基本信息

汪思佳 男 博导 中国科学院上海营养与健康研究所
电子邮件: wangsijia@picb.ac.cn
通信地址: 岳阳路320号
邮政编码:
电子邮件: wangsijia@picb.ac.cn
通信地址: 岳阳路320号
邮政编码:
招生信息
招生专业
0710Z2-计算生物学
招生方向
计算生物学-皮肤基因组学;人类表型组学
教育背景
2003-09--2009-02 伦敦大学 博士2002-09--2003-09 杜伦大学 硕士1998-09--2002-06 复旦大学 学士
工作经历
工作简历
2012-10~现在, 中国科学院上海营养与健康研究所, 研究员2009-02~2012-05,哈佛大学, 博士后研究员2003-09~2009-02,伦敦大学, 博士2002-09~2003-09,杜伦大学, 硕士1998-09~2002-06,复旦大学, 学士
社会兼职
2017-05-31-今,第七届上海人类学学会, 副会长
2015-12-31-今,Ann Hum Genet, 副主编
2015-12-31-今,Ann Hum Genet, 副主编
专利与奖励
专利成果
( 1 ) P53通路抑制剂在拮抗毛发衰老与白化中的应用, 2022, 第 3 作者, 专利号: CN115463213A( 2 ) 一种多功能一体化肤纹与面部图像采集设备, 2022, 第 1 作者, 专利号: CN217902459U( 3 ) 生理生化指标的预测及预测模型的构建方法、系统, 2022, 第 1 作者, 专利号: CN115312200A( 4 ) 靶向TERT在调节皮肤及毛发色素中的应用, 2022, 第 2 作者, 专利号: CN114306602A( 5 ) 用于确定影响面部衰老程度的局部区域的方法和装置, 2021, 第 1 作者, 专利号: CN113761985A( 6 ) 一种获得中国人群个体年龄的方法, 2021, 第 2 作者, 专利号: CN113373236A( 7 ) 基于机器学习算法搭建的唐氏综合征肤纹辅助筛查, 2021, 第 1 作者, 专利号: CN111202492B
出版信息
发表论文
(1) Genetic variants associated with sweat gland phenotypes in 6,210 Han Chinese individuals, J Invest Dermatol, 2024, 第 1 作者 通讯作者(2) Epigenome-wide association study on short-, intermediate- and long-term ozone exposure in Han Chinese, the NSPT study, JOURNAL OF HAZARDOUS MATERIALS, 2024, 第 10 作者 通讯作者(3) Analysis of blood methylation quantitative trait loci in East Asians reveals ancestry-specific impacts on complex traits, Nat Genet, 2024, 第 1 作者 通讯作者(4) A novel approach to the detection of facial wrinkles: Database, detection algorithm, and evaluation metrics, Comput Biol Med, 2024, 第 1 作者 通讯作者(5) Combined genome-wide association study of 136 quantitative ear morphology traits in multiple populations reveal 8 novel loci, PLOS GENETICS, 2023, 第 32 作者 通讯作者(6) Automatic landmarking identifies new loci associated with face morphology and implicates Neanderthal introgression in human nasal shape, COMMUNICATIONS BIOLOGY, 2023, 第 37 作者(7) The developmental basis of fingerprint pattern formation and variation, CELL, 2023, 第 18 作者(8) GWAs Identify DNA Variants Influencing Eyebrow Thickness Variation in Europeans and Across Continental Populations, JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2023, 第 23 作者(9) Scalp hair loss is not random across follicular units: A new insight into human hair ageing, INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, 2023, 第 18 作者 通讯作者(10) GWASs Identify Genetic Loci Associated with Human Scalp Hair Whorl Direction, JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2023, 第 12 作者(11) Ultrasonic Through-Transmission Measurements of Human Musculoskeletal and Fat Properties, ULTRASOUND IN MEDICINE AND BIOLOGY, 2023, 第 8 作者(12) DNA methylation age acceleration contributes to the development and prediction of non-alcoholic fatty liver disease, Geroscience, 2023, 第 1 作者(13) Genetic Variants in Telomerase Reverse Transcriptase Contribute to Solar Lentigines, JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2023, 第 18 作者 通讯作者(14) Multi-target landmark detection with incomplete images via reinforcement learning and shape prior embedding, MEDICAL IMAGE ANALYSIS, 2023, 第 10 作者(15) Twelve Loci Associated With Bone Density in Middle-aged and Elderly Chinese: The Shanghai Changfeng Study, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2023, 第 9 作者 通讯作者(16) Analysis of factors influencing skin reactions to sunscreens, skin whitening products, and deodorants: Results from a large-scale patch test dataset in China, JOURNAL OF COSMETIC DERMATOLOGY, 2022, 第 9 作者 通讯作者(17) Palmprint Phenotype Feature Extraction and Classification Based on Deep Learning, Palmprint Phenotype Feature Extraction and Classification Based on Deep Learning, 表型组学(英文), 2022, 第 5 作者(18) An additional whole-exome sequencing study in 102 panel-undiagnosed patients: A retrospective study in a Chinese craniosynostosis cohort, FRONTIERS IN GENETICS, 2022, 第 10 作者 通讯作者(19) The challenges in finding your home as a multidisciplinary scientist, CELL, 2022, 第 1 作者(20) Single-cell transcriptomics reveals lineage trajectory of human scalp hair follicle and informs mechanisms of hair graying, Cell Discov, 2022, (21) NAFLD-related gene polymorphisms and all-cause and cause-specific mortality in an Asian population: the Shanghai Changfeng Study, ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2022, 第 19 作者(22) Genetic evidence for facial variation being a composite phenotype of cranial variation and facial soft tissue thickness, JOURNAL OF GENETICS AND GENOMICS, 2022, 第 13 作者(23) Genetic variants underlying differences in facial morphology in East Asian and European populations, NATURE GENETICS, 2022, 第 19 作者 通讯作者(24) From musk to body odor: Decoding olfaction through genetic variation, PLOS GENETICS, 2022, 第 8 作者 通讯作者(25) Limb development genes underlie variation in human fingerprint patterns, CELL, 2022, 第 46 作者 通讯作者(26) A Genome-Wide Scan on Individual Typology Angle Found Variants at SLC24A2 Associated with Skin Color Variation in Chinese Populations, JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2022, 第 20 作者 通讯作者(27) A Genome-Wide Association Study Finds Variants at 2p21 Associated with Self-Reported Sensitive Skin in the Han Chinese population, JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2022, 第 7 作者(28) Genetic evidence for facial variation being a composite phenotype of cranial variation and facial soft tissue thickness, J Genet Genomics, 2022, (29) Genetically predicted body composition in relation to cardiometabolic traits: a Mendelian randomization study, EUROPEANJOURNALOFEPIDEMIOLOGY, 2021, 第 3 作者 通讯作者(30) A genome-wide association study of facial morphology identifies novel genetic loci in Han Chinese, A genome-wide association study of facial morphology identifies novel genetic loci in Han Chinese, JOURNAL OF GENETICS AND GENOMICS, 2021, 第 12 作者 通讯作者(31) Dissecting dynamics and differences of selective pressures in the evolution of human pigmentation, BIOLOGY OPEN, 2021, 第 2 作者(32) A custom-designed panel sequencing study in 201 Chinese patients with craniosynostosis revealed novel variants and distinct mutation spectra, A custom-designed panel sequencing study in 201 Chinese patients with craniosynostosis revealed novel variants and distinct mutation spectra, JOURNAL OF GENETICS AND GENOMICS, 2021, 第 10 作者 通讯作者(33) Insights into contribution of genetic variants towards the susceptibility of MAFLD revealed by the NMR-based lipoprotein profiling, JOURNAL OF HEPATOLOGY, 2021, 第 3 作者(34) Type 2 Diabetes Is Causally Associated With Reduced Serum Osteocalcin: A Genomewide Association and Mendelian Randomization Study, JOURNALOFBONEANDMINERALRESEARCH, 2021, 第 9 作者 通讯作者(35) Analysis of factors influencing patch test reactions: Results from a large- population-based study in Chinese, JOURNAL OF COSMETIC DERMATOLOGY, 2021, 第 9 作者 通讯作者(36) Identification of factors associated with minimal erythema dose variations in a large���scale population study of 22146 subjects, JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2020, (37) A cell-type deconvolution meta-analysis of whole blood EWAS reveals lineage-specific smoking-associated DNA methylation changes, NATURE COMMUNICATIONS, 2020, 第 9 作者 通讯作者(38) Genome-wide scan identified genetic variants associated with skin aging in a Chinese female population, JOURNAL OF DERMATOLOGICAL SCIENCE, 2019, 第 15 作者 通讯作者(39) Genome-wide variants of Eurasian facial shape differentiation and a prospective model of DNA based face prediction, Genome-wide variants of Eurasian facial shape differentiation and a prospective model of DNA based face prediction, 遗传学报:英文版, 2018, 第 15 作者(40) Towards broadening Forensic DNA Phenotyping beyond pigmentation: Improving the prediction of head hair shape from DNA, FORENSIC SCIENCE INTERNATIONAL-GENETICS, 2018, 第 30 作者(41) CETP (Cholesteryl Ester Transfer Protein) Concentration A Genome-Wide Association Study Followed by Mendelian Randomization on Coronary Artery Disease, CIRCULATION-GENOMIC AND PRECISION MEDICINE, 2018, (42) Genome-wide association studies and CRISPR/Cas9-mediated gene editing identify regulatory variants influencing eyebrow thickness in humans, PLOS GENETICS, 2018, 第 36 作者 通讯作者(43) Genome-wide variants of Eurasian facial shape differentiation and a prospective model of DNA based face prediction, JOURNAL OF GENETICS AND GENOMICS, 2018, 第 15 作者 通讯作者(44) Meta-analysis of genome-wide association studies identifies 8 novel loci involved in shape variation of human head hair, HUMAN MOLECULAR GENETICS, 2018, 第 29 作者(45) A Genome-Wide Association Study of Basal Transepidermal Water Loss Finds that Variantsat 9q34.3 Are Associated with SkinBarrier Function, JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2017, 第 13 作者 通讯作者(46) Genetic History of ***'s Uyghurs Suggests Bronze Age Multiple-Way Contacts in Eurasia, MOLECULAR BIOLOGY AND EVOLUTION, 2017, 第 22 作者 通讯作者(47) Indoor PM2.5 exposure affects skin aging manifestation in a Chinese population, SCIENTIFIC REPORTS, 2017, 第 11 作者(48) Genetic variants associated with skin aging in the Chinese Han population, JOURNAL OF DERMATOLOGICAL SCIENCE, 2017, 第 11 作者 通讯作者(49) Multiethnic GWAS Reveals Polygenic Architecture of Earlobe Attachment, AMERICAN JOURNAL OF HUMAN GENETICS, 2017, 第 29 作者 通讯作者(50) Large-scale genome-wide scans do not support petaloid toenail as a Mendelian trait, JOURNAL OF GENETICS AND GENOMICS, 2016, 第 14 作者 通讯作者(51) EDARV370A associated facial characteristics in Uyghur population revealing further pleiotropic effects, HUMAN GENETICS, 2016, 第 17 作者(52) Ancestry variation and footprints of natural selection along the genome in Latin American populations, SCIENTIFIC REPORTS, 2016, 第 4 作者 通讯作者(53) Traffic-Related Air Pollution Contributes to Development of Facial Lentigines: Further Epidemiological Evidence from Caucasians and Asians, JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2016, 第 10 作者 通讯作者(54) Genome-wide scans reveal variants at EDAR predominantly affecting hair straightness in Han Chinese and Uyghur populations, HUMAN GENETICS, 2016, 第 20 作者 通讯作者(55) Epidemiological evidence that indoor air pollution from cooking with solid fuels accelerates skin aging in Chinese women, JOURNAL OF DERMATOLOGICAL SCIENCE, 2015, 第 16 作者(56) Characteristics of dental morphology in the *** Uyghurs and correlation with the EDARV370A variant, SCIENCE CHINA-LIFE SCIENCES, 2014, 第 8 作者 通讯作者(57) Modeling Recent Human Evolution in Mice by Expression of a Selected EDAR Variant, CELL, 2013, 第 2 作者(58) The adaptive variant EDARV370A is associated with straight hair in East Asians, HUMAN GENETICS, 2013, 第 6 作者(59) Genetic Divergence Disclosing a Rapid Prehistorical Dispersion of Native Americans in Central and South America, PLOS ONE, 2012, 第 4 作者(60) Exploring Population Admixture Dynamics via Empirical and Simulated Genome-wide Distribution of Ancestral Chromosomal Segments, AMERICAN JOURNAL OF HUMAN GENETICS, 2012, 第 2 作者(61) X-Chromosomal Genetic Diversity and Linkage Disequilibrium Patterns in Amerindians and Non-Amerindian Populations, AMERICAN JOURNAL OF HUMAN BIOLOGY, 2011, 第 2 作者(62) Epigenome-wide association study on ambient PM2.5 exposure in Han Chinese, the NSPT study, ENVIRONMENTAL RESEARCH, 第 8 作者(63) Comparison between UK Biobank and Shanghai Changfeng suggests distinct hip morphology may contribute to ethnic differences in the prevalence of hip osteoarthritis, OSTEOARTHRITIS AND CARTILAGE, 第 16 作者 通讯作者
科研活动
科研项目
( 1 ) 人类体质特征的遗传基础及其一因多效性, 负责人, 国家任务, 2024-01--2028-12( 2 ) 基于多器官衰老表型组的数据集成和人工智能计算的衰老预警系统, 参与, 国家任务, 2023-01--2024-12( 3 ) 人体外貌特征差异的影响因素及其与健康疾病的关系, 负责人, 地方任务, 2022-09--2025-08( 4 ) 复杂性状与重大疾病解析, 负责人, 中国科学院计划, 2022-07--2027-07( 5 ) 体质表型组队列多组学参比数据的采集, 负责人, 中国科学院计划, 2020-01--2024-12( 6 ) 多维生命组学数据智能整合分析, 负责人, 国家任务, 2018-07--2020-12( 7 ) 亚欧人群色素相关表型的进化与多基因作用机制, 负责人, 国家任务, 2017-01--2019-12( 8 ) 家犬表型组的量化研究及整合解析, 负责人, 中国科学院计划, 2017-01--2019-06( 9 ) 国际人类表型组计划(一期)-人类表型组数据的有效挖掘及分析方法构建, 负责人, 地方任务, 2017-01--2021-12( 10 ) 表型组数据库的构建和遗传分析研究 16JC1400504 2016/7/1 2019/6/30 240, 负责人, 地方任务, 2016-07--2019-06( 11 ) EDA通路基因影响东亚人群形态特征的微进化机制研究, 负责人, 国家任务, 2014-01--2016-12( 12 ) 东亚人群的适应性进化, 负责人, 国家任务, 2014-01--2016-12( 13 ) 国家中央组织部“****”计划, 负责人, 国家任务, 2014-01--2016-12