1) The molecular mechanisms of trace metal elements metabolism in biological systems.

2)Trace elements metabolism and neurodegeneration diseases (e.g. Alzheimer's disease, Parkinson's disease) 

2001/03-2005/07: Ph.D. in Biochemistry and Molecular Biology, Graduate University, Chinese Academy of Sciences, Beijing, China

1993/09-1996/07: M.S. in Plant Genetics and Breeding, Hebei Agricultural University, Baoding, China

1989/09-1993/07: B.S. in Plant Genetics and Breeding, Hebei Agricultural University, Baoding, China

   

2013.9-now  Associate Professor, Professor,  College of Life Science, University of Chinese Academy of Sciences, Beijing, China

2008.9-2013.4  Research Associate, Biochemistry Department, Kansas State University, Manhattan, KS, USA

2005.10-2007.11 Postdoctoral Fellow of Molecular Genetics, State Key Laboratory of Biomembrane and Membrane Biotechnology, College of Life Sciences, Tsinghua University, Beijing, China

2004.11- 2013.9 Associate Professor of Molecular Genetics and Breeding, College of Life Sciences, Hebei Agricultural University, Baoding, China 

1996.7-2004.10 Assistant Professor of Molecular Genetics and Breeding, College of Life Sciences, Hebei Agricultural University, Baoding, China

1. The Second-class Award of Science & Technology Progress Prize of Hebei Province (2011).

2. ASBMB Postdoctoral Travel Award Program, 2009 in New Orleans, LA. and 2010 in Anaheim, CA.

3. National Special Program on Developing New Transgenic Varieties (No.2009ZX08002- 012B).

4. China Postdoctoral Science Foundation (No.20060390497)

5. The First-class Award of DI-AO Scholarship of the Chinese Academy of Sciences (CAS) (2005)

6. The Research and Development Fund of Hebei Agricultural University (No. 050012)

7. Expert of Intellectual Property Appraisal Appointed by Beijing JZSC Intellectual Property Appraisal Centre of Judicatory (2005)

8. The First- class Award of Science & Technology Progress Prize of Hebei Province (2000).

9. The Prize for Outstanding Contribution to Science and Technology Progress of Hebei Agricultural University (1996).

10. Chinese National Natural Sciences Foundation (39170488, 30370128), and National High Technology Plan Program of China (J00-A-00803, JY03A20-02).

Representive Publications:
      

1.  Peng Y, Chang X, Lang M. Iron Homeostasis Disorder and Alzheimer's Disease. Int J Mol Sci 2021 Nov 18; 22(22).

2.   Mehboob MZ, Lang M. Structure, function, and pathology of protein O-glucosyltransferases. Cell Death Dis 2021 Jan 12; 12(1): 71.

3.   Li X, Wang H, Zhu Y, Cao W, Song M, Wang Y, et al. Heritability Enrichment of Immunoglobulin G N-Glycosylation in Specific Tissues. Front Immunol 2021; 12: 741705.

4.   Xu D, Liu L, Lang M. [Progress in lentiviral vector-mediated gene therapy for Alzheimer's disease and Parkinson's disease]. Sheng Wu Gong Cheng Xue Bao 2020 Dec 25; 36(12): 2707-2718.

5.   Ejaz HW, Wang W, Lang M. Copper Toxicity Links to Pathogenesis of Alzheimer's Disease and Therapeutics Approaches. Int J Mol Sci 2020 Oct 16; 21(20).

6.   Xu Y, Xiao G, Liu L, Lang M. Zinc transporters in Alzheimer's disease. Mol Brain 2019 Dec 9; 12(1): 106.

7.   Chen M, Zeng L, Luo X, Mehboob MZ, Ao T, Lang M. Identification and functional characterization of a novel selenocysteine methyltransferase from Brassica juncea L. J Exp Bot 2019 Nov 18; 70(21): 6401-6416.

8.   Gao X, Wang YX, Lang ML, Yuan L, Reece AS, Wang W. Contribution of Genetic Polymorphisms and Haplotypes in DRD2, BDNF, and Opioid Receptors to Heroin Dependence and Endophenotypes Among the Han Chinese. Omics 2017 Jul; 21(7): 404-412.

9.   Fang HH, Chu QY, Zhang J, Wang H, Yu XW, Ge SQ, et al. Human CAP10-Like Protein 46kDa Gene Promotes Malignancy in Colorectal Cancer. Omics 2017 May; 21(5): 266-274.

10. Ao TGBY, Gao LJ, Wang LC, Li YQ, Zhao Y, Lang ML, et al. Cloning and Expression Analysis of AP2/EREBP Transcription Factor Gene (MwAP2/EREBP) in Agropyron mongolicum Keng. Nanosci Nanotech Let 2017 Dec; 9(12): 2031-2038.

11. Shen DX, Li M, Chu Y, Lang ML, An CJ. Cellular immune response of the Asian corn borer, Ostrinia furnacalis (Lepidoptera: Pyralidae), to infection by the entomopathogenic fungus, Beauveria bassiana. Eur J Entomol 2016; 113: 415-422.

12. Lang ML, Gorman MJ, Kanost MR. The Active Role of Multicopper Oxidase-1 in Iron Metabolism in Drosophila: A Ferroxidase and/or an Ascorbate Oxidase? Am J Hematol 2016 Mar; 91(3): E209-E209.

13. Peng ZY, Dittmer NT, Lang ML, Brummett LM, Braun CL, Davis LC, et al. Multicopper oxidase-1 orthologs from diverse insect species have ascorbate oxidase activity. Insect Biochem Molec 2015 Apr; 59: 58-71.

14. Cui F, Li MX, Chang HJ, Mao Y, Zhang HY, Lu LX, et al. Carboxylesterase-mediated insecticide resistance: Quantitative increase induces broader metabolic resistance than qualitative change. Pestic Biochem Phys 2015 Jun; 121: 88-96.

15. Huang YP, Wu ZH, Cao Y, Lang ML, Lu BW, Zhou B. Zinc Binding Directly Regulates Tau Toxicity Independent of Tau Hyperphosphorylation. Cell Reports 2014 Aug 7; 8(3): 831-842.

16. Lang ML, Fan QW, Wang L, Zheng YJ, Xiao GR, Wang XX, et al. Inhibition of human high-affinity copper importer Ctr1 orthologous in the nervous system of Drosophila ameliorates A beta 42-induced Alzheimer's disease-like symptoms. Neurobiol Aging 2013 Nov; 34(11): 2604-2612.

17. Lang ML, Wang L, Fan QW, Xiao GR, Wang XX, Zhong Y, et al. Genetic Inhibition of Solute-Linked Carrier 39 Family Transporter 1 Ameliorates A beta Pathology in a Drosophila Model of Alzheimer's Disease. PLoS Genet 2012 Apr; 8(4): 623-639.

18. Lang ML, Kanost MR, Gorman MJ. Multicopper Oxidase-3 Is a Laccase Associated with the Peritrophic Matrix of Anopheles gambiae. Plos One 2012 Mar 27; 7(3).

19. Lang ML, Braun CL, Kanost MR, Gorman MJ. Multicopper oxidase-1 is a ferroxidase essential for iron homeostasis in Drosophila melanogaster. P Natl Acad Sci USA 2012 Aug 14; 109(33): 13337-13342.

20. Lang ML, Hao MY, Fan QW, Wang W, Mo SJ, Zhao WC, et al. Functional characterization of BjCET3 and BjCET4, two new cation-efflux transporters from Brassica juncea L. J Exp Bot 2011 Aug; 62(13): 4467-4480.

21. Lang ML, Gorman MJ, Gardner SG, Yungeberg SL, Kanost MR. Possible immune functions of two mosquito multicopper oxidases. Faseb J 2010 Apr; 24.

22. Xu J, Chai TY, Zhang YX, Lang ML, Han L. The cation-efflux transporter BjCET2 mediates zinc and cadmium accumulation in Brassica juncea L. leaves. Plant Cell Rep 2009 Aug; 28(8): 1235-1242.

23. Lang ML, Gorman MJ, Gardner SG, Yungeberg SL, Kanost MR. Gene expression and functional characterization of two multicopper oxidase genes in the malaria mosquito, Anopheles gambiae. Faseb J 2009 Apr; 23.

24. Lang ML, Fan QW, Wang XX, Wu ZH, Zhou B. Studies on dCtr1C function and its role in fly neurodegenerative models. J Neurochem 2009 May; 109: 299-299.

25. Minglin L, Yuxiu Z, Tuanyao C. Identification of genes up-regulated in response to Cd exposure in Brassica juncea L. Gene 2005 Dec 19; 363: 151-158.

26. Lang ML, Mang YX, Guan ZQ, Chai TY. PCR-enriched cDNA pool method for cloning of gene homologues. Plant Mol Biol Rep 2005 Sep; 23(3): 219-226.

 

Books:

1. Minglin Lang. Brassicaceae: Characterization, Functional Genomics and Health Benefits, Nova Publisher, New York, USA,  110,000 words，2013

2. Raman Chandrasekar, Brintha Parasumanna Girinathan, Minglin Lang, Murugesan Chandrasekaran and Kadararai Murugan. Three-Dimensional Molecular Structure Prediction of Selenocysteine Methyltransferase (BoSMT) from Brassica oleracea. In: Brassicaceae: Characterization, Functional Genomics and Health Benefits.   Nova Publisher, New York, USA,  6,000 words，2013

1. Lang Minglin, Wang Wei, Yang Xueju, Liu Guiru, Wen Shumin, Zhang Guiyou. An Agrobacterium-mediated floral dip method for obtaining transgenic wheat. Oct 09, 2013: CN201110418620. (Authorized)

2. Lang Minglin, Fan Qiangwang, Wang Lei, Zhou Bing. A target protein for treating Alzheimer’s disease and its encoding gene and application. Oct 09, 2013: CN201110031664. (Authorized)

3. Lang Minglin, Hao Mengyu, Yang Xueju. A plant resistance-associated membrane protein BjCRP1 its gene and application. Nov 11, 2011: CN201010171914. (Authorized)

4. Chai Tuanyao, Lang Minglin: Gene BjCET1 of India nmustard cationic output transfer protein family and its protein. Dec 1, 2004: CN 200410004656. (Authorized)

5. Chai Tuanyao, Lang Minglin: Gene BjCET4 of Indian mustard cation output transporting proteins and its protein. Sep 22, 2004: CN 200410004655. (Authorized)

1. The trace elements role  in Human Neurodegenerative Diseases, such as Alzheimer's disease, Parkinson’s disease.

     Using Drosophila as an animal model, our study aims to clarify the key genetic factors that determine the metabolic balance mechanism of transition metal ions (e.g. Fe, Cu, Zn) in the digestive system and central nerve system of Drosophila, and explore the influence of the disorders of these metals on insect development and behavior. Based on our discoveries, we want to find new ideas for insect control (such as vector mosquito) and prevention or treatment of human neurodegenerative diseases.

2. How metal ions (e.g. Zn, Cu, Fe) acquired and balanced in plant cells. The end aim of this study is to help making artificial plants for strengthening micronutrient of human stable food.

1. Third Annual ApoE, ApoE Receptors & Neurodegeneration Symposium: ApoE Receptor Biology. June 4th‐5th, Mayo Clinic Jacksonville, FL, 2012, USA

2. International Conference and Exhibition on Neurology & Therapeutics, May 14-16, Embassy Suites Las Vegas, USA, 2012, USA. (Invited speaker)

3. 6th Annual Arthropod Genomics Symposium, May 30 - June 2, Marriott on the Country Club Plaza, Kansas City, 2012, USA

4. The American Society for Biochemistry and Molecular Biology, ASBMB postdoctoral travel award program in Anaheim, CA, April, 2010, USA

5. 5th Annual Arthropod Genomics Symposium, June 10-13, Marriott on the Country Club Plaza, Kansas City, 2010, USA

6. The American Society for Biochemistry and Molecular Biology, ASBMB postdoctoral travel award program in New Orleans, LA, 2009, USA

7. The 3rd ISN Special Neurochemistry Conference, Neurodegeneration and Regeneration, Beijing, June 27-July 1, 2008, China

8. The 2007 International Conference on Genomics, New Breakthroughs in Genomics and Sequencing Technology, October 30 - November 2, 2007, Shenzhen and Hong Kong, China