基本信息
刘翟  男  博导  中国科学院武汉病毒研究所
电子邮件: liud@wh.iov.cn
通信地址: 湖北省武汉市武昌区小洪山中区44号中国科学院武汉病毒研究所
邮政编码: 430071

研究领域

传染病一直以来都是人类健康的重要威胁,据WHO统计每年全球有约1500万人因传染病丧生。病毒作为重要的传染病病原,由于其变异速率快、遗传与传播模式独特,经常会造成较大规模的暴发与流行。近年来,国际上相继出现了(禽)流感病毒、埃博拉病毒、中东呼吸综合征冠状病毒、寨卡病毒暴发等事件,严重影响公共卫生和全球经济的发展。造成人群中暴发的新发病毒主要来源于野生动物宿主,明确新发病毒的起源、跨宿主传播、以及在人群中的进化规律至关重要。这是切断病毒传播途径,实现有效监测,指导药物治疗与疫苗开发的前提与基础,具有重要的科学价值和现实意义。刘翟研究员专注于病毒进化与传播规律研究,利用病毒基因组学和生物信息学作为主要研究手段,重点面向病毒起源、进化模型、遗传变异和传播动力学等科学问题。在包括禽流感、埃博拉等重要病毒的起源进化和遗传变异研究领域取得了重要研究成果;在病毒精准溯源、基因动态重配与传播、以及病毒宿主内进化等研究方向上取得了重要突破;提出了新发病毒进化新的理论和模型。

招生信息

   
招生专业
071021-生物信息学
071005-微生物学
招生方向
病原生物学
生物信息学
进化生物学

教育背景

2000-09--2005-07   北京大学   博士
1996-09--2000-07   北京大学   理学学士
学历
博士研究生

学位
生物信息学 博士

工作经历

   
工作简历
2017-07~现在, 中国科学院武汉病毒所, 研究员
2016-09~现在, 中国科学院大学, 教授
2014-07~2017-06,中国科学院微生物研究所, 研究员
2011-07~2014-07,中国科学院微生物研究所, 副研究员
2009-07~2011-07,中国科学院微生物研究所, 助理研究员
2005-12~2009-07,中国科学院微生物研究所, 博士后
社会兼职
2017-11-12-今,中国医疗促进会分子诊断学分会, 常务委员
2017-03-01-今,国际应急管理协会亚太卫生应急专业委员会, 常务委员
2017-01-01-今,Virologica Sinica, 编委
2016-11-01-今,中国微生物学会生物安全专业委员会, 副主任委员
2015-01-01-今,Infectious Disease and Translational Medicine, 副主编
2013-08-01-今,中国遗传学会青年委员会, 委员

教授课程

病原基因组学
生物信息学
微生物学前沿-微生物生物信息学及组学研究

专利与奖励

   
奖励信息
(1) 中华预防医学会科学技术奖, 一等奖, 其他, 2017
(2) 国家科学技术进步特等奖, 特等奖, 国家级, 2017
(3) 中华预防医学会科学技术一等奖, 一等奖, 部委级, 2017
(4) 山东省高等学校科学技术奖, 一等奖, 省级, 2016
(5) 科技部2015中国十大科技进展, 部委级, 2015
专利成果
[1] 刘翟, 陈全姣, 马莉萍. 尼帕病毒检测试剂盒及其专用引物. CN: CN109022621B, 2020-12-11.

[2] 袁静, 刘翟, 陈晨, 马莉萍, 崔晶花, 李少丽, 曾辉, 蒋栋. 用于检测黄热病毒的RT-LAMP试剂盒及其专用引物. CN: CN111139316A, 2020-05-12.

[3] 薛晨玉, 刘翟, 袁静, 李伟, 闫超, 王丹, 汪启, 李南南, 宋丽萍. 一种单核细胞增生李斯特氏菌的多位点基因分型方法. CN: CN110592189A, 2019-12-20.

出版信息

近五年来,本人的研究工作系统揭示了禽流感和埃博拉等病毒的遗传与传播规律,共发表研究论文46篇;其中作为通讯作者或第一作者在Lancet, Nature, Cell Host & MicrobeNature MicrobiologyNature Communications等科学杂志发表SCI论文18篇,单篇论文最高他引251次。2016年以通讯作者身份分别在Cell Host & MicrobeNature Microbiology杂志发表封面文章。研究论文近五年总引用超过2200次,他引约1800次,H-index27

发表论文
[1] Wu, Jun, Liang, Boyun, Chen, Cunrong, Wang, Hua, Fang, Yaohui, Shen, Shu, Yang, Xiaoli, Wang, Baoju, Chen, Liangkai, Chen, Qi, Wu, Yang, Liu, Jia, Yang, Xuecheng, Li, Wei, Zhu, Bin, Zhou, Wenqing, Wang, Huan, Li, Sumeng, Lu, Sihong, Liu, Di, Li, Huadong, Krawczyk, Adalbert, Lu, Mengji, Yang, Dongliang, Deng, Fei, Dittmer, Ulf, Trilling, Mirko, Zheng, Xin. SARS-CoV-2 infection induces sustained humoral immune responses in convalescent patients following symptomatic COVID-19. NATURE COMMUNICATIONS[J]. 2021, 12(1): https://doaj.org/article/87b5e3b2d655425da4c2ff45fb7884d0.
[2] Liu, William J, Xiao, Haixia, Dai, Lianpan, Liu, Di, Chen, Jianjun, Qi, Xiaopeng, Bi, Yuhai, Shi, Yi, Gao, George F, Liu, Yingxia. Avian influenza A (H7N9) virus: from low pathogenic to highly pathogenic. FRONTIERS OF MEDICINEnull. 2021, 15(4): 507-527, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8190734/.
[3] Zhu, Zhenglin, Liu, Gexin, Meng, Kaiwen, Yang, Liuqing, Liu, Di, Meng, Geng. Rapid Spread of Mutant Alleles in Worldwide SARS-CoV-2 Strains Revealed by Genome-Wide Single Nucleotide Polymorphism and Variation Analysis. GENOME BIOLOGY AND EVOLUTION[J]. 2021, 13(2): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7883668/.
[4] 刘翟. Ginseng polysaccharides alter the gut microbiota and kynurenine/tryptophan ratio, potentiating the antitumour effect of antiprogrammed cell death 1/programmed cell death ligand 1 (anti-PD-1/PD-L1) immunotherapy. Gut. 2021, [5] Lu, Bo, Yan, Yi, Dong, Liting, Han, Lingling, Liu, Yawei, Yu, Junping, Chen, Jianjun, Yi, Danyang, Zhang, Meiling, Deng, Xin, Wang, Chao, Wang, Runkun, Wang, Dengpeng, Wei, Hongping, Liu, Di, Yi, Chengqi. Integrated characterization of SARS-CoV-2 genome, microbiome, antibiotic resistance and host response from single throat swabs. CELL DISCOVERY[J]. 2021, 7(1): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8008776/.
[6] Yan, Yi, Wu, Ke, Chen, Jun, Liu, Haizhou, Huang, Yi, Zhang, Yong, Xiong, Jin, Quan, Weipeng, Wu, Xin, Liang, Yu, He, Kunlun, Jia, Zhilong, Wang, Depeng, Liu, Di, Wei, Hongping, Chen, Jianjun. Rapid Acquisition of High-Quality SARS-CoV-2 Genome via Amplicon-Oxford Nanopore Sequencing. VIROLOGICA SINICA[J]. 2021, 36(5): 901-912, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8043101/.
[7] Decheng Wang, Mingxin Li, Chaochao Xiong, Yi Yan, Juefu Hu, Mengchan Hao, Bilin Liang, Jing Chen, Guang Chen, Guoxiang Yang, Yong Li, Jun Zhang, Marina Gulyaeva, Alexander Shestopalov, Weifeng Shi, Yuhai Bi, Haizhou Liu, Hanzhong Wang, Di Liu, Jianjun Chen. Ecology of avian influenza viruses in migratory birds wintering within the Yangtze River wetlands. Science Bulletin[J]. 2021, 66(19): 2014-2024, [8] Liu, Qing, Li, Wei, Liu, Di, Li, Lingyan, Li, Jie, Lv, Na, Liu, Fei, Zhu, Baoli, Zhou, Yuguang, Xin, Yuhua, Dong, Xiuzhu. Light stimulates anoxic and oligotrophic growth of glacial Flavobacterium strains that produce zeaxanthin. ISME JOURNAL[J]. 2021, 15(6): 1844-1857, http://dx.doi.org/10.1038/s41396-020-00891-w.
[9] Jia, Lijia, Chen, Jianjun, Liu, Haizhou, Fan, Wenhui, Wang, Depeng, Li, Jing, Liu, Di. Potential m6A and m5C Methylations within the Genome of A Chinese African Swine Fever Virus Strain. VIROLOGICA SINICAnull. 2021, 36(2): 321-324, https://www.webofscience.com/wos/woscc/full-record/WOS:000557028000002.
[10] Wang, Miao, Wang, Liying, Liu, Haizhou, Chen, Jianjun, Liu, Di. Transcriptome Analyses Implicate Endogenous Retroviruses Involved in the Host Antiviral Immune System through the Interferon Pathway. VIROLOGICA SINICA. 2021, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8131884/.
[11] Li, YanHong, Cao, Ying, Liu, Fen, Zhao, Qian, Adi, Dilare, Huo, Qiang, Liu, Zheng, Luo, JunYi, Fang, BinBin, Tian, Ting, Li, XiaoMei, Liu, Di, Yang, YiNing. Visualization and Analysis of Gene Expression in Stanford Type A Aortic Dissection Tissue Section by Spatial Transcriptomics. FRONTIERS IN GENETICS[J]. 2021, 12: http://dx.doi.org/10.3389/fgene.2021.698124.
[12] Li, Guoli, Li, Jiarui, Zhang, Henghui, Zhang, Yu, Liu, Di, Hao, Yu, Han, Junyan, Du, Juan, Zhu, Liuluan, Zeng, Yongqin, Li, Bei, Li, Rui, Song, Chuan, Zhang, Fujie, Chen, Chen, Zhao, Hongxin, Zeng, Hui. Partial recovery of disturbed V-J pairing profiles of T-cell receptor in people living with HIV receiving long-term antiretroviral therapy. SCIENCE CHINA-LIFE SCIENCES[J]. 2021, 64(1): 152-161, http://lib.cqvip.com/Qikan/Article/Detail?id=7103797656.
[13] Yang, Qiqi, Zhao, Xiang, Lemey, Philippe, Suchard, Marc A, Bi, Yuhai, Shi, Weifeng, Liu, Di, Qi, Wenbao, Zhang, Guogang, Stenseth, Nils Chr, Pybus, Oliver G, Tian, Huaiyu. Assessing the role of live poultry trade in community-structured transmission of avian influenza in China. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2020, 117(11): 5949-5954, http://dx.doi.org/10.1073/pnas.1906954117.
[14] Zhao, Fen, Dong, Ting, Yuan, KeYong, Wang, NingJian, Xia, FangZhen, Liu, Di, Wang, ZhiMin, Ma, Rui, Lu, YingLi, Huang, ZhengWei. Shifts in the Bacterial Community of Supragingival Plaque Associated With Metabolic-Associated Fatty Liver Disease. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY[J]. 2020, 10: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7770214/.
[15] Xiaoxia Lu, Jingjing Zhang, Yuan Y. Li, Di Liu, Kunling Shen, Shunqing Xu, Gary W.K. Wong. SARS-CoV-2 Infection in Children. The New England Journal of Medicine. 2020, [16] Lu, Xiaoxia, Zhang, Liqiong, Du, Hui, Zhang, Jingjing, Li, Yuan Y, Qu, Jingyu, Zhang, Wenxin, Wang, Youjie, Bao, Shuangshuang, Li, Ying, Wu, Chuansha, Liu, Hongxiu, Liu, Di, Shao, Jianbo, Peng, Xuehua, Yang, Yonghong, Liu, Zhisheng, Xiang, Yun, Zhang, Furong, Silva, Rona M, Pinkerton, Kent E, Shen, Kunling, Xiao, Han, Xu, Shunqing, Wong, Gary W K, Chinese Pediat Novel Coronavirus. Anifrolumab in Systemic Lupus Erythematosus. NEW ENGLAND JOURNAL OF MEDICINEnull. 2020, 382(17): 1665-1666, https://www.webofscience.com/wos/woscc/full-record/WOS:000529493200019.
[17] Huang, Min, Lu, QingBin, Zhao, Han, Zhang, Yulan, Sui, Zhiwei, Fang, Liqun, Liu, Di, Sun, Xiulian, Peng, Ke, Liu, Wei, Guan, Wuxiang. Temporal antibody responses to SARS-CoV-2 in patients of coronavirus disease 2019. CELL DISCOVERYnull. 2020, 6(1): http://dx.doi.org/10.1038/s41421-020-00209-2.
[18] Yu, Fang, Yan, Yi, Shi, Mang, Liu, HaiZhou, Zhang, HongLiang, Yang, YongBo, Huang, XinYi, Gauger, Phillip C, Zhang, Jianqiang, Zhang, YanHe, Tong, GuangZhi, Tian, ZhiJun, Chen, JianJun, Cai, XueHui, Liu, Di, Li, Ganwu, An, TongQing. Phylogenetics, Genomic Recombination, and NSP2 Polymorphic Patterns of Porcine Reproductive and Respiratory Syndrome Virus in China and the United States in 2014-2018. JOURNAL OF VIROLOGY[J]. 2020, 94(6): https://www.webofscience.com/wos/woscc/full-record/WOS:000518387200024.
[19] Cao, Ying, Sun, Yeping, Tian, Xiaodong, Bai, Zhihua, Gong, Yue, Qi, Jianxun, Liu, Di, Liu, Wenjun, Li, Jing, 巩玥. Analysis of ACE2 Gene-Encoded Proteins Across Mammalian Species. FRONTIERS IN VETERINARY SCIENCE[J]. 2020, 7: https://doaj.org/article/ac2208b05d1c4b098eb991a70552c8dd.
[20] Jia, Lijia, Jiang, Mengwei, Wu, Ke, Hu, Juefu, Wang, Yang, Quan, Weipeng, Hao, Mengchan, Liu, Haizhou, Wei, Hongping, Fan, Wenhui, Liu, Wenjun, Hu, Rongliang, Wang, Depeng, Li, Jing, Chen, Jianjun, Liu, Di. Nanopore sequencing of African swine fever virus. SCIENCE CHINA-LIFE SCIENCESnull. 2020, 63(1): 160-164, http://lib.cqvip.com/Qikan/Article/Detail?id=7100908169.
[21] Wang, Miao, Qiu, Yang, Liu, Haizhou, Liang, Bilin, Fan, Baofeng, Zhou, Xi, Liu, Di. Transcription profile of human endogenous retroviruses in response to dengue virus serotype 2 infection. VIROLOGY[J]. 2020, 544: 21-30, http://dx.doi.org/10.1016/j.virol.2020.01.014.
[22] Du, Pengcheng, Ding, Nan, Li, Jiarui, Zhang, Fujie, Wang, Qi, Chen, Zhihai, Song, Chuan, Han, Kai, Xie, Wen, Liu, Jingyuan, Wang, Linghang, Wei, Lirong, Ma, Shanfang, Hua, Mingxi, Yu, Fengting, Wang, Lin, Wang, Wei, An, Kang, Chen, Jianjun, Liu, Haizhou, Gao, Guiju, Wang, Sa, Huang, Yanyi, Wu, Angela R, Wang, Jianbin, Liu, Di, Zeng, Hui, Chen, Chen. Genomic surveillance of COVID-19 cases in Beijing. NATURE COMMUNICATIONS[J]. 2020, 11(1): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7603498/.
[23] 刘翟. 基因组——了解新型冠状病毒的最直接手段. 结核病与肺部健康杂志. 2020, 9(1): 16-18, http://lib.cqvip.com/Qikan/Article/Detail?id=7101623310.
[24] 曹影, 李伟, 褚鑫, 吴珂, 刘海舟, 刘翟. 单分子纳米孔测序技术及其应用研究进展. 生物工程学报[J]. 2020, 36(5): 811-819, http://lib.cqvip.com/Qikan/Article/Detail?id=7101937131.
[25] 袁静, 刘翟, 杨瑞馥, Chen Chen, Jinghua Cui, Jing Lu, Chao Yan, Xiao Wei, Xiangna Zhao, NanNan Li, Shaoli Li, Guanhua Xue, Weiwei Cheng, Boxing Li, Huan Li, Weishi Lin, Changyu Tian, Jiangtao Zhao, Juqiang Han, Daizhi An, Qiong Zhang, Hong Wei, Minghua Zheng, Xuejun Ma, Wei Li, Xiao Chen, Zheng Zhang, Hui Zeng, Sun Ying, JianXin Wu. 高产酒精肺炎克雷伯菌引起的非酒精性脂肪肝病. 科学新闻. 2020, 54-, http://lib.cqvip.com/Qikan/Article/Detail?id=7102181329.
[26] Bangyao Sun, Xin Zhang, Huan Zhang, Haizhou Liu, Lina Sun, Qiqi Tan, Mifang Liang, De Wu, Di Liu. Genomic epidemiological characteristics of dengue fever in Guangdong province, China from 2013 to 2017. PLOS NEGLECTED TROPICAL DISEASES[J]. 2020, 14(3): http://dx.doi.org/10.1371/journal.pntd.0008049.
[27] Xue, Guanhua, Li, Shaoli, Zhang, Weiwei, Du, Bing, Cui, Jinghua, Yan, Chao, Huang, Lei, Chen, Lu, Zhao, Linqing, Sun, Yu, Li, Nannan, Zhao, Hanqing, Feng, Yanling, Wang, Zhimin, Liu, Shiyu, Zhang, Qun, Xie, Xianghui, Liu, Di, Yao, Hailan, Yuan, Jing. Reverse-Transcription Recombinase-Aided Amplification Assay for Rapid Detection of the 2019 Novel Coronavirus (SARS-CoV-2). ANALYTICAL CHEMISTRY[J]. 2020, 92(14): 9699-9705, http://dx.doi.org/10.1021/acs.analchem.0c01032.
[28] Zhou, Hong, Chen, Xing, Hu, Tao, Li, Juan, Song, Hao, Liu, Yanran, Wang, Peihan, Liu, Di, Yang, Jing, Holmes, Edward C, Hughes, Alice C, Bi, Yuhai, Shi, Weifeng. A Novel Bat Coronavirus Closely Related to SARS-CoV-2 Contains Natural Insertions at the S1/S2 Cleavage Site of the Spike Protein. CURRENT BIOLOGY[J]. 2020, 30(11): 2196-+, http://dx.doi.org/10.1016/j.cub.2020.05.023.
[29] Wang, Ziming, Jia, Lijia, Li, Jing, Liu, Haizhou, Liu, Di. Pan-Genomic Analysis of African Swine Fever Virus. VIROLOGICA SINICAnull. 2020, 35(5): 662-665, http://lib.cqvip.com/Qikan/Article/Detail?id=00002EGOLH3O7JP0MPDO4JP16FR.
[30] Yan, C, Cui, J, Huang, L, Du, B, Chen, L, Xue, G, Li, S, Zhang, W, Zhao, L, Sun, Y, Yao, H, Li, N, Zhao, H, Feng, Y, Liu, S, Zhang, Q, Liu, D, Yuan, J. Rapid and visual detection of 2019 novel coronavirus (SARS-CoV-2) by a reverse transcription loop-mediated isothermal amplification assay. CLINICAL MICROBIOLOGY AND INFECTION[J]. 2020, 26(6): 773-779, http://dx.doi.org/10.1016/j.cmi.2020.04.001.
[31] Chen, Jianjun, Liang, Bilin, Hu, Juefu, Liu, Haizhou, Sun, Jianqing, Li, Mingxin, Chen, Quanjiao, He, Yubang, Liu, Di. Circulation, Evolution and Transmission of H5N8 virus, 2016-2018. JOURNAL OF INFECTION[J]. 2019, 79(4): 363-372, http://dx.doi.org/10.1016/j.jinf.2019.07.005.
[32] []. Fatty liver disease caused by high alcohol-producing Klebsiella pneumoniae. 中国科学基金:英文版. 2019, 27(4): 41-41, http://lib.cqvip.com/Qikan/Article/Detail?id=7101069576.
[33] Yuan, Jing, Chen, Chen, Cui, Jinghua, Lu, Jing, Yan, Chao, Wei, Xiao, Zhao, Xiangna, Li, NanNan, Li, Shaoli, Xue, Guanhua, Cheng, Weiwei, Li, Boxing, Li, Huan, Lin, Weishi, Tian, Changyu, Zhao, Jiangtao, Han, Juqiang, An, Daizhi, Zhang, Qiong, Wei, Hong, Zheng, Minghua, Ma, Xuejun, Li, Wei, Chen, Xiao, Zhang, Zheng, Zeng, Hui, Ying, Sun, Wu, JianXin, Yang, Ruifu, Liu, Di. Fatty Liver Disease Caused by High-Alcohol-Producing Klebsiella pneumoniae. CELL METABOLISM[J]. 2019, 30(4): 675-+, http://dx.doi.org/10.1016/j.cmet.2019.08.018.
[34] Cao, Ying, Li, Jing, Chu, Xin, Liu, Haizhou, Liu, Wenjun, Liu, Di. Nanopore sequencing: a rapid solution for infectious disease epidemics. SCIENCE CHINA-LIFE SCIENCESnull. 2019, 62(8): 1101-1103, http://lib.cqvip.com/Qikan/Article/Detail?id=74678871504849574856484951.
[35] Wang Songwang, Li Yangfei, Chen Qiang, Feng Xiaoyu, Shi Xiju, Huang Ying, Mei Li, Li Wei, Liu Haizhou, Qi Xiaopeng, Liu Di. Integration of biosafety surveillance through Biosafety Surveillance Conceptual Data Model. 生物安全与健康(英文)[J]. 2019, 1(2): 98-104, http://lib.cqvip.com/Qikan/Article/Detail?id=7105414249.
[36] Ma, Liping, Chen, Zhen, Guan, Wuxiang, Chen, Quanjiao, Liu, Di. Rapid and Specific Detection of All Known Nipah virus Strains' Sequences With Reverse Transcription-Loop-Mediated Isothermal Amplification. FRONTIERS IN MICROBIOLOGY[J]. 2019, 10: http://www.corc.org.cn/handle/1471x/2373173.
[37] Ma, Liping, Liu, Haizhou, Wang, Runkun, Jin, Tao, Liu, Di, Gao, George Fu, Chen, Quanjiao. Low Pathogenic Avian Influenza A (H5N7) Virus Isolated from a Domestic Duck in Dongting Lake Wetland of China, 2016. VIROLOGICA SINICAnull. 2019, 34(1): 97-101, http://lib.cqvip.com/Qikan/Article/Detail?id=90666888504849574849484949.
[38] Chen, Chen, Jiang, Dong, Ni, Ming, Li, Jing, Chen, Zhihai, Liu, Jingyuan, Ye, Hanhui, Wong, Gary, Li, Wei, Zhang, Yuanyuan, Wang, Beibei, Bi, Yuhai, Chen, Danying, Zhang, Ping, Zhao, Xuesen, Kong, Yaxian, Shi, Weifeng, Du, Pengcheng, Xiao, Gengfu, Ma, Juncai, Gao, George F, Cui, Jie, Zhang, Fujie, Liu, Wenjun, Bo, Xiaochen, Li, Ang, Zeng, Hui, Liu, Di. Phylogenomic analysis unravels evolution of yellow fever virus within hosts. PLOS NEGLECTED TROPICAL DISEASES[J]. 2018, 12(9): http://202.127.146.157/handle/2RYDP1HH/5913.
[39] 刘翟. Emergence and adaptation of a novel highly pathogenic H7N9 influenza virus in birds and humans from a 2013-human-infecting low pathogenic ancestor. Journal of Virology. 2018, [40] Li, Jing, Zhang, Kun, Chen, Quanjiao, Zhang, Xiaoshuang, Sun, Yeping, Bi, Yuhai, Zhang, Shuang, Gu, Jinyan, Li, Jiarong, Liu, Di, Liu, Wenjun, Zhou, Jiyong. Three amino acid substitutions in the NS1 protein change the virus replication of H5N1 influenza virus in human cells. VIROLOGY[J]. 2018, 519: 64-73, http://dx.doi.org/10.1016/j.virol.2018.04.004.
[41] Chen, Can, Fan, Wenhui, Li, Jing, Zheng, Weinan, Zhang, Shuang, Yang, Limin, Liu, Di, Liu, Wenjun, Sun, Lei. A Promising IFN-Deficient System to Manufacture IFN-Sensitive Influenza Vaccine Virus. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY[J]. 2018, 8: http://202.127.146.157/handle/2RYDP1HH/5226.
[42] Ming Ni, Chen Chen, Di Liu. An Assessment of Amplicon-Sequencing Based Method for Viral Intrahost Analysis. 中国病毒学:英文版null. 2018, 557-560, http://lib.cqvip.com/Qikan/Article/Detail?id=90666888504849564854484950.
[43] 刘翟, 卜东波, 石铁流, 权建校, 汪德鹏, 师咏勇, 伯晓晨, 韩文报. 生物芯概念计算——生物信息计算的新概念. 中国科学:生命科学[J]. 2018, 48(3): 341-342, http://lib.cqvip.com/Qikan/Article/Detail?id=674863033.
[44] Di Liu, Dongbo Bu, Tieliu Shi, Jianxiao Quan, Depeng Wang, Yongyong Shi, Xiao-Chen Bo, Wenbao Han. Biological data processing based on bio-processor unit(BPU), a new concept for next generation computational biology. 中国科学:生命科学英文版. 2018, 61(5): 597-598, http://lib.cqvip.com/Qikan/Article/Detail?id=675306505.
[45] Liu, Haizhou, Xiong, Chaochao, Chen, Jing, Chen, Guang, Zhang, Jun, Li, Yong, Xiong, Yanping, Wang, Runkun, Cao, Ying, Chen, Quanjiao, Liu, Di, Wang, Hanzhong, Chen, Jianjun. Two genetically diverse H7N7 avian influenza viruses isolated from migratory birds in central China. EMERGING MICROBES & INFECTIONS[J]. 2018, 7: http://www.corc.org.cn/handle/1471x/2373330.
[46] Ma, Liping, Jin, Tao, Wang, Hanzhong, Liu, Haizhou, Wang, Runkun, Li, Yong, Yang, Guoxiang, Xiong, Yanping, Chen, Jing, Zhang, Jun, Chen, Guang, Li, Wei, Liu, Di, Lin, Peng, Huang, Yueying, Gao, George F, Chen, Quanjiao. Two reassortant types of highly pathogenic H5N8 avian influenza virus from wild birds in Central China in 2016. EMERGING MICROBES & INFECTIONS[J]. 2018, 7: http://www.corc.org.cn/handle/1471x/2373311.
[47] Sun, Bangyao, Jia, Lijia, Liang, Bilin, Chen, Quanjiao, Liu, Di. Phylogeography, Transmission, and Viral Proteins of Nipah Virus. VIROLOGICA SINICAnull. 2018, 33(5): 385-393, http://lib.cqvip.com/Qikan/Article/Detail?id=6100074068.
[48] Liu, Di, Bu, Dongbo, Shi, Tieliu, Quan, Jianxiao, Wang, Depeng, Shi, Yongyong, Bo, XiaoChen, Han, Wenbao. Biological data processing based on bio-processor unit (BPU), a new concept for next generation computational biology. SCIENCE CHINA-LIFE SCIENCESnull. 2018, 61(5): 597-598, http://lib.cqvip.com/Qikan/Article/Detail?id=675306505.
[49] Bangyao Sun, Lijia Jia, Bilin Liang, Quanjiao Chen, Di Liu. Phylogeography,Transmission,and Viral Proteins of Nipah Virus. 中国病毒学:英文版null. 2018, 33(5): 385-393, http://lib.cqvip.com/Qikan/Article/Detail?id=6100074068.
[50] Ni, Ming, Chen, Chen, Liu, Di. An Assessment of Amplicon-Sequencing Based Method for Viral Intrahost Analysis. VIROLOGICA SINICAnull. 2018, 33(6): 557-560, http://lib.cqvip.com/Qikan/Article/Detail?id=90666888504849564854484950.
[51] Li, Tao, Yao, HongWu, Liu, Di, Ren, HongGuang, Hu, Yi, Kargbo, David, Teng, Yue, Deng, YongQiang, Lu, HuiJun, Liu, Xiong, Liu, Kun, Fang, LiQun, Ning, NianZhi, Wong, Gary, Dafae, Foday, Kamara, Abdul, Wu, AiPing, Jiang, TaiJiao, Li, Zhan, Huang, Jie, Sun, Yu, Qian, Jun, Kargbo, Brima, Jiang, JiaFu, Wang, Hui, Cao, WuChun. Mapping the clinical outcomes and genetic evolution of Ebola virus in Sierra Leone. JCI INSIGHT[J]. 2017, 2(15): https://www.webofscience.com/wos/woscc/full-record/WOS:000407042000001.
[52] Su, Shuo, Gu, Min, Liu, Di, Cui, Jie, Gao, George F, Zhou, Jiyong, Liu, Xiufan. Epidemiology, Evolution, and Pathogenesis of H7N9 Influenza Viruses in Five Epidemic Waves since 2013 in China. TRENDS IN MICROBIOLOGYnull. 2017, 25(9): 713-728, http://www.corc.org.cn/handle/1471x/2373368.
[53] Dudas, Gytis, Carvalho, Luiz Max, Bedford, Trevor, Tatem, Andrew J, Baele, Guy, Faria, Nuno R, Park, Daniel J, Ladner, Jason T, Arias, Armando, Asogun, Danny, Bielejec, Filip, Caddy, Sarah L, Cotten, Matthew, DAmbrozio, Jonathan, Dellicour, Simon, Di Caro, Antonino, Diclaro, Joseph W, Duraffour, Sophie, Elmore, Michael J, Iii, Lawrence S Fakoli, Faye, Ousmane, Gilbert, Merle L, Gevao, Sahr M, Gire, Stephen, GladdenYoung, Adrianne, Gnirke, Andreas, Goba, Augustine, Grant, Donald S, Haagmans, Bart L, Hiscox, Julian A, Jah, Umaru, Kugelman, Jeffrey R, Liu, Di, Lu, Jia, Malboeuf, Christine M, Mate, Suzanne, Matthews, David A, Matranga, Christian B, Meredith, Luke W, Qu, James, Quick, Joshua, Pas, Suzan D, Phan, My V T, Pollakis, Georgios, Reusken, Chantal B, SanchezLockhart, Mariano, Schaffner, Stephen F, Schieffelin, John S, Sealfon, Rachel S, SimonLoriere, Etienne, Smits, Saskia L, Stoecker, Kilian, Thorne, Lucy, Tobin, Ekaete Alice, Vandi, Mohamed A, Watson, Simon J, West, Kendra, Whitmer, Shannon, Wiley, Michael R, Winnicki, Sarah M, Wohl, Shirlee, Wolfel, Roman, Yozwiak, Nathan L, Andersen, Kristian G, Blyden, Sylvia O, Bolay, Fatorma, Carroll, Miles W, Dahn, Bernice, Diallo, Boubacar, Formenty, Pierre, Fraser, Christophe, Gao, George F, Garry, Robert F, Goodfellow, Ian, Gnther, Stephan, Happi, Christian T, Holmes, Edward C, Kargbo, Brima, Keita, Sakoba, Kellam, Paul, Koopmans, Marion P G, Kuhn, Jens H, Loman, Nicholas J, Magassouba, NFaly, Naidoo, Dhamari, Nichol, Stuart T, Nyenswah, Tolbert, Palacios, Gustavo, Pybus, Oliver G, Sabeti, Pardis C, Sall, Amadou, Stroher, Ute, Wurie, Isatta, Suchard, Marc A, Lemey, Philippe, Rambaut, Andrew. Virus genomes reveal factors that spread and sustained the Ebola epidemic. NATURE[J]. 2017, 544(7650): 309-+, http://dx.doi.org/10.1038/nature22040.
[54] Liu, William J, Liu, Di. The triphibious warfare against viruses. SCIENCE CHINA-LIFE SCIENCESnull. 2017, 60(12): 1295-1298, http://www.corc.org.cn/handle/1471x/2373309.
[55] Ni, Ming, Chen, Chen, Qian, Jun, Xiao, HaiXia, Shi, WeiFeng, Luo, Yang, Wang, HaiYin, Li, Zhen, Wu, Jun, Xu, PeiSong, Chen, SuHong, Wong, Gary, Bi, Yuhai, Xia, ZhiPing, Li, Wei, Lu, HuiJun, Ma, Juncai, Tong, YiGang, Zeng, Hui, Wang, ShengQi, Gao, George F, Bo, XiaoChen, Liu, Di. Intra-host dynamics of Ebola virus during 2014. Nature Microbiology[J]. 2016, 1(11): http://124.16.173.210/handle/834782/2287.
[56] Bi, Yuhai, Chen, Quanjiao, Wang, Qianli, Chen, Jianjun, Jin, Tao, Wong, Gary, Quan, Chuansong, Liu, Jun, Wu, Jun, Yin, Renfu, Zhao, Lihua, Li, Mingxin, Ding, Zhuang, Zou, Rongrong, Xu, Wen, Li, Hong, Wang, Huijun, Tian, Kegong, Fu, Guanghua, Huang, Yu, Shestopalov, Alexander, Li, Shoujun, Xu, Bing, Yu, Hongjie, Luo, Tingrong, Lu, Lin, Xu, Xun, Luo, Yang, Liu, Yingxia, Shi, Weifeng, Liu, Di, Gao, George Fu. Genesis, Evolution and Prevalence of H5N6 Avian Influenza Viruses in China. Cell Host & Microbe[J]. 2016, 20(6): 810-821, http://www.corc.org.cn/handle/1471x/2373476.
[57] Tong, YiGang, Shi, WeiFeng, Liu, Di, Qian, Jun, Liang, Long, Bo, XiaoChen, Liu, Jun, Ren, HongGuang, Fan, Hang, Ni, Ming, Sun, Yang, Jin, Yuan, Teng, Yue, Li, Zhen, Kargbo, David, Dafae, Foday, Kanu, Alex, Chen, ChengChao, Lan, ZhiHeng, Jiang, Hui, Luo, Yang, Lu, HuiJun, Zhang, XiaoGuang, Yang, Fan, Hu, Yi, Cao, YuXi, Deng, YongQiang, Su, HaoXiang, Sun, Yu, Liu, WenSen, Wang, Zhuang, Wang, ChengYu, Bu, ZhaoYang, Guo, ZhenDong, Zhang, LiuBo, Nie, WeiMin, Bai, ChangQing, Sun, ChunHua, An, XiaoPing, Xu, PeiSong, Zhang, XiangLiLan, Huang, Yong, Mi, ZhiQiang, Yu, Dong, Yao, HongWu, Feng, Yong, Xia, ZhiPing, Zheng, XueXing, Yang, SongTao, Lu, Bing, Jiang, JiaFu, Kargbo, Brima, He, FuChu, Gao, George F, Cao, WuChun, China Mobile Lab Testing Team. Genetic diversity and evolutionary dynamics of Ebola virus in Sierra Leone. NATURE[J]. 2015, 524(7563): 93-U191, https://www.webofscience.com/wos/woscc/full-record/WOS:000359002300038.
[58] Yang, Xi, Liu, Di, Lv, Na, Zhao, Fangqing, Liu, Fei, Zou, Jing, Xiao, Xue, Wu, Jun, Liu, Peipei, Gao, Jing, Hu, Yongfei, Shi, Yi, Liu, Jun, Zhang, Ruifen, Chen, Chen, Ma, Juncai, Gao, George F, Zhu, Baoli. TCRklass: A New K-String-Based Algorithm for Human and Mouse TCR Repertoire Characterization. JOURNAL OF IMMUNOLOGY[J]. 2015, 194(1): 446-454, https://www.webofscience.com/wos/woscc/full-record/WOS:000346700500047.
[59] Yanqun Wang, Di Liu, Weifeng Shi, Roujian Lu, Wenling Wang, Yanjie Zhao, Yao Deng, Weimin Zhou, Hongguang Ren, Jun Wu, Yu Wang, Guizhen Wu, George F Gao, Wenjie Tan. Origin and Possible Genetic Recombination of the Middle East Respiratory Syndrome Coronavirus from the First Imported Case in China: Phylogenetics and Coalescence Analysis. MBIO[J]. 2015, 6(5): http://www.corc.org.cn/handle/1471x/2374161.
[60] Wenbao Qi, Weifeng Shi, Wei Li, Lihong Huang, Huanan Li, Ying Wu, Jinghua Yan, Peirong Jiao, Baoli Zhu, Juncai Ma, George F. Gao, Ming Liao, Di Liu. Continuous reassortments with local chicken H9N2 virus underlie the human-infecting influenza A (H7N9) virus in the new influenza season, Guangdong, China. 蛋白质与细胞:英文版. 2014, 878-882, http://lib.cqvip.com/Qikan/Article/Detail?id=663125388.
[61] Tian, Chan, Liu, Di, Xiang, Wei, Kretzschmar, Hans A, Sun, QingLan, Gao, Chen, Xu, Yin, Wang, Hui, Fan, XueYu, Meng, Ge, Li, Wei, Dong, XiaoPing. Analyses of the Similarity and Difference of Global Gene Expression Profiles in Cortex Regions of Three Neurodegenerative Diseases: Sporadic Creutzfeldt-Jakob Disease (sCJD), Fatal Familial Insomnia (FFI), and Alzheimer's Disease (AD). MOLECULAR NEUROBIOLOGY[J]. 2014, 50(2): 473-481, https://www.webofscience.com/wos/woscc/full-record/WOS:000343157900017.
[62] Zhang Yi, Yao Li, Liu Wei, Li Wei, Tian Chan, Wang Zhao Yang, Liu Di. Bioinformatics Analysis Raises Candidate Genes in Blood for Early Screening of Parkinson's Disease. BIOMEDICAL AND ENVIRONMENTAL SCIENCESnull. 2014, 27(6): 462-465, http://lib.cqvip.com/Qikan/Article/Detail?id=50286827.
[63] Liu Di, Gao, George F. The new emerging H7N9 influenza virus indicates poultry as new mixing vessels. SCIENCE CHINA-LIFE SCIENCESnull. 2014, 57(7): 731-732, https://www.webofscience.com/wos/woscc/full-record/WOS:000339348600012.
[64] 高福. Dynamic reassortments and genetic heterogeneity of the human-infecting influenza A (H7N9) virus. Nature communications[J]. 2014, 5: 3142-, https://www.webofscience.com/wos/woscc/full-record/WOS:000331097100006.
[65] Shi, Weifeng, Li, Wei, Li, Xianbin, Haywood, Joel, Ma, Juncai, Gao, George F, Liu, Di. Phylogenetics of varied subtypes of avian influenza viruses in China: potential threat to humans. PROTEIN & CELLnull. 2014, 5(4): 253-257, https://www.webofscience.com/wos/woscc/full-record/WOS:000334428400002.
[66] 高福. Poultry carrying H9N2 act as incubators for novel human avian influenza viruses. The Lancet. 2014, 381(9920): 869-, [67] Shi, Weifeng, Shi, Yi, Wu, Ying, Liu, Di, Gao, George F. Origin and molecular characterization of the human-infecting H6N1 influenza virus in Taiwan. PROTEIN & CELL[J]. 2013, 4(11): 846-853, https://www.webofscience.com/wos/woscc/full-record/WOS:000326939900006.
[68] Tian, Chan, Liu, Di, Chen, Chen, Xu, Yin, Gong, HanShi, Chen, Cao, Shi, Qi, Zhang, BaoYun, Han, Jun, Dong, XiaoPing. Global transcriptional profiling of the postmortem brain of a patient with G114V genetic Creutzfeldt-Jakob disease. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE[J]. 2013, 31(3): 676-688, https://www.webofscience.com/wos/woscc/full-record/WOS:000314905500024.
[69] 高福. Origin and diversity of novel avian influenza A H7N9 viruses causing human infection: phylogenetic, structural, and coalescent analyses. The Lancet. 2013, 381(9881): 1926-32, [70] Tian, Chan, Liu, Di, Sun, QingLan, Chen, Chen, Xu, Yin, Wang, Hui, Xiang, Wei, Kretzschmar, Hans A, Li, Wei, Chen, Cao, Shi, Qi, Gao, Chen, Zhang, Jin, Zhang, BaoYun, Han, Jun, Dong, XiaoPing. Comparative Analysis of Gene Expression Profiles Between Cortex and Thalamus in Chinese Fatal Familial Insomnia Patients. MOLECULAR NEUROBIOLOGYnull. 2013, 48(1): 36-48, https://www.webofscience.com/wos/woscc/full-record/WOS:000322138900004.
[71] Liu, D, Liu, L, Guo, G, Wang, W, Sun, Q, Parani, M, Ma, J. BOLDMirror: a global mirror system of DNA barcode data. MOLECULAR ECOLOGY RESOURCES[J]. 2013, 13(6): 991-995, http://dx.doi.org/10.1111/1755-0998.12048.
[72] Jianjun Chen, Biling Liang, Juefu Hu, Haizhou Liu, Jianqing Sun, Mingxin Li, Quanjiao Chen, Yubang He, Di Liu. Circulation, Evolution and Transmission of Highly Pathogenic Avian Influenza A (H5N8) virus, 2016-2018. Journal of Infection. http://dx.doi.org/10.1016/j.jinf.2019.07.005.
发表著作
(1) Molecular Epidemiology of the Human-Infecting Influenza A Virus (H7N9) and its Potential to the Pandemics, Nova Science Publishers, 2014-10, 第 1 作者

科研活动

   
科研项目
( 1 ) 国家生物安全监测网络系统集成技术研究, 主持, 国家级, 2016-07--2018-12
( 2 ) 利用大数据信息挖掘和基因进化方法研究禽流感病毒的跨地域传播, 主持, 国家级, 2015-01--2018-12
( 3 ) 中俄地区野鸟中禽流感病毒调查与系统发生研究, 主持, 部委级, 2015-01--2015-12
( 4 ) 中国科学院流感专项研究项目, 参与, 部委级, 2013-05--2014-12
( 5 ) 中国生命条形码数据库建立, 主持, 国家级, 2012-05--2017-05
( 6 ) DNA条形码信息系统构建, 主持, 国家级, 2011-06--2016-05
( 7 ) 细胞感染模型中RNA病毒的准种微进化理论和方法学研究, 主持, 国家级, 2017-01--2018-12
参与会议
(1)Pathogen Genomics and Evolution   第三届亚太微生物应急体系建设及医改策略国际大会   2017-03-30
(2)Intra-host dynamics of Ebola virus   2015-10-16
(3)Intra-host dynamics of Ebola virus   中美科学院联合会议   2015-09-25

指导学生

现指导学生

贾李佳  硕士研究生  071010-生物化学与分子生物学  

王德诚  博士研究生  071010-生物化学与分子生物学  

孙邦耀  博士研究生  071005-微生物学