qikan/Article/Detail?id=667808860.[27] Liu, Bingqiang, Zhang, Hanyuan, Zhou, Chuan, Li, Guojun, Fennell, Anne, Wang, Guanghui, Kang, Yu, Liu, Qi, Ma, Qin. An integrative and applicable phylogenetic footprinting framework for cis-regulatory motifs identification in prokaryotic genomes. BMC GENOMICS[J]. 2016, 第 7 作者17(1): http://dx.doi.org/10.1186/s12864-016-2982-x.[28] Wang, Fang, Li, Ran, Shang, Ying, Wang, Can, Wang, GuoQing, Zhou, DeXun, Yang, DongHong, Xi, Wen, Wang, KeQiang, Bao, Jing, Kang, Yu, Gao, ZhanCheng. A Pilot Study of Quantitative Loop-mediated Isothermal Amplification-guided Target Therapies for Hospital-acquired Pneumonia. CHINESE MEDICAL JOURNAL[J]. 2016, 第 11 作者129(2): 181-186, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=5620030&detailType=1.[29] Zhu, Lingxiang, Zhong, Jun, Jia, Xinmiao, Liu, Guan, Kang, Yu, Dong, Mengxing, Zhang, Xiuli, Li, Qian, Yue, Liya, Li, Cuidan, Fu, Jing, Xiao, Jingfa, Yan, Jiangwei, Zhang, Bing, Lei, Meng, Chen, Suting, Lv, Lingna, Zhu, Baoli, Huang, Hairong, Chen, Fei. Precision methylome characterization of Mycobacterium tuberculosis complex (MTBC) using PacBio single-molecule real-time (SMRT) technology. Nucleic Acids Research[J]. 2016, 第 5 作者44(2): 730-743, http://dx.doi.org/10.1093/nar/gkv1498.[30] Xiaorong Wang, Yu Kang, Chunxiong Luo, Tong Zhao, Lin Liu, Xiangdan Jiang, Rongrong Fu, Shuchang An, Jichao Chen, Ning Jiang, Lufeng Ren, Qi Wang, J Kenneth Baillie, Zhancheng Gao, Jun Yu. Heteroresistance at the Single-Cell Level: Adapting to Antibiotic Stress through a Population-Based Strategy and Growth-Controlled Interphenotypic Coordination. MBIO[J]. 2014, 第 2 作者5(1): https://www.webofscience.com/wos/woscc/full-record/WOS:000332526500050.[31] Gao Zhancheng, Kang Yu, Yu Jun, Ren Lufeng. Human Pharyngeal Microbiome May Play A Protective Role in Respiratory Tract Infections. GENOMICS, PROTEOMICS & BIOINFORMATICS[J]. 2014, 第 2 作者12(3): 144-150, http://dx.doi.org/10.1016/j.gpb.2014.06.001.[32] Jiang, Xiangdan, Kang, Yu, Pan, Xingjie, Yu, Jun, Ouyang, Qi, Luo, Chunxiong. Studies of the drug resistance response of sensitive and drug-resistant strains in a microfluidic system. INTEGRATIVE BIOLOGY[J]. 2014, 第 2 作者6(2): 143-151, http://dx.doi.org/10.1039/c3ib40164b.[33] Yu Kang, Chaohao Gu, Lina Yuan, Yue Wang, Yanmin Zhu, Xinna Li, Qibin Luo, Jingfa Xiao, Daquan Jiang, Minping Qian, Aftab Ahmed Khan, Fei Chen, Zhang Zhang, Jun Yu. Flexibility and Symmetry of Prokaryotic Genome Rearrangement Reveal Lineage-Associated Core-Gene-Defined Genome Organizational Frameworks. MBIO[J]. 2014, 第 1 作者5(6): https://www.webofscience.com/wos/woscc/full-record/WOS:000347073600014.[34] Li DeZhi, Chu YaNan, Ren LuFeng, Li XinGang, Yuan Lina, Kang Yu, Zhang Wei, Yang Yu, Wang XuMin, Baillie, J Kenneth, Yu Jun, Gao ZhanCheng. Complete genome sequence of methicillin-sensitive Staphylococcus aureus containing a heterogeneic staphylococcal cassette chromosome element. SCIENCE CHINA-LIFE SCIENCES[J]. 2013, 第 6 作者56(3): 268-274, https://www.webofscience.com/wos/woscc/full-record/WOS:000316747000011.[35] 李德志, 楚亚男, 任鲁风, 李欣刚, 袁丽娜, 康禹, 张伟, 杨宇, 王绪敏, Kenneth Baillie J, 于军, 高占成. 类SCC样甲氧西林敏感性金黄色葡萄球菌的基因组学分析. 中国科学. 生命科学[J]. 2013, 第 6 作者43(3): 247-253, https://www.sciengine.com/doi/10.1360/scls-2012-0161.R4.[36] WANG Xiao-rong, CHEN Ji-chao, KANG Yu, JIANG Ning, AN Shu-chang, GAO Zhan-cheng. Prevalence and characterization of plasmid-mediated blaEsBL with their genetic environment in Escherichia coli and Klebsiella pneumoniae in patients with pneumonia. 中华医学杂志:英文版[J]. 2012, 第 3 作者894-900, http://lib.cqvip.com/Qikan/Article/Detail?id=41307199.[37] Wang Xiaorong, Chen Jichao, Kang Yu, Jiang Ning, An Shuchang, Gao Zhancheng. Prevalence and characterization of plasmid-mediated bla(ESBL) with their genetic environment in Escherichia coli and Klebsiella pneumoniae in patients with pneumonia. CHINESE MEDICAL JOURNAL[J]. 2012, 第 3 作者125(5): 894-900, http://lib.cqvip.com/Qikan/Article/Detail?id=41307199.[38] Kang, Yu, Deng, Rui, Wang, Can, Deng, Tao, Peng, Peichao, Cheng, Xiaoxing, Wang, Guoqing, Qian, Minping, Gao, Huafang, Han, Bei, Chen, Yusheng, Hu, Yinghui, Geng, Rong, Hu, Chengping, Zhang, Wei, Yang, Jingping, Wan, Huanying, Yu, Qin, Wei, Liping, Li, Jiashu, Tian, Guizhen, Wang, Qiuyue, Hu, Ke, Wang, Siqin, Wang, Ruiqin, Du, Juan, He, Bei, Ma, Jianjun, Zhong, Xiaoning, Mu, Lan, Cai, Shaoxi, Zhu, Xiangdong, Xing, Wanli, Yu, Jun, Deng, Minghua, Gao, Zhancheng. Etiologic Diagnosis of Lower Respiratory Tract Bacterial Infections Using Sputum Samples and Quantitative Loop-Mediated Isothermal Amplification. PLOS ONE[J]. 2012, 第 1 作者7(6): http://dx.doi.org/10.1371/journal.pone.0038743.[39] Yao Zhai, Daixi Li, Pengcheng Du, Zhao Zhang, Zilong He, Yatao Guo, Yusheng Chen, Yu Kang, Songnian Hu, Zhancheng Gao. Complete sequences of two new KPC-harboring plasmids in Klebsiella pneumoniae ST11 strains in China. JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE. 第 8 作者http://dx.doi.org/10.1016/j.jgar.2020.11.023.
发表著作
(1) 基因组学与精准医学, 上海交通大学出版社, 2017-01, 第 其他 作者
科研活动
科研项目
( 1 ) 基于组学特征谱的社区获得性肺炎分子分型研究, 负责人, 国家任务, 2016-01--2018-12( 2 ) 能量调控在细胞表型异质化中的主导作用, 负责人, 国家任务, 2015-01--2018-12( 3 ) 基于电学特性的高通量活体单细胞分析仪, 负责人, 中国科学院计划, 2018-01--2019-12( 4 ) 从复杂样品中获取微量微生物物种的高质量基因组的实验和分析系统的建立,及其在疫情处置中的应用与评价, 负责人, 国家任务, 2019-01--2020-12( 5 ) 局部氧化压力在呼吸道条件感染过程中的重要作用, 负责人, 国家任务, 2020-01--2023-12( 6 ) mRNA药物5’UTR区海量随机序列文库的高通量筛选技术, 负责人, 国家任务, 2024-01--2027-12
参与会议
(1)整合赢未来健康在肠道 中国肠道大会 2021-05-28(2)微生物基因组研究 2019年用户大会暨技术交流会 2019-10-11