基本信息
赵瑞芳 女 硕导 国家纳米科学中心
电子邮件： zhaorf@nanoctr.cn
通信地址： 北京市海淀区中关村北一条11号
邮政编码： 100190
电子邮件： zhaorf@nanoctr.cn
通信地址： 北京市海淀区中关村北一条11号
邮政编码： 100190
教育背景
2012-09--2017-07 清华大学 理学博士学位
2009-09--2012-07 华中农业大学 理学硕士
2005-09--2009-07 华中农业大学 工学学士
2009-09--2012-07 华中农业大学 理学硕士
2005-09--2009-07 华中农业大学 工学学士
学历
（1）2012.9–2017.6，国家纳米科学中心，物理化学专业，博士
（2）2012.9–2017.6，清华大学，化学系，化学专业，博士
（3）2009.9–2012.6，华中农业大学，生命科学技术学院，微生物学专业
（4）2005.9–2009.6，华中农业大学，生命科学技术学院，生物工程专业
工作经历
（1）2020.5–至今，国家纳米科学中心，副研究员
（2）2017.9–2020.4，国家纳米科学中心，助理研究员
专利与奖励
专利成果
[1] 聂广军, 赵瑞芳, 陈龙, 覃好, 赵宇亮. 一种肿瘤疫苗及其制备方法和应用. CN: CN115697390A, 2023-02-03.
[2] 聂广军, 赵瑞芳, 吴雁, 陈龙, 覃好, 覃裕婷, 林靓茹. 一种预防癌症术后复发的肿瘤疫苗及其制备方法和应用. CN: CN113679829A, 2021-11-23.
[3] 聂广军, 杨霄, 季天骄, 赵晓政, 赵瑞芳, 赵潇. 一种聚乙二醇化氨磷汀、制备方法及其用途. CN: CN104693433A, 2015-06-10.
[4] 聂广军, 赵瑞芳, 季天骄. 两亲性聚合物及其制备方法和两亲性聚合物纳米颗粒及其制备方法和应用. CN: CN105646886A, 2016-06-08.
[5] 赵颖, 聂广军, 季天骄, 赵瑞芳, 郎佳妍. 多肽和药物组合物及其制备方法. CN: CN104447949A, 2015-03-25.
[2] 聂广军, 赵瑞芳, 吴雁, 陈龙, 覃好, 覃裕婷, 林靓茹. 一种预防癌症术后复发的肿瘤疫苗及其制备方法和应用. CN: CN113679829A, 2021-11-23.
[3] 聂广军, 杨霄, 季天骄, 赵晓政, 赵瑞芳, 赵潇. 一种聚乙二醇化氨磷汀、制备方法及其用途. CN: CN104693433A, 2015-06-10.
[4] 聂广军, 赵瑞芳, 季天骄. 两亲性聚合物及其制备方法和两亲性聚合物纳米颗粒及其制备方法和应用. CN: CN105646886A, 2016-06-08.
[5] 赵颖, 聂广军, 季天骄, 赵瑞芳, 郎佳妍. 多肽和药物组合物及其制备方法. CN: CN104447949A, 2015-03-25.
出版信息
发表论文
[1] Qin, Hao, Li, Hejia, Zhu, Jin, Qin, Yuting, Li, Nan, Shi, Jian, Nie, Guangjun, Zhao, Ruifang. Biogenetic Vesicle-Based Cancer Vaccines with Tunable Surface Potential and Immune Potency. SMALL. 2023, 第 8 作者 通讯作者 http://dx.doi.org/10.1002/smll.202303225.
[2] Lin, Yixuan, Chen, Yang, Deng, Ronghui, Qin, Hao, Li, Nan, Qin, Yuting, Chen, Hanqing, Wei, Yaohua, Wang, Zeming, Sun, Qing, Qiu, Wenyi, Shi, Jian, Chen, Long, Wang, Yuguang, Nie, Guangjun, Zhao, Ruifang. Delivery of neutrophil membrane encapsulated non-steroidal anti- inflammatory drugs by degradable biopolymer microneedle patch for rheumatoid arthritis therapy. NANO TODAY[J]. 2023, 第 16 作者 通讯作者 49: http://dx.doi.org/10.1016/j.nantod.2023.101791.
[3] Qin, Hao, Chen, Yang, Wang, Zeming, Li, Nan, Sun, Qing, Lin, Yixuan, Qiu, Wenyi, Qin, Yuting, Chen, Long, Chen, Hanqing, Li, Yiye, Shi, Jian, Nie, Guangjun, Zhao, Ruifang. Biosynthesized gold nanoparticles that activate Toll-like receptors and elicit localized light-converting hyperthermia for pleiotropic tumor immunoregulation. NATURE COMMUNICATIONS[J]. 2023, 第 14 作者 通讯作者 14(1): http://dx.doi.org/10.1038/s41467-023-40851-4.
[4] Lin, Liangru, Chen, Hanqing, Zhao, Ruifang, Zhu, Motao, Nie, Guangjun. Nanomedicine targets iron metabolism for cancer therapy. CANCER SCIENCE. 2022, 第 3 作者113(3): 828-837, http://dx.doi.org/10.1111/cas.15250.
[5] Zhao, Xiao, Zhao, Ruifang, Nie, Guangjun. Nanocarriers based on bacterial membrane materials for cancer vaccine delivery. NATURE PROTOCOLS[J]. 2022, 第 2 作者17(10): 2240-2274, http://dx.doi.org/10.1038/s41596-022-00713-7.
[6] Qin, Hao, Zhao, Ruifang, Qin, Yuting, Zhu, Jin, Chen, Long, Di, Chunzhi, Han, Xuexiang, Cheng, Keman, Zhang, Yinlong, Zhao, Ying, Shi, Jian, Anderson, Gregory J, Zhao, Yuliang, Nie, Guangjun. Development of a Cancer Vaccine Using In Vivo Click-Chemistry-Mediated Active Lymph Node Accumulation for Improved Immunotherapy. ADVANCED MATERIALS[J]. 2021, 第 2 作者 通讯作者 33(20): http://dx.doi.org/10.1002/adma.202006007.
[7] Yin, Yue, Li, Xiaoyang, Ma, Haixia, Zhang, Jie, Yu, Di, Zhao, Ruifang, Yu, Shengji, Nie, Guangjun, Wang, Hai. In Situ Transforming RNA Nanovaccines from Polyethylenimine Functionalized Graphene Oxide Hydrogel for Durable Cancer Immunotherapy. NANO LETTERS[J]. 2021, 第 6 作者21(5): 2224-2231, http://dx.doi.org/10.1021/acs.nanolett.0c05039.
[8] Chen, Long, Qin, Hao, Zhao, Ruifang, Zhao, Xiao, Lin, Liangru, Che, Yang, Lin, Yixuan, Li, Yao, Qin, Yuting, Li, Yiyi, Liu, Shaoli, Cheng, Keman, Chen, Hanqing, Shi, Jian, Anderson, Gregory J, Wu, Yan, Zhao, Yuliang, Nie, Guangjun. Bacterial cytoplasmic membranes synergistically enhance the antitumor activity of autologous cancer vaccines. SCIENCE TRANSLATIONAL MEDICINE[J]. 2021, 第 3 作者 通讯作者 13(601): eabc2816, http://dx.doi.org/10.1126/scitranslmed.abc2816.
[9] Cheng, Keman, Zhao, Ruifang, Li, Yao, Qi, Yingqiu, Wang, Yazhou, Zhang, Yinlong, Qin, Hao, Qin, Yuting, Chen, Long, Li, Chen, Liang, Jie, Li, Yujing, Xu, Jiaqi, Han, Xuexiang, Anderson, Gregory J, Shi, Jian, Ren, Lei, Zhao, Xiao, Nie, Guangjun. Bioengineered bacteria-derived outer membrane vesicles as a versatile antigen display platform for tumor vaccination via Plug-and-Display technology. NATURE COMMUNICATIONS[J]. 2021, 第 2 作者12(1): http://dx.doi.org/10.1038/s41467-021-22308-8.
[10] Zhao, Ruifang, Zhu, Meilin, Zhou, Shuang, Feng, Weiyue, Chen, Hanqing. Rapamycin-Loaded mPEG-PLGA Nanoparticles Ameliorate Hepatic Steatosis and Liver Injury in Non-alcoholic Fatty Liver Disease. FRONTIERS IN CHEMISTRY[J]. 2020, 第 1 作者8: https://doaj.org/article/e83ecfc6aa314afdb897e44ded18354f.
[11] Zhu, Motao, Du, Libo, Zhao, Ruifang, Wang, Helen Y, Zhao, Yuliang, Nie, Guangjun, Wang, RongFu. Cell-Penetrating Nanoparticles Activate the Inflammasome to Enhance Antibody Production by Targeting Microtubule-Associated Protein 1-Light Chain 3 for Degradation. ACS NANO[J]. 2020, 第 3 作者14(3): 3703-3717, https://www.webofscience.com/wos/woscc/full-record/WOS:000526301400104.
[12] Han, Xuexiang, Cheng, Keman, Xu, Ying, Wang, Yazhou, Mm, Huan, Zhang, Yinlong, Zhao, Xiao, Zhao, Ruifang, Anderson, Gregory J, Ren, Lei, Nie, Guangjun, Li, Yiye. Modularly Designed Peptide Nanoprodrug Augments Antitumor Immunity of PD-L1 Checkpoint Blockade by Targeting Indoleamine 2,3-Dioxygenase. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2020, 第 8 作者142(5): 2490-2496, https://www.webofscience.com/wos/woscc/full-record/WOS:000512222700054.
[13] Li, Yao, Zhao, Ruifang, Cheng, Keman, Zhang, Kaiyue, Wang, Yazhou, Zhang, Yinlong, Li, Yujing, Liu, Guangna, Xu, Junchao, Xu, Jiaqi, Anderson, Gregory J, Shi, Jian, Ren, Lei, Zhao, Xiao, Nie, Guangjun. Bacterial Outer Membrane Vesicles Presenting Programmed Death 1 for Improved Cancer Immunotherapy via Immune Activation and Checkpoint Inhibition. ACS NANO[J]. 2020, 第 2 作者14(12): 16698-16711, http://dx.doi.org/10.1021/acsnano.0c03776.
[14] Ji, Tianjiao, Lang, Jiayan, Ning, Bo, Qi, Feifei, Wang, Hui, Zhang, Yinlong, Zhao, Ruifang, Yang, Xiao, Zhang, Lijing, Li, Wei, Shi, Xinghua, Qin, Zhihai, Zhao, Ying, Nie, Guangjun. Enhanced Natural Killer Cell Immunotherapy by Rationally Assembling Fc Fragments of Antibodies onto Tumor Membranes. ADVANCED MATERIALS[J]. 2019, 第 7 作者31(6):
[15] Lang, Jiayan, Zhao, Xiao, Wang, Xiuchao, Zhao, Ying, Li, Yiye, Zhao, Ruifang, Cheng, Keman, Li, Yao, Han, Xuexiang, Zheng, Xiaowei, Qin, Hao, Geranpayehvaghei, Marzieh, Shi, Jian, Anderson, Gregory J, Hao, Jihui, Ren, He, Nie, Guangjun. Targeted Co-delivery of the Iron Chelator Deferoxamine and a HIF1 alpha Inhibitor Impairs Pancreatic Tumor Growth. ACS NANO[J]. 2019, 第 6 作者13(2): 2176-2189, http://dx.doi.org/10.1021/acsnano.8b08823.
[16] Hu, Yili, Zhu, Xiaoyang, Zhao, Ruifang, Wang, Jin, Song, Yipeng, Nie, Guangjun, Tang, Huiru, Wang, Yulan. Doxorubicin and paclitaxel carried by methoxy poly(ethylene glycol)-poly(lactide-co-glycolide) is superior than traditional drug-delivery methods. NANOMEDICINE[J]. 2018, 第 3 作者13(8): 913-928, https://www.webofscience.com/wos/woscc/full-record/WOS:000432932200008.
[17] 赵宇亮. The effects of orally administered Ag, TiO2 and SiO2 nanoparticles on gut microbiota composition and colitis induction in mice. NANOIMPACT[J]. 2017, 8: 80-88, http://dx.doi.org/10.1016/j.impact.2017.07.005.
[18] Li, Suping, Zhang, Yinlong, Wang, Jing, Zhao, Ying, Ji, Tianjiao, Zhao, Xiao, Ding, Yanping, Zhao, Xiaozheng, Zhao, Ruifang, Li, Feng, Yang, Xiao, Liu, Shaoli, Liu, Zhaofei, Lai, Jianhao, Whittaker, Andrew K, Anderson, Gregory J, Wei, Jingyan, Nie, Guangjun. Nanoparticle-mediated local depletion of tumour-associated platelets disrupts vascular barriers and augments drug accumulation in tumours. NATURE BIOMEDICAL ENGINEERING[J]. 2017, 第 9 作者1(8): 667-679, https://www.webofscience.com/wos/woscc/full-record/WOS:000418858400001.
[19] Ruifang Zhao, Xuexiang Han, Yiye Li, Hai Wang, Ji, Tianjiao, Yuliang Zhao, Guangjun Nie. Photothermal Effect Enhanced Cascade-Targeting Strategy for Improved Pancreatic Cancer Therapy by Gold Nanoshell@ Mesoporous Silica Nanorod. ACS NANO[J]. 2017, 第 1 作者11(8): 8103-8113, http://www.corc.org.cn/handle/1471x/2177783.
[20] 赵宇亮. Biodegradable cationic ε-poly-L-lysine-conjugated polymeric nanoparticles as a new effective antibacterial agent. SCIENCE BULLETIN. 2015, 60(2): 216-226, http://dx.doi.org/10.1007/s11434-014-0704-9.
[21] Li, Suping, Tian, Yanhua, Zhao, Ying, Zhang, Yinlong, Su, Shishuai, Wang, Jing, Wu, Meiyu, Shi, Quanwei, Anderson, Gregory J, Thomsen, Johannes, Zhao, Ruifang, Ji, Tianjiao, Wang, Jie, Nie, Guangjun. pHLIP-mediated targeting of truncated tissue factor to tumor vessels causes vascular occlusion and impairs tumor growth. ONCOTARGET[J]. 2015, 第 11 作者6(27): 23523-23532, http://dx.doi.org/10.18632/oncotarget.4395.
[22] Zhu Motao, Ding Xilai, Zhao Ruifang, Liu Xuewu, Shen Haifa, Cai Chunmei, Ferrari Mauro, Wang Helen Y, Wang RongFu. Co-delivery of tumor antigen and dual toll-like receptor ligands into dendritic cell by silicon microparticle enables efficient immunotherapy against melanoma. JOURNAL OF CONTROLLED RELEASE : OFFICIAL JOURNAL OF THE CONTROLLED RELEASE SOCIETY. 第 3 作者272: 72-82, http://www.corc.org.cn/handle/1471x/2178049.
[2] Lin, Yixuan, Chen, Yang, Deng, Ronghui, Qin, Hao, Li, Nan, Qin, Yuting, Chen, Hanqing, Wei, Yaohua, Wang, Zeming, Sun, Qing, Qiu, Wenyi, Shi, Jian, Chen, Long, Wang, Yuguang, Nie, Guangjun, Zhao, Ruifang. Delivery of neutrophil membrane encapsulated non-steroidal anti- inflammatory drugs by degradable biopolymer microneedle patch for rheumatoid arthritis therapy. NANO TODAY[J]. 2023, 第 16 作者 通讯作者 49: http://dx.doi.org/10.1016/j.nantod.2023.101791.
[3] Qin, Hao, Chen, Yang, Wang, Zeming, Li, Nan, Sun, Qing, Lin, Yixuan, Qiu, Wenyi, Qin, Yuting, Chen, Long, Chen, Hanqing, Li, Yiye, Shi, Jian, Nie, Guangjun, Zhao, Ruifang. Biosynthesized gold nanoparticles that activate Toll-like receptors and elicit localized light-converting hyperthermia for pleiotropic tumor immunoregulation. NATURE COMMUNICATIONS[J]. 2023, 第 14 作者 通讯作者 14(1): http://dx.doi.org/10.1038/s41467-023-40851-4.
[4] Lin, Liangru, Chen, Hanqing, Zhao, Ruifang, Zhu, Motao, Nie, Guangjun. Nanomedicine targets iron metabolism for cancer therapy. CANCER SCIENCE. 2022, 第 3 作者113(3): 828-837, http://dx.doi.org/10.1111/cas.15250.
[5] Zhao, Xiao, Zhao, Ruifang, Nie, Guangjun. Nanocarriers based on bacterial membrane materials for cancer vaccine delivery. NATURE PROTOCOLS[J]. 2022, 第 2 作者17(10): 2240-2274, http://dx.doi.org/10.1038/s41596-022-00713-7.
[6] Qin, Hao, Zhao, Ruifang, Qin, Yuting, Zhu, Jin, Chen, Long, Di, Chunzhi, Han, Xuexiang, Cheng, Keman, Zhang, Yinlong, Zhao, Ying, Shi, Jian, Anderson, Gregory J, Zhao, Yuliang, Nie, Guangjun. Development of a Cancer Vaccine Using In Vivo Click-Chemistry-Mediated Active Lymph Node Accumulation for Improved Immunotherapy. ADVANCED MATERIALS[J]. 2021, 第 2 作者 通讯作者 33(20): http://dx.doi.org/10.1002/adma.202006007.
[7] Yin, Yue, Li, Xiaoyang, Ma, Haixia, Zhang, Jie, Yu, Di, Zhao, Ruifang, Yu, Shengji, Nie, Guangjun, Wang, Hai. In Situ Transforming RNA Nanovaccines from Polyethylenimine Functionalized Graphene Oxide Hydrogel for Durable Cancer Immunotherapy. NANO LETTERS[J]. 2021, 第 6 作者21(5): 2224-2231, http://dx.doi.org/10.1021/acs.nanolett.0c05039.
[8] Chen, Long, Qin, Hao, Zhao, Ruifang, Zhao, Xiao, Lin, Liangru, Che, Yang, Lin, Yixuan, Li, Yao, Qin, Yuting, Li, Yiyi, Liu, Shaoli, Cheng, Keman, Chen, Hanqing, Shi, Jian, Anderson, Gregory J, Wu, Yan, Zhao, Yuliang, Nie, Guangjun. Bacterial cytoplasmic membranes synergistically enhance the antitumor activity of autologous cancer vaccines. SCIENCE TRANSLATIONAL MEDICINE[J]. 2021, 第 3 作者 通讯作者 13(601): eabc2816, http://dx.doi.org/10.1126/scitranslmed.abc2816.
[9] Cheng, Keman, Zhao, Ruifang, Li, Yao, Qi, Yingqiu, Wang, Yazhou, Zhang, Yinlong, Qin, Hao, Qin, Yuting, Chen, Long, Li, Chen, Liang, Jie, Li, Yujing, Xu, Jiaqi, Han, Xuexiang, Anderson, Gregory J, Shi, Jian, Ren, Lei, Zhao, Xiao, Nie, Guangjun. Bioengineered bacteria-derived outer membrane vesicles as a versatile antigen display platform for tumor vaccination via Plug-and-Display technology. NATURE COMMUNICATIONS[J]. 2021, 第 2 作者12(1): http://dx.doi.org/10.1038/s41467-021-22308-8.
[10] Zhao, Ruifang, Zhu, Meilin, Zhou, Shuang, Feng, Weiyue, Chen, Hanqing. Rapamycin-Loaded mPEG-PLGA Nanoparticles Ameliorate Hepatic Steatosis and Liver Injury in Non-alcoholic Fatty Liver Disease. FRONTIERS IN CHEMISTRY[J]. 2020, 第 1 作者8: https://doaj.org/article/e83ecfc6aa314afdb897e44ded18354f.
[11] Zhu, Motao, Du, Libo, Zhao, Ruifang, Wang, Helen Y, Zhao, Yuliang, Nie, Guangjun, Wang, RongFu. Cell-Penetrating Nanoparticles Activate the Inflammasome to Enhance Antibody Production by Targeting Microtubule-Associated Protein 1-Light Chain 3 for Degradation. ACS NANO[J]. 2020, 第 3 作者14(3): 3703-3717, https://www.webofscience.com/wos/woscc/full-record/WOS:000526301400104.
[12] Han, Xuexiang, Cheng, Keman, Xu, Ying, Wang, Yazhou, Mm, Huan, Zhang, Yinlong, Zhao, Xiao, Zhao, Ruifang, Anderson, Gregory J, Ren, Lei, Nie, Guangjun, Li, Yiye. Modularly Designed Peptide Nanoprodrug Augments Antitumor Immunity of PD-L1 Checkpoint Blockade by Targeting Indoleamine 2,3-Dioxygenase. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2020, 第 8 作者142(5): 2490-2496, https://www.webofscience.com/wos/woscc/full-record/WOS:000512222700054.
[13] Li, Yao, Zhao, Ruifang, Cheng, Keman, Zhang, Kaiyue, Wang, Yazhou, Zhang, Yinlong, Li, Yujing, Liu, Guangna, Xu, Junchao, Xu, Jiaqi, Anderson, Gregory J, Shi, Jian, Ren, Lei, Zhao, Xiao, Nie, Guangjun. Bacterial Outer Membrane Vesicles Presenting Programmed Death 1 for Improved Cancer Immunotherapy via Immune Activation and Checkpoint Inhibition. ACS NANO[J]. 2020, 第 2 作者14(12): 16698-16711, http://dx.doi.org/10.1021/acsnano.0c03776.
[14] Ji, Tianjiao, Lang, Jiayan, Ning, Bo, Qi, Feifei, Wang, Hui, Zhang, Yinlong, Zhao, Ruifang, Yang, Xiao, Zhang, Lijing, Li, Wei, Shi, Xinghua, Qin, Zhihai, Zhao, Ying, Nie, Guangjun. Enhanced Natural Killer Cell Immunotherapy by Rationally Assembling Fc Fragments of Antibodies onto Tumor Membranes. ADVANCED MATERIALS[J]. 2019, 第 7 作者31(6):
[15] Lang, Jiayan, Zhao, Xiao, Wang, Xiuchao, Zhao, Ying, Li, Yiye, Zhao, Ruifang, Cheng, Keman, Li, Yao, Han, Xuexiang, Zheng, Xiaowei, Qin, Hao, Geranpayehvaghei, Marzieh, Shi, Jian, Anderson, Gregory J, Hao, Jihui, Ren, He, Nie, Guangjun. Targeted Co-delivery of the Iron Chelator Deferoxamine and a HIF1 alpha Inhibitor Impairs Pancreatic Tumor Growth. ACS NANO[J]. 2019, 第 6 作者13(2): 2176-2189, http://dx.doi.org/10.1021/acsnano.8b08823.
[16] Hu, Yili, Zhu, Xiaoyang, Zhao, Ruifang, Wang, Jin, Song, Yipeng, Nie, Guangjun, Tang, Huiru, Wang, Yulan. Doxorubicin and paclitaxel carried by methoxy poly(ethylene glycol)-poly(lactide-co-glycolide) is superior than traditional drug-delivery methods. NANOMEDICINE[J]. 2018, 第 3 作者13(8): 913-928, https://www.webofscience.com/wos/woscc/full-record/WOS:000432932200008.
[17] 赵宇亮. The effects of orally administered Ag, TiO2 and SiO2 nanoparticles on gut microbiota composition and colitis induction in mice. NANOIMPACT[J]. 2017, 8: 80-88, http://dx.doi.org/10.1016/j.impact.2017.07.005.
[18] Li, Suping, Zhang, Yinlong, Wang, Jing, Zhao, Ying, Ji, Tianjiao, Zhao, Xiao, Ding, Yanping, Zhao, Xiaozheng, Zhao, Ruifang, Li, Feng, Yang, Xiao, Liu, Shaoli, Liu, Zhaofei, Lai, Jianhao, Whittaker, Andrew K, Anderson, Gregory J, Wei, Jingyan, Nie, Guangjun. Nanoparticle-mediated local depletion of tumour-associated platelets disrupts vascular barriers and augments drug accumulation in tumours. NATURE BIOMEDICAL ENGINEERING[J]. 2017, 第 9 作者1(8): 667-679, https://www.webofscience.com/wos/woscc/full-record/WOS:000418858400001.
[19] Ruifang Zhao, Xuexiang Han, Yiye Li, Hai Wang, Ji, Tianjiao, Yuliang Zhao, Guangjun Nie. Photothermal Effect Enhanced Cascade-Targeting Strategy for Improved Pancreatic Cancer Therapy by Gold Nanoshell@ Mesoporous Silica Nanorod. ACS NANO[J]. 2017, 第 1 作者11(8): 8103-8113, http://www.corc.org.cn/handle/1471x/2177783.
[20] 赵宇亮. Biodegradable cationic ε-poly-L-lysine-conjugated polymeric nanoparticles as a new effective antibacterial agent. SCIENCE BULLETIN. 2015, 60(2): 216-226, http://dx.doi.org/10.1007/s11434-014-0704-9.
[21] Li, Suping, Tian, Yanhua, Zhao, Ying, Zhang, Yinlong, Su, Shishuai, Wang, Jing, Wu, Meiyu, Shi, Quanwei, Anderson, Gregory J, Thomsen, Johannes, Zhao, Ruifang, Ji, Tianjiao, Wang, Jie, Nie, Guangjun. pHLIP-mediated targeting of truncated tissue factor to tumor vessels causes vascular occlusion and impairs tumor growth. ONCOTARGET[J]. 2015, 第 11 作者6(27): 23523-23532, http://dx.doi.org/10.18632/oncotarget.4395.
[22] Zhu Motao, Ding Xilai, Zhao Ruifang, Liu Xuewu, Shen Haifa, Cai Chunmei, Ferrari Mauro, Wang Helen Y, Wang RongFu. Co-delivery of tumor antigen and dual toll-like receptor ligands into dendritic cell by silicon microparticle enables efficient immunotherapy against melanoma. JOURNAL OF CONTROLLED RELEASE : OFFICIAL JOURNAL OF THE CONTROLLED RELEASE SOCIETY. 第 3 作者272: 72-82, http://www.corc.org.cn/handle/1471x/2178049.
科研活动
科研项目
（ 1 ） 基于淋巴结靶向的纳米肿瘤疫苗平台的设计及抗肿瘤机制研究, 主持, 国家级, 2019-01--2021-12