The proliferation and differentiation mechanism of neuroepithelial cell

The development mechanism of function of visual neural circuit

2000-2005   The Institute of Biophysics, Chinese Academy of  Sciences, Ph.D

1996-2000   Zhejiang University, B.S

   

2005 – 2010  Postdoctoral Fellow, Stowers Institute for Medical Research, USA.

2010 – 2013  Postdoctoral Fellow, The Department of Physiology, Development and  Neuroscience, University of Cambridge, UK 

2013 – Now  Investigator, the Laboratory of Stem Cells and Neurogenesis, The Institute  of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China

   

•  Li, Y., Yu, S., Jia, X., Qiu, X., and He, J.* (2024) Defining morphologically and genetically distinct GABAergic/cholinergic amacrine cell subtypes in the vertebrate retina. PLoS Biol 22: e3002506.
•  Krylov, A., Yu, S., Veen, K., Newton, A., Ye, A., Qin, H., He, J.* and Jusuf, P.* (2023) Heterogeneity in quiescent Müller glia in the uninjured zebrafish retina drive differential responses following photoreceptor ablation. Front. Mol. Neurosci. 16: 1087136
•  Li, Y., Xu, B., Jin, M., Zhang, H., Ren, N., Hu, J.,He, J.* (2023) Homophilic interaction of cell adhesion molecule 3 coordinates retina neuroepithelial cell proliferation. J. Cell Biol. 222(6): (As a cover article, JCB 2023 Special Collection on Stem Cells and Development)
•  Han, R., Jin, M., Xu, G.*, He, J.* (2022) Progressively Decreased HCN1 Channels Results in Cone Morphological Defects in Diabetic Retinopathy. J. Neurosci. 42(43): 8200-12.
•  Jin, M., Zhang, H., Xu, B., Li, Y., Qin, H., Yu, S., He, J.* (2022) Jag2b-Notch3/1b-mediated neuron-to-glia crosstalk controls retinal gliogenesis. EMBO Rep. 23: e54922
•  Zhang, H., Wang, H., Shen, X., Jia, X., Yu, S., Qiu, X., Wang, Y., Du, J.*, Yan, J.* , He, J.* (2021) The landscape of regulatory genes in brain-wide neuronal phenotypes of a vertebrate brain. elife 10: e68224
•  Wang, M., Du, L., Lee, A., Li, Y., Qin, H., He, J.* (2020) Different lineage contexts direct common pro-neural factors to specify distinct retinal cell subtypes. J. Cell Biol. 219: e202003026. (As a cover article, JCB 2021 Special Collection on Editors’picks)
•  Xu, B., Tang, X., Jin, M., Zhang, H., Du, L., Yu, S., He, J.* (2020) Unifying developmental programs for embryonic and postembryonic neurogenesis in the zebrafish retina. Development 147: dev185660. (As a cover article)
•  Wang , H., Yang , Z., Li , X., Huang, D., Yu, S., He , J.*, Li , Y.*, Yan, J.* (2020) Single-cell in vivo imaging of cellular circadian oscillators in zebrafish. PLOS Biol. 18: e3000435
•  Yu,S., He , J.* (2019) Stochastic cell-cycle entry and cell-state-dependent fate outputs of injury-reactivated tectal radial glia in zebrafish eLife : 1-27
•  Tang, X., Gao, J., Jia, X., Zhao, W., Zhang, Y., Pan, W., He , J.* (2017) Bipotent progenitors as embryonic origin of retinal stem cells J. Cell Biol. 216: 1833-1847 (As a cover article, JCB 2018 Special Collection on Stem Cells and Development)
•  He , J.* ，Zhang, G., Almeida, A., Cayouette, M., Simons, B., Harris, W.* (2012) How Variable Clones Build an Invariable Retina Neuron 75: 786-798
•  He , J.* ，Ma, L., Kim, S., Schwartz, J., Santilli, M., Wood, C., Durnin, M., Yu, C.* (2010) Distinct Signals Conveyed by Pheromone Concentrations to the Mouse Vomeronasal Organ J. Neurosci. 30: 7473-7483
•  He, J., Ma, L., Kim, S., Nakai, J., Yu, C.* (2008) Encoding Gender and Individual Information in the Mouse Vomeronasal Organ Science 320: 535-538
•  He, J., Wang, T., Han, P., Yin, Q., Chen, C.* (2007) A novel mechanism underlying the susceptibility of neuronal cells to nitric oxide: the occurrence and regulation of protein S-nitrosylation is the checkpoint J. Neurochem. 102: 1863-1874
•  He, J., Kang, H., Fan, F., Chen, C.* (2004) The endoplasmic reticulum-related events in S-nitrosoglutathione-induced neurotoxicity in cerebellar granule cells Brain Res. 1015: 25-33

Brain complexity is implemented by astounding diversity of cell types connected in appropriate numbers and combinations. The precise control of neural progenitor/stem cell (NPC/NSC) division and differentiation is a prerequisite for the development and maintenance of circuit integrity, plasticity and regeneration. In the laboratory, our present interest is to develop various genetic and optical tools, by which we hope to gain access to the complete development from single stem (progenitor) cells to their progeny-derived neural circuits in distinct brain regions of zebrafish (Danio rerio), and thereby elucidating the fundamental logics underlying the determination of cell number, neuronal diversity, functional property of neural circuits.

已指导学生

徐佰杰  博士研究生  071006-神经生物学  

李艳  博士研究生  071006-神经生物学  

王梅  博士研究生  071006-神经生物学  

张慧  博士研究生  071006-神经生物学  

喻曙光  博士研究生  071006-神经生物学  

杜蕾  博士研究生  071006-神经生物学  

金梦梦  博士研究生  071006-神经生物学  

现指导学生

杨简  博士研究生  071006-神经生物学  

秦慧雯  博士研究生  071006-神经生物学  

李亚男  博士研究生  071006-神经生物学  

王晓鸥  博士研究生  071006-神经生物学  

陇兴涛  硕士研究生  071008-发育生物学